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Journal of Neuroinflammation, ISSN 1742-2094, 01/2015, Volume 12, Issue 1, pp. 6 - 6
Background: Microglia/macrophages (MG/M Phi) are found in the subretinal space in both mice and humans. Our goal was to study the spatial and temporal... 
macrophages | rd8 | CD16 | subretinal | aging | activation | microglia | Crb1 | gene expression | Iba-1 | RD8 MUTATION | CELLS | INVOLVEMENT | IMMUNOLOGY | NEUROSCIENCES | MACROPHAGE ACTIVATION | LESIONS | SENILE MACULAR DEGENERATION | CRB1 GENE | RETINAL MICROGLIA | ACCUMULATION | AGE | Mannose-Binding Lectins - metabolism | Microglia - metabolism | Retinal Pigment Epithelium - metabolism | Retina - metabolism | Age Factors | Cell Count | Neural Pathways - pathology | Lectins, C-Type - genetics | Receptors, IgG - metabolism | Lectins, C-Type - metabolism | Retinal Pigment Epithelium - pathology | Receptors, IgG - genetics | Microfilament Proteins - metabolism | Microfilament Proteins - genetics | Disease Models, Animal | Calcium-Binding Proteins - metabolism | Macrophages - ultrastructure | Gene Expression Regulation - genetics | Retinal Degeneration - genetics | Mice, Inbred C57BL | Receptors, Cell Surface - metabolism | Mice, Transgenic | Mutation - genetics | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Macrophages - metabolism | Phenotype | Animals | Mannose-Binding Lectins - genetics | Microglia - ultrastructure | Neural Pathways - metabolism | Mice | Retinal Degeneration - pathology | Retina - pathology | Calcium-Binding Proteins - genetics | Receptors, Cell Surface - genetics | Genetic research | Fc receptors | Genetic transcription | Analysis | Genes | Index Medicus
Journal Article
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ISSN 0146-0404, 07/2019, Volume 60, Issue 8, pp. 2875 - 2887
PURPOSE. We previously found a dominant mutation, Rwhs, causing white spots on the retina accompanied by retinal folds. Here we identify the mutant gene to be... 
mouse models | genetic diseases | CRB1 | BESTROPHIN | FRIZZLED-RELATED PROTEIN | DEGENERATION | POSTERIOR MICROPHTHALMOS | MFRP | retina | CRUMBS HOMOLOG-1 | OPHTHALMOLOGY | GENOME-WIDE | RECESSIVE SYNDROME | RETINITIS-PIGMENTOSA | nanophthalmos
Journal Article
Journal Article
Ophthalmic Genetics, ISSN 1381-6810, 05/2019, Volume 40, Issue 3, pp. 288 - 292
Background: To characterize the phenotype and genotype of a rare syndrome associating posterior microphthalmos (PM), retinitis pigmentosa (RP), and... 
foveoschisis | optic nerve drusen | retinitis pigmentosa | Posterior microphthalmos | membrane frizzled-related protein | NANOPHTHALMOS | CRB1 | GENETICS & HEREDITY | OPHTHALMOLOGY | RECESSIVE SYNDROME
Journal Article
Fresenius Environmental Bulletin, ISSN 1018-4619, 11/2018, Volume 27, Issue 11, p. 7739
To apply targeted next-generation sequencing to detect a novel mutation in the Crumbs homologue- 1 (CRB1) gene in a non-consanguineous Chinese family with... 
Pathogens | CRB1 gene | Pathogenesis | Homology | Patients | Gene sequencing | Pathogenicity | Next-generation sequencing | Pedigree | Blindness | Mutation | DNA testing | Deoxyribonucleic acid--DNA
Journal Article
Journal Article
by Ye, YC and Chen, JJ and Zhang, J and Li, M and Yang, XX
FRESENIUS ENVIRONMENTAL BULLETIN, ISSN 1018-4619, 2018, Volume 27, Issue 11, pp. 7739 - 7745
To apply targeted next-generation sequencing to detect a novel mutation in the Crumbs homologue-1 (CRB1) gene in a non-consanguineous Chinese family with Leber... 
CRB1 | MOLECULAR-GENETICS | ENVIRONMENTAL SCIENCES | targeted next-generation sequencing | gene mutation | UPDATE | LCA | Sanger sequencing
Journal Article
Journal Article
Zhonghua Shiyan Yanke Zazhi/Chinese Journal of Experimental Ophthalmology, ISSN 2095-0160, 07/2018, Volume 36, Issue 7, pp. 526 - 530
Journal Article
Journal Article
Journal Article
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ISSN 0146-0404, 01/2014, Volume 55, Issue 1, pp. 387 - 395
PURPOSE. We directly corrected the mouse Crb1(rd8) gene mutation, which is present in many inbred laboratory strains derived from C57BL/6N and complicates... 
CRB1 | KOMP | gene therapy | EMBRYO MICROINJECTION | MODEL | genetic engineering | DEGENERATION | ZINC-FINGER TARGETER | CONSORTIUM | MOUSE STRAINS | GENE | TALEN | CRB1 associated disease | OPHTHALMOLOGY | MUTATIONS | DROSOPHILA-CRUMBS
Journal Article
Developmental Biology, ISSN 0012-1606, 11/2016, Volume 419, Issue 2, pp. 336 - 347
Journal Article
ASN Neuro, ISSN 1759-0914, 2013, Volume 5, Issue 5, pp. 309 - 319
AMD (age-related macular degeneration) is a neurodegenerative disease causing irreversible central blindness in the elderly. Apoptosis and inflammation play... 
Neuroprotection | Retina | Inflammation | Pigment epithelium-derived factor | Age-related macular degeneration | Apoptosis | CELLS | CCL2/CX3CR1-DEFICIENT MICE | apoptosis | MACULAR DEGENERATION | INTERPHOTORECEPTOR MATRIX | pigment epithelium-derived factor | IDENTIFICATION | NEUROSCIENCES | LESIONS | FACTOR PEDF | inflammation | retina | neuroprotection | NEOVASCULARIZATION | age-related macular degeneration | PHOTORECEPTOR DEGENERATION | ENDOTHELIAL GROWTH-FACTOR | Retinoids - metabolism | Epithelial Cells - metabolism | Apoptosis - drug effects | Epithelial Cells - drug effects | Humans | Nerve Growth Factors - metabolism | Nerve Growth Factors - pharmacology | Retina - cytology | Anti-Inflammatory Agents - therapeutic use | Receptors, Chemokine - genetics | Cytokines - genetics | Disease Models, Animal | Cytokines - metabolism | Serpins - metabolism | Anti-Inflammatory Agents - pharmacology | Gene Expression Regulation - genetics | Retinal Degeneration - drug therapy | Retinal Degeneration - genetics | Mice, Inbred C57BL | Cells, Cultured | Chemokine CCL2 - genetics | Mice, Transgenic | Eye Proteins - therapeutic use | Serpins - therapeutic use | Mutation - genetics | Nerve Tissue Proteins - genetics | Serpins - pharmacology | Nerve Growth Factors - therapeutic use | Gene Expression Regulation - drug effects | Animals | Eye Proteins - metabolism | Mice | Pyridinium Compounds - metabolism | Retinal Degeneration - pathology | CX3C Chemokine Receptor 1 | Eye Proteins - pharmacology | Index Medicus
Journal Article