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The Journal of clinical investigation, ISSN 0021-9738, 2015, Volume 125, Issue 10, pp. 3981 - 3991
.... Here, in an attempt to develop a strategy for facilitating the isolation, expansion, and study of mutated antigen-specific T cells, we performed whole-exome sequencing on matched tumor and normal DNA... 
CD4+T CELLS | MEDICINE, RESEARCH & EXPERIMENTAL | METASTATIC MELANOMA | TCR | THERAPY | RECOGNITION | ANTI-CTLA-4 | MUTATIONAL LANDSCAPE | CD4(+) | ANTIGENS | BLOCKADE | Humans | Middle Aged | Neoplasm Proteins - immunology | Molecular Sequence Data | Male | Antigen-Antibody Reactions | Epitopes - immunology | Exome | Melanoma - genetics | Peptide Fragments - immunology | Adult | Female | Receptor, ErbB-2 - immunology | Neoplasm Proteins - genetics | Nuclear Proteins - genetics | Transcription Factors - immunology | Amino Acid Sequence | Antigens, Neoplasm - genetics | DNA-Binding Proteins - immunology | HLA-A2 Antigen - immunology | Antigens, Neoplasm - immunology | Interferon-gamma Release Tests | Cells, Cultured | HLA-A1 Antigen - chemistry | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Epitopes - genetics | Nuclear Proteins - immunology | Melanoma - secondary | HLA-A2 Antigen - chemistry | Algorithms | Genes, erbB-2 | Melanoma - immunology | Adolescent | RNA, Neoplasm - genetics | T-Cell Antigen Receptor Specificity | T-Lymphocytes - immunology | HLA-A1 Antigen - immunology | DNA, Neoplasm - genetics | Mutation | Antigens, Neoplasm - classification | Lymphocytes, Tumor-Infiltrating - immunology | Physiological aspects | T cells | Lymphocytes | Identification and classification | Health aspects | Tumors | Antigens | Peptides | Cloning | Melanoma | T cell receptors | Metastasis | Cancer therapies | Patients | Studies | Immunotherapy | Cancer
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2013, Volume 8, Issue 12, p. e83139
... synapse between T cells and antigen-presenting cells (APCs). What remains incompletely understood is how CD28 leads to the activation of effector T cells (Teff... 
IN-VITRO | ACTIVATION | HOMEOSTASIS | DENDRITIC CELLS | TOLERANCE | MULTIDISCIPLINARY SCIENCES | EXTRINSIC CONTROL | ANTI-CD28 ANTIBODY | UP-REGULATION | CUTTING EDGE | LYMPHOCYTES | B7-1 Antigen - antagonists & inhibitors | Cell Communication - immunology | B7-2 Antigen - genetics | B7-1 Antigen - genetics | Dendritic Cells - immunology | Humans | Molecular Targeted Therapy | T-Lymphocytes, Regulatory - immunology | T-Lymphocytes, Cytotoxic - drug effects | CD28 Antigens - genetics | Protein Binding - drug effects | CD28 Antigens - antagonists & inhibitors | T-Lymphocytes, Regulatory - cytology | Dendritic Cells - drug effects | B7-2 Antigen - immunology | T-Lymphocytes, Cytotoxic - immunology | Gene Expression | B7-2 Antigen - antagonists & inhibitors | B7-1 Antigen - immunology | Antibodies, Monoclonal - pharmacology | CTLA-4 Antigen - genetics | CD28 Antigens - immunology | CTLA-4 Antigen - immunology | B7-H1 Antigen - genetics | B7-H1 Antigen - immunology | Cell Movement - drug effects | T-Lymphocytes, Regulatory - drug effects | B7-H1 Antigen - antagonists & inhibitors | Lymphocyte Activation - drug effects | Cell Communication - drug effects | Dendritic Cells - cytology | CTLA-4 Antigen - antagonists & inhibitors | T-Lymphocytes, Cytotoxic - cytology | Viral antibodies | Antibodies | Antigens | B cells | T cells | Motility | Transplants & implants | Calcium | Blocking antibodies | Homeostasis | Effector cells | Reversing | Immunological synapses | Lymphocytes T | Kinases | CD28 antigen | T-cell receptor | CTLA-4 protein | Cell activation | Immunology | Lymphocytes | Dwell time | Cell cycle | Cytokines | Immunoregulation | CD80 antigen | T cell receptors | Costimulator | Microscopy | Antigen-presenting cells | PD-L1 protein | Ligands | Cell migration | Synapses | Apoptosis | Life Sciences | Human health and pathology
Journal Article
Trends in Immunology, ISSN 1471-4906, 2011, Volume 32, Issue 9, pp. 428 - 433
Journal Article
Nature immunology, ISSN 1529-2916, 2009, Volume 10, Issue 11, pp. 1185 - 1192
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 2011, Volume 332, Issue 6029, pp. 600 - 603
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2003, Volume 100, Issue 14, pp. 8372 - 8377
Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) is a critical immunoregulatory molecule... 
T lymphocytes | Autoimmunity | Antigens | Biological Sciences | Lungs | Lymphocytes | Vaccination | Immunotherapy | Melanoma | Biopsies | Tumors | IMMUNIZATION | ACTIVATION | INHIBITION | DENDRITIC CELLS | 4 CTLA-4 | MULTIDISCIPLINARY SCIENCES | COMBINATION IMMUNOTHERAPY | CD28 | CELL-CYCLE PROGRESSION | EXPRESSION | VACCINES | Peptides | Humans | Middle Aged | Neoplasm Proteins - immunology | Hepatitis, Autoimmune - etiology | Antibodies, Monoclonal - therapeutic use | Male | Antigens, Neoplasm - administration & dosage | gp100 Melanoma Antigen | Neoplasm Metastasis | Injections, Subcutaneous | Peptide Fragments - immunology | Autoimmune Diseases - pathology | Antibodies, Monoclonal - immunology | Antigens, Neoplasm - immunology | Lymphocyte Activation | Hepatitis, Autoimmune - immunology | Neoplasm Proteins - chemistry | Antigens, Differentiation - physiology | CTLA-4 Antigen | Dermatitis - etiology | Antigens, CD | Antigens, Differentiation - immunology | T-Lymphocyte Subsets - immunology | Antibodies, Neoplasm - therapeutic use | Injections, Intravenous | Dermatitis - immunology | Membrane Glycoproteins - chemistry | Antibodies, Monoclonal - adverse effects | Salvage Therapy | Colitis - pathology | Autoimmune Diseases - etiology | Hepatitis, Autoimmune - pathology | Immune Tolerance - immunology | Adult | Female | Membrane Glycoproteins - immunology | Colitis - immunology | T-Lymphocytes, Cytotoxic - immunology | Antibodies, Neoplasm - immunology | HLA-A2 Antigen - immunology | Peptide Fragments - administration & dosage | Vitiligo - immunology | Autoimmune Diseases - immunology | Vitiligo - etiology | Dermatitis - pathology | Colitis - etiology | Vitiligo - pathology | Melanoma - immunology | Melanoma - therapy | Antibodies, Neoplasm - adverse effects | Cancer regression | Physiological aspects | T cells
Journal Article
Cancer research (Chicago, Ill.), ISSN 1538-7445, 2013, Volume 73, Issue 12, pp. 3591 - 3603
Tumor progression is facilitated by regulatory T cells (Treg) and restricted by effector T cells. In this study, we document parallel regulation of CD8(+) T... 
DISTINCT MECHANISMS | ONCOLOGY | PROGRAMMED DEATH-1 | IMMUNE ESCAPE | MYELOID-LEUKEMIA | SYNGENEIC MOUSE MODEL | REGULATORY T | GROWTH-FACTOR | CHRONIC VIRAL-INFECTION | ANTITUMOR-ACTIVITY | HUMAN OVARIAN-CANCER | T-Lymphocytes, Regulatory - metabolism | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Antibodies, Blocking - pharmacology | T-Lymphocytes, Regulatory - immunology | CD4-Positive T-Lymphocytes - immunology | Neoplasms, Experimental - pathology | Flow Cytometry | T-Lymphocytes - metabolism | Neoplasms, Experimental - immunology | CD8-Positive T-Lymphocytes - metabolism | Female | Lymphocytes, Tumor-Infiltrating - metabolism | Cytokines - immunology | Cytokines - metabolism | Cancer Vaccines - administration & dosage | Mice, Inbred C57BL | CD4-Positive T-Lymphocytes - metabolism | Neoplasms, Experimental - therapy | CTLA-4 Antigen - metabolism | Lymphocytes, Tumor-Infiltrating - transplantation | Programmed Cell Death 1 Receptor - metabolism | Combined Modality Therapy | CTLA-4 Antigen - immunology | B7-H1 Antigen - immunology | Cancer Vaccines - immunology | B7-H1 Antigen - metabolism | Animals | Antibodies, Blocking - immunology | T-Lymphocytes - immunology | Mice | Mice, Inbred BALB C | Programmed Cell Death 1 Receptor - immunology | CD8-Positive T-Lymphocytes - immunology | CTLA-4 Antigen - antagonists & inhibitors | Lymphocytes, Tumor-Infiltrating - immunology | Tumor Burden - immunology
Journal Article
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