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Journal Article
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 04/2011, Volume 31, Issue 17, pp. 6518 - 6526
Orexin-A and orexin-B are hypothalamic neuropeptides that play critical roles in the maintenance of wakefulness. Intracerebroventricular (ICV) administration... 
TEGMENTAL NEURONS | IN-VITRO | HUMAN NARCOLEPSY | MOLECULAR-CLONING | RAT-BRAIN | SEROTONIN NEURONS | KNOCKOUT MICE | TUBEROMAMMILLARY NUCLEUS | NEUROSCIENCES | HYPOCRETIN OREXIN | WAKEFULNESS | Intracellular Signaling Peptides and Proteins - pharmacology | Receptors, Neuropeptide - deficiency | Wakefulness - drug effects | Oligodeoxyribonucleotides, Antisense - pharmacology | Vesicular Acetylcholine Transport Proteins - genetics | Vesicular Monoamine Transport Proteins - metabolism | Male | Electroencephalography | Brain - physiology | Antigens, Surface - physiology | Brain - metabolism | Dose-Response Relationship, Drug | Vesicular Acetylcholine Transport Proteins - metabolism | Neuropeptides - pharmacology | Neurotransmitter Agents - pharmacology | Sleep Stages - physiology | Electromyography | Receptors, Cell Surface - physiology | Receptors, Neuropeptide - physiology | Receptors, G-Protein-Coupled - physiology | Orexins | Wakefulness - genetics | Mice, Inbred C57BL | Antigens, Surface - genetics | Receptors, Neuropeptide - genetics | Glutamate Decarboxylase - genetics | Orexin Receptors | Sleep Stages - drug effects | Mice, Knockout | Brain - drug effects | Animals | Receptors, G-Protein-Coupled - deficiency | Analysis of Variance | Receptors, Cell Surface - deficiency | Vesicular Monoamine Transport Proteins - genetics | Sleep Stages - genetics | Glutamate Decarboxylase - metabolism | Wakefulness - physiology | Mice | Receptors, G-Protein-Coupled - genetics | Models, Neurological | Injections, Intraventricular - methods | Receptors, Cell Surface - genetics | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 4/2013, Volume 110, Issue 15, pp. 5864 - 5869
Journal Article
American Journal of Respiratory Cell and Molecular Biology, ISSN 1044-1549, 12/2010, Volume 43, Issue 6, pp. 662 - 673
Sphingosine 1-phosphate(S1P) is a key endogenous regulator of the response to lung injury, maintaining endothelial barrier integrity through interaction with... 
S1P | Fibrosis | Vascular leak | Lung injury | Sphingosine 1-phosphate | ORAL FINGOLIMOD FTY720 | BIOCHEMISTRY & MOLECULAR BIOLOGY | BARRIER INTEGRITY | PRODUCTION IN-VIVO | RANDOMIZED CONTROLLED-TRIAL | NOVO RENAL-TRANSPLANTATION | CELL BIOLOGY | CIRCULATING MATURE LYMPHOCYTES | lung injury | MULTIPLE-SCLEROSIS | INDUCED PULMONARY-FIBROSIS | PROTEIN-COUPLED RECEPTOR | RESPIRATORY SYSTEM | vascular leak | fibrosis | GROWTH-FACTOR | sphingosine 1-phosphate | Lysophospholipids - metabolism | Lung Injury - pathology | Pneumonia - physiopathology | Vascular Diseases - pathology | Vascular Diseases - complications | Humans | Pneumonia - pathology | Male | Lung Injury - mortality | Bleomycin | Oxadiazoles - pharmacology | beta-Alanine - pharmacology | Pulmonary Alveoli - drug effects | Sphingosine - metabolism | Pulmonary Alveoli - physiopathology | Receptors, Lysosphingolipid - metabolism | beta-Alanine - analogs & derivatives | Propylene Glycols - pharmacology | Pulmonary Alveoli - pathology | Endothelial Cells - metabolism | Mice, Inbred C57BL | Fingolimod Hydrochloride | Thiophenes - pharmacology | Vascular Diseases - physiopathology | Sphingosine - pharmacology | Lung Injury - physiopathology | Sphingosine - analogs & derivatives | Animals | Blood Coagulation - drug effects | Signal Transduction - drug effects | Survival Analysis | Pneumonia - complications | Receptors, Lysosphingolipid - agonists | Lung Injury - complications | Mice | Endothelial Cells - pathology | Endothelial Cells - drug effects | Index Medicus | sphingosine 1–phosphate | S1P1
Journal Article
Endocrinology, ISSN 0013-7227, 02/2012, Volume 153, Issue 2, pp. 672 - 682
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 08/2010, Volume 285, Issue 35, pp. 26798 - 26805
Journal Article
Journal Article
Breast Cancer Research and Treatment, ISSN 0167-6806, 4/2012, Volume 132, Issue 2, pp. 565 - 573
Metabotropic glutamate receptors are G-protein-coupled receptors normally expressed in the central nervous system where they mediate neuronal excitability,... 
Oncology | mGluR1 | Breast cancer | Medicine & Public Health | GRM1 | Apoptosis | TRANSFORMATION | RILUZOLE | ACTIVATION | GLUTAMATE-RECEPTOR-1 | PROTEIN-COUPLED RECEPTORS | AMYOTROPHIC-LATERAL-SCLEROSIS | NEUROPROTECTION | MELANOMA | ONCOLOGY | SIGNALING PATHWAY | LONG-TERM DEPRESSION | Receptors, Metabotropic Glutamate - drug effects | Apoptosis - drug effects | Humans | Receptors, Metabotropic Glutamate - metabolism | Antineoplastic Agents - administration & dosage | Breast Neoplasms - metabolism | Dose-Response Relationship, Drug | Transfection | RNA Interference | Receptors, Metabotropic Glutamate - genetics | Time Factors | Female | Antineoplastic Agents - pharmacology | Injections, Intraperitoneal | Excitatory Amino Acid Antagonists - administration & dosage | Excitatory Amino Acid Agonists - pharmacology | Excitatory Amino Acid Antagonists - pharmacology | Breast Neoplasms - drug therapy | Naphthalenes - pharmacology | Riluzole - administration & dosage | Xenograft Model Antitumor Assays | Phenotype | Animals | Breast Neoplasms - genetics | Signal Transduction - drug effects | Tumor Burden - drug effects | Breast Neoplasms - pathology | Mice, Nude | Naphthalenes - administration & dosage | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Riluzole - pharmacology | Quisqualic Acid - pharmacology | Care and treatment | Melanoma | Amino acids | Drug therapy | Glutamate | Health aspects | Riluzole | Cancer | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2015, Volume 10, Issue 3, pp. e0119715 - e0119715
Long chain fatty acids (LCFAs), which are ligands for the G-protein coupled receptor FFAR1 (GPR40), are increased in cow plasma after parturition, a period in... 
ACTIVATION | INTRACELLULAR CALCIUM MOBILIZATION | SUPEROXIDE-PRODUCTION | GRANULE RELEASE | MULTIDISCIPLINARY SCIENCES | INSULIN-SECRETION | PHOSPHOLIPASE-C | OLEIC-ACID | BETA-GAMMA-SUBUNITS | GPR40 | MAPK PHOSPHORYLATION | Propionates - pharmacology | Neutrophils - cytology | Reactive Oxygen Species - metabolism | Cricetulus | Receptors, G-Protein-Coupled - metabolism | Calcium - metabolism | Linoleic Acid - metabolism | Humans | Molecular Sequence Data | Type C Phospholipases - metabolism | Calcium - analysis | Recombinant Proteins - biosynthesis | Type C Phospholipases - antagonists & inhibitors | Matrix Metalloproteinase 9 - metabolism | Cattle | Estrenes - pharmacology | Pyrrolidinones - pharmacology | Cloning, Molecular | Ion Transport - drug effects | Methylamines - pharmacology | Neutrophils - metabolism | CHO Cells | Amino Acid Sequence | Cricetinae | Oleic Acid - metabolism | Neutrophils - drug effects | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Sequence Alignment | Animals | Receptors, G-Protein-Coupled - genetics | Receptors, G-Protein-Coupled - chemistry | Monounsaturated fatty acids | Analysis | Cloning | Parturition | Reactive oxygen species | Protein kinase C | G protein-coupled receptors | Calcium | Laboratories | Science | Chains | Homology | Matrix metalloproteinase | Kinases | Proteins | Oleic acid | Rodents | Physiology | Metalloproteinase | Chain mobility | Calcium mobilization | Calcium (intracellular) | Propionic acid | Neutrophils | Leukocytes (neutrophilic) | Pharmacology | Breast cancer | Fatty acids | Insulin | Linoleic acid | Phospholipase C | Phospholipase | Infectious diseases | Ligands | Intracellular | Index Medicus
Journal Article
Journal Article