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STEM CELLS, ISSN 1066-5099, 02/2012, Volume 30, Issue 2, pp. 314 - 325
Metastasis to multiple organs is the primary cause of mortality in breast cancer patients. The poor prognosis for patients with metastatic breast cancer and... 
Cancer invasion | Stem cell‐mediated therapy | CPT‐11 | Cytokines | Stem cell tropism | Breast cancer metastasis | Neural stem cells | siRNA | Carboxylesterase | Interleukin‐6 | Gene therapy | Stem cell-mediated therapy | CPT-11 | Interleukin-6 | TARGET | ACTIVATION | DEFICIENT MICE | DELIVERY | CELL BIOLOGY | ENZYME/PRODRUG THERAPY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | BRAIN METASTASES | HEMATOLOGY | MIGRATION | GLIOMAS | CELL & TISSUE ENGINEERING | ONCOLOGY | GENE-THERAPY | Prodrugs - administration & dosage | Lung Neoplasms - drug therapy | Carboxylesterase - secretion | Humans | Drug Delivery Systems | Antineoplastic Agents, Phytogenic - administration & dosage | Lung Neoplasms - secondary | Biotransformation | Mammary Neoplasms, Experimental - pathology | Neural Stem Cells - transplantation | Camptothecin - administration & dosage | Female | Antineoplastic Agents, Phytogenic - therapeutic use | Antineoplastic Agents, Phytogenic - pharmacokinetics | Carboxylesterase - biosynthesis | Interleukin-6 - metabolism | Camptothecin - analogs & derivatives | Mammary Neoplasms, Experimental - drug therapy | Camptothecin - pharmacokinetics | Cell Survival - drug effects | Rabbits | Camptothecin - therapeutic use | Interleukin-6 - genetics | Neoplasm Invasiveness | Lymphatic Metastasis | Neural Stem Cells - enzymology | Xenograft Model Antitumor Assays | Animals | Prodrugs - pharmacokinetics | Mice, Nude | Cell Line, Tumor | Neural Stem Cells - secretion | Mice | Prodrugs - therapeutic use | Cell Movement | Enzymes | Chemotherapy | Lymphatic system | Stem cells | Breast cancer | Metastasis | Cancer therapies | Index Medicus
Journal Article
Journal of Pharmacy and Pharmacology, ISSN 0022-3573, 12/2017, Volume 69, Issue 12, pp. 1773 - 1785
Journal Article
Journal Article
Journal Article
The Journal of Pathology, ISSN 0022-3417, 05/2012, Volume 227, Issue 1, pp. 118 - 129
Journal Article
Cancer, ISSN 0008-543X, 01/2005, Volume 103, Issue 2, pp. 329 - 338
Journal Article
STEM CELLS Translational Medicine, ISSN 2157-6564, 12/2013, Volume 2, Issue 12, pp. 983 - 992
Irinotecan (CPT‐11) is a chemotherapeutic agent used for therapy of several systemic solid tumors, and has also been investigated as a treatment for malignant... 
Irinotecan | CPT‐11 | Microdialysis | Glioma | Immunogenicity | Cancer therapy | Neural stem cells | Carboxylesterase | CPT-11 | BRAIN METASTASIS | SOLID TUMORS | RABBIT LIVER CARBOXYLESTERASE | STRATEGIES | CELL & TISSUE ENGINEERING | BREAST-CANCER | TROPISM | PRODRUG | ENZYME/PRODRUG THERAPY | MOUSE MODEL | Humans | Brain Neoplasms - pathology | Feasibility Studies | Dose-Response Relationship, Drug | Glioma - genetics | Tissue Distribution | Topoisomerase I Inhibitors - pharmacology | Transfection | Time Factors | Biotransformation | Glioma - pathology | Glioma - therapy | Adenoviridae - genetics | Neural Stem Cells - transplantation | Carboxylesterase - deficiency | Carboxylic Ester Hydrolases - genetics | Camptothecin - analogs & derivatives | Camptothecin - pharmacokinetics | Topoisomerase I Inhibitors - pharmacokinetics | Rabbits | Brain Neoplasms - enzymology | Glioma - enzymology | Transduction, Genetic | Neural Stem Cells - drug effects | Brain Neoplasms - genetics | Mice, SCID | Neural Stem Cells - enzymology | Mice, Knockout | Xenograft Model Antitumor Assays | Animals | Brain Neoplasms - therapy | Carboxylesterase - genetics | Cell Line, Tumor | Mice | Genetic Vectors | Camptothecin - pharmacology | Carboxylic Ester Hydrolases - metabolism | Enzymes | Cell culture | Data analysis | Brain tumors | Brain cancer | Stockholders | Clinical trials | Breast cancer | Neuroblastoma | Experiments | Cancer therapies | Cell adhesion & migration | Quality of life | Studies | Stem cells | Writing | Solid tumors | Pharmaceuticals | Tumors | Index Medicus | Enabling Technologies for Cell-Based Clinical Translation
Journal Article