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1. Full Text Cas4-Dependent Prespacer Processing Ensures High-Fidelity Programming of CRISPR Arrays
by Lee, Hayun and Zhou, Yi and Taylor, David W and Sashital, Dipali G
Molecular cell, ISSN 1097-2765, 04/2018, Volume 70, Issue 1, pp. 48 - 59.e5
Cas4 | CRISPR-Cas | Cas1-Cas2 | DNA cleavage | DNA integration | negative stain EM | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Protein Subunits | Multienzyme Complexes | CRISPR-Associated Protein 9 - immunology | DNA, Bacterial - metabolism | Substrate Specificity | DNA, Bacterial - immunology | CRISPR-Associated Protein 9 - genetics | CRISPR-Associated Protein 9 - metabolism | Clustered Regularly Interspaced Short Palindromic Repeats | Endodeoxyribonucleases - metabolism | Nucleic Acid Conformation | CRISPR-Associated Protein 9 - isolation & purification | CRISPR-Associated Proteins - immunology | Escherichia coli - enzymology | CRISPR-Associated Proteins - genetics | Models, Molecular | Escherichia coli Proteins - metabolism | Endodeoxyribonucleases - genetics | DNA, Bacterial - genetics | Escherichia coli - genetics | CRISPR-Associated Proteins - metabolism | CRISPR-Cas Systems | Escherichia coli Proteins - genetics | Protein Conformation | Gene Editing - methods | Proteins | Molecular biology | Nucleases | Index Medicus
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2. Full Text Structure of the DNA-Bound Spacer Capture Complex of a Type II CRISPR-Cas System
by Wilkinson, Martin and Drabavicius, Gediminas and Silanskas, Arunas and Gasiunas, Giedrius and Siksnys, Virginijus and Wigley, Dale B
Molecular cell, ISSN 1097-2765, 07/2019, Volume 75, Issue 1, pp. 90 - 101.e5
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Protein Multimerization | Substrate Specificity | Isoenzymes - chemistry | CRISPR-Associated Protein 9 - genetics | CRISPR-Associated Protein 9 - metabolism | Streptococcus thermophilus - metabolism | Isoenzymes - metabolism | Base Sequence | DNA, Intergenic - metabolism | Cloning, Molecular | Escherichia coli - metabolism | Protein Interaction Domains and Motifs | Streptococcus thermophilus - genetics | Nucleic Acid Conformation | Binding Sites | Recombinant Proteins - metabolism | Protein Conformation, alpha-Helical | Gene Expression | Genetic Vectors - chemistry | Isoenzymes - genetics | Genetic Vectors - metabolism | Recombinant Proteins - chemistry | CRISPR-Associated Protein 9 - chemistry | Recombinant Proteins - genetics | DNA - metabolism | DNA, Intergenic - genetics | DNA, Intergenic - chemistry | Cryoelectron Microscopy | DNA - genetics | DNA - chemistry | Protein Conformation, beta-Strand | Escherichia coli - genetics | CRISPR-Cas Systems | Protein Binding | Molecular Docking Simulation | Proteins | DNA | Index Medicus
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3. Full Text Temperature-Responsive Competitive Inhibition of CRISPR-Cas9
by Jiang, Fuguo and Liu, Jun-Jie and Osuna, Beatriz A and Xu, Michael and Berry, Joel D and Rauch, Benjamin J and Nogales, Eva and Bondy-Denomy, Joseph and Doudna, Jennifer A and Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Molecular cell, ISSN 1097-2765, 02/2019, Volume 73, Issue 3, pp. 601 - 610.e5
anti-CRISPR | genome editing | CRISPR-Cas9 | CRISPR-Cas | temperature-dependent inhibition | Cas9 | Cas9 inhibitors | PAM blockage | AcrIIA2 | bacteriophage | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Temperature | Pseudomonas Phages - metabolism | RNA, Guide - genetics | RNA, Guide - metabolism | Pseudomonas aeruginosa - virology | RNA, Guide - ultrastructure | DNA - ultrastructure | Structure-Activity Relationship | CRISPR-Associated Protein 9 - antagonists & inhibitors | CRISPR-Associated Protein 9 - ultrastructure | Viral Proteins - metabolism | Pseudomonas Phages - genetics | CRISPR-Associated Protein 9 - genetics | CRISPR-Associated Protein 9 - metabolism | Pseudomonas aeruginosa - enzymology | Nucleic Acid Conformation | Binding, Competitive | Escherichia coli - enzymology | Models, Molecular | Viral Proteins - genetics | DNA - metabolism | Viral Proteins - ultrastructure | Cryoelectron Microscopy | DNA - genetics | Pseudomonas aeruginosa - genetics | Escherichia coli - genetics | CRISPR-Cas Systems | Protein Binding | Protein Conformation | Gene Editing - methods | Gene Expression Regulation, Bacterial | Enzymes | Nucleases | RNA | Genomics | Bacteria | DNA binding proteins | DNA-ligand interactions | Cells | Protein binding | Index Medicus | BASIC BIOLOGICAL SCIENCES | AcrllA2
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4. Full Text CRISPR screens are feasible in TP53 wild‐type cells
by Brown, Kevin R and Mair, Barbara and Soste, Martin and Moffat, Jason
Molecular systems biology, ISSN 1744-4292, 08/2019, Volume 15, Issue 8, pp. e8679 - n/a
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Retinal Pigment Epithelium - metabolism | Proto-Oncogene Proteins c-mdm2 - genetics | Epithelial Cells - metabolism | RNA, Guide - genetics | Neuroglia - pathology | RNA, Guide - metabolism | Humans | Tumor Suppressor Protein p53 - genetics | CRISPR-Associated Protein 9 - genetics | CRISPR-Associated Protein 9 - metabolism | Cyclin-Dependent Kinase Inhibitor p21 - genetics | Cell Cycle Proteins - genetics | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Retinoblastoma Binding Proteins - genetics | Epithelial Cells - cytology | Retinoblastoma Binding Proteins - metabolism | Proto-Oncogene Proteins c-mdm2 - metabolism | Quality Control | Proto-Oncogene Proteins - metabolism | Cell Line | Gene Editing - standards | HCT116 Cells | Cell Cycle Proteins - metabolism | Gene Expression Regulation | Tumor Suppressor Protein p53 - metabolism | Ubiquitin-Protein Ligases - metabolism | Proto-Oncogene Proteins - genetics | Organ Specificity | CRISPR-Cas Systems | Cell Line, Tumor | Neuroglia - metabolism | Gene Editing - methods | HeLa Cells | Ubiquitin-Protein Ligases - genetics | Cell Line, Transformed | Retinal Pigment Epithelium - cytology | Index Medicus
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5. Full Text CRISPR-Mediated Tagging of Endogenous Proteins with a Luminescent Peptide
by Schwinn, Marie K and Machleidt, Thomas and Zimmerman, Kris and Eggers, Christopher T and Dixon, Andrew S and Hurst, Robin and Hall, Mary P and Encell, Lance P and Binkowski, Brock F and Wood, Keith V
ACS chemical biology, ISSN 1554-8929, 02/2018, Volume 13, Issue 2, pp. 467 - 474
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Luciferases - metabolism | Antibodies - chemistry | Humans | Luminescence | Neoplasm Proteins - metabolism | CRISPR-Associated Protein 9 - genetics | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Kruppel-Like Transcription Factors - metabolism | Early Growth Response Transcription Factors - genetics | Luminescent Proteins - chemistry | Membrane Proteins - metabolism | Neoplasm Proteins - genetics | Oligopeptides - chemistry | Proto-Oncogene Proteins - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Membrane Proteins - genetics | Oligopeptides - genetics | Genes, Reporter - genetics | Proto-Oncogene Proteins - genetics | Oligopeptides - metabolism | Bioluminescence Resonance Energy Transfer Techniques | CRISPR-Cas Systems - genetics | Carrier Proteins - genetics | Leupeptins - pharmacology | Carrier Proteins - metabolism | Early Growth Response Transcription Factors - metabolism | Streptococcus pyogenes - enzymology | Luminescent Proteins - genetics | Gene Editing - methods | Protein Processing, Post-Translational | HeLa Cells | Kruppel-Like Transcription Factors - genetics | Luminescent Proteins - metabolism | Index Medicus
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6. Full Text BAG3 directly stabilizes Hexokinase 2 mRNA and promotes aerobic glycolysis in pancreatic cancer cells
by An, Ming-Xin and Li, Si and Yao, Han-Bing and Li, Chao and Wang, Jia-Mei and Sun, Jia and Li, Xin-Yu and Meng, Xiao-Na and Wang, Hua-Qin
The Journal of cell biology, ISSN 0021-9525, 2017, Volume 216, Issue 12, pp. 4091 - 4105
Life Sciences & Biomedicine | Science & Technology | Cell Biology | Neoplasm Transplantation | RNA-Binding Proteins - genetics | Endonucleases - genetics | Adenocarcinoma - pathology | Cell Proliferation | Pancreatic Neoplasms - metabolism | RNA, Guide - genetics | RNA, Guide - metabolism | Humans | Gene Expression Regulation, Neoplastic | CRISPR-Associated Protein 9 | Endonucleases - metabolism | RNA, Messenger - metabolism | Glycolysis - genetics | Adenocarcinoma - metabolism | Clustered Regularly Interspaced Short Palindromic Repeats | Apoptosis Regulatory Proteins - genetics | Adenocarcinoma - genetics | Hexokinase - genetics | Fibroblasts - metabolism | Pancreatic Neoplasms - pathology | RNA, Messenger - genetics | Bacterial Proteins - genetics | Ubiquitin-Protein Ligases - metabolism | Pancreatic Neoplasms - genetics | Gene Editing | Apoptosis Regulatory Proteins - metabolism | Animals | Mice, Nude | Adaptor Proteins, Signal Transducing - genetics | CRISPR-Cas Systems | Cell Line, Tumor | Glucose - metabolism | Bacterial Proteins - metabolism | Fibroblasts - cytology | Mice | Mice, Inbred BALB C | Primary Cell Culture | Adaptor Proteins, Signal Transducing - metabolism | Hexokinase - metabolism | Ubiquitin-Protein Ligases - genetics | RNA-Binding Proteins - metabolism | Adenocarcinoma | Post-transcription | mRNA | Glucose | Ribonucleic acid--RNA | Metabolism | Promotion | Gene expression | Cells | Hexokinase | Anticancer properties | Recruitment | Proteins | Glucose metabolism | RNA-binding protein | Molecular modelling | Antitumor agents | Historical account | Pancreatic cancer | Glycolysis | Aberration | Cancer | Index Medicus
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7. Full Text NP220 mediates silencing of unintegrated retroviral DNA
by Zhu, Yiping and Wang, Gary Z and Cingöz, Oya and Goff, Stephen P
Nature (London), ISSN 0028-0836, 12/2018, Volume 564, Issue 7735, pp. 278 - 282
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Humans | Gene Silencing | Histone Deacetylases - metabolism | Nuclear Proteins - metabolism | Phosphoproteins - metabolism | Virus Integration | Protein Methyltransferases - metabolism | CRISPR-Associated Protein 9 - genetics | CRISPR-Associated Protein 9 - metabolism | DNA-Binding Proteins - metabolism | Multiprotein Complexes - metabolism | Chromatin Immunoprecipitation | Proviruses - genetics | Retroviridae - genetics | Antigens, Neoplasm - metabolism | Clustered Regularly Interspaced Short Palindromic Repeats - genetics | DNA, Viral - genetics | Repressor Proteins - metabolism | Histone Deacetylase 1 - metabolism | Physiological aspects | Retrovirus infections | Zinc finger proteins | Integrase | Molecular machines | CRISPR | Chromatin | Immunoprecipitation | Proviruses | Viruses | Genomes | Permissive cells | Infections | Kinases | Gene expression | Experiments | Virology | Proteins | DNA-binding protein | Herpes viruses | Stem cells | Epigenetics | Histone methyltransferase | Deoxyribonucleic acid--DNA | Immune system | Index Medicus
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8. Full Text Massively parallel kinetic profiling of natural and engineered CRISPR nucleases
by Jones, Stephen K and Hawkins, John A and Johnson, Nicole V and Jung, Cheulhee and Hu, Kuang and Rybarski, James R and Chen, Janice S and Doudna, Jennifer A and Press, William H and Finkelstein, Ilya J
Nature biotechnology, ISSN 1087-0156, 09/2020, Volume 39, Issue 1, pp. 84 - 93
Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Science & Technology | CRISPR-Associated Proteins - chemistry | Protein Binding - genetics | RNA, Guide - genetics | CRISPR-Associated Proteins - genetics | RNA, Guide - metabolism | Bacterial Proteins - chemistry | Bacterial Proteins - genetics | CRISPR-Associated Protein 9 - chemistry | Endodeoxyribonucleases - chemistry | Substrate Specificity - genetics | Gene Editing | CRISPR-Associated Protein 9 - genetics | CRISPR-Associated Protein 9 - metabolism | Endodeoxyribonucleases - genetics | RNA, Guide - chemistry | CRISPR-Associated Proteins - metabolism | CRISPR-Cas Systems | Endodeoxyribonucleases - metabolism | Protein Engineering | Bacterial Proteins - metabolism | Kinetics | High-Throughput Nucleotide Sequencing - methods | Nucleases | Scientific equipment and supplies industry | DNA binding proteins | RNA | Multiprocessing | DNA | Binding | CRISPR | Profiling | Cleavage | Nucleotides | Nuclease | Ribonucleic acid--RNA | Deoxyribonucleic acid--DNA | Index Medicus
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9. Full Text Protein Inhibitors of CRISPR-Cas9
by Bondy-Denomy, Joseph
ACS chemical biology, ISSN 1554-8929, 02/2018, Volume 13, Issue 2, pp. 417 - 423
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | CRISPR-Associated Proteins - genetics | Humans | DNA - metabolism | CRISPR-Associated Protein 9 - antagonists & inhibitors | Bacteria - genetics | CRISPR-Cas Systems - genetics | Viral Proteins - metabolism | Gene Editing | CRISPR-Associated Protein 9 - genetics | CRISPR-Associated Proteins - antagonists & inhibitors | CRISPR-Associated Protein 9 - metabolism | DNA - chemistry | Bacteriophages - metabolism | CRISPR-Associated Proteins - metabolism | Streptococcus pyogenes - enzymology | Clustered Regularly Interspaced Short Palindromic Repeats | Protein Binding | Index Medicus
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10. Full Text An enhanced CRISPR repressor for targeted mammalian gene regulation
by Yeo, Nan Cher and Chavez, Alejandro and Lance-Byrne, Alissa and Chan, Yingleong and Menn, David and Milanova, Denitsa and Kuo, Chih-Chung and Guo, Xiaoge and Sharma, Sumana and Tung, Angela and Cecchi, Ryan J and Tuttle, Marcelle and Pradhan, Swechchha and Lim, Elaine T and Davidsohn, Noah and Ebrahimkhani, Mo R and Collins, James J and Lewis, Nathan E and Kiani, Samira and Church, George M
Nature methods, ISSN 1548-7091, 08/2018, Volume 15, Issue 8, pp. 611 - 616
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Biochemical Research Methods | Science & Technology | RNA, Guide - genetics | Humans | Gene Expression Regulation | Gene Silencing | Genes, Synthetic | Methyl-CpG-Binding Protein 2 - metabolism | Repressor Proteins - genetics | Recombinant Fusion Proteins - metabolism | Methyl-CpG-Binding Protein 2 - genetics | CRISPR-Associated Protein 9 - genetics | CRISPR-Associated Protein 9 - metabolism | CRISPR-Cas Systems | HEK293 Cells | Recombinant Fusion Proteins - genetics | Repressor Proteins - metabolism | Gene silencing | Genetic transcription | Research | Genetic regulation | Analysis | CRISPR | Repressing | Transcription | Genes | Gene regulation | Ribonucleic acid--RNA | Gene expression | Screens | Methyl-CpG binding protein | MeCP2 protein | Nuclease | Endonuclease | Index Medicus
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