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Nature Medicine, ISSN 1078-8956, 12/2014, Volume 20, Issue 12, pp. 1410 - 1416
The protein cytotoxic T lymphocyte antigen-4 (CTLA-4) is an essential negative regulator of immune responses, and its loss causes fatal autoimmunity in mice.... 
PATHWAYS | MEDICINE, RESEARCH & EXPERIMENTAL | CLINICAL-PICTURE | HOMEOSTASIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | AUTOIMMUNITY | REGULATORY T-CELLS | GERMLINE MUTATIONS | MICE | BLOCKADE | IMMUNODEFICIENCY | ABATACEPT | Recurrence | Agammaglobulinemia - immunology | Agammaglobulinemia - genetics | Purpura, Thrombocytopenic, Idiopathic - genetics | Exons | Immune System Diseases - genetics | Humans | Middle Aged | Male | Anemia, Hemolytic, Autoimmune - genetics | Mutation, Missense | Respiratory Tract Infections - genetics | T-Lymphocytes, Regulatory - immunology | Autoimmune Diseases - genetics | Young Adult | Purpura, Thrombocytopenic, Idiopathic - immunology | Adult | Female | Endocytosis - genetics | Polyendocrinopathies, Autoimmune - genetics | Child | Endocytosis - immunology | Granuloma - genetics | Autoimmune Diseases - immunology | CTLA-4 Antigen - genetics | B7-1 Antigen - metabolism | Codon, Nonsense | CTLA-4 Antigen - immunology | Syndrome | Polyendocrinopathies, Autoimmune - immunology | Lung Diseases, Interstitial - immunology | Animals | B-Lymphocytes - immunology | Lung Diseases, Interstitial - genetics | Pedigree | Anemia, Hemolytic, Autoimmune - immunology | Adolescent | Respiratory Tract Infections - immunology | Granuloma - immunology | Heterozygote | Mice | Antigens | Gene mutations | Physiological aspects | Genetic aspects | Immunologic diseases | Research | Risk factors | Proteins | Homeostasis | Cytotoxicity | Ligands | T cell receptors | Mutation | Immune system | Index Medicus
Journal Article
Journal Article
Leukemia, ISSN 0887-6924, 2014, Volume 28, Issue 6, pp. 1280 - 1288
Blockade of immune checkpoints is emerging as a new form of anticancer therapy. We studied the expression of programmed death ligand 1 (PD-L1), PD-L2,... 
DNA methylation | myelodysplastic syndromes | programmed death-1 | SURVIVAL | DECITABINE | 5-AZACYTIDINE | PHASE-III | OPEN-LABEL | ACUTE MYELOID-LEUKEMIA | IMMUNE-SYSTEM | THERAPY | ONCOLOGY | IMMUNOTHERAPY | REGULATORY T-CELLS | HEMATOLOGY | Leukocytes, Mononuclear - metabolism | Prognosis | Humans | Leukemia, Myelomonocytic, Chronic - genetics | Middle Aged | Programmed Cell Death 1 Ligand 2 Protein - metabolism | Male | Leukemia, Myelomonocytic, Chronic - drug therapy | Immunoenzyme Techniques | DNA Methylation | Flow Cytometry | Aged, 80 and over | Biomarkers, Tumor - metabolism | Leukemia, Myeloid, Acute - drug therapy | Adult | Antimetabolites, Antineoplastic - pharmacology | Female | Tumor Cells, Cultured | Real-Time Polymerase Chain Reaction | Myelodysplastic Syndromes - drug therapy | Leukocytes, Mononuclear - drug effects | Programmed Cell Death 1 Ligand 2 Protein - genetics | Leukemia, Myelomonocytic, Chronic - mortality | RNA, Messenger - genetics | CTLA-4 Antigen - metabolism | Programmed Cell Death 1 Receptor - metabolism | Azacitidine - analogs & derivatives | CTLA-4 Antigen - genetics | Survival Rate | Reverse Transcriptase Polymerase Chain Reaction | B7-H1 Antigen - genetics | Leukemia, Myeloid, Acute - mortality | Azacitidine - pharmacology | B7-H1 Antigen - metabolism | Myelodysplastic Syndromes - mortality | Aged | Biomarkers, Tumor - genetics | Myelodysplastic Syndromes - genetics | Programmed Cell Death 1 Receptor - genetics | Cohort Studies | Leukemia, Myeloid, Acute - genetics | Antimitotic agents | Cellular proteins | Physiological aspects | Genetic aspects | Research | Drug therapy | Antineoplastic agents | Health aspects | Myelodysplastic syndromes | Index Medicus
Journal Article
Immunity, ISSN 1074-7613, 12/2014, Volume 41, Issue 6, pp. 1013 - 1025
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2013, Volume 8, Issue 12, pp. e83139 - e83139
CD28, CTLA-4 and PD-L1, the three identified ligands for CD80/86, are pivotal positive and negative costimulatory molecules that, among other functions,... 
IN-VITRO | ACTIVATION | DENDRITIC CELLS | TCR STOP-SIGNAL | TOLERANCE | MULTIDISCIPLINARY SCIENCES | EXTRINSIC CONTROL | ANTI-CD28 ANTIBODY | UP-REGULATION | CUTTING EDGE | LYMPHOCYTES | B7-1 Antigen - antagonists & inhibitors | Cell Communication - immunology | B7-2 Antigen - genetics | B7-1 Antigen - genetics | Dendritic Cells - immunology | Humans | Molecular Targeted Therapy | T-Lymphocytes, Regulatory - immunology | T-Lymphocytes, Cytotoxic - drug effects | CD28 Antigens - genetics | Protein Binding - drug effects | CD28 Antigens - antagonists & inhibitors | T-Lymphocytes, Regulatory - cytology | Dendritic Cells - drug effects | B7-2 Antigen - immunology | T-Lymphocytes, Cytotoxic - immunology | Gene Expression | B7-2 Antigen - antagonists & inhibitors | B7-1 Antigen - immunology | Antibodies, Monoclonal - pharmacology | CTLA-4 Antigen - genetics | CD28 Antigens - immunology | CTLA-4 Antigen - immunology | B7-H1 Antigen - genetics | B7-H1 Antigen - immunology | Cell Movement - drug effects | T-Lymphocytes, Regulatory - drug effects | B7-H1 Antigen - antagonists & inhibitors | Lymphocyte Activation - drug effects | Cell Communication - drug effects | Dendritic Cells - cytology | CTLA-4 Antigen - antagonists & inhibitors | T-Lymphocytes, Cytotoxic - cytology | Viral antibodies | Antibodies | Antigens | B cells | T cells | Motility | Transplants & implants | Calcium | Blocking antibodies | Homeostasis | Effector cells | Reversing | Immunological synapses | Lymphocytes T | Kinases | CD28 antigen | T-cell receptor | CTLA-4 protein | Cell activation | Immunology | Lymphocytes | Dwell time | Cell cycle | Cytokines | Immunoregulation | CD80 antigen | T cell receptors | Costimulator | Microscopy | Antigen-presenting cells | PD-L1 protein | Ligands | Cell migration | Synapses | Apoptosis | Index Medicus | Life Sciences | Human health and pathology
Journal Article
Nature Genetics, ISSN 1061-4036, 12/2012, Volume 44, Issue 12, pp. 1294 - 1301
Journal Article
Science, ISSN 0036-8075, 10/2015, Volume 350, Issue 6257, pp. 207 - 211
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 08/2017, Volume 23, Issue 15, pp. 4429 - 4440
Purpose: Pancreatic ductal adenocarcinoma (PDAC) is associated with an immunosuppressive milieu that supports immune system evasion and disease progression.... 
TUMOR-INFILTRATING LYMPHOCYTES | BREAST-CANCER | ONCOLOGY | IMMUNOTHERAPY | SUBTYPES | POOR-PROGNOSIS | MACROPHAGES | IMMUNOSURVEILLANCE | TNF-ALPHA | PROGNOSTIC VALUE | T-CELLS | Antigens, CD - immunology | Adenocarcinoma - pathology | CD8-Positive T-Lymphocytes - pathology | Prognosis | Stromal Cells - pathology | Humans | Middle Aged | Male | Antigens, CD - genetics | Carcinoma, Pancreatic Ductal - genetics | Female | Adenocarcinoma - genetics | Carcinoma, Pancreatic Ductal - immunology | Antigens, Differentiation, Myelomonocytic - immunology | Gene Expression Regulation, Neoplastic - genetics | Adenocarcinoma - immunology | CTLA-4 Antigen - genetics | Gene Expression Regulation, Neoplastic - immunology | Stromal Cells - immunology | CTLA-4 Antigen - immunology | B7-H1 Antigen - genetics | B7-H1 Antigen - immunology | Carcinoma, Pancreatic Ductal - pathology | Receptors, Cell Surface - immunology | Antigens, Differentiation, Myelomonocytic - genetics | Whole Exome Sequencing | Biomarkers | Mutation | CD8-Positive T-Lymphocytes - immunology | Receptors, Cell Surface - genetics | Adenocarcinoma | Regulators | CD8 antigen | Genomes | Macrophages | CTLA-4 protein | Lymphocytes | Immunotherapy | Foxp3 protein | Bioindicators | Conditioning | Pancreas | Immune system | Enumeration | Cell survival | Gene expression | Clustering | Survival | CD163 antigen | Immunosuppression | Immune checkpoint | Experimental design | Medical prognosis | Glycolysis | Hypoxia | Combinatorial analysis | Cancer | Index Medicus
Journal Article