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European Journal of Pharmacology, ISSN 0014-2999, 04/2019, Volume 848, pp. 105 - 111
Nimesulide is a relatively selective cyclooxygenase (COX)-2 inhibitor, non-steroidal anti-inflammatory drug; it has been discovered in 1971 and firstly... 
Adenosine | Inflammation | Nimesulide | COX-2 | COX-1 | NSAIDs
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 10/2017, Volume 813, pp. 140 - 146
This study aimed to determine whether prostaglandin D (PGD ) is a major uterine cyclooxygenase (COX) product and if so, we wanted to examine the underlying... 
Myometrial contraction | Prostaglandin | COX-1 | Prepartum
Journal Article
Journal of Ethnopharmacology, ISSN 0378-8741, 2011, Volume 136, Issue 1, pp. 75 - 82
Korth (Rubiaceae) is one of the medicinal plants used traditionally to treat various types of diseases especially in Thailand and Malaysia. Its... 
Mitragyna speciosa | COX-2 | COX-1 | Anti-inflammatory | Mitragynine
Journal Article
ACS Chemical Neuroscience, 11/2018, Volume 9, Issue 11, pp. 2620 - 2627
In our preceding paper (Part 1), we identified three 1,5-bis-diaryl-1,2,4-triazole-based compounds that merited evaluation as potential positron emission... 
radioligand | carbon-11 | fluorine-18 | brain | COX-1 | PET
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 09/2019, Volume 27, Issue 17, pp. 3918 - 3928
In the present paper we describe the biological activity of newly designed and synthesized series of pyrrolo[3,4- ]pyrrole Mannich bases ( - ). The Mannich... 
COX-1/COX-2 | Pyrrolo[3,4-c]pyrrole | Mannich bases | Cyclooxygenase inhibition | Molecular docking | ANTIINFLAMMATORY ACTIVITY | CHEMISTRY, MEDICINAL | COX-1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | ANTIBACTERIAL | CHEMISTRY, ORGANIC | CYCLOOXYGENASE | IN-VITRO | ANTICANCER | BIOLOGICAL EVALUATION | CHALCONES | DERIVATIVES | COX-2 inhibitors | Analysis | Formaldehyde | Resveratrol
Journal Article
ACS Chemical Neuroscience, ISSN 1948-7193, 11/2018, Volume 9, Issue 11, pp. 2620 - 2627
In our preceding paper (Part 1), we identified three 1,5-bis-diaryl-1,2,4-triazole-based compounds that merited evaluation as potential positron emission... 
Brain | carbon-11 | fluorine-18 | Radioligand | COX-1 | PET
Journal Article
Cancer prevention research (Philadelphia, Pa.), ISSN 1940-6207, 2/2017, Volume 10, Issue 2, pp. 142 - 152
The mechanism by which aspirin consumption is linked to significant reductions in the incidence of multiple forms of cancer and metastatic spread to distant... 
aspirin | platelet | chemoprevention | colorectal cancer | COX-1
Journal Article
Cellular Signalling, ISSN 0898-6568, 07/2018, Volume 47, pp. 88 - 100
Melatonin and its metabolites have been demonstrated to modulate the glucose, dyslipidemia and other metabolic disorders. This study aimed to explore a novel... 
Diabetic cardiomyopathy | Melatonin | Syk | SERCA | COX-1 | MIGRATION | STEM-CELLS | ACTIVATION | INJURY | PROLIFERATION | CELL BIOLOGY | SPLEEN TYROSINE KINASE | REACTIVE OXYGEN | EXENDIN-4 | STRESS | INHIBITOR | Tyrosine | Care and treatment | Metabolites | Cardiomyopathy | Superoxide | Glucose | Heart diseases | Dextrose
Journal Article
Medicinal Chemistry Research, ISSN 1054-2523, 08/2012, Volume 21, Issue 8, pp. 1869 - 1875
Journal Article
Acta Informatica Medica, ISSN 0353-8109, 2016, Volume 24, Issue 5, pp. 332 - 337
Virtual molecular dynamic sesquiterpenoid Pogostemon Herba (CID56928117, CID94275, CID107152, and CID519743) have screening as cyclooxygenase (COX-1/COX-2)... 
Molecular dynamic screening | Sesquiterpenoid compounds | Scoring binding energy | COX-1/ COX-2 inhibitor selective | scoring binding energy | Original Paper | molecular dynamic screening | COX-1 | COX-2 inhibitor selective | sesquiterpenoid compounds
Journal Article
Future medicinal chemistry, 07/2019, Volume 11, Issue 13, p. 1583
Cyclooxygenase-2 (COX-2) inhibition and scavenging-free radicals are important targets in cancer treatment. Sulfanylpyrimidines and triazolopyrimidines were... 
Journal Article
ACS Chemical Neuroscience, 11/2018, Volume 9, Issue 11, pp. 2610 - 2619
Cyclooxygenase-1 (COX-1) is a key enzyme in the biosynthesis of proinflammatory thromboxanes and prostaglandins and is found in glial and neuronal cells within... 
radioligand | carbon-11 | fluorine-18 | brain | COX-1 | PET
Journal Article
STROKE, ISSN 0039-2499, 07/2012, Volume 43, Issue 7, pp. 1964 - 1967
Background and Purpose-Cyclooxygenase-2 (COX-2) and Microsomal Prostaglandin E-2 Synthase-1 (mPGES-1) catalyze isomerization of the cyclooxygenase product... 
aneurysm | OVEREXPRESSION | mPGES-1 | COX-2 | inflammation | COX-1 | PERIPHERAL VASCULAR DISEASE | STRESS | PLAQUE | EXPRESSION | CLINICAL NEUROLOGY
Journal Article
International Journal of Oncology, ISSN 1019-6439, 11/2010, Volume 37, Issue 5, pp. 1143 - 1152
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 10/2019, Volume 180, pp. 86 - 98
The aim of this study was to design and synthesize COX-1/COX-2 balanced inhibitors incorporating the structural motifs of anti-inflammatory ascidian... 
COX-1/COX-2 | Anti-Inflammatory | Balanced inhibition | Indole | NF-κB pathway | Ascidian metabolite
Journal Article
Inflammation Research, ISSN 1023-3830, 12/2011, Volume 60, Issue 12, pp. 1083 - 1092
Journal Article
The American Journal of Sports Medicine, ISSN 0363-5465, 4/2019, Volume 47, Issue 5, pp. 1223 - 1229
Background: The benefits of platelet-rich plasma (PRP) are believed to be in part dependent on growth factor release after platelet activation. Platelet... 
aspirin | activation | COX-1 | NSAIDs | platelet rich plasma | SPORT SCIENCES | THROMBIN | MECHANISMS | ORTHOPEDICS | Blood platelets | Laboratories | Vascular endothelial growth factor
Journal Article
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