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PLoS ONE, ISSN 1932-6203, 01/2012, Volume 7, Issue 1, p. e28936
The Clinic for Special Children (CSC) has integrated biochemical and molecular methods into a rural pediatric practice serving Old Order Amish and Mennonite... 
DOMAIN | POSTERIOR COLUMN ATAXIA | INTERACTING PROTEIN | MULTIDISCIPLINARY SCIENCES | C-MYC | SNIP1 | DEATH | TRANSFER-RNA | MUTATIONS | IDENTIFICATION | DISCOVERY | Seizures - genetics | Microtubule-Associated Proteins - genetics | CRADD Signaling Adaptor Protein | Humans | Child, Preschool | Infant | Amino Acyl-tRNA Synthetases | Receptors, Virus - genetics | Intellectual Disability - genetics | Amish - genetics | Ethnic Groups - genetics | Usher Syndromes - genetics | Membrane Transport Proteins - genetics | Chromosome Mapping - methods | Epilepsy - genetics | Parkinsonian Disorders - genetics | Nuclear Proteins - genetics | Child | Intracellular Signaling Peptides and Proteins - genetics | Infant, Newborn | Genetic Predisposition to Disease - genetics | Genetic Association Studies - methods | Dopamine Plasma Membrane Transport Proteins - genetics | Exome - genetics | Polymorphism, Single Nucleotide | Sequence Analysis, DNA - methods | Genetic aspects | Nucleotide sequencing | Single nucleotide polymorphisms | DNA sequencing | Neurosciences | Disease | Genes | Business improvement districts | Mapping | Biology | Single-nucleotide polymorphism | Gene polymorphism | Population genetics | Data bases | Gene sequencing | Coupling (molecular) | Enterprise zones | Lists | Children | Pathogens | Nuclear electric power generation | Pathogenicity | Medicine | Hospitals | DNA microarrays | Genotyping | Mutation | Gene mapping | Polymorphism
Journal Article
Cell, ISSN 0092-8674, 2004, Volume 116, Issue 1, pp. 75 - 86
Gene expression is a coordinated multistep process that begins with transcription and RNA processing in the nucleus followed by mRNA export to the cytoplasm... 
HNRNP-LIKE PROTEINS | YEAST | COACTIVATOR | POLY(A)(+) RNA | INTERACTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VIVO | COUPLING TRANSCRIPTION | QUALITY-CONTROL | SACCHAROMYCES-CEREVISIAE | NUCLEOCYTOPLASMIC TRANSPORT | CELL BIOLOGY | Nucleocytoplasmic Transport Proteins | RNA-Binding Proteins - genetics | Yeasts | Acetyltransferases - metabolism | Transcriptional Activation - genetics | Histone Acetyltransferases | Nuclear Proteins - isolation & purification | Active Transport, Cell Nucleus - physiology | DNA, Complementary - genetics | Molecular Sequence Data | Amino Acid Sequence - genetics | RNA, Messenger - metabolism | RNA-Binding Proteins - isolation & purification | Acetyltransferases - genetics | Promoter Regions, Genetic - genetics | Porins | Genes, Regulator - genetics | Cell Nucleus - metabolism | Nuclear Proteins - deficiency | Ribonucleoproteins - genetics | Saccharomyces cerevisiae Proteins - isolation & purification | Gene Expression Regulation, Fungal - genetics | Fungal Proteins - isolation & purification | Nuclear Proteins - genetics | DNA, Complementary - analysis | Base Sequence - genetics | RNA, Messenger - genetics | Nuclear Pore - genetics | Nuclear Proteins - metabolism | Ribonucleoproteins - metabolism | Fungal Proteins - genetics | Saccharomyces cerevisiae Proteins - genetics | Nuclear Pore - metabolism | Genes, Lethal - genetics | Saccharomyces cerevisiae Proteins - metabolism | RNA-Binding Proteins - metabolism | Fungal Proteins - metabolism | Histones | Genetic research | Messenger RNA | Genetic transcription | Research
Journal Article
PLoS Genetics, ISSN 1553-7390, 02/2017, Volume 13, Issue 2, p. e1006508
Recent advances in the scale and diversity of population genomic datasets for bacteria now provide the potential for genome-wide patterns of co-evolution to be... 
STATISTICAL-METHODS | PENICILLIN RESISTANCE | TRANSMISSION | STREPTOCOCCUS-PNEUMONIAE | EVOLUTION | RESIDUE CONTACTS | GENETICS & HEREDITY | MODEL | MUTATIONS | DIRECT-COUPLING ANALYSIS | PROTEINS | beta-Lactams - metabolism | Genetics, Population | Streptococcus pneumoniae - drug effects | Gene Regulatory Networks - genetics | Peptidyl Transferases - genetics | Streptococcus pyogenes - drug effects | Genomics | Humans | Aminoacyltransferases - genetics | Bacterial Proteins - genetics | Genotype | Penicillin-Binding Proteins - genetics | Selection, Genetic - genetics | Microbial Sensitivity Tests | Streptococcus pyogenes - genetics | Anti-Bacterial Agents - therapeutic use | Genome, Bacterial - genetics | Streptococcus pyogenes - pathogenicity | Penicillin-Binding Proteins - chemistry | Streptococcus pneumoniae - pathogenicity | Epistasis, Genetic | Streptococcus pneumoniae - genetics | beta-Lactam Resistance - genetics | Drug resistance in microorganisms | Virulence (Microbiology) | Analysis | Statistical analysis | Funding | Genes | Colleges & universities | Biology | Genomes | Machinery | Streptococcus infections | Proteins | Medicine | Computer science | Datasets | Pathology | Hypotheses | Infectious diseases | Population | Dihydrofolate reductase | Biological Sciences | Naturvetenskap | Natural Sciences | Biologiska vetenskaper
Journal Article
Nucleic Acids Research, ISSN 0305-1048, 02/2014, Volume 42, Issue 4, pp. 2366 - 2379
Sub-inhibitory concentrations (sub-MIC) of antibiotics play a very important role in selection and development of resistances. Unlike Escherichia coli, Vibrio... 
WATER TREATMENT PLANTS | GENOME INSTABILITY | NUCLEOTIDE-EXCISION-REPAIR | WASTE-WATER | BIOCHEMISTRY & MOLECULAR BIOLOGY | REPAIR COUPLING FACTOR | ESCHERICHIA-COLI | IN-VIVO | BACTERICIDAL ANTIBIOTICS | STABLE DNA-REPLICATION | RNA-POLYMERASE | Tobramycin - pharmacology | Escherichia coli - radiation effects | Vibrio cholerae - enzymology | Ultraviolet Rays | Gene Deletion | SOS Response (Genetics) | MutS DNA Mismatch-Binding Protein - genetics | Transcription, Genetic | DNA Helicases - genetics | Genes, Bacterial | Transcription Factors - physiology | Vibrio cholerae - genetics | Bacterial Proteins - genetics | Transcription Factors - genetics | Bacterial Proteins - physiology | Transcription Factors - metabolism | DNA Helicases - metabolism | Bacterial Proteins - metabolism | Anti-Bacterial Agents - pharmacology | DNA Damage | Mutation | DNA-Directed RNA Polymerases - metabolism | Vibrio cholerae - drug effects | DNA Helicases - physiology | Ribonuclease H - metabolism | Anti-Bacterial Agents/pharmacology | Transcription Factors/physiology | Life Sciences | DNA Helicases/metabolism | MutS DNA Mismatch-Binding Protein/genetics | Transcription Factors/metabolism | Vibrio cholerae/drug effects | DNA-Directed RNA Polymerases/metabolism | Ribonuclease H/metabolism | Genetics | DNA Helicases/physiology | Tobramycin/pharmacology | Vibrio cholerae/genetics | Biochemistry, Molecular Biology | DNA Helicases/genetics | Transcription Factors/genetics | Escherichia coli/radiation effects | Bacteriology | Microbiology and Parasitology | Bacterial Proteins/metabolism | Bacterial Proteins/genetics | Vibrio cholerae/enzymology | Bacterial Proteins/physiology | Molecular biology | Genome Integrity, Repair and
Journal Article
Journal Article
Nature Structural & Molecular Biology, ISSN 1545-9993, 02/2005, Volume 12, Issue 2, pp. 175 - 182
Journal Article
American Journal of Medical Genetics Part A, ISSN 1552-4825, 10/2015, Volume 167, Issue 10, pp. 2366 - 2374
We report on clinical, genetic and metabolic investigations in a family with optic neuropathy, non‐progressive cardiomyopathy and cognitive disability.... 
mitochondrial tRNA | mtDNA | mitochondria | optic neuropathy | cognitive disability | cardiomyopathy | MTO1 | respiratory chain | Mitochondria | MtDNA | Respiratory chain | Optic neuropathy | Cardiomyopathy | Cognitive disability | Mitochondrial tRNA | HUMANS | DISORDERS | COUPLING DEFECT | HYPERTROPHIC CARDIOMYOPATHY | DATABASE | DNA | DISEASE | GENETICS & HEREDITY | LACTIC-ACIDOSIS | TRANSFER-RNA | Electron Transport Complex III - genetics | Humans | Middle Aged | Optic Nerve Diseases - diagnosis | Intellectual Disability - complications | Male | Intellectual Disability - genetics | Optic Nerve Diseases - pathology | Cardiomyopathies - genetics | Optic Nerve Diseases - complications | DNA Mutational Analysis | Electron Transport Complex I - genetics | Cardiomyopathies - diagnosis | Optic Disk - metabolism | Membrane Potential, Mitochondrial - genetics | Adult | Female | Gene Expression | Electron Transport Complex II - genetics | RNA, Transfer, Phe - genetics | Intellectual Disability - pathology | Cardiomyopathies - pathology | Mitochondria - metabolism | Electron Transport Complex IV - genetics | Mitochondria - pathology | Visual Acuity | Optic Nerve Diseases - genetics | Carrier Proteins - genetics | Homozygote | Pedigree | Intellectual Disability - diagnosis | Cardiomyopathies - complications | Mutation | Optic Disk - pathology | Care and treatment | Analysis | Genetic research | Genetic aspects | Mitochondrial DNA | Cognition disorders | Heart diseases | Optic nerve | Cognitive ability | Visual evoked potentials | Neuropathy | Acuity | Electroretinograms | Atrophy | Optic atrophy | Biopsy | Electron transport | DNA sequencing | Life Sciences | Genetics
Journal Article
Nature communications, ISSN 2041-1723, 2013, Volume 4, Issue 1, pp. 1952 - 1952
Excitation-contraction coupling, the process that regulates contractions by skeletal muscles, transduces changes in membrane voltage by activating release of... 
SKELETAL-MUSCLE | RELAXED MUTANTS | CALCIUM-RELEASE CHANNEL | ZEBRAFISH | PROTEIN | RYANODINE RECEPTOR | MULTIDISCIPLINARY SCIENCES | CA2+ CHANNELS | CONGENITAL MYOPATHY | MUTATIONS | REM | Adaptor Proteins, Signal Transducing - chemistry | Central Nervous System - metabolism | Excitation Contraction Coupling | Malignant Hyperthermia - physiopathology | Humans | Embryo, Nonmammalian - metabolism | Central Nervous System - pathology | Molecular Sequence Data | Ryanodine Receptor Calcium Release Channel - metabolism | Cleft Palate - genetics | Myotonia Congenita - physiopathology | RNA, Messenger - metabolism | Touch | Zebrafish - embryology | Mutation, Missense - genetics | Malignant Hyperthermia - genetics | Organ Specificity - genetics | Nerve Tissue Proteins - chemistry | Myofibrils - ultrastructure | Base Sequence | Swimming | Myotonia Congenita - genetics | Amino Acid Sequence | Zebrafish Proteins - chemistry | Zebrafish Proteins - metabolism | RNA, Messenger - genetics | Cleft Palate - physiopathology | Myotonia Congenita - pathology | Mutation - genetics | Nerve Tissue Proteins - genetics | Zebrafish - genetics | Nerve Tissue Proteins - metabolism | Phenotype | Animals | Adaptor Proteins, Signal Transducing - genetics | Alleles | Myofibrils - metabolism | Zebrafish Proteins - genetics | Adaptor Proteins, Signal Transducing - metabolism
Journal Article
Journal Article
The Plant Journal, ISSN 0960-7412, 06/2018, Volume 94, Issue 5, pp. 895 - 909
Journal Article