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1. Full Text Phage AcrIIA2 DNA Mimicry: Structural Basis of the CRISPR and Anti-CRISPR Arms Race
by Liu, Liang and Yin, Maolu and Wang, Min and Wang, Yanli
Molecular Cell, ISSN 1097-2765, 02/2019, Volume 73, Issue 3, pp. 611 - 620.e3
CRISPR-Cas (clustered regularly interspaced short palindromic repeats-CRISPR-associated proteins) systems provide prokaryotic cells with adaptive immunity... 
AcrIIA2 | sgRNA | SpyCas9 | anti-CRISPR protein | COMPLEX | INHIBITION | PROTEIN | RNA | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | RESISTANCE | CAS9 | VIRAL SUPPRESSORS | INSIGHTS | CELL BIOLOGY | RNA, Guide - genetics | RNA, Guide - metabolism | Structure-Activity Relationship | CRISPR-Associated Protein 9 - antagonists & inhibitors | Viral Proteins - metabolism | CRISPR-Associated Protein 9 - genetics | CRISPR-Associated Protein 9 - metabolism | Molecular Mimicry | Escherichia coli - virology | RNA, Guide - chemistry | Clustered Regularly Interspaced Short Palindromic Repeats | Bacteriophages - genetics | Protein Interaction Domains and Motifs | Nucleic Acid Conformation | Binding Sites | Binding, Competitive | Escherichia coli - enzymology | Viral Proteins - chemistry | Models, Molecular | Viral Proteins - genetics | CRISPR-Associated Protein 9 - chemistry | DNA - metabolism | DNA - genetics | DNA - chemistry | Escherichia coli - genetics | Bacteriophages - metabolism | CRISPR-Cas Systems | Protein Binding | Protein Conformation | Gene Editing - methods | Proteins | Microbiology | Genomics | DNA | Crystals | Structure
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2. Full Text Structure of the DNA-Bound Spacer Capture Complex of a Type II CRISPR-Cas System
by Wilkinson, Martin and Drabavicius, Gediminas and Silanskas, Arunas and Gasiunas, Giedrius and Siksnys, Virginijus and Wigley, Dale B
Molecular Cell, ISSN 1097-2765, 07/2019, Volume 75, Issue 1, pp. 90 - 101.e5
CRISPR and associated Cas proteins function as an adaptive immune system in prokaryotes to combat bacteriophage infection. During the immunization step, new... 
IMMUNITY | PROTEIN | ENDONUCLEASE | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ADAPTATION | ACQUISITION | CRYO-EM | BEAM-INDUCED MOTION | CSN2 | PAM | CELL BIOLOGY | Protein Multimerization | Substrate Specificity | Isoenzymes - chemistry | CRISPR-Associated Protein 9 - genetics | CRISPR-Associated Protein 9 - metabolism | Streptococcus thermophilus - metabolism | Isoenzymes - metabolism | Base Sequence | DNA, Intergenic - metabolism | Cloning, Molecular | Escherichia coli - metabolism | Protein Interaction Domains and Motifs | Streptococcus thermophilus - genetics | Nucleic Acid Conformation | Binding Sites | Recombinant Proteins - metabolism | Protein Conformation, alpha-Helical | Gene Expression | Genetic Vectors - chemistry | Isoenzymes - genetics | Genetic Vectors - metabolism | Recombinant Proteins - chemistry | CRISPR-Associated Protein 9 - chemistry | Recombinant Proteins - genetics | DNA - metabolism | DNA, Intergenic - genetics | DNA, Intergenic - chemistry | Cryoelectron Microscopy | DNA - genetics | DNA - chemistry | Protein Conformation, beta-Strand | Escherichia coli - genetics | CRISPR-Cas Systems | Protein Binding | Molecular Docking Simulation | Proteins | DNA
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3. Full Text Protein Inhibitors of CRISPR-Cas9
by Bondy-Denomy, Joseph
ACS Chemical Biology, ISSN 1554-8929, 02/2018, Volume 13, Issue 2, pp. 417 - 423
Bacteria are under constant predation from viruses, called bacteriophages (phages). This threat has driven the evolution of multiple defense systems, including... 
COMPLEX | ENDONUCLEASE | DNA | BIOCHEMISTRY & MOLECULAR BIOLOGY | ANTI-CRISPR | CLASSIFICATION | MECHANISMS | VIRUSES | NUCLEASES | CRISPR-Associated Proteins - genetics | Humans | DNA - metabolism | CRISPR-Associated Protein 9 - antagonists & inhibitors | Bacteria - genetics | CRISPR-Cas Systems - genetics | Viral Proteins - metabolism | Gene Editing | CRISPR-Associated Protein 9 - genetics | CRISPR-Associated Proteins - antagonists & inhibitors | CRISPR-Associated Protein 9 - metabolism | DNA - chemistry | Bacteriophages - metabolism | CRISPR-Associated Proteins - metabolism | Streptococcus pyogenes - enzymology | Clustered Regularly Interspaced Short Palindromic Repeats | Protein Binding
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4. Full Text Temperature-Responsive Competitive Inhibition of CRISPR-Cas9
by Jiang, Fuguo and Liu, Jun-Jie and Osuna, Beatriz A and Xu, Michael and Berry, Joel D and Rauch, Benjamin J and Nogales, Eva and Bondy-Denomy, Joseph and Doudna, Jennifer A
Molecular Cell, ISSN 1097-2765, 02/2019, Volume 73, Issue 3, pp. 601 - 610.e5
CRISPR-Cas immune systems utilize RNA-guided nucleases to protect bacteria from bacteriophage infection. Bacteriophages have in turn evolved inhibitory... 
anti-CRISPR | genome editing | CRISPR-Cas9 | CRISPR-Cas | temperature-dependent inhibition | Cas9 | Cas9 inhibitors | PAM blockage | AcrIIA2 | bacteriophage | IMMUNITY | COMPLEX | BACTERIA | RNA | BIOCHEMISTRY & MOLECULAR BIOLOGY | ANTI-CRISPR | CRYO-EM | CLASSIFICATION | CAS SYSTEMS | MECHANISMS | DISCOVERY | CELL BIOLOGY | Temperature | Pseudomonas Phages - metabolism | RNA, Guide - genetics | RNA, Guide - metabolism | Pseudomonas aeruginosa - virology | RNA, Guide - ultrastructure | DNA - ultrastructure | Structure-Activity Relationship | CRISPR-Associated Protein 9 - antagonists & inhibitors | CRISPR-Associated Protein 9 - ultrastructure | Viral Proteins - metabolism | Pseudomonas Phages - genetics | CRISPR-Associated Protein 9 - genetics | CRISPR-Associated Protein 9 - metabolism | Pseudomonas aeruginosa - enzymology | Nucleic Acid Conformation | Binding, Competitive | Escherichia coli - enzymology | Models, Molecular | Viral Proteins - genetics | DNA - metabolism | Viral Proteins - ultrastructure | Cryoelectron Microscopy | DNA - genetics | Pseudomonas aeruginosa - genetics | Escherichia coli - genetics | CRISPR-Cas Systems | Protein Binding | Protein Conformation | Gene Editing - methods | Gene Expression Regulation, Bacterial | Enzymes | Nucleases | Genomics | Bacteria | DNA binding proteins | DNA-ligand interactions | Cells | Protein binding
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5. Full Text BAG3 directly stabilizes Hexokinase 2 mRNA and promotes aerobic glycolysis in pancreatic cancer cells
by An, Ming-Xin and Li, Si and Yao, Han-Bing and Li, Chao and Wang, Jia-Mei and Sun, Jia and Li, Xin-Yu and Meng, Xiao-Na and Wang, Hua-Qin
Journal of Cell Biology, ISSN 0021-9525, 2017, Volume 216, Issue 12, pp. 4091 - 4105
Aerobic glycolysis, a phenomenon known historically as the Warburg effect, is one of the hallmarks of cancer cells. In this study, we characterized the role of... 
APOPTOSIS | DECAY | PATHWAY | ANTIAPOPTOTIC PROTEIN BAG3 | CELL BIOLOGY | Neoplasm Transplantation | RNA-Binding Proteins - genetics | Endonucleases - genetics | Adenocarcinoma - pathology | Cell Proliferation | Pancreatic Neoplasms - metabolism | RNA, Guide - genetics | RNA, Guide - metabolism | Humans | Gene Expression Regulation, Neoplastic | CRISPR-Associated Protein 9 | Endonucleases - metabolism | RNA, Messenger - metabolism | Glycolysis - genetics | Adenocarcinoma - metabolism | Clustered Regularly Interspaced Short Palindromic Repeats | Apoptosis Regulatory Proteins - genetics | Adenocarcinoma - genetics | Hexokinase - genetics | Fibroblasts - metabolism | Pancreatic Neoplasms - pathology | RNA, Messenger - genetics | Bacterial Proteins - genetics | Ubiquitin-Protein Ligases - metabolism | Pancreatic Neoplasms - genetics | Gene Editing | Apoptosis Regulatory Proteins - metabolism | Animals | Mice, Nude | Adaptor Proteins, Signal Transducing - genetics | CRISPR-Cas Systems | Cell Line, Tumor | Glucose - metabolism | Bacterial Proteins - metabolism | Fibroblasts - cytology | Mice | Mice, Inbred BALB C | Primary Cell Culture | Adaptor Proteins, Signal Transducing - metabolism | Hexokinase - metabolism | Ubiquitin-Protein Ligases - genetics | RNA-Binding Proteins - metabolism
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6. Full Text NP220 mediates silencing of unintegrated retroviral DNA
by Zhu, Yiping and Wang, Gary Z and Cingöz, Oya and Goff, Stephen P
Nature, ISSN 0028-0836, 12/2018, Volume 564, Issue 7735, pp. 278 - 282
The entry of foreign DNA into many mammalian cell types triggers the innate immune system, a complex set of responses to prevent infection by pathogens. One... 
COMPLEX | VIRUS | PROTEIN | GENE | MULTIDISCIPLINARY SCIENCES | ICP0 | RESTRICTION | Humans | Gene Silencing | Histone Deacetylases - metabolism | Nuclear Proteins - metabolism | Phosphoproteins - metabolism | Virus Integration | Protein Methyltransferases - metabolism | CRISPR-Associated Protein 9 - genetics | CRISPR-Associated Protein 9 - metabolism | DNA-Binding Proteins - metabolism | Multiprotein Complexes - metabolism | Chromatin Immunoprecipitation | Proviruses - genetics | Retroviridae - genetics | Antigens, Neoplasm - metabolism | Clustered Regularly Interspaced Short Palindromic Repeats - genetics | DNA, Viral - genetics | Repressor Proteins - metabolism | Histone Deacetylase 1 - metabolism | Physiological aspects | Retrovirus infections | Zinc finger proteins | Integrase | Molecular machines | CRISPR | Chromatin | Immunoprecipitation | Proviruses | Viruses | Genomes | Permissive cells | Infections | Kinases | Gene expression | Experiments | Virology | Proteins | DNA-binding protein | Herpes viruses | Stem cells | Epigenetics | Histone methyltransferase | Deoxyribonucleic acid--DNA | Immune system
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7. Full Text 53BP1 Integrates DNA Repair and p53-Dependent Cell Fate Decisions via Distinct Mechanisms
by Cuella-Martin, Raquel and Oliveira, Catarina and Lockstone, Helen E and Snellenberg, Suzanne and Grolmusova, Natalia and Chapman, J. Ross
Molecular Cell, ISSN 1097-2765, 10/2016, Volume 64, Issue 1, pp. 51 - 64
The tumor suppressor protein 53BP1, a pivotal regulator of DNA double-strand break (DSB) repair, was first identified as a p53-interacting protein over two... 
BRCT DOMAINS | ACTIVATION | STRAND BREAK REPAIR | RESECTION | DAMAGE-RESPONSE | BIOCHEMISTRY & MOLECULAR BIOLOGY | V(D)J RECOMBINATION | TUMOR-SUPPRESSOR | CLASS-SWITCH RECOMBINATION | P53 PATHWAY | PROTEINS | CELL BIOLOGY | Gamma Rays | Endonucleases - genetics | Tumor Suppressor p53-Binding Protein 1 - chemistry | RNA, Guide - genetics | RNA, Guide - metabolism | Humans | Protein Multimerization | CRISPR-Associated Protein 9 | Endonucleases - metabolism | DNA Breaks, Double-Stranded | Tumor Suppressor Protein p53 - genetics | MCF-7 Cells | Base Sequence | Clustered Regularly Interspaced Short Palindromic Repeats | Ubiquitin Thiolesterase - metabolism | Protein Interaction Domains and Motifs | Binding Sites | Tumor Suppressor p53-Binding Protein 1 - metabolism | Promoter Regions, Genetic | Protein Conformation, alpha-Helical | Tumor Suppressor p53-Binding Protein 1 - genetics | Signal Transduction | Bacterial Proteins - genetics | Gene Expression Regulation | Tumor Suppressor Protein p53 - metabolism | Ubiquitin Thiolesterase - genetics | Gene Editing | Protein Conformation, beta-Strand | DNA Repair | Protein Binding | Bacterial Proteins - metabolism | Tumor Suppressor Protein p53 - chemistry | Ubiquitin Thiolesterase - chemistry | Oligomers | Ubiquitin | Ionizing radiation | Chromatin | Proteases | Genes | Genomics | DNA | Tumor proteins | DNA repair
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8. Full Text CRISPR-Mediated Tagging of Endogenous Proteins with a Luminescent Peptide
by Schwinn, Marie K and Machleidt, Thomas and Zimmerman, Kris and Eggers, Christopher T and Dixon, Andrew S and Hurst, Robin and Hall, Mary P and Encell, Lance P and Binkowski, Brock F and Wood, Keith V
ACS Chemical Biology, ISSN 1554-8929, 02/2018, Volume 13, Issue 2, pp. 467 - 474
Intracellular signaling pathways are mediated by changes in protein abundance and post-translational modifications. A common approach for investigating... 
REPORTER | CELLS | HYPOXIA-INDUCIBLE FACTOR-1-ALPHA | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENES | HIF PROLYL | PROBE | Luciferases - metabolism | Antibodies - chemistry | Humans | Luminescence | Neoplasm Proteins - metabolism | CRISPR-Associated Protein 9 - genetics | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Kruppel-Like Transcription Factors - metabolism | Early Growth Response Transcription Factors - genetics | Luminescent Proteins - chemistry | Membrane Proteins - metabolism | Neoplasm Proteins - genetics | Oligopeptides - chemistry | Proto-Oncogene Proteins - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Membrane Proteins - genetics | Oligopeptides - genetics | Genes, Reporter - genetics | Proto-Oncogene Proteins - genetics | Oligopeptides - metabolism | Bioluminescence Resonance Energy Transfer Techniques | CRISPR-Cas Systems - genetics | Carrier Proteins - genetics | Leupeptins - pharmacology | Carrier Proteins - metabolism | Early Growth Response Transcription Factors - metabolism | Streptococcus pyogenes - enzymology | Luminescent Proteins - genetics | Gene Editing - methods | Protein Processing, Post-Translational | HeLa Cells | Kruppel-Like Transcription Factors - genetics | Luminescent Proteins - metabolism
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9. Full Text P53 inhibits CRISPR-Cas9 engineering in human pluripotent stem cells
by Ihry, Robert J and Worringer, Kathleen A and Salick, Max R and Frias, Elizabeth and Ho, Daniel and Theriault, Kraig and Kommineni, Sravya and Chen, Julie and Sondey, Marie and Ye, Chaoyang and Randhawa, Ranjit and Kulkarni, Tripti and Yang, Zinger and McAllister, Gregory and Russ, Carsten and Reece-Hoyes, John and Forrester, William and Hoffman, Gregory R and Dolmetsch, Ricardo and Kaykas, Ajamete
Nature Medicine, ISSN 1078-8956, 07/2018, Volume 24, Issue 7, pp. 939 - 946
CRISPR/Cas9 has revolutionized our ability to engineer genomes and conduct genome-wide screens in human cells(1-3). Whereas some cell types are amenable to... 
MEDICINE, RESEARCH & EXPERIMENTAL | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | NETWORKS | CANCER | NUCLEASES | CELL BIOLOGY | PATHWAY | DISEASE | GENERATION | HOMOLOGOUS RECOMBINATION | CAS9 | HUMAN ESCS | RNA, Guide - metabolism | Humans | RNA, Messenger - genetics | Tumor Suppressor Protein p53 - metabolism | RNA, Messenger - metabolism | fas Receptor - metabolism | CRISPR-Cas Systems - genetics | DNA Breaks, Double-Stranded | CRISPR-Associated Protein 9 - metabolism | Pluripotent Stem Cells - metabolism | Cyclin-Dependent Kinase Inhibitor p21 - genetics | Genetic Engineering | Gene Deletion | fas Receptor - genetics | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Transcription, Genetic | Polymerase chain reaction | Usage | Stem cells | Nucleotide sequencing | Research | Gene expression | Tumor proteins | DNA sequencing | CRISPR | Toxicity | p53 Protein | Ribonucleoproteins | Insertion | Stem cell transplantation | Genomes | Tumor cell lines | Engineering | Transfection | Clonal deletion | Efficiency | Engineers | Pluripotency | Tumors
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10. Full Text Engineering of high-precision base editors for site-specific single nucleotide replacement
by Tan, Junjie and Tan, Junjie and Zhang, Fei and Zhang, Fei and Karcher, Daniel and Karcher, Daniel and Bock, Ralph and Bock, Ralph
Nature Communications, ISSN 2041-1723, 01/2019, Volume 10, Issue 1, pp. 439 - 10
RNA-guided nucleases of the CRISPR/Cas type can be repurposed as programmable nucleotide deaminases to mediate targeted nucleotide substitutions. Such base... 
MUTAGENESIS | CAS9 | RNA | MULTIDISCIPLINARY SCIENCES | GENOMIC DNA | Amino Acid Transport Systems, Basic - genetics | RNA, Guide - genetics | RNA, Guide - metabolism | Saccharomyces cerevisiae - genetics | APOBEC-1 Deaminase - genetics | Isoenzymes - chemistry | APOBEC-1 Deaminase - chemistry | CRISPR-Associated Protein 9 - genetics | CRISPR-Associated Protein 9 - metabolism | Isoenzymes - metabolism | Base Sequence | Sensitivity and Specificity | Clustered Regularly Interspaced Short Palindromic Repeats | Cytidine - genetics | Thymidine - metabolism | Genetic Engineering - methods | Mutagenesis, Site-Directed | Thymidine - genetics | Isoenzymes - genetics | CRISPR-Associated Protein 9 - chemistry | APOBEC-1 Deaminase - metabolism | Saccharomyces cerevisiae Proteins - genetics | CRISPR-Cas Systems | Saccharomyces cerevisiae Proteins - metabolism | Saccharomyces cerevisiae - enzymology | Cytidine - metabolism | Gene Editing - methods | Amino Acid Transport Systems, Basic - metabolism | Engineering | CRISPR | Breeding | Editors | Editing | Genomes | Nucleotides | Mutation | Ribonucleic acid--RNA | Gene therapy | Cytidine deaminase
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11. Full Text Precise and Predictable CRISPR Chromosomal Rearrangements Reveal Principles of Cas9-Mediated Nucleotide Insertion
by Shou, Jia and Li, Jinhuan and Liu, Yingbin and Wu, Qiang
Molecular Cell, ISSN 1097-2765, 08/2018, Volume 71, Issue 4, pp. 498 - 509.e4
Chromosomal rearrangements including large DNA-fragment inversions, deletions, and duplications by Cas9 with paired sgRNAs are important to investigate genome... 
DNA-fragment editing | CRISPR | PAM configurations | chromosomal rearrangements | FANCD2 | CtIP | Cas9 variants | NHEJ | staggered cleavage | precise and predictable genome editing | REPAIR | DUPLICATIONS | ENDONUCLEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CTIP | TARGET DNA | GUIDE RNA | CLEAVAGE | DNA-END RESECTION | GENOME | INVERSIONS | CELL BIOLOGY | Gene Duplication | Sequence Deletion | Fanconi Anemia Complementation Group D2 Protein - genetics | RNA, Guide - genetics | RNA, Guide - metabolism | Humans | DNA Breaks, Double-Stranded | CRISPR-Associated Protein 9 - genetics | CRISPR-Associated Protein 9 - metabolism | Base Sequence | DNA End-Joining Repair | Clustered Regularly Interspaced Short Palindromic Repeats | HEK293 Cells | Nuclear Proteins - genetics | Nuclear Proteins - metabolism | Sequence Inversion | DNA - metabolism | DNA - genetics | Carrier Proteins - genetics | Carrier Proteins - metabolism | Fanconi Anemia Complementation Group D2 Protein - metabolism | CRISPR-Cas Systems | Gene Editing - methods | Mutagenesis, Insertional | Genome, Human | Nucleases | Anopheles | Analysis | Genes | Genomics | Nucleotides | DNA binding proteins
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12. Full Text Mutagenesis of putative ciliary genes with the CRISPR/Cas9 system in zebrafish identifies genes required for retinal development
by Hu, RK and Huang, WL and Liu, JF and Jin, MM and Wu, Y and Li, JY and Wang, JY and Yu, ZH and Wang, H and Cao, Y
FASEB JOURNAL, ISSN 0892-6638, 04/2019, Volume 33, Issue 4, pp. 5248 - 5256
Cilia are conserved microtubule-based organelles that function as mechanical and chemical sensors in various cell types. By bioinformatic, genomic, and... 
SURVIVAL | COMPLEX | genetic screen | BIOCHEMISTRY & MOLECULAR BIOLOGY | MEMBRANES | GENOME | CELL BIOLOGY | cilium | TRANSPORT | retina | CILIOPATHY PROTEIN | DISSECTION | INTERACTS | DISEASE | BIOLOGY | PHOTORECEPTORS | Clustered Regularly Interspaced Short Palindromic Repeats - physiology | Proto-Oncogene Proteins - metabolism | Retina - metabolism | Zebrafish Proteins - metabolism | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Proto-Oncogene Proteins - genetics | Zebrafish | Retina - embryology | CRISPR-Associated Protein 9 - genetics | CRISPR-Associated Protein 9 - metabolism | Animals | In Situ Hybridization | Mutagenesis | Neural Tube - metabolism | Cell Cycle Proteins - genetics | Clustered Regularly Interspaced Short Palindromic Repeats - genetics | Neural Tube - embryology | Protein-Serine-Threonine Kinases - metabolism | Index Medicus
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13. Full Text The initiation, propagation and dynamics of CRISPR-SpyCas9 R-loop complex
by Zeng, Yan and Cui, Yang and Zhang, Yong and Zhang, Yanruo and Liang, Meng and Chen, Hui and Lan, Jie and Song, Guangtao and Lou, Jizhong
Nucleic Acids Research, ISSN 0305-1048, 01/2018, Volume 46, Issue 1, pp. 350 - 361
Abstract CRISPR-Cas9 system has been widely used for efficient genome editing. Although the structures of Cas9 protein in complex with single-guided RNA... 
CRISPR-CAS SYSTEMS | SINGLE-MOLECULE FRET | SPECIFICITY | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | RNA-GUIDED ENDONUCLEASE | FORCE-FIELD | PROVIDES ACQUIRED-RESISTANCE | CLEAVAGE | TARGET DNA RECOGNITION | NUCLEASES | RNA, Guide - genetics | RNA, Guide - metabolism | Bacterial Proteins - chemistry | Bacterial Proteins - genetics | Models, Molecular | CRISPR-Associated Protein 9 - chemistry | DNA - metabolism | Sequence Homology, Nucleic Acid | CRISPR-Associated Protein 9 - genetics | CRISPR-Associated Protein 9 - metabolism | DNA - genetics | Streptococcus pyogenes - genetics | DNA - chemistry | Base Sequence | Streptococcus pyogenes - enzymology | CRISPR-Cas Systems | Protein Binding | Protein Domains | Bacterial Proteins - metabolism | Gene Editing - methods | Nucleic Acid Conformation | DNA Cleavage | RNA and RNA-protein complexes
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14. Full Text Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 with improved proof-reading enhances homology-directed repair
by Kato-Inui, Tomoko and Takahashi, Gou and Hsu, Szuyin and Miyaoka, Yuichiro
Nucleic Acids Research, ISSN 0305-1048, 05/2018, Volume 46, Issue 9, pp. 4677 - 4688
Abstract Genome editing using clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) predominantly induces... 
CELLS | DNA CLEAVAGE | ENDONUCLEASE | RNA | BIOCHEMISTRY & MOLECULAR BIOLOGY | CRISPR-CAS9 | CAS9 | EFFICIENCY | GENOMIC DNA | NUCLEASES | BASE | Recombinational DNA Repair | Humans | CRISPR-Associated Protein 9 - chemistry | DNA - metabolism | RNA - chemistry | Gene Editing | Guanine | CRISPR-Associated Protein 9 - genetics | CRISPR-Associated Protein 9 - metabolism | Genetic Variation | DNA End-Joining Repair | HEK293 Cells | Polymerase Chain Reaction | Protein Conformation | HeLa Cells | Nucleic Acid Enzymes
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15. Full Text The orphan G‐protein‐coupled receptor 75 signaling is activated by the chemokine CCL5
by Dedoni, Simona and Campbell, Lee A and Harvey, Brandon K and Avdoshina, Valeria and Mocchetti, Italo
Journal of Neurochemistry, ISSN 0022-3042, 09/2018, Volume 146, Issue 5, pp. 526 - 539
The chemokine CCL5 prevents neuronal cell death mediated both by amyloid β, as well as the human immunodeficiency virus viral proteins gp120 and Tat. Because... 
CXCR4 | AKT | CCR5 | signal transduction | CRISPR‐Cas9 | ERK | CRISPR-Cas9 | NEURONAL APOPTOSIS | ALZHEIMERS-DISEASE | DESENSITIZATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | GP120 | NEUROSCIENCES | PEPTIDE | CELL-DEATH | INTERNALIZATION | MOUSE MODEL | Receptors, G-Protein-Coupled - metabolism | Embryo, Mammalian | Humans | Protein Transport - drug effects | Cerebral Cortex - cytology | CRISPR-Associated Protein 9 - genetics | CRISPR-Associated Protein 9 - metabolism | Antineoplastic Agents - pharmacology | Chemokine CCL5 - metabolism | Neurons - metabolism | Neurons - drug effects | Neuroblastoma - pathology | Pertussis Toxin - pharmacology | Tretinoin - pharmacology | T-Lymphocytes | Cells, Cultured | Enzyme Inhibitors - pharmacology | Mutagenesis - genetics | Gene Expression Regulation - physiology | Rats | Protein Transport - genetics | Animals | Chemokine CCL5 - pharmacology | Signal Transduction - drug effects | Chemokine CCL5 - genetics | Signal Transduction - physiology | Receptors, G-Protein-Coupled - genetics | Synthesis | Viral proteins | Glycogen | Cell death | Cellular signal transduction | Protein kinases | Protein binding | Neuroprotection | CC chemokine receptors | Flow cytometry | Phosphorylation | Viruses | AKT protein | Antagonists | Kinases | Neuroblastoma cells | Proteins | CCR1 protein | Time dependence | Receptors | Human immunodeficiency virus--HIV | CRISPR | CCR5 protein | Extracellular signal-regulated kinase | Glycogen synthase kinase 3 | Pharmacology | Tat protein | Signaling | Internalization | Chemokines | Glycoprotein gp120
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