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Journal Article
Molecular Cell, ISSN 1097-2765, 07/2019, Volume 75, Issue 1, pp. 90 - 101.e5
Journal Article
Molecular Cell, ISSN 1097-2765, 02/2019, Volume 73, Issue 3, pp. 601 - 610.e5
CRISPR-Cas immune systems utilize RNA-guided nucleases to protect bacteria from bacteriophage infection. Bacteriophages have in turn evolved inhibitory... 
anti-CRISPR | genome editing | CRISPR-Cas9 | CRISPR-Cas | temperature-dependent inhibition | Cas9 | Cas9 inhibitors | PAM blockage | AcrIIA2 | bacteriophage | IMMUNITY | COMPLEX | BACTERIA | RNA | BIOCHEMISTRY & MOLECULAR BIOLOGY | ANTI-CRISPR | CRYO-EM | CLASSIFICATION | CAS SYSTEMS | MECHANISMS | DISCOVERY | CELL BIOLOGY | Temperature | Pseudomonas Phages - metabolism | RNA, Guide - genetics | RNA, Guide - metabolism | Pseudomonas aeruginosa - virology | RNA, Guide - ultrastructure | DNA - ultrastructure | Structure-Activity Relationship | CRISPR-Associated Protein 9 - antagonists & inhibitors | CRISPR-Associated Protein 9 - ultrastructure | Viral Proteins - metabolism | Pseudomonas Phages - genetics | CRISPR-Associated Protein 9 - genetics | CRISPR-Associated Protein 9 - metabolism | Pseudomonas aeruginosa - enzymology | Nucleic Acid Conformation | Binding, Competitive | Escherichia coli - enzymology | Models, Molecular | Viral Proteins - genetics | DNA - metabolism | Viral Proteins - ultrastructure | Cryoelectron Microscopy | DNA - genetics | Pseudomonas aeruginosa - genetics | Escherichia coli - genetics | CRISPR-Cas Systems | Protein Binding | Protein Conformation | Gene Editing - methods | Gene Expression Regulation, Bacterial | Enzymes | Nucleases | Genomics | Bacteria | DNA binding proteins | DNA-ligand interactions | Cells | Protein binding
Journal Article
Journal of Cell Biology, ISSN 0021-9525, 2017, Volume 216, Issue 12, pp. 4091 - 4105
Journal Article
Journal Article
Molecular Cell, ISSN 1097-2765, 10/2016, Volume 64, Issue 1, pp. 51 - 64
The tumor suppressor protein 53BP1, a pivotal regulator of DNA double-strand break (DSB) repair, was first identified as a p53-interacting protein over two... 
BRCT DOMAINS | ACTIVATION | STRAND BREAK REPAIR | RESECTION | DAMAGE-RESPONSE | BIOCHEMISTRY & MOLECULAR BIOLOGY | V(D)J RECOMBINATION | TUMOR-SUPPRESSOR | CLASS-SWITCH RECOMBINATION | P53 PATHWAY | PROTEINS | CELL BIOLOGY | Gamma Rays | Endonucleases - genetics | Tumor Suppressor p53-Binding Protein 1 - chemistry | RNA, Guide - genetics | RNA, Guide - metabolism | Humans | Protein Multimerization | CRISPR-Associated Protein 9 | Endonucleases - metabolism | DNA Breaks, Double-Stranded | Tumor Suppressor Protein p53 - genetics | MCF-7 Cells | Base Sequence | Clustered Regularly Interspaced Short Palindromic Repeats | Ubiquitin Thiolesterase - metabolism | Protein Interaction Domains and Motifs | Binding Sites | Tumor Suppressor p53-Binding Protein 1 - metabolism | Promoter Regions, Genetic | Protein Conformation, alpha-Helical | Tumor Suppressor p53-Binding Protein 1 - genetics | Signal Transduction | Bacterial Proteins - genetics | Gene Expression Regulation | Tumor Suppressor Protein p53 - metabolism | Ubiquitin Thiolesterase - genetics | Gene Editing | Protein Conformation, beta-Strand | DNA Repair | Protein Binding | Bacterial Proteins - metabolism | Tumor Suppressor Protein p53 - chemistry | Ubiquitin Thiolesterase - chemistry | Oligomers | Ubiquitin | Ionizing radiation | Chromatin | Proteases | Genes | Genomics | DNA | Tumor proteins | DNA repair
Journal Article
ACS Chemical Biology, ISSN 1554-8929, 02/2018, Volume 13, Issue 2, pp. 467 - 474
Journal Article
Nature Medicine, ISSN 1078-8956, 07/2018, Volume 24, Issue 7, pp. 939 - 946
Journal Article
Nature Communications, ISSN 2041-1723, 01/2019, Volume 10, Issue 1, pp. 439 - 10
Journal Article
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 09/2018, Volume 146, Issue 5, pp. 526 - 539
The chemokine CCL5 prevents neuronal cell death mediated both by amyloid β, as well as the human immunodeficiency virus viral proteins gp120 and Tat. Because... 
CXCR4 | AKT | CCR5 | signal transduction | CRISPR‐Cas9 | ERK | CRISPR-Cas9 | NEURONAL APOPTOSIS | ALZHEIMERS-DISEASE | DESENSITIZATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | GP120 | NEUROSCIENCES | PEPTIDE | CELL-DEATH | INTERNALIZATION | MOUSE MODEL | Receptors, G-Protein-Coupled - metabolism | Embryo, Mammalian | Humans | Protein Transport - drug effects | Cerebral Cortex - cytology | CRISPR-Associated Protein 9 - genetics | CRISPR-Associated Protein 9 - metabolism | Antineoplastic Agents - pharmacology | Chemokine CCL5 - metabolism | Neurons - metabolism | Neurons - drug effects | Neuroblastoma - pathology | Pertussis Toxin - pharmacology | Tretinoin - pharmacology | T-Lymphocytes | Cells, Cultured | Enzyme Inhibitors - pharmacology | Mutagenesis - genetics | Gene Expression Regulation - physiology | Rats | Protein Transport - genetics | Animals | Chemokine CCL5 - pharmacology | Signal Transduction - drug effects | Chemokine CCL5 - genetics | Signal Transduction - physiology | Receptors, G-Protein-Coupled - genetics | Synthesis | Viral proteins | Glycogen | Cell death | Cellular signal transduction | Protein kinases | Protein binding | Neuroprotection | CC chemokine receptors | Flow cytometry | Phosphorylation | Viruses | AKT protein | Antagonists | Kinases | Neuroblastoma cells | Proteins | CCR1 protein | Time dependence | Receptors | Human immunodeficiency virus--HIV | CRISPR | CCR5 protein | Extracellular signal-regulated kinase | Glycogen synthase kinase 3 | Pharmacology | Tat protein | Signaling | Internalization | Chemokines | Glycoprotein gp120
Journal Article