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Biochemical Journal, ISSN 0264-6021, 05/2015, Volume 467, Issue 3, pp. 365 - 386
In the last decade, the ubiquitin-proteasome system has emerged as a valid target for the development of novel therapeutics. E3 ubiquitin ligases are... 
Ubiquitin | Ubiquitination | Small molecule | Structure | Structure-based design | Assembly | small molecule | ANAPHASE-PROMOTING COMPLEX | SOCS-BOX | BIOCHEMISTRY & MOLECULAR BIOLOGY | F-BOX PROTEINS | KAPPA-B-ALPHA | structure | structure-based design | ubiquitin | CANCER-THERAPY | ubiquitination | COP9 SIGNALOSOME | assembly | TUMOR-SUPPRESSOR PROTEIN | SUBSTRATE-ASSISTED INHIBITION | CELL-CYCLE | PROTEASOME SYSTEM | Protein Structure, Tertiary | Protein Subunits | Cullin Proteins - antagonists & inhibitors | Proteasome Inhibitors - pharmacology | Humans | Models, Molecular | Proteasome Inhibitors - chemistry | Drug Discovery - methods | Cullin Proteins - chemistry | Cullin Proteins - genetics | Drug Design | Protein Structure, Quaternary | Molecular Structure | MEL26, maternal effect lethal 26 | HECT, homologous with E6-associated protein C-terminus | DCAF, DDB1–Cul4A-associated factor | CPH, conserved within Cul7, PARC and HERC2 | CSA, Cockayne syndrome A | NAE, NEDD8-activating enzyme | Rbx1, RING-box protein 1 | PPI, protein–protein interaction | C, anaphase-promoting complex | SV5, simian virus 5 | Fbxw, F-box | Skp2, S-phase kinase-associated protein 2 | IAA, indole-3-acetic acid | Cpd, compound | Fbw | SMER3, small-molecule enhancer of rapamycin 3 | mTOR, mammalian target of rapamycin | HERC2, HECT domain- and RLD (regulator of chromosome condensation 1 protein-like domain) domain-containing E3 ubiquitin protein ligase 2 | IκB, inhibitor of NF-κB | UPS, ubiquitin–proteasome system | Nrf2, nuclear factor-erythroid 2-related factor 2 | Protac, proteolysis-targeting chimaeric molecule | WD repeat-containing protein | ZIM (zinc finger expressed in inflorescence) domain protein 1 | NF-κB, nuclear factor κB | leucine-rich motif-containing protein | CTD, C-terminal domain | Ub, ubiquitin | Vif, virion infectivity factor | NTD, N-terminal domain | GHR, growth hormone receptor | CRBN, cereblon | HIF-1α, hypoxia-inducible factor 1α | SH2, Src homology 2 | BP, β-propeller | UBL, ubiquitin-like protein | FP, fluorescence polarization | Cks1, cyclin-dependent protein kinase regulatory subunit 1 | CSN, COP9 (constitutive photomorphogenesis 9) signalosome complex | ITC, isothermal titration calorimetry | RING, really interesting new gene | Ubc12, ubiquitin-conjugating enzyme 12 | KLHL, Kelch-like protein | Review | VPRBP, Vpr-binding protein | SCF, Skp1–Cdc53–F-box Cdc4 | POZ, pox virus and zinc finger | JAZ1, jasmonate | Keap1, Kelch-like enoyl-CoA hydratase-associated protein 1 | PARC, p53-associated parkin-like cytoplasmic protein | DDB, damage-specific DNA-binding protein | JA-Ile, jasmonoyl-isoleucine | Fbxl, F-box | MATH, meprin and TRAF (tumour necrosis factor receptor-associated factor) homology | CRL, Cullin–RING E3 ubiquitin ligase | other domain-containing protein | COI1, coronatine-insensitive protein 1 | EloBC, ElonginB–ElonginC complex | broad complex | VHL, von Hippel–Lindau | Vpr, viral protein R | Aux, auxin | STAT, signal transducer and activator of transcription | CAND1, Cullin-associated NEDD8-dissociated protein 1 | Fbxo, F-box | TIR1, transport inhibitor response 1 | CBFβ, core binding factor β | BCR, BTB–Cul3–Rbx1 | cyclosome | SOCS, suppressor of cytokine signalling | NEDD, neural-precursor-cell-expressed developmentally down-regulated | BTB, bric-a-brac | APC | Cdc, cell division cycle | Cul, Cullin | SPOP, speckle-type POZ protein | β-TrCP, β-transducin repeat-containing protein | tramtrack | ASB, ankyrin repeat and SOCS-box
Journal Article
FRONTIERS IN PHYSIOLOGY, ISSN 1664-042X, 10/2019, Volume 10
Treatment with ionizing radiation (IR) remains the cornerstone of therapy for multiple cancer types, including disseminated and aggressive diseases in the... 
E3-ligases | PHYSIOLOGY | SOCS-BOX | REDUCTASE M2 SUBUNIT | BETA-TRCP | HPV-POSITIVE HEAD | cullins | MEDIATED DEGRADATION | DNA-damage | cullin ring ligases (CRLs) | double-strand breaks (DSBs) | DNA END RESECTION | ionizing radiation (IR) | CUL3-BASED E3 LIGASE | CELL-CYCLE EXIT | HOMOLOGOUS RECOMBINATION | F-BOX PROTEIN | Ubiquitin | Care and treatment | Ionizing radiation | Ligases | Cancer
Journal Article
Biochemical Journal, ISSN 0264-6021, 04/2013, Volume 451, Issue 1, pp. 111 - 122
The WNK (with no lysine kinase)-SPAK (SPS1-related proline/alanine-rich kinase)/OSR1 (oxidative stress-responsive kinase 1) signalling pathway plays an... 
Ubiquitin | Cullin-RING E3 ligase (CRL) | SPS1-related proline/alanine-rich kinase/oxidative stress-responsive kinase 1 (SPAK/OSR1) | co-transporter (NCC) | co-transporter 2 (NKCC2) | BTB domain | Cl | 2Cl | Kelch-like domain (KLHL domain) | SPAK | OSR1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | Na+/K+/2Cl(-) co-transporter 2 (NKCC2) | ubiquitin | BLOOD-PRESSURE | DOMINANT RETINITIS-PIGMENTOSA | Na+/Cl- co-transporter (NCC) | NA+-CL-COTRANSPORTER | PSEUDOHYPOALDOSTERONISM TYPE-II | ADAPTER | BTB-KELCH PROTEINS | RING UBIQUITIN LIGASES | KINASES | Minor Histocompatibility Antigens | Pseudohypoaldosteronism - genetics | Humans | Protein-Serine-Threonine Kinases - genetics | Sodium-Potassium-Chloride Symporters - genetics | Intracellular Signaling Peptides and Proteins - metabolism | Mutation, Missense | Transcription Factors - genetics | Sodium-Potassium-Chloride Symporters - metabolism | Cullin Proteins - genetics | Transcription Factors - metabolism | Carrier Proteins - genetics | Pseudohypoaldosteronism - enzymology | Ubiquitination | Carrier Proteins - metabolism | Solute Carrier Family 12, Member 2 | WNK Lysine-Deficient Protein Kinase 1 | HEK293 Cells | Cullin Proteins - metabolism | HeLa Cells | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Amino Acid Substitution | HEK, human embryonic kidney | 2Cl− co-transporter | RT, reverse transcription | TTBS, Tris-buffered saline containing Tween 20 | DTT, dithiothreitol | rTEV, recombinant tobacco etch virus | HRP, horseradish peroxidase | LC, liquid chromatography | UBE2D3, ubiquitin-conjugating enzyme E2 D3 | qRT-PCR, real time quantitative reverse transcription PCR | TAL, thick ascending limb | OSR1, oxidative stress-responsive kinase 1 | GST, glutathione transferase | RBX1, RING-box 1, E3 ubiquitin protein ligase | 2Cl− co-transporter 2 (NKCC2) | GAPDH, glyceraldehyde-3-phosphate dehydrogenase | UBE1, ubiquitin-like modifier-activating enzyme 1 | Cullin–RING E3 ligase (CRL) | GFP, green fluorescent protein | Cl− co-transporter | NKCC, Na+ | DCT, distal convoluted tubule | KEAP1, Kelch-like ECH-associated protein 1 | CRL, Cullin–RING E3 ligase | SPAK, SPS1-related proline | Accelerated Publication | Cl− co-transporter (NCC) | siRNA, small interfering RNA | NRF2, NF-E2-related factor 2 | oxidative stress-responsive kinase 1 (SPAK | WNK, with no lysine kinase | RPL13A, ribosomal protein L13a | KLHL3, Kelch-like 3 | CUL3, Cullin-3 | Na+ | SPS1-related proline | NCC, Na+ | alanine-rich kinase
Journal Article
Cell Division, ISSN 1747-1028, 06/2016, Volume 11, Issue 1, p. 8
Cullin-RING ligases (CRLs), the largest E3 ubiquitin ligase family, promote ubiquitination and degradation of various cellular key regulators involved in a... 
Ubiquitin | ATG | CRL E3 ligase | UPS | NEDD8 | Autophagy | MTOR | SKELETAL-MUSCLE ATROPHY | CHAPERONE-MEDIATED AUTOPHAGY | BETA-TRCP | PROTEASOMAL DEGRADATION | F-BOX PROTEINS | ONCOGENE-INDUCED SENESCENCE | CELL BIOLOGY | SIGNALING PATHWAY | COP9 SIGNALOSOME | mTOR | TUMOR-SUPPRESSOR | E3 UBIQUITIN LIGASE
Journal Article
by Zhao, Y and Xiong, X and Jia, L and Sun, Y
Cell Death and Disease, ISSN 2041-4889, 09/2012, Volume 3, Issue 9, pp. e386 - e386
MLN4924, a newly discovered small molecule inhibitor of NEDD8-activating enzyme (NAE), inactivates Cullin-RING E3 ubiquitin Ligases (CRLs) by blocking cullin... 
mTOR | CRL E3 ligases | DEPTOR | Cullin neddylation | Autophagy | HIF1α | CANCER-CELLS | APOPTOSIS | ACTIVATION | autophagy | BETA-TRCP | E3 UBIQUITIN LIGASES | CELL BIOLOGY | HIF1 alpha | DEGRADATION | NEDD8-ACTIVATING ENZYME-INHIBITOR | SENESCENCE | MTOR INHIBITOR | Microtubule-Associated Proteins - genetics | TOR Serine-Threonine Kinases - metabolism | Tumor Suppressor Proteins - antagonists & inhibitors | Microtubule-Associated Proteins - metabolism | Humans | Hypoxia-Inducible Factor 1, alpha Subunit - antagonists & inhibitors | Autophagy - drug effects | Mechanistic Target of Rapamycin Complex 1 | Multiprotein Complexes - antagonists & inhibitors | TOR Serine-Threonine Kinases - antagonists & inhibitors | Multiprotein Complexes - metabolism | TOR Serine-Threonine Kinases - genetics | MCF-7 Cells | RNA Interference | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Tumor Suppressor Proteins - genetics | Tumor Suppressor Proteins - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | HCT116 Cells | Ubiquitin-Protein Ligases - metabolism | Intracellular Signaling Peptides and Proteins | Transcription Factors - antagonists & inhibitors | Cyclopentanes - pharmacology | Microtubule-Associated Proteins - antagonists & inhibitors | Pyrimidines - pharmacology | Transcription Factors - genetics | Transcription Factors - metabolism | Autophagy-Related Protein 5 | Cell Line, Tumor | HeLa Cells | RNA, Small Interfering - metabolism | mTOR; CRL E3 ligases | Original
Journal Article
by Zhang, XZ and Rao, F
BIOMOLECULES, ISSN 2218-273X, 08/2019, Volume 9, Issue 8, p. 349
The E3 ligase activity of Cullin RING Ligases (CRLs) is controlled by cycles of neddylation/deneddylation and intimately regulated by the deneddylase COP9... 
COP9 signalosome | COMPLEX | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | inositol pyrophosphates | UBIQUITIN-LIGASE | ARABIDOPSIS COP9 | 1,3,4-TRISPHOSPHATE 5/6-KINASE | PCI DOMAIN | E3 LIGASE | neddylation | LIGHT CONTROL | Cullin ring ubiquitin ligases (CRL) | deneddylase | inositol hexakisphosphate (IP6) | SCF | IP6K | F-BOX PROTEIN | CSN
Journal Article
Journal Article