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Biochemical and Biophysical Research Communications, ISSN 0006-291X, 01/2018, Volume 496, Issue 1, pp. 153 - 158
Advanced breast cancer is resistant to chemotherapy and its underlying mechanisms are not fully explored. In this work, we identified cytosolic phospholipase... 
mTOR | Breast cancer | cPLA2α | Doxorubicin | ERK | TARGET | CELLS | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | cPLA2 alpha | BIOPHYSICS | CALCIUM | GROWTH | CPLA
Journal Article
ChemMedChem, ISSN 1860-7179, 1/2018, Volume 13, Issue 2, pp. 138 - 146
Cytosolic phospholipase A2α (cPLA2α) may play a critical role in neuropsychiatric and neurodegenerative disorders associated with oxidative stress and... 
radiopharmaceuticals | carbon-11 | Carbonylation | cPLA2α | neuroinflammation
Journal Article
ChemMedChem, ISSN 1860-7179, 01/2018, Volume 13, Issue 2, pp. 127 - 127
The Front Cover shows the in vivo evaluation of a prospective radioligand for cPLA2a, a biomarker for neuroinflammation, in a mouse brain by positron emission... 
radiopharmaceuticals | carbon-11 | cPLA2α | neuroinflammation | carbonylation
Journal Article
Fertility and Sterility, ISSN 0015-0282, 2005, Volume 83, Issue 1, pp. 156 - 162
To identify the distribution of the enzymes cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2), and cytosolic phospholipase A 2 (cPLA 2) in the human ovary and... 
cPLA2 | endometrium | pinopodes | COX
Journal Article
Cancer Biology & Therapy, ISSN 1538-4047, 06/2019, Volume 20, Issue 6, pp. 912 - 921
Cytosolic phospholipase A2alpha (cPLA2α) is a key mediator of tumorigenesis. In this study, by using a combination of pharmacological and genetic approaches in... 
Cpla2α | β-catenin | chemoresistance | Akt | cervical cancer
Journal Article
Journal of Cellular Biochemistry, ISSN 0730-2312, 12/2017, Volume 118, Issue 12, pp. 4370 - 4382
ABSTRACT The activity of α‐type cytosolic phospholipase A2 (cPLA2α, group IVA PLA2), which releases arachidonic acid (AA), is mainly regulated by the... 
TNFα | ERK1/2 | LACTOSYLCERAMIDE | cPLA2α | PROTEIN KINASE C | ROS | cPLA
Journal Article
Brain Research, ISSN 0006-8993, 09/2017, Volume 1670, pp. 248 - 252
Cytosolic phospholipase A2α (cPLA2α) is a key enzyme in regulation of inflammation process and neuromembrane homeostasis, both of which are critical in... 
cPLA2 | APPswe/PS1 transgenic mouse | Alzheimer's disease | Cytosolic phospholipase A2 | Knockout mouse
Journal Article
Brain Research, ISSN 0006-8993, 09/2017, Volume 1670, pp. 248 - 252
•Cytosolic phospholipase A2 alpha (cPLA2α) regulates integrity of the cell membrane and inflammation.•Semi-knockout of cPLA2α in APP/PS1 transgenic mice... 
Alzheimer’s disease | Knockout mouse | cPLA2 | APPswe/PS1 transgenic mouse | Cytosolic phospholipase A2
Journal Article
Arthritis Research and Therapy, ISSN 1478-6354, 01/2019, Volume 21, Issue 1, pp. 29 - 13
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 05/2003, Volume 197, Issue 10, pp. 1303 - 1310
Prostaglandin E (PGE)2 produced by osteoblasts acts as a potent stimulator of bone resorption. Inflammatory bone loss is accompanied by osteoclast formation... 
Lipopolysaccharide | Osteoblast | Osteoclast | cPLA2α | Bone loss | MEDICINE, RESEARCH & EXPERIMENTAL | CELLS | ESTROGEN DEFICIENCY | RECEPTOR | osteoblast | IMMUNOLOGY | bone loss | E-2 SYNTHASE | cPLA2 alpha | TUMOR-NECROSIS-FACTOR | EICOSANOID GENERATION | MICE | LIGAND | osteoclast | lipopolysaccharide | OSTEOCLAST DIFFERENTIATION
Journal Article
Autophagy, ISSN 1554-8627, 03/2020, Volume 16, Issue 3, pp. 466 - 485
Lysosomal membrane permeabilization (LMP) is observed under many pathological conditions, leading to cellular dysfunction and death. However, the mechanisms by... 
membrane lipidomic analysis | traumatic brain injury (TBI) | autophagy | cytosolic phospholipase A2 (cPLA2) | Amyloid β | lysosomal membrane permeabilization (LMP)
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 05/2018, Volume 38, Issue 18, pp. 4301 - 4315
The blood-brain barrier is dysfunctional in epilepsy, thereby contributing to seizure genesis and resistance to antiseizure drugs. Previously, several groups... 
MMP | Barrier leakage | cPLA | Barrier dysfunction | Blood-Brain barrier | CYTOSOLIC PHOSPHOLIPASE A | NMDA RECEPTOR | ACID | MICROVASCULAR NETWORK | barrier dysfunction | NEUROSCIENCES | INDUCED UP-REGULATION | P-GLYCOPROTEIN | DISRUPTION | barrier leakage | GLUTAMATE | SEIZURE | EXPRESSION | cPLA2
Journal Article
Bioconjugate Chemistry, ISSN 1043-1802, 12/2015, Volume 26, Issue 12, pp. 2360 - 2370
Activatable fluorophores selective to cytosolic phospholipase A2 (cPLA2) were synthesized and evaluated for their ability to image triple negative breast... 
Phospholipase A2 | Fluorescence optical imaging | cPLA2 | sPLA2 | Breast cancer | NIR fluorescence imaging | Activatable fluorescence
Journal Article
American Journal of Hypertension, ISSN 0895-7061, 04/2018, Volume 31, Issue 5, pp. 622 - 629
Abstract BACKGROUND Recently, we reported that angiotensin II (Ang II)-induced hypertension is mediated by group IV cytosolic phospholipase A2α (cPLA2α) via... 
Hypertension | Blood pressure | Subfornical organ | Angiotensin II | CPLA | mice | Cytosolic phospholipase A | blood pressure | cytosolic phospholipase A2α | Original Contributions | angiotensin II | subfornical organ | cPLA2α | hypertension
Journal Article
Biochimie, ISSN 0300-9084, 12/2014, Volume 107, pp. 95 - 104
Pseudomonas aeruginosa pulmonary infection is a leading cause of death in numerous diseases such as cystic fibrosis (CF). The host cytosolic phospholipase A2α... 
Pseudomonas aeruginosa | IL6 | Inflammation | Cytosolic phospholipase A2α (cPLA2α) | Acute lung infection | Inflammation IL6 | AIRWAY EPITHELIAL-CELLS | LUNG | INDUCED APOPTOSIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | Cytosolic phospholipase A2 alpha (cPLA2 alpha) | IL-6 | TRANSMEMBRANE CONDUCTANCE REGULATOR | HOST-DEFENSE | CYSTIC-FIBROSIS | III SECRETION SYSTEM | Group IV Phospholipases A2 - genetics | Lung Diseases - metabolism | Group IV Phospholipases A2 - antagonists & inhibitors | Species Specificity | Lung Diseases - microbiology | Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors | Immunoblotting | Male | Pseudomonas Infections - mortality | Pseudomonas aeruginosa - physiology | Extracellular Signal-Regulated MAP Kinases - metabolism | Pseudomonas Infections - metabolism | Group IV Phospholipases A2 - metabolism | Female | p38 Mitogen-Activated Protein Kinases - metabolism | Interleukin-6 - metabolism | Cell Line | Mice, Inbred CFTR | Macrophages, Alveolar - microbiology | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Survival Rate | Arachidonate 15-Lipoxygenase - metabolism | Arachidonic Acids - pharmacology | Mice, Knockout | Pseudomonas Infections - genetics | Host-Pathogen Interactions | Lung Diseases - genetics | Animals | Macrophages, Alveolar - drug effects | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Cyclooxygenase 2 - metabolism | Bronchoalveolar Lavage Fluid - chemistry | Macrophages, Alveolar - metabolism | Pseudomonas aeruginosa - classification
Journal Article