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Chemico-Biological Interactions, ISSN 0009-2797, 10/2018, Volume 294, pp. 128 - 134
Because of the great interest for research on the potential use of cannabis preparations as co-medication for alleviation of toxic effects in cancer... 
Urine | Irinotecan | CPT-11 | Rat | THC | Index Medicus
Journal Article
Organic and Biomolecular Chemistry, ISSN 1477-0520, 2016, Volume 14, Issue 37, pp. 8815 - 8820
In this study, we report a direct fluorometric assay for butyrylcholinesterase (BChE) activity and screening of its inhibitor, using a fluorescent substrate.... 
CHEMISTRY, ORGANIC | ACETYLCHOLINESTERASE | CPT-11 | INHIBITOR | GLUCOSE | BRAIN
Journal Article
JOURNAL OF CLINICAL ONCOLOGY, ISSN 0732-183X, 07/2006, Volume 24, Issue 19, pp. 3061 - 3068
Purpose UGT1A1*28 polymorphism has been associated with decreased glucuronidation of SN38, the active metabolite of irinotecan. This could increase toxicity... 
UDP-GLUCURONOSYLTRANSFERASE | METABOLITES | SN-38 | UGT1A1 | CPT-11 | ONCOLOGY | DRUG-INTERACTIONS | PREDICT | GENETIC-VARIANTS | TOXICITY | FLUOROURACIL
Journal Article
BRITISH JOURNAL OF CANCER, ISSN 0007-0920, 06/2003, Volume 88, Issue 12, pp. 1979 - 1986
Promising preclinical activity with agents blocking the function of vascular endothelial growth factor (VEGF) has been observed in various cancer types,... 
tumour delivery | CYTOTOXIC CANCER THERAPIES | IRINOTECAN CPT-11 | perfusion | CPT-11 | SOLID TUMORS | fanti-VEGF mAb | SUBCUTANEOUS TUMORS | CLINICAL PHARMACOKINETICS | LEWIS-LUNG-CARCINOMA | ONCOLOGY | IN-VIVO | VASCULAR ARCHITECTURE | ANGIOGENESIS INHIBITOR TNP-470 | Hoechst 33342 | ACTIVE METABOLITE
Journal Article
Journal Article
CHEMICAL SCIENCE, ISSN 2041-6520, 09/2019, Volume 10, Issue 35, pp. 8164 - 8170
The ability to measure drugs in the body rapidly and in real time would advance both our understanding of pharmacokinetics and our ability to optimally dose... 
DRUG | PLASMA | CPT-11 | METABOLISM | EFFICACY | CLINICAL PHARMACOKINETICS | BINDING | CHEMISTRY, MULTIDISCIPLINARY
Journal Article
CANCER SCIENCE, ISSN 1347-9032, 10/2011, Volume 102, Issue 10, pp. 1868 - 1873
Irinotecan-induced severe neutropenia is associated with homozygosity for the UGT1A1(star)28 or UGT1A1(star)6 alleles. In this study, we determined the... 
BILIRUBIN | PHARMACOKINETICS | CPT-11 | GENE | METABOLISM | ONCOLOGY | CAMPTOTHECIN | GLUCURONIDATION | JAPANESE | PHARMACOGENETICS | PHASE-I
Journal Article
New Journal of Chemistry, ISSN 1144-0546, 01/2019, Volume 43, Issue 1, pp. 481 - 491
Polymer prodrug micelles, combining the advantages of prodrugs and polymer micelles, can greatly improve the solubility, permeability and stability of drugs.... 
VITRO | NANOPARTICLES | SN-38 | CPT-11 | DNA TOPOISOMERASE-I | CANCER | CHEMISTRY, MULTIDISCIPLINARY | CARRIER | DELIVERY
Journal Article
Journal Article
Japanese Journal of Cancer and Chemotherapy, ISSN 0385-0684, 2013, Volume 40, Issue 7, pp. 929 - 932
Journal Article
Chinese Journal of Clinical Oncology, ISSN 1000-8179, 04/2014, Volume 41, Issue 7, pp. 430 - 433
Journal Article
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 09/2000, Volume 343, Issue 13, pp. 905 - 914
The antimetabolite fluorouracil is widely used to treat metastatic colorectal cancer, the second-leading cause of death from cancer in North America. 1 The... 
MEDICINE, GENERAL & INTERNAL | PHASE-II TRIAL | HEPATIC METASTASES | CPT-11 | CAMPTOTHECIN | TOPOISOMERASE-I | CARCINOMA | MODULATION | Chemotherapy, Combination | Analysis | Colorectal cancer | Leucovorin | Drug therapy | Health aspects | Fluorouracil | Drug dosages
Journal Article