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Nature, ISSN 0028-0836, 10/2015, Volume 526, Issue 7571, pp. 136 - 139
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2014, Volume 111, Issue 46, pp. 16359 - 16364
Mobile genetic elements in bacteria are neutralized by a system based on clustered regularly interspaced short palindromic repeats (CRISPRs) and... 
Proteins | Molecules | RNA | Active sites | DNA | Adenosine triphosphatases | Nucleic acids | Tunnels | Crystal structure | Metal ions | Bacterial immunity | Cas3 | CRISPR | Cas proteins | Cascade | COMPLEX | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | ESCHERICHIA-COLI | bacterial immunity | ADAPTIVE IMMUNITY | ANTIVIRAL DEFENSE | STRUCTURAL BASIS | BACTERIAL IMMUNE-SYSTEM | IN-VITRO RECONSTITUTION | CRISPR-Associated Proteins - chemistry | DNA, Bacterial - metabolism | Interspersed Repetitive Sequences | Bacterial Proteins - chemistry | Molecular Sequence Data | Crystallography, X-Ray | Recombinant Fusion Proteins - metabolism | Deoxyribonucleases - metabolism | Bacteria - immunology | Adenosine Triphosphate - metabolism | DNA Helicases - genetics | RNA, Bacterial - metabolism | Deoxyribonucleases - chemistry | Clustered Regularly Interspaced Short Palindromic Repeats - physiology | Protein Structure, Tertiary | Amino Acid Sequence | DNA Helicases - chemistry | Mutagenesis, Site-Directed | CRISPR-Associated Proteins - genetics | DNA, Single-Stranded - metabolism | Bacterial Proteins - genetics | Models, Molecular | Magnesium - metabolism | DNA - metabolism | Recombinant Fusion Proteins - chemistry | Bacteria - genetics | Amino Acid Motifs | Host-Pathogen Interactions | Sequence Homology, Amino Acid | DNA Helicases - metabolism | Deoxyribonucleases - genetics | Sequence Alignment | Manganese - metabolism | CRISPR-Associated Proteins - metabolism | CRISPR-Cas Systems - physiology | Protein Binding | Recombinant Fusion Proteins - genetics | Bacteria - enzymology | Bacterial Proteins - metabolism | Protein Conformation | Biochemistry | Molecular structure | Deoxyribonucleic acid--DNA | Binding sites | Adenosine triphosphatase | Index Medicus | Biological Sciences | crystal-structure | bacterial immune-system | rna | cascade | complex | escherichia-coli | structural basis | antiviral defense | in-vitro reconstitution | adaptive immunity
Journal Article
Molecular Cell, ISSN 1097-2765, 09/2016, Volume 63, Issue 5, pp. 852 - 864
Prokaryotes use a mechanism called priming to update their CRISPR immunological memory to rapidly counter revisiting, mutated viruses, and plasmids. Here we... 
priming | Cas3 | Cas2 | Cas1 | spacer acquisition | CRISPR-Cas | interference | phage resistance | adaptive immunity | Cascade | FOREIGN DNA | IMMUNOLOGICAL MEMORY | CAS ADAPTIVE IMMUNITY | STRUCTURAL BASIS | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | GUIDED SURVEILLANCE COMPLEX | R-LOOP FORMATION | IN-VITRO RECONSTITUTION | SPACER ACQUISITION | CELL BIOLOGY | CRISPR-Associated Proteins - chemistry | Substrate Specificity | Nucleotide Motifs | Cloning, Molecular | Clustered Regularly Interspaced Short Palindromic Repeats | Escherichia coli - metabolism | RNA, Bacterial - genetics | Protein Interaction Domains and Motifs | Nucleic Acid Conformation | Binding Sites | DNA Helicases - genetics | RNA, Bacterial - metabolism | Recombinant Proteins - metabolism | DNA Helicases - chemistry | Gene Expression | CRISPR-Associated Proteins - genetics | Models, Molecular | Recombinant Proteins - chemistry | Escherichia coli Proteins - metabolism | Recombinant Proteins - genetics | DNA - metabolism | Plasmids - metabolism | DNA - genetics | DNA Helicases - metabolism | DNA - chemistry | Escherichia coli - genetics | CRISPR-Associated Proteins - metabolism | RNA, Bacterial - chemistry | CRISPR-Cas Systems | Plasmids - chemistry | Escherichia coli Proteins - genetics | Protein Binding | Kinetics | Escherichia coli Proteins - chemistry | DNA Cleavage | Pyrimidines | DNA | Index Medicus
Journal Article
Nature Biotechnology, ISSN 1087-0156, 2014, Volume 32, Issue 3, pp. 279 - 284
Clustered, regularly interspaced, short palindromic repeat (CRISPR) RNA-guided nucleases (RGNs) are highly efficient genome editing tools(1-3).... 
ZINC-FINGER TARGETER | TRANSCRIPTION FACTORS | HUMAN GENOME | NICKING | ZIFIT | NICKASES | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | HUMAN-CELLS | GENES | SYSTEMS | TOOL | Genetic research | Nucleases | Genetic engineering | Research | RNA | Methods | Enzymes | Mutation | Ribonucleic acid--RNA | Genomics | Index Medicus
Journal Article
Journal Article
ACS Chemical Biology, ISSN 1554-8929, 02/2018, Volume 13, Issue 2, pp. 467 - 474
Journal Article
Journal Article