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2016, Methods in pharmacology and toxicology, ISBN 1493937960
Web Resource
2016, Methods in pharmacology and toxicology, ISBN 1493937960
Web Resource
03/2012
The role of NMDAR subtypes in synaptic plasticity is very controversial, partially caused by the lack of specific GluN2A containing NMDA receptor (GluN2AR)... 
G protein coupled receptor | NMDA receptor | 0317
Dissertation
NATURE, ISSN 0028-0836, 09/2011, Volume 477, Issue 7366, pp. 549 - U311
G protein-coupled receptors (GPCRs) are responsible for the majority of cellular responses to hormones and neurotransmitters as well as the senses of sight,... 
CRYSTALLIZATION | LIPIDIC MESOPHASES | ALPHA-SUBUNIT | MULTIDISCIPLINARY SCIENCES | COUPLED RECEPTOR | MEDIATED ACTIVATION | MEMBRANE-PROTEINS | ADENYLATE-CYCLASE | BINDING | BETA-ADRENERGIC RECEPTOR | INSIGHTS
Journal Article
NATURE, ISSN 0028-0836, 10/2013, Volume 502, Issue 7472, pp. 575 - 575
G-protein-coupled receptors (GPCRs) are integral membrane proteins that have an essential role in human physiology, yet the molecular processes through which... 
ADRENOCEPTOR | COMPLEX | DISPLAY | LIGAND-BINDING | SERINE | PROTEIN-COUPLED RECEPTOR | MULTIDISCIPLINARY SCIENCES | RHODOPSIN | STATE | ADRENERGIC-RECEPTOR | AGONIST
Journal Article
NATURE, ISSN 0028-0836, 05/2014, Volume 509, Issue 7498, pp. 115 - 118
P2Y receptors (P2YRs), a family of purinergic G-protein-coupled receptors (GPCRs), are activated by extracellular nucleotides. There are a total of eight... 
ACTIVATION | NUCLEOTIDE RECEPTORS | CLOPIDOGREL | INHIBITION | PROTEIN-COUPLED RECEPTOR | CRYSTAL-STRUCTURE | AMINO-ACIDS | MULTIDISCIPLINARY SCIENCES | ANTAGONISTS | IDENTIFICATION | ACTIVE METABOLITE
Journal Article
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, ISSN 0002-7863, 08/2010, Volume 132, Issue 33, pp. 11443 - 11445
G protein-coupled receptors (GPCRs) represent a large fraction of current pharmaceutical targets, and of the GPCRs, the beta(2) adrenergic receptor (beta(2)AR)... 
CONFORMATIONAL-CHANGES | PROTEIN-COUPLED RECEPTOR | LIGAND | CHEMISTRY, MULTIDISCIPLINARY | BETA-ADRENERGIC RECEPTOR | PREDICTION
Journal Article
NATURE, ISSN 0028-0836, 08/2015, Volume 524, Issue 7565, pp. 315 - 315
Activation of the mu-opioid receptor (mu OR) is responsible for the efficacy of the most effective analgesics. To shed light on the structural basis for mu OR... 
CRYSTALLIZING MEMBRANE-PROTEINS | COMPLEX | LIPIDIC MESOPHASES | PROTEIN-COUPLED RECEPTOR | MULTIDISCIPLINARY SCIENCES | FORCE-FIELD | ADRENERGIC-RECEPTOR | MOLECULAR-DYNAMICS SIMULATIONS | CHARMM | MICE LACKING | MUSCARINIC ACETYLCHOLINE-RECEPTOR
Journal Article
Journal of Molecular Biology, ISSN 0022-2836, 10/2011, Volume 413, Issue 3, pp. 628 - 638
Conformational thermostabilisation of G-protein-coupled receptors is a successful strategy for their structure determination. The thermostable mutants tolerate... 
membrane protein, thermostabilisation | G-protein-coupled receptor
Journal Article
CELL, ISSN 0092-8674, 05/2015, Volume 161, Issue 5, pp. 1101 - 1111
G-protein-coupled receptors (GPCRs) transduce signals from the extracellular environment to intracellular proteins. To gain structural insight into the... 
ADRENOCEPTOR | ACTIVATION | COMPLEX | MECHANISM | PROTEIN-COUPLED RECEPTOR | CRYSTAL-STRUCTURE | KINETICS | BIOCHEMISTRY & MOLECULAR BIOLOGY | EQUILIBRIUM | RHODOPSIN | CONFORMATIONAL STATES | CELL BIOLOGY
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2011, Volume 108, Issue 38, pp. 16086 - 16091
Journal Article
NATURE, ISSN 0028-0836, 08/2015, Volume 524, Issue 7565, pp. 375 - 375
mu-Opioid receptors (mu ORs) are G-protein-coupled receptors that are activated by a structurally diverse spectrum of natural and synthetic agonists including... 
DYNAMIC PROCESS | COMPLEX | EFFICACY | PROTEIN-COUPLED RECEPTOR | CRYSTAL-STRUCTURE | NMR-SPECTROSCOPY | MULTIDISCIPLINARY SCIENCES | RHODOPSIN | BETA-ADRENERGIC RECEPTOR | ANALGESIA | AGONIST
Journal Article
Nature, ISSN 0028-0836, 07/2011, Volume 475, Issue 7354, pp. 65 - 72
The biogenic amine histamine is an important pharmacological mediator involved in pathophysiological processes such as allergies and inflammations. Histamine... 
H1 RECEPTOR | PROTEIN-COUPLED RECEPTOR | STRUCTURE-BASED DISCOVERY | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | BINDING-SITE | ANTAGONISTS | SITE-DIRECTED MUTAGENESIS | MUTATIONAL ANALYSIS | A(2A) ADENOSINE RECEPTOR | AGONIST
Journal Article
SCIENCE, ISSN 0036-8075, 04/2011, Volume 332, Issue 6027, pp. 322 - 327
Activation of G protein-coupled receptors upon agonist binding is a critical step in the signaling cascade for this family of cell surface proteins. We report... 
SUBTYPE-SELECTIVITY | COMPLEX | CONFORMATIONAL-CHANGES | ANTAGONIST | CRYSTAL-STRUCTURE | LIGAND RECOGNITION | MULTIDISCIPLINARY SCIENCES | BINDING-SITE | ALLOSTERIC MODULATION | RESIDUES | PROTEIN-COUPLED-RECEPTOR | Adenosine | Research | Properties | Protein binding
Journal Article
NATURE, ISSN 0028-0836, 09/2011, Volume 477, Issue 7366, pp. 611 - U143
G protein-coupled receptors represent the largest family of membrane receptors(1) that instigate signalling through nucleotide exchange on heterotrimeric G... 
ACTIVATION | HETEROTRIMERIC G-PROTEINS | MECHANISM | INTERFACE | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | COUPLED RECEPTOR | DYNAMICS | EXCHANGE | MASS-SPECTROMETRY | HYDROGEN/DEUTERIUM
Journal Article
SCIENCE, ISSN 0036-8075, 03/2012, Volume 335, Issue 6072, pp. 1106 - 1110
Extracellular ligand binding to G protein-coupled receptors (GPCRs) modulates G protein and beta-arrestin signaling by changing the conformational states of... 
PARTIAL AGONISTS | BETA-2-ADRENERGIC RECEPTOR | BETA ADRENERGIC-RECEPTOR | CONFORMATIONAL-CHANGES | LIGAND-BINDING | PROTEIN-COUPLED RECEPTOR | TRANSMEMBRANE RECEPTORS | CRYSTAL-STRUCTURE | NMR-SPECTROSCOPY | MULTIDISCIPLINARY SCIENCES | A(2A) ADENOSINE RECEPTOR
Journal Article
Circulation Research, ISSN 0009-7330, 06/2009, Volume 104, Issue 12, pp. 1399 - 1409
TRPC6 is a non-voltage-gated Ca entry/depolarization channel associated with vascular tone regulation and remodeling. Expressed TRPC6 channel responds to both... 
Entry channel | Gq/11 protein coupled receptor | Mechanotransduction | Ca2
Journal Article
FEBS Letters, ISSN 0014-5793, 05/2019, Volume 593, Issue 10, pp. 1113 - 1121
Large membrane proteins such as G protein‐coupled receptors ( GPCR s) are difficult for NMR study due to severe signal overlaps and unfavorable relaxation... 
adrenergic receptor | trimethylsilylmethanethiol | G protein‐coupled receptor | nuclear magnetic resonance
Journal Article
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