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Genesis, ISSN 1526-954X, 05/2015, Volume 53, Issue 5, pp. 329 - 336
Journal Article
by Miwa, H and Era, T
GENESIS, ISSN 1526-954X, 05/2015, Volume 53, Issue 5, pp. 329 - 336
Platelet-derived growth factor (PDGF) and its receptor play an important role in embryogenesis. PDGF receptor (PDGFR) is expressed specifically in the... 
CELL-DEVELOPMENT | neural crest | knock-in | DEVELOPMENTAL BIOLOGY | mesoderm | MORPHOGENESIS | mesenchyme | PDGF RECEPTOR-ALPHA | GENE | MUTATION | GENETICS & HEREDITY | PDGFR | MICE | GROWTH-FACTOR | DIFFERENTIATION | EXPRESSION | EMBRYOGENESIS | CreER(T2)
Journal Article
GENESIS, ISSN 1526-954X, 11/2009, Volume 47, Issue 11, pp. 729 - 735
The generation of cell type specific inducible Cre transgenic mice is the most challenging and limiting part in the development of spatio-temporally controlled... 
PATHWAYS | MUTAGENESIS | MOUSE | DEVELOPMENTAL BIOLOGY | B cells | CELL DEVELOPMENT | Cre recombinase | ESTROGEN-RECEPTOR | somatic mutagenesis | GROWTH | GENETICS & HEREDITY | MICE | AUTOIMMUNE-DISEASE | BINDING | tamoxifen | CreER(T2)
Journal Article
American Journal of Physiology - Renal Physiology, ISSN 0363-6127, 04/2018, Volume 314, Issue 4, pp. F572 - F583
Journal Article
DIABETOLOGIA, ISSN 0012-186X, 12/2017, Volume 60, Issue 12, pp. 2399 - 2408
Aims/hypothesis The Cre/loxP system, which enables tissue-specific manipulation of genes, is widely used in mice for diabetes research. Our aim was to develop... 
INSULIN | Cre/loxP | GLUCAGON-LIKE PEPTIDE-1 | GLUCOSE | BETA-CELLS | ENDOCRINE | ENDOCRINOLOGY & METABOLISM | RECEPTOR | CreER(T2) | Pancreatic alpha cells | Proglucagon
Journal Article
JOURNAL OF LIPID RESEARCH, ISSN 0022-2275, 11/2014, Volume 55, Issue 11, pp. 2276 - 2286
Journal Article
Cell Metabolism, ISSN 1550-4131, 05/2015, Volume 21, Issue 5, pp. 650 - 651
In this Letter, Dorninger et al. show that the deficiency in ether lipid biosynthesis alone is not sufficient to induce neutropenia or leukopenia, as has been... 
SYSTEMIC ACTIVATION | CREER(T2) | DIRECT HEMATOLOGICAL TOXICITY | ENDOCRINOLOGY & METABOLISM | CELL BIOLOGY | Animals | Lipids - biosynthesis | Phospholipids - metabolism | Fatty Acid Synthases - metabolism | Neutrophils - metabolism | Humans | Analysis | Neutropenia
Journal Article
Diabetologia, ISSN 0012-186X, 12/2017, Volume 60, Issue 12, pp. 2399 - 2408
The Cre/loxP system, which enables tissue-specific manipulation of genes, is widely used in mice for diabetes research. Our aim was to develop a new Cre-driver... 
Cre/loxP | Medicine & Public Health | Human Physiology | Metabolic Diseases | Internal Medicine | CreER T2 | Pancreatic alpha cells | Proglucagon | Immunohistochemistry | Animals | Glucagon-Secreting Cells - metabolism | Tamoxifen - pharmacology | Female | Glucagon-Like Peptide 1 - blood | Male | Mice, Transgenic | Mice | Proglucagon - genetics | Proglucagon - metabolism | Glucagon - blood
Journal Article
International Journal of Molecular Sciences, ISSN 1661-6596, 12/2016, Volume 17, Issue 12, p. 2149
Current genetically-engineered mouse melanoma models are often based on Tyr::CreER(T2)-controlled MAPK pathway activation by the BRAF(V600E) mutation and PI3K... 
CreER | Dermal delivery | Melanoma | TARGETED THERAPY | BIOCHEMISTRY & MOLECULAR BIOLOGY | melanoma | COMBINATION | CHEMISTRY, MULTIDISCIPLINARY | BRAF(V600E) | dermal delivery | IMMUNOTHERAPY | PROMOTER | EXPRESSION | IPILIMUMAB | CreER(T2) | VEMURAFENIB | MELANOCYTES | Genetic engineering | Mutation | CreERT2
Journal Article
GENESIS, ISSN 1526-954X, 12/2012, Volume 50, Issue 12, pp. 908 - 913
After thymic emigration CD4-T-cells continue to differentiate into multiple effector and suppressor sublineages in peripheral lymphoid organs. In vivo analysis... 
CreER(T2) recombinase | SOMATIC MUTAGENESIS | MOUSE | CRE RECOMBINASE | DEVELOPMENTAL BIOLOGY | CD4 T-cell differentiation | DELIVERY | DELETION | VECTOR | SITE-SPECIFIC RECOMBINATION | GENE | GENETICS & HEREDITY | T-CELLS
Journal Article
Transgenic Research, ISSN 0962-8819, 10/2012, Volume 21, Issue 5, pp. 1117 - 1123
Keratin 8 (K8) is a type II keratin that is associated with the type I keratins K18 or K19 in single layered epithelia. We generated a bacterial artificial... 
Human Genetics | Simple epithelia | Biomedicine | Molecular Medicine | Keratin 8 | CreER T2 | BAC transgenesis | Plant Sciences | Plant Genetics & Genomics | Animal Genetics and Genomics | CreER | CreERT2
Journal Article
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