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BBA - General Subjects, ISSN 0304-4165, 12/2018, Volume 1862, Issue 12, pp. 2764 - 2778
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 06/2017, Volume 127, Issue 7, pp. 2789 - 2804
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 07/2017, Volume 23, Issue 13, pp. 3416 - 3427
Purpose: To generate and characterize a murine GITR ligand fusion protein (mGITRL-FP) designed to maximize valency and the potential to agonize the GITR... 
EFFECTOR | RESPONSES | ACTIVATION | FC-GAMMA RECEPTORS | ONCOLOGY | IN-VIVO | REGULATORY T-CELLS | CANCER-IMMUNOTHERAPY | SUPPRESSION | TNF | TUMOR-IMMUNITY | Tumor Necrosis Factors - agonists | Tumor Necrosis Factors - genetics | Humans | Melanoma, Experimental - therapy | Membrane Glycoproteins - agonists | Glucocorticoid-Induced TNFR-Related Protein - administration & dosage | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Oncogene Proteins, Fusion - administration & dosage | CTLA-4 Antigen - immunology | Tumor Necrosis Factors - immunology | B7-H1 Antigen - immunology | Oncogene Proteins, Fusion - immunology | Animals | B7-H1 Antigen - antagonists & inhibitors | Melanoma, Experimental - genetics | Melanoma, Experimental - immunology | CD8-Positive T-Lymphocytes - drug effects | Glucocorticoid-Induced TNFR-Related Protein - immunology | Mice | Membrane Glycoproteins - immunology | Programmed Cell Death 1 Receptor - immunology | CD8-Positive T-Lymphocytes - immunology | CTLA-4 Antigen - antagonists & inhibitors | Disease Models, Animal | Cell proliferation | Animal models | PD-1 protein | CD8 antigen | Antibodies | Antagonists | Lymphocytes T | Immunity | Anticancer properties | Proteins | CTLA-4 protein | Lymphocytes | Immunotherapy | Fusion protein | Valency | CD4 antigen | Ox40L protein | Immune checkpoint | Experimental design | Tumor necrosis factor | PD-L1 protein | Antitumor activity | Ligands | Cancer | Tumors | Index Medicus
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 08/2017, Volume 23, Issue 15, pp. 4242 - 4250
Journal Article
NATURE IMMUNOLOGY, ISSN 1529-2908, 05/2014, Volume 15, Issue 5, pp. 465 - 465
Regulatory T (T-reg) cells, which maintain immune homeostasis and self-tolerance, form an immunological synapse (IS) with antigen-presenting cells (APCs).... 
LOCALIZATION | IN-VITRO | ACTIVATION | DENDRITIC CELLS | COLITIS | TCR STOP-SIGNAL | IMMUNOLOGY | IMMUNOLOGICAL SYNAPSE | FOXP3 | CTLA-4 FUNCTION | ANTIGEN
Journal Article
Cancer, ISSN 0008-543X, 10/2016, Volume 122, Issue 19, pp. 3051 - 3058
Journal Article
Journal of Cellular Biochemistry, ISSN 0730-2312, 12/2012, Volume 113, Issue 12, pp. 3797 - 3809
Regulatory T cells (Tregs) are critical for maintaining self‐tolerance and homeostasis, and have potential application in clinical disease therapy, such as... 
CYTOKINES | PTD‐HFOXP3 | PROLIFERATION | REGULATORY T CELLS | TREG‐LIKE CELLS | TREG-LIKE CELLS | PTD-HFOXP3 | TGF-BETA | SCID-X1 | TOLERANCE | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | SUPPRESSION | FOXP3 | CELL BIOLOGY | GENE-THERAPY | AUTOIMMUNE-DISEASE | EXPRESSION | DOMAINS | Forkhead Transcription Factors - immunology | Recombinant Fusion Proteins - immunology | Cell Proliferation | Humans | Cytoplasm - metabolism | Interferon-gamma - metabolism | T-Lymphocytes, Regulatory - immunology | CD4-Positive T-Lymphocytes - immunology | Interleukin-2 Receptor alpha Subunit - genetics | Chromatin Immunoprecipitation | Plasmids - genetics | T-Lymphocytes, Regulatory - cytology | HIV - metabolism | Cell Differentiation | Active Transport, Cell Nucleus | Interferon-gamma - genetics | Interleukin-2 - metabolism | Gene Transfer Techniques | Green Fluorescent Proteins - metabolism | Promoter Regions, Genetic | Jurkat Cells | Lymphocyte Activation | tat Gene Products, Human Immunodeficiency Virus - genetics | CD4-Positive T-Lymphocytes - cytology | CTLA-4 Antigen - metabolism | CTLA-4 Antigen - genetics | Protein Structure, Tertiary - genetics | Forkhead Transcription Factors - genetics | Plasmids - metabolism | Protein Transport | Interleukin-2 - genetics | Interleukin-2 Receptor alpha Subunit - metabolism | Protein Binding | Recombinant Fusion Proteins - genetics | HIV - genetics | tat Gene Products, Human Immunodeficiency Virus - metabolism | Chromatin | Biological products | Genes | Genetic research | Lymphomas | Genetic transcription | Transforming growth factors | T cells | HIV (Viruses) | Cells | Index Medicus
Journal Article
Urologic Oncology: Seminars and Original Investigations, ISSN 1078-1439, 2017, Volume 35, Issue 5, pp. 257 - 263
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2013, Volume 8, Issue 1, pp. e54295 - e54295
HIV-1 Nef protein down-regulates several cell surface receptors through its interference with the cell sorting and trafficking machinery. Here we demonstrate... 
LYMPHOCYTE-ASSOCIATED MOLECULE-4 | CYTOPLASMIC DOMAIN | DILEUCINE MOTIF | MULTIDISCIPLINARY SCIENCES | IMMUNODEFICIENCY-VIRUS TYPE-1 | CD4(+) T-CELLS | SURFACE CD4 | BETA-COP | ADAPTER PROTEIN | UP-REGULATION | PHYSICAL INTERACTION | Recombinant Fusion Proteins - pharmacology | nef Gene Products, Human Immunodeficiency Virus - pharmacology | Humans | Recombinant Fusion Proteins - metabolism | Endosomes - metabolism | Lysosomes - metabolism | Transfection | HIV-1 - chemistry | Endosomes - drug effects | HEK293 Cells | nef Gene Products, Human Immunodeficiency Virus - metabolism | CD4 Antigens - genetics | Lysosomes - drug effects | Endocytosis - drug effects | CTLA-4 Antigen - metabolism | CTLA-4 Antigen - genetics | Down-Regulation - drug effects | HIV-1 - genetics | Amino Acid Motifs | Host-Pathogen Interactions | Signal Transduction - drug effects | nef Gene Products, Human Immunodeficiency Virus - genetics | Recombinant Fusion Proteins - genetics | HeLa Cells | CTLA-4 Antigen - antagonists & inhibitors | CD4 Antigens - metabolism | Viral proteins | HIV (Viruses) | T cells | Regulations | Phosphorylation | Trafficking | Confocal microscopy | Lymphocytes T | Infections | Activation | Confocal | pH effects | Machinery | Cell surface | Protein turnover | Proteins | Receptors | CTLA-4 protein | Cell activation | Immunology | Lymphocytes | Compartments | Human immunodeficiency virus--HIV | Down-regulation | Localization | Virology | Nef protein | Microscopy | Automobile industry | Gene therapy | Endosomes | Apoptosis | Index Medicus | HIV-1 | Signal Transduction | Antigens, CD4 | Down-Regulation | Lysosomes | Recombinant Fusion Proteins | CTLA-4 Antigen | Life Sciences | Microbiology and Parasitology | Endocytosis | nef Gene Products, Human Immunodeficiency Virus | HIV | Human immunodeficiency virus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2018, Volume 115, Issue 40, pp. 10094 - 10099
Potent immunosuppressive mechanisms within the tumor microenvironment contribute to the resistance of aggressive human cancers to immune checkpoint blockade... 
Immune checkpoint blockade | LCK | Prostate cancer | Myeloid-derived suppressor cells | Protein nitration | PATHWAYS | PHOSPHORYLATION | PEROXYNITRITE | MULTIDISCIPLINARY SCIENCES | protein nitration | TUMORS | myeloid-derived suppressor cells | SIGNAL-TRANSDUCTION | RESPONSES | prostate cancer | PROTEIN-TYROSINE NITRATION | IMMUNOTHERAPY | RESISTANT PROSTATE-CANCER | immune checkpoint blockade | ANTIGEN | Myeloid-Derived Suppressor Cells - immunology | Jurkat Cells | Lymphocyte Activation | Humans | Carcinoma, Lewis Lung - immunology | Prostatic Neoplasms, Castration-Resistant - immunology | Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - immunology | Male | Prostatic Neoplasms, Castration-Resistant - genetics | Prostatic Neoplasms, Castration-Resistant - pathology | Animals | Carcinoma, Lewis Lung - genetics | Carcinoma, Lewis Lung - pathology | Receptors, Antigen, T-Cell - immunology | T-Lymphocytes - immunology | Mice | Receptors, Antigen, T-Cell - genetics | Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - genetics | T-Lymphocytes - pathology | Myeloid-Derived Suppressor Cells - pathology | Physiological aspects | Suppressor cells | Phosphotransferases | Cancer | Cell proliferation | Therapy | p53 Protein | Lung cancer | Interleukin | Reactive nitrogen species | Antibodies | Lymphocytes T | Activation | Nitrates | Inactivation | Cancer therapies | Smad4 protein | Proteins | T-cell receptor | Cell activation | CTLA-4 protein | Interleukin 2 | Clonal deletion | Castration | Lymphocytes | Rodents | Deletion | Protein-tyrosine kinase | Tyrosine | Nitration | Immunoglobulins | Deactivation | Secretion | Transgenic mice | T cell receptors | Reducing agents | Immunological tolerance | Organic chemistry | Immunosuppression | Immune checkpoint | Cell death | Lck protein | Nitrotyrosine | Prostate | PTEN protein | Apoptosis | Index Medicus | Biological Sciences
Journal Article