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Cancer science, ISSN 1347-9032, 07/2016, Volume 107, Issue 7, pp. 972 - 980
Journal Article
ACS medicinal chemistry letters, ISSN 1948-5875, 10/2019, Volume 10, Issue 10, pp. 1486 - 1491
C-terminal Src kinase (CSK) functions as a negative regulator of T cell activation through inhibitory phosphorylation of LCK, so inhibitors of CSK are of interest as potential immuno-oncology agents... 
kinase inhibitor | CHEMISTRY, MEDICINAL | immuno-oncology | Metabolite ID | CSK inhibitor | PHOSPHORYLATION
Journal Article
Journal Article
Biochemical journal, ISSN 1470-8728, 2007, Volume 408, Issue 3, pp. 297 - 315
The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a panel of 70-80 protein kinases... 
Drug discovery | Kinase profiling | Protein kinase | Anti-cancer drugs | Inhibitor specificity | RHO-ASSOCIATED KINASE | TUMOR PROGRESSION | FAMILY-MEMBERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-PROLIFERATION | protein kinase | P38 MAP KINASE | CYCLIN-DEPENDENT KINASES | RECEPTOR TYROSINE KINASES | drug discovery | kinase profiling | SB 203580 | anti-cancer drugs | ISOFORMS IN-VITRO | P90 RSK | inhibitor specificity | Amino Acid Sequence | Cell Line | Phosphorylation | Recombinant Proteins - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Drug Design | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Spodoptera | Yes1, Yamaguchi sarcoma viral oncogene homologue 1 | CSK, C-terminal Src kinase | Lck, lymphocyte cell-specific protein-tyrosine kinase | EGF, epidermal growth factor | FGF-R, fibroblast-growth-factor receptor | PAK, p21-activated protein kinase | PDK, 3-phosphoinositide-dependent protein kinase | PI3K, phosphatidylinositol (phosphoinositide) 3-kinase | NEK, NIMA (never in mitosis in Aspergillus nidulans)-related kinase | RSK, p90 ribosomal S6 kinase | HEK-293 cells, human embryonic kidney-293 cells | VEGF, vascular endothelial growth factor (vasoendothelial growth factor) | EF2K, elongation-factor-2 kinase | CK, casein kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | ATM, ataxia telangiectasia mutated | SRPK, serine-arginine protein kinase | IL-1, interleukin 1 | MNK, MAPK-integrating protein kinase | ROCK, Rho-dependent protein kinase | CaMKK, CaMK kinase | GST, glutathione transferase | MKK1, MAPK kinase-1 (also called MEK1, MAPK or ERK kinase 1) | GAK, cyclin G-associated kinase | FMK, fluoromethylketone | MST, mammalian homologue Ste20-like kinase | PKA, cAMP-dependent protein kinase | FKBP, FK506-binding protein | PPAR, peroxisome-proliferator-activated receptor | IKK, inhibitory κB kinase | PH, pleckstrin homology | MBP, myelin basic protein | AICAR, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside | MAPKAP-K, MAPK-activated protein kinase | Sf21, Spodoptera frugiperda (fall armyworm) 21 | MARK, microtubule-affinity-regulating kinase | PIM, provirus integration site for Moloney murine leukaemia virus | LPS, lipopolysaccharide | MSK, mitogen- and stress-activated protein kinase | MAPK, mitogen-activated protein kinase | MELK, maternal embryonic leucine-zipper kinase | His6, hexahistidine | CAK, cyclin-dependent kinase-activating kinase | Eph-A2, Ephrin A2 receptor | PLK, polo-like kinase | ATF2, activating transcription factor 2 | PKD, protein kinase D | Src, sarcoma kinase | AMPK, AMP-activated protein kinase | MMS, methyl methanesulfonate | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | TORC1, mTOR (mammalian target of rapamycin)–raptor (regulatory associated protein of mTOR) complex | BRSK, brain-specific kinase | RIP2, receptor-interacting protein 2 | IGF-1, insulin-like growth factor-1 | S6K1, S6 kinase 1 | DYRK, dual-specificity tyrosine-phosphorylated and -regulated kinase | HIPK, homeodomain-interacting protein kinase | ZMP, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside monophosphate | PRAK, p38-regulated activated kinase | PKC, protein kinase C | Src-I1, Src inhibitor 1 | TANK, TRAF (tumour-necrosis-factor-receptor-associated factor)-family-member-associated nuclear factor κB activator | NFAT, nuclear factor for activated T-cells | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | CaMK, calmodulin-dependent kinase | CDK, cyclin-dependent protein kinase | NDRG, N-myc downstream-regulated gene | SmMLCK, smooth-muscle myosin light-chain kinase | TBK1, TANK-binding kinase 1 | PRK, protein kinase C-related kinase | SGK, serum- and glucocorticoid-induced kinase
Journal Article
Journal Article
The EMBO journal, ISSN 0261-4189, 03/2007, Volume 26, Issue 5, pp. 1234 - 1244
Journal Article
The Journal of biological chemistry, ISSN 0021-9258, 05/2011, Volume 286, Issue 18, pp. 15698 - 15706
The transmembrane adaptor protein Cbp (or PAG1) functions as a suppressor of Src-mediated tumor progression by promoting the inactivation of Src... 
TRANSFORMATION | FAMILY TYROSINE KINASES | COMPLEX | METHYLATION | TRANSMEMBRANE ADAPTER | GENE | BIOCHEMISTRY & MOLECULAR BIOLOGY | T-CELL-ACTIVATION | CSK | V-SRC | CANCER | Neoplasms - metabolism | ras Proteins - genetics | Epigenesis, Genetic | Humans | ras Proteins - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Phosphoproteins - metabolism | Embryo, Mammalian - metabolism | MAP Kinase Signaling System | Neoplasms - genetics | Cell Transformation, Neoplastic - genetics | Tumor Suppressor Proteins - genetics | Histone Deacetylase 1 - antagonists & inhibitors | Membrane Proteins - metabolism | Histone Deacetylase 1 - genetics | Fibroblasts - metabolism | Histone Deacetylase 2 - genetics | Tumor Suppressor Proteins - metabolism | Histone Deacetylase 2 - antagonists & inhibitors | MAP Kinase Kinase Kinases - genetics | Membrane Proteins - genetics | MAP Kinase Kinase Kinases - metabolism | Phosphoproteins - genetics | Cell Transformation, Neoplastic - metabolism | Mice, Knockout | Phosphatidylinositol 3-Kinases - genetics | Animals | Histones - genetics | Methylation - drug effects | Proto-Oncogene Proteins pp60(c-src) - genetics | Proto-Oncogene Proteins pp60(c-src) - metabolism | Adaptor Proteins, Signal Transducing - genetics | Histone Deacetylase Inhibitors - pharmacology | Mitogen-Activated Protein Kinases - genetics | Mice | Protein Processing, Post-Translational | Histone Deacetylase 2 - metabolism | Histones - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Histone Deacetylase 1 - metabolism | Mitogen-Activated Protein Kinases - metabolism | MAP Kinases (MAPKs) | DNA Methylation | Gene Expression | Transformation | Signal Transduction | Ras | Src | Epigenetics | Adaptor Proteins | Histone Deacetylase | Receptor Tyrosine Kinase
Journal Article