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Genes and Development, ISSN 0890-9369, 08/2011, Volume 25, Issue 15, pp. 1568 - 1582
Journal Article
Molecular Cell, ISSN 1097-2765, 03/2013, Volume 49, Issue 6, pp. 1147 - 1158
Journal Article
GENES & DEVELOPMENT, ISSN 0890-9369, 09/2008, Volume 22, Issue 18, pp. 2496 - 2506
The DNA polymerase delta processivity factor Proliferating Cell Nuclear Antigen (PCNA) promotes the DNA damage-induced degradation of the replication... 
CDT1 DEGRADATION | UV-IRRADIATION | PCNA | P21(WAF1/CIP1) | DNA-DAMAGE | CRL4 | CELL-CYCLE ARREST | DEVELOPMENTAL BIOLOGY | p21 ubiquitylation | PROTEOLYSIS | P21(CIP1/WAF1) | CELL BIOLOGY | DDB1 | cdt2 | DCAFs | GENETICS & HEREDITY | S-PHASE | PROTEINS | BINDING
Journal Article
CELL CYCLE, ISSN 1538-4101, 11/2014, Volume 13, Issue 22, pp. 3602 - 3610
The bZIP transcription factor, C/EBP is highly inducible by UVB and other DNA damaging agents in keratinocytes. C/EBP-deficient keratinocytes fail to undergo... 
PCNA | CELL NUCLEAR ANTIGEN | UBIQUITIN LIGASE | C/EBP alpha | keratinocytes | p21 | CELL BIOLOGY | CYCLIN-DEPENDENT KINASES | G/S DNA damage checkpoint | IN-VIVO | GROWTH | S-PHASE | CRL4(Cdt2) | INHIBITOR | EXPRESSION | SKIN-CANCER
Journal Article
Journal Article
Molecular Cell, ISSN 1097-2765, 12/2018, Volume 72, Issue 5, pp. 823 - 835.e5
High-risk human papilloma viruses (HPVs) cause cervical, anal, and oropharyngeal cancers, unlike the low-risk HPVs, which cause benign lesions. E6 oncoproteins... 
USP46 | Cdt2 | oncogenic virus | cervical cancer | deubiquitinase | HPV | E6 | CRL4(CDT2) UBIQUITIN LIGASE | MATRIX-ASSOCIATED PROTEIN | HUMAN-PAPILLOMAVIRUS TYPE-16 | BIOCHEMISTRY & MOLECULAR BIOLOGY | UBIQUITYLATION | DEGRADATION | CELL-CYCLE | REGULATED NUCLEAR | EXPRESSION | PROMOTES | CELL BIOLOGY | RNA, Small Interfering - genetics | Humans | Uterine Cervical Neoplasms - pathology | Recombinant Fusion Proteins - metabolism | DNA-Binding Proteins - metabolism | Papillomavirus Infections - pathology | Injections, Intralesional | Human papillomavirus 18 - metabolism | Female | Oncogene Proteins, Viral - genetics | Papillomavirus Infections - virology | Human papillomavirus 18 - genetics | Nuclear Proteins - genetics | Repressor Proteins - metabolism | Oncogene Proteins, Viral - metabolism | Endopeptidases - metabolism | Histone-Lysine N-Methyltransferase - genetics | Human papillomavirus 16 - pathogenicity | Uterine Cervical Neoplasms - enzymology | Signal Transduction | Papillomavirus Infections - enzymology | Gene Expression Regulation | Ubiquitin-Protein Ligases - metabolism | Repressor Proteins - genetics | Nuclear Proteins - metabolism | DNA-Binding Proteins - genetics | Uterine Cervical Neoplasms - genetics | Human papillomavirus 16 - metabolism | Papillomavirus Infections - genetics | Xenograft Model Antitumor Assays | Animals | Endopeptidases - genetics | Cell Cycle | Histone-Lysine N-Methyltransferase - metabolism | Host-Pathogen Interactions - genetics | Human papillomavirus 18 - pathogenicity | Cell Line, Tumor | Recombinant Fusion Proteins - genetics | Uterine Cervical Neoplasms - virology | Mice | HeLa Cells | Ubiquitin-Protein Ligases - genetics | Human papillomavirus 16 - genetics | RNA, Small Interfering - metabolism | Ubiquitin | Cellular proteins | Epigenetic inheritance | Growth | Ligases | Health aspects | Papillomavirus infections | Cervical cancer | Cancer
Journal Article
Journal Article
NEOPLASIA, ISSN 1476-5586, 04/2018, Volume 20, Issue 4, pp. 305 - 323
Whether the antimutagenic DNA repair protein MGMT works solo in human cells and if it has other cellular functions is not known. Here, we show that human MGMT... 
HUMAN-LYMPHOCYTES | REPAIR PROTEIN | ONCOLOGY | ALKYLATION | NUCLEAR ANTIGEN PCNA | DEGRADATION | TUMOR-CELLS | CRL4(CDT2) | HUMAN O-6-METHYLGUANINE-DNA METHYLTRANSFERASE | POSTTRANSLATIONAL REGULATION | E3 UBIQUITIN LIGASE
Journal Article
by Fan, KQ and Wang, F and Li, YY and Chen, L and Gao, ZJ and Zhang, Y and Duan, JY and Huang, T and Zhong, JY and Liu, RB and Mao, XT and Fan, HY and Guo, X and Jin, J
JOURNAL OF AUTOIMMUNITY, ISSN 0896-8411, 01/2019, Volume 96, pp. 74 - 85
The proliferation of T cells in peripheral lymphoid tissues requires T cell receptor (TCR)-mediated cell cycle entry. However, the underlying mechanism... 
PCNA | TRANSCRIPTION | KINASE | PROLIFERATION | CRL4(CDT2) | IMMUNOLOGY | CRL4(DCAF2) | MICE LACKING | P27(KIP1) | H4K20me1 | INHIBITOR P21 | Cell cycle | CYCLE PROGRESSION | Aurora B | Proteasome activity | E3 UBIQUITIN LIGASE
Journal Article
Cell Cycle, ISSN 1538-4101, 11/2018, Volume 17, Issue 21-22, pp. 2496 - 2516
Cell cycle phase transitions are tightly orchestrated to ensure efficient cell cycle progression and genome stability. Interrogating these transitions is... 
single-cell dynamics | G1/S transition | Live-cell imaging | CDT1 | UBIQUITIN LIGASE | NUCLEAR ANTIGEN | CRL4(CDT2) | CDK INHIBITOR | P21 | DNA-REPLICATION | CELL BIOLOGY | S-PHASE | DEGRADATION | PROGRESSION
Journal Article
Cell Cycle, ISSN 1538-4101, 11/2014, Volume 13, Issue 22, pp. 3602 - 3610
The bZIP transcription factor, C/EBPα is highly inducible by UVB and other DNA damaging agents in keratinocytes. C/EBPα-deficient keratinocytes fail to undergo... 
Cdt2 | C/EBPα | 1 | keratinocytes, p21 | G | CRL4 | S DNA damage checkpoint
Journal Article
Cell Cycle, ISSN 1538-4101, 11/2014, Volume 13, Issue 22, pp. 3529 - 3540
We recently reported that the p12 subunit of human DNA polymerase δ (Pol δ4) is degraded by CRL4 Cdt2 which regulates the licensing factor Cdt1 and p21 WAF1... 
Cdt2 | p12 | Cdt1 | DNA replication | cell proliferation | cell cycle | CRL4 | EdU labeling | polymerase δ | S-phase | laser scanning cytometry | p21 | Cell proliferation | P12 | Polymerase δ | Cell cycle | Laser scanning cytometry | P21
Journal Article