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Neurochemical Research, ISSN 0364-3190, 9/2012, Volume 37, Issue 9, pp. 1886 - 1897
Methyl CpG binding protein-2 (MeCP2) is a multifunctional nuclear protein, and regulates dendritic morphology, synaptic transmission, spontaneous... 
Biochemistry, general | Neurochemistry | Neurology | Neurosciences | Biomedicine | Synaptic transmission | Methyl CpG binding protein-2 | Temporal lobe epilepsy | Lithium chloride/pilocarpine epilepsy model | Cell Biology | RETT-SYNDROME | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTIONAL REPRESSION | MECP2 DEFICIENCY | MATURATION | SYNAPTIC PLASTICITY | NEUROSCIENCES | MOUSE MODEL | ANIMAL-MODELS | EXPRESSION | HISTONE DEACETYLASE | BRAIN | Immunohistochemistry | Kindling, Neurologic | Up-Regulation | Humans | Middle Aged | Child, Preschool | Neuronal Plasticity - drug effects | Male | Tomography, X-Ray Computed | Electroencephalography | Hippocampus - drug effects | Cerebral Cortex - metabolism | Actins - genetics | Young Adult | RNA - isolation & purification | Adult | Female | Neurons - metabolism | Cerebral Cortex - drug effects | Neurons - drug effects | Child | Real-Time Polymerase Chain Reaction | Actins - biosynthesis | Rats | Epilepsy, Temporal Lobe - metabolism | Rats, Sprague-Dawley | Methyl-CpG-Binding Protein 2 - biosynthesis | Hippocampus - metabolism | RNA - biosynthesis | Animals | Adolescent | Fluorescent Antibody Technique | Temporal lobe | Animal models | Astrocytes | Lithium chloride | Epilepsy | Central nervous system | Cortex | Gene expression | Trauma | Polymerase chain reaction | Plasticity (synaptic) | Methyl-CpG binding protein | MeCP2 protein | Immunofluorescence | Cortex (temporal) | Hippocampus | Neurotransmission | CpG islands | Seizures
Journal Article
Journal Article
JOURNAL OF NEUROSCIENCE, ISSN 0270-6474, 04/2009, Volume 29, Issue 16, pp. 5051 - 5061
MECP2, an X-linked gene encoding the epigenetic factor methyl-CpG-binding protein-2, is mutated in Rett syndrome (RTT) and aberrantly expressed in autism. Most... 
NEURODEVELOPMENTAL DISORDERS | MOUSE MODEL | DISEASE | BRAIN-DEVELOPMENT | NEURONS | CULTURED ASTROCYTES | MICE | WILD-TYPE MECP2 | CPG-BINDING PROTEIN-2 | EXPRESSION | NEUROSCIENCES
Journal Article
Nature Biotechnology, ISSN 1087-0156, 01/2015, Volume 33, Issue 1, pp. 102 - 106
Probing gene function in the mammalian brain can be greatly assisted with methods to manipulate the genome of neurons in vivo. The clustered, regularly... 
MECP2 | RETT-SYNDROME | REPRESSION | DUAL-RNA | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | TRANSCRIPTION | NEURONS | CAS9 | MODEL | CPG-BINDING PROTEIN-2 | EXPRESSION | Clustered Regularly Interspaced Short Palindromic Repeats - physiology | Streptococcus pyogenes - genetics | Animals | Physiological aspects | Nucleases | Genetic aspects | Research | Genes | Neurophysiology
Journal Article
NEURON, ISSN 0896-6273, 02/2006, Volume 49, Issue 3, pp. 341 - 348
Mutations in the MECP2 gene cause Rett syndrome (RTT). Bdnf is a MeCP2 target gene; however, its role in RTT pathogenesis is unknown. We examined Bdnf... 
SURVIVAL | CNS NEURONS | RETT-SYNDROME | CHROMATIN | NEUROTROPHIC FACTOR | MOUSE MODEL | METHYLATED DNA | MUTATIONS | CPG-BINDING PROTEIN-2 | NEUROSCIENCES | TRANSCRIPTIONAL REPRESSOR
Journal Article
NEURON, ISSN 0896-6273, 06/2015, Volume 86, Issue 5, pp. 1119 - 1130
Intellectual disability, autism spectrum disorder, and epilepsy are prime examples of neurodevelopmental disorders that collectively affect a significant... 
CHILDHOOD ABSENCE EPILEPSY | REDUCED SODIUM CURRENT | DE-NOVO MUTATIONS | RETT-SYNDROME | AMINOBUTYRIC ACID(A) RECEPTOR | MOUSE MODEL | FRAGILE-X-SYNDROME | AUTISM SPECTRUM DISORDER | SEVERE MYOCLONIC EPILEPSY | CPG-BINDING PROTEIN-2 | NEUROSCIENCES
Journal Article
Nature Neuroscience, ISSN 1097-6256, 02/2014, Volume 17, Issue 2, pp. 192 - 200
Journal Article
FASEB JOURNAL, ISSN 0892-6638, 08/2010, Volume 24, Issue 8, pp. 3036 - 3051
Autism is currently considered a multigene disorder with epigenetic influences. To investigate the contribution of DNA methylation to autism spectrum... 
DSM-IV | RETT-SYNDROME | BIOCHEMISTRY & MOLECULAR BIOLOGY | ALPHA | CPG-BINDING PROTEIN-2 | NUCLEAR RECEPTOR | CELL BIOLOGY | CpG island microarrays | EXPLORATION | BIOLOGY | DNA methylation | brain expression | STAGGERER MUTANT MICE | CEREBELLUM | immunohistochemistry | BLC-2 gene expression | EXPRESSION
Journal Article
Nature Neuroscience, ISSN 1097-6256, 12/2011, Volume 14, Issue 12, pp. 1607 - 1616
Journal Article