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Allergy, ISSN 0105-4538, 03/2013, Volume 68, Issue 3, pp. 375 - 385
Background Eosinophilic esophagitis (EoE) is a chronic, Th2‐type inflammatory disease. Chemoattractant receptor‐homologous molecule on Th2 cells (CRTH2) is a... 
immunopharmacology | remodeling | thymic stromal lymphopoietin | CRTH2 antagonist | eosinophilic esophagitis | ADULT PATIENTS | HISTOPATHOLOGIC VARIABILITY | FOOD IMPACTION | BUDESONIDE | IMMUNOLOGY | CHILDREN | FLUTICASONE PROPIONATE | ALLERGY | DOUBLE-BLIND | PLACEBO-CONTROLLED TRIAL | CORTICOSTEROIDS | CONSENSUS RECOMMENDATIONS | Proton Pump Inhibitors - pharmacology | Eosinophils - drug effects | Humans | Middle Aged | Eosinophilic Esophagitis - pathology | Male | Quinolines - administration & dosage | Receptors, Prostaglandin - metabolism | Quinolines - pharmacology | Receptors, Immunologic - antagonists & inhibitors | Young Adult | Anti-Inflammatory Agents - adverse effects | Anti-Inflammatory Agents - therapeutic use | Adult | Anti-Inflammatory Agents - administration & dosage | Female | Drug Therapy, Combination | Receptors, Prostaglandin - antagonists & inhibitors | Eosinophilic Esophagitis - metabolism | Anti-Inflammatory Agents - pharmacology | Treatment Outcome | Proton Pump Inhibitors - therapeutic use | Indoleacetic Acids - therapeutic use | Indoleacetic Acids - adverse effects | Indoleacetic Acids - administration & dosage | Indoleacetic Acids - pharmacology | Eosinophilic Esophagitis - drug therapy | Aged | Quinolines - therapeutic use | Quinolines - adverse effects | Receptors, Immunologic - metabolism | Esophagitis | Cells | Clinical trials | Drug therapy | Inflammatory diseases
Journal Article
Journal Article
Allergy, ISSN 0105-4538, 12/2012, Volume 67, Issue 12, pp. 1572 - 1579
Journal Article
Clinical & Experimental Allergy, ISSN 0954-7894, 08/2014, Volume 44, Issue 8, pp. 1007 - 1007
Journal Article
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, ISSN 0091-6749, 02/2015, Volume 135, Issue 2, pp. 395 - U536
Background: The D prostanoid receptor 2 (DP2; also known as chemoattractant receptor-homologous molecule expressed on T(H)2 cells) is implicated in the... 
BRONCHOALVEOLAR LAVAGE FLUID | CRTH2 ANTAGONIST OC000459 | ACTIVATION | EFFICACY | EOSINOPHILS | MEDIATOR CONCENTRATIONS | asthma | INNATE LYMPHOID-CELLS | IMMUNOLOGY | prostaglandin D-2 | ALLERGY | Expression | EPIDERMAL-GROWTH-FACTOR | biopsy | DOUBLE-BLIND | immunohistochemistry
Journal Article
Journal Article
Drugs, ISSN 0012-6667, 8/2017, Volume 77, Issue 12, pp. 1281 - 1294
Prostaglandin D2 (PGD2) released by degranulating mast cells is believed to play a key role in orchestrating mechanisms of inflammation in allergies and... 
Pharmacotherapy | Internal Medicine | Medicine & Public Health | Pharmacology/Toxicology | CRTH2 ANTAGONIST OC000459 | NASAL-MUCOSA | EOSINOPHILIC AIRWAY INFLAMMATION | CYTOKINE PRODUCTION | DP RECEPTOR | ANTIGEN CHALLENGE | PHARMACOLOGY & PHARMACY | HUMAN TH2 CELLS | TOXICOLOGY | HELPER TYPE-2 CELLS | PROSTAGLANDIN D-2 RECEPTOR | CUTTING EDGE | Leading
Journal Article
Pharmacology and Therapeutics, ISSN 0163-7258, 01/2019, Volume 193, pp. 1 - 19
Prostaglandins are synthesized through the metabolism of arachidonic acid via the cyclooxygenase pathway. There are five primary prostaglandins, PGD , PGE ,... 
Allergy | Cyclooxygenase | Prostaglandin | Lung | Asthma | CRTH2 ANTAGONIST OC000459 | RECEPTOR-HOMOLOGOUS MOLECULE | INFLAMMATORY MEDIATOR RELEASE | E-PROSTANOID 2 | EXERCISE-INDUCED BRONCHOCONSTRICTION | PHARMACOLOGY & PHARMACY | AIRWAY SMOOTH-MUSCLE | EXACERBATED RESPIRATORY-DISEASE | HELPER TYPE-2 CELLS | THROMBOXANE A | EXHALED NITRIC-OXIDE
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2014, Volume 134, Issue 3, pp. 530 - 544
Journal Article