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Engineering Structures, ISSN 0141-0296, 02/2013, Volume 47, pp. 134 - 147
► A model for biochemical, biomechanical and geometrical regulations of bone cells. ► Osteoporosis is affected by ongoing changes in microscopic bone surface... 
Specific surface | Osteoporosis | Geometrical feedback | Bone stiffness | Bone remodelling | Mechanical feedback | REDEFINING WOLFF LAW | POROSITY | CORTICAL BONE | ANABOLIC RESPONSE | SKELETAL STRUCTURAL ADAPTATIONS | ELASTIC PROPERTIES | ANISOTROPIC ELASTICITY | ENGINEERING, CIVIL | LINING CELLS | PARATHYROID-HORMONE | MECHANICAL USAGE SATMU | Analysis | Models
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2014, Volume 9, Issue 3, p. e92368
The gut microbiota (GM) modulates the hosts metabolism and immune system. Probiotic bacteria are defined as live microorganisms which when administered in... 
C-REACTIVE PROTEIN | TRABECULAR BONE | WOMEN | MINERAL DENSITY | IMMUNE-SYSTEM | MULTIDISCIPLINARY SCIENCES | ESTROGEN-RECEPTOR-ALPHA | OSTEOPROTEGERIN LIGAND | REGULATORY T-CELLS | GUT MICROBIOTA | TNF-ALPHA | Bone and Bones - pathology | Ovariectomy - adverse effects | T-Lymphocytes, Regulatory - metabolism | RANK Ligand - metabolism | Body Weight - drug effects | Bone and Bones - drug effects | Lactobacillus - drug effects | Bone Marrow - metabolism | Bone and Bones - metabolism | Inflammation Mediators - metabolism | Female | Minerals - metabolism | Bone Marrow - drug effects | Bone Resorption - etiology | Bone Resorption - blood | Cytokines - metabolism | Mice, Inbred C57BL | Bone Resorption - drug therapy | Biomarkers - blood | Probiotics - pharmacology | Lactobacillus - metabolism | Bone Resorption - prevention & control | Organ Size - drug effects | T-Lymphocytes, Regulatory - drug effects | Animals | Bone Marrow - pathology | Probiotics - therapeutic use | Mice | Osteoprotegerin - metabolism | Transforming Growth Factor beta - metabolism | Probiotics | Ovariectomy | Microbiota (Symbiotic organisms) | Physiological aspects | Bones | T cells | Density | Drinking water | Calcium | Lymphocytes T | Genomes | Arthritis | Immune status | Osteoprotegerin | Bone resorption | Osteoporosis | Microorganisms | Biomedical materials | Microbiota | Lymphocytes | Bone marrow | Bacteria | Tumor necrosis factor-TNF | Biocompatibility | Bone density | Bone loss | Bone (cortical) | Bone composition | Food | Immune system | Calcium (urinary) | Excretion | Gnotobiotics | Cytokines | Nutrition | Immunoregulation | Rheumatology | Inflammation | Tumor necrosis factor-α | IL-1β | Metabolism | Gene expression | Bone mineral content | Medicine | Serum levels | Osteoclastogenesis | Bone mass | Antibiotics | Womens health | Ligands | Bone | Endokrinologi och diabetes | Endocrinology and Diabetes
Journal Article
Journal of Bone and Mineral Research, ISSN 0884-0431, 08/2016, Volume 31, Issue 8, pp. 1541 - 1549
ABSTRACT Although projections from cross‐sectional studies have shown that bone loss leading to osteoporosis begins around menopause in women and later in life... 
ADULTS | CORTICAL POROSITY | BONE MICROARCHITECTURE | HIGH‐RESOLUTION PERIPHERAL QUANTITATIVE TOMOGRAPHY | Cortical porosity | Adults | High-resolution peripheral quantitative tomography | Bone microarchitecture | HIGH-RESOLUTION PERIPHERAL QUANTITATIVE TOMOGRAPHY | POROSITY | SKELETAL SITES | TIBIA | QUANTITATIVE COMPUTED-TOMOGRAPHY | DENSITY | SPINAL TRABECULAR BONE | DISTAL RADIUS | MEN | ENDOCRINOLOGY & METABOLISM | HR-PQCT | POSTMENOPAUSAL WOMEN | Prospective Studies | Age Factors | Humans | Middle Aged | Radius - physiology | Tibia - anatomy & histology | Tomography, X-Ray Computed - methods | Male | Radius - anatomy & histology | Young Adult | Bone and Bones - anatomy & histology | Cortical Bone - anatomy & histology | Cancellous Bone - diagnostic imaging | Bone and Bones - diagnostic imaging | Aged, 80 and over | Adult | Cortical Bone - physiology | Female | Cancellous Bone - physiology | Bone Density | Bone and Bones - physiology | Tibia - physiology | Tibia - diagnostic imaging | Sex Characteristics | Absorptiometry, Photon | Aging - physiology | Cancellous Bone - anatomy & histology | Aged | Porosity | Cortical Bone - diagnostic imaging | Radius - diagnostic imaging | Osteoporosis | Bones | Postmenopausal women | Density | Epidemiology | Menopause | Women | Radius | Population studies | Bone (trabecular) | Post-menopause | Fractures | Computed tomography | Tibia | Hormone replacement therapy | Bone mineral density | Bone loss | Bone (cortical) | Bone strength | Age | Index Medicus
Journal Article
Journal of Bone and Mineral Research, ISSN 0884-0431, 09/2012, Volume 27, Issue 9, pp. 1936 - 1950
Like bone mass, bone quality is specified in development, actively maintained postnatally, and disrupted by disease. The roles of osteoblasts, osteoclasts, and... 
MATRIX METALLOPROTEINASE–13 | OSTEOCYTE | REMODELING | FRACTURE RESISTANCE | BONE QUALITY | OSTEOCYTE PERILACUNAR REMODELING | BONE MATRIX | MATRIX METALLOPROTEINASE-13 | CORTICAL BONE | BIOCHEMICAL MARKERS | CALCIUM DEFICIENCY | MECHANICAL-PROPERTIES | GROWTH-FACTOR-BETA | BIOMECHANICAL PROPERTIES | 1-YEAR TREATMENT | CANCELLOUS BONE | AGE-RELATED-CHANGES | NONENZYMATIC GLYCATION | ENDOCRINOLOGY & METABOLISM | Bone Matrix - metabolism | Lactation | Bone Matrix - diagnostic imaging | Osteocytes - enzymology | X-Ray Microtomography | Tibia - pathology | Matrix Metalloproteinase 13 - deficiency | Fractures, Bone - enzymology | Female | Fractures, Bone - diagnostic imaging | Tibia - physiopathology | Tibia - enzymology | Bone Resorption - physiopathology | Osteoclasts - pathology | Tibia - diagnostic imaging | Organ Size | Osteoclasts - metabolism | Bone Matrix - pathology | Matrix Metalloproteinase 13 - metabolism | Protein Transport | Bone Resorption - diagnostic imaging | Collagen - metabolism | Osteoblasts - pathology | Biomechanical Phenomena | Animals | Calcification, Physiologic | Bone Resorption - pathology | Fractures, Bone - physiopathology | Osteocytes - pathology | Fractures, Bone - pathology | Mice | Osteoblasts - metabolism | Bone Remodeling | Osteogenesis | Biological products | Fractures | Phosphatases | Collagen | Analysis | Stem cells | Bones | Health aspects | Density | Bone remodelling | Mechanical properties | Osteocytes | SOST protein | Matrix metalloproteinase | Collagenase 3 | Osteoblasts | Diaphysis | Bone histomorphometry | Bone mass | Molecular modelling | Cross-linking | Extracellular matrix | Osteoclasts | Acid phosphatase (tartrate-resistant) | Bone loss | Bone matrix | matrix metalloproteinase-13 | remodeling | fracture resistance | bone matrix | osteocyte | bone quality | osteocyte perilacunar remodeling
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2014, Volume 9, Issue 5, p. e95144
Adult Ibsp-knockout mice (BSP-/-) display shorter stature, lower bone turnover and higher trabecular bone mass than wild type, the latter resulting from... 
OSTEOCLASTOGENESIS | OSTEOPONTIN | DEFECTS | CHONDROCYTES | MULTIDISCIPLINARY SCIENCES | ARCHITECTURE | PLATE | Osteopontin - blood | Osteopontin - genetics | Osteopontin - deficiency | Male | Insulin-Like Growth Factor I - genetics | Mice, 129 Strain | Growth Plate - growth & development | Behavior, Animal | Hedgehog Proteins - genetics | Bone Resorption - genetics | Gene Expression Regulation, Developmental | Female | Tibia - growth & development | Tibia - metabolism | Femur - growth & development | Osteogenesis - genetics | Animals, Newborn | Femur - metabolism | Growth Plate - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Osteoclasts - metabolism | Mice, Knockout | Animals | Bone Development - genetics | Osteoblasts - metabolism | Bones | Growth | Density | Analysis | Neonates | Femur | Insulin-like growth factor I | Bone sialoprotein | Insulin-like growth factors | Birth | Bone (trabecular) | Accumulation | Bone resorption | Cartilage | Genotype & phenotype | Reproductive behavior | Biomedical materials | Bone growth | Mineralization | Tibia | Rodents | Sutures | Biocompatibility | Bone (cortical) | Bone (endochondral) | Genotypes | Cbfa-1 protein | Heredity | Bone turnover | Gene expression | Mutants | Childbirth & labor | Bone mass | Hedgehog protein | Skull | Bone mineral density | Adults | Mice | Bone (long) | Bone | Osteogenesis
Journal Article
Nature Medicine, ISSN 1078-8956, 09/2017, Volume 23, Issue 9, pp. 1072 - 1079
Aging is associated with increased cellular senescence, which is hypothesized to drive the eventual development of multiple comorbidities(1). Here we... 
MEDICINE, RESEARCH & EXPERIMENTAL | CELLS | SECRETORY PHENOTYPE | BIOCHEMISTRY & MOLECULAR BIOLOGY | MATURE | IDENTIFICATION | CELL BIOLOGY | OSTEOCLASTOGENESIS | ACTIVATOR | MASS | ESTROGEN | FRACTURES | DYSFUNCTION | Osteocytes - drug effects | Cancellous Bone - metabolism | beta-Galactosidase | Cellular Senescence - drug effects | Apoptosis - genetics | Cancellous Bone - drug effects | Gene Expression Profiling | Osteoclasts - cytology | Bone and Bones - drug effects | Caspase 8 - genetics | Flow Cytometry | Osteoporosis - metabolism | Bone and Bones - metabolism | Osteoporosis - genetics | Cell Differentiation | Osteoblasts - cytology | Real-Time Polymerase Chain Reaction | Pyrazoles - pharmacology | Cellular Senescence - genetics | Osteoblasts - drug effects | Mice, Transgenic | Absorptiometry, Photon | Cortical Bone - metabolism | Janus Kinases - antagonists & inhibitors | Culture Media, Conditioned | Animals | Cortical Bone - drug effects | Weight-Bearing | Mice | In Vitro Techniques | Osteoclasts - drug effects | Prevention | Osteoporosis | Aging | Physiological aspects | Genetic aspects | Research | Cells | Senescence | Bone (trabecular) | Suicide | Bone resorption | Bone growth | Biomedical materials | Mineralization | Rodents | Computer architecture | Biocompatibility | Inhibition | Conditioning | Bone loss | Bone (cortical) | Suicide genes | Age | Cardiovascular system | Cell survival | Aging (artificial) | Caspase | Pharmacology | Secretome | Inflammation | Insulin | Osteoclastogenesis | Caspase-8 | Bone mass | Cellular biology | Sensitivity enhancement | Bone | In vitro methods and tests | Osteogenesis | Disease prevention | Osteoclast | Drug therapy | Osteocyte
Journal Article
Journal of Bone and Mineral Research, ISSN 0884-0431, 01/2017, Volume 32, Issue 1, pp. 24 - 33
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