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cux2 (23) 23
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1. Full Text Cux2 expression regulated by Lhx2 in the upper layer neurons of the developing cortex
by Yang, Hayoung and Kim, Jiwoo and Kim, Yujin and Jang, Sung-Wuk and Sestan, Nenad and Shim, Sungbo
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 11/2019
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2. Full Text CuX2-mediated halocyclization of 1,1-difluoro-2,3-allenylphosphonic acid monoesters –synthesis of novel cyclic phosphate mimics
by Jiang, Xu and Cai, Xiang and Lin, Yun and Liu, Jintao
Tetrahedron, ISSN 0040-4020, 08/2018, Volume 74, Issue 34, pp. 4466 - 4470
Novel six-membered cyclic phosphate mimics (5-halo-3,3-difluoro-3,6-dihydro-2 -1,2-oxaphosphinine 2-oxides) were synthesized via CuX (X = Br, Cl)-mediated... 
1,1-Difluoro-2,3-allenylphosphonic acid monoesters | Cyclic phosphate mimics | Synthesis | CuX2 | Halocyclization | NUCLEOTIDE ANALOGS | PHOSPHONATES | GAMMA-HYDROXYLATION | EFFICIENT SYNTHESIS | CHEMISTRY, ORGANIC | HALOLACTONIZATION
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3. Full Text Lmx1a drives Cux2 expression in the cortical hem through activation of a conserved intronic enhancer
by Fregoso, SP and Dwyer, BE and Franco, SJ
DEVELOPMENT, ISSN 0950-1991, 03/2019, Volume 146, Issue 5, p. dev170068
During neocortical development, neurons are produced by a diverse pool of neural progenitors. A subset of progenitors express the Cux2 gene and are fate... 
MIGRATION | EMX2 | Enhancer | Lmx1a | NEOCORTICAL PROJECTION NEURONS | MOUSE | Telencephalon | Cortical hem | LAYER NEURONS | DEVELOPMENTAL BIOLOGY | Corticogenesis | Cux2 | CEREBRAL-CORTEX | HOMEOBOX GENES | PROGENITOR | RHOMBIC LIP
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4. Full Text Association of FAM65B, AGBL4, and CUX2 genetic polymorphisms with susceptibility to antituberculosis drug-induced hepatotoxicity: validation study in a Chinese Han population
by Pan, Hongqiu and Yang, Miaomiao and Lu, Lihuan and Tao, Bilin and He, Xiaomin and Chen, Hongbo and Yi, Honggang and Tang, Shaowen
Pharmacogenetics and Genomics, ISSN 1744-6872, 06/2019, Volume 29, Issue 4, pp. 84 - 90
OBJECTIVEAntituberculosis (anti-TB) drug-induced hepatotoxicity (ATDH) is a serious adverse drug reaction, and its pathogenic mechanism has not been elucidated... 
PROTEIN | GSTM1 | RISK | antituberculosis drug | INDUCED LIVER-INJURY | AGBL4 | SLCO1B1 | CUX2 | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | hepatotoxicity | GENETICS & HEREDITY | PHARMACOLOGY & PHARMACY | FAM65B | SUPEROXIDE-DISMUTASE | GENOME-WIDE ASSOCIATION | Index Medicus
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5. Full Text The crux of Cux genes in neuronal function and plasticity
by Weiss, Linnea A and Nieto, Marta
Brain Research, ISSN 0006-8993, 02/2019, Volume 1705, pp. 32 - 42
Cux1 and Cux2 are the vertebrate members of a family of homeodomain transcription factors (TF) containing Cut repeat DNA-binding sequences. Perturbation of... 
Cutl1 | Transcription factors | Upper layers | Reprogramming | Brain disorders | Superficial layers | Cortex | Cux1 | Cux2 | Cutl2 | Selector | DNA-BINDING | NEOCORTICAL PROJECTION NEURONS | ALZHEIMERS-DISEASE | HOMEODOMAIN PROTEINS | NEUROSCIENCES | BASE EXCISION-REPAIR | HAPLOINSUFFICIENT TUMOR-SUPPRESSOR | CORPUS-CALLOSUM | GENOME-WIDE ANALYSIS | CCAAT-DISPLACEMENT PROTEIN | TRANSCRIPTION FACTOR | Autism | Neurons | Analysis | Genes | Genetic transcription | DNA binding proteins | Neurophysiology
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6. Full Text Neural stem cells to cerebral cortex: Emerging mechanisms regulating progenitor behavior and productivity
by Dwyer, Noelle D and Chen, Bin and Chou, Shen-Ju and Hippenmeyer, Simon and Nguyen, Laurent and Ghashghaei, H. Troy
Journal of Neuroscience, ISSN 0270-6474, 11/2016, Volume 36, Issue 45, pp. 11394 - 11401
This review accompanies a 2016 SFN mini-symposium presenting examples of current studies that address a central question: How do neural stem cells (NSCs)... 
Lineage | Cux2 | Cytokinesis | Microcephaly | Fezf2 | Neurogenesis | Kif20b | Lhx2 | Mouse | Sp2 | UPR | Cortical development | MADM | lineage | microcephaly | MIDBODY | cytokinesis | SPINDLE ORIENTATION | RADIAL GLIA | NEUROSCIENCES | PRIMARY CILIUM | mouse | CORTICAL NEUROGENESIS | ASYMMETRIC INHERITANCE | PYRAMIDAL NEURONS | UNFOLDED PROTEIN RESPONSE | BASAL PROCESS | neurogenesis | cortical development | SUBCORTICAL PROJECTION NEURONS | Animals | Neuronal Plasticity - physiology | Cytokinesis - physiology | Neurogenesis - physiology | Humans | Cell Proliferation - physiology | Neurons - physiology | Cerebral Cortex - physiology | Neurons - cytology | Cell Differentiation - physiology | Cerebral Cortex - cytology | Symposium and Mini-Symposium
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7. Full Text The generation of granule cells during the development and evolution of the cerebellum
by Iulianella, Angelo and Wingate, Richard J and Moens, Cecilia B and Capaldo, Emily
Developmental Dynamics, ISSN 1058-8388, 07/2019, Volume 248, Issue 7, pp. 506 - 513
The cerebellum coordinates vestibular input into the hindbrain to control balance and movement, and its anatomical complexity is increasingly viewed as a... 
amniotes | anamniotes | granule cells | Cux2 | cerebellum | external granular layer | Atoh1 | PURKINJE-CELLS | ANATOMY & MORPHOLOGY | PATTERNS | DEVELOPMENTAL BIOLOGY | MONOSYNAPTIC INHIBITION | MATH1 | NUCLEI | GENE-EXPRESSION | MOSSY FIBERS | RHOMBIC-LIP | DEVELOPING CHICK CEREBELLUM | LAYER | Brain | Cerebellum | Sensory integration | Granular materials | Granule cells | Information processing | Cognitive ability | Hindbrain | Cortex (somatosensory) | Vestibular system | Ventricle | Ventricular zone
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8. Full Text The epilepsy phenotypic spectrum associated with a recurrent CUX2 variant
by Chatron, Nicolas and Moller, R.S and Champaigne, Neena L and Schneider, A and Kuechler, Alma and Labalme, Auey and Kamsteeg, E.J and Pfundt, R.P and Carvill, Gemma L and Lesca, Gaetan
Annals of Neurology, ISSN 0364-5134, 2018, Volume 83, Issue 5, pp. 926 - 934
Objective Cut homeodomain transcription factor CUX2 plays an important role in dendrite branching, spine development, and synapse formation in layer II to III... 
INTELLECTUAL DISABILITY | ENCEPHALOPATHIES | PROTEIN | SYNGAP1 | AUTISM | DE-NOVO MUTATIONS | STABILITY | NEUROSCIENCES | CLINICAL NEUROLOGY | PREDICTION | Neuroimaging | Cerebral cortex | Synaptogenesis | Identification methods | Spine | Epilepsy | Cognitive ability | Males | Drug resistance | Gene sequencing | Homeobox | Dendritic spines | Encephalopathy | Deoxyribonucleic acid--DNA | Seizures | Seizing | Firing pattern | EEG | Cortex | Valproic acid | Patients | Autism | Phenotyping | Females | Dendritic structure | Dendritic branching | Glutamine | de novo variant | developmental and epileptic encephalopathy | CUX2 | CUT domain | myoclonic seizures | intellectual disability
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9. Full Text Automated immunohistochemical method to analyze large areas of the human cortex
by Abbass, Mohamad and Trought, Kathleen and Long, David and Semechko, Anton and Wong, Albert H.C
Journal of Neuroscience Methods, ISSN 0165-0270, 01/2018, Volume 294, pp. 81 - 90
There have been inconsistencies in the histological abnormalities found in the cerebral cortex from patients with schizophrenia, bipolar disorder and major... 
Immunohistochemistry | ImageJ | CUX2 | FEZF2 | MATLAB | NEURONAL DENSITY | ANTERIOR CINGULATE CORTEX | HUMAN ORBITOFRONTAL CORTEX | SIZE | BIOCHEMICAL RESEARCH METHODS | BIPOLAR-DISORDER | SCHIZOPHRENIA | MAJOR-DEPRESSIVE-DISORDER | NEUROSCIENCES | PREFRONTAL CORTEX | BRAIN SECTIONS | GLIAL-CELL DENSITY | Schizophrenia | Bipolar disorder | Algorithms | Analysis | Depression, Mental | Methods
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10. Full Text Genome‐wide association study identifies gastric cancer susceptibility loci at 12q24.11‐12 and 20q11.21
by Tanikawa, Chizu and Kamatani, Yoichiro and Toyoshima, Osamu and Sakamoto, Hiromi and Ito, Hidemi and Takahashi, Atsushi and Momozawa, Yukihide and Hirata, Makoto and Fuse, Nobuo and Takai‐Igarashi, Takako and Shimizu, Atsushi and Sasaki, Makoto and Yamaji, Taiki and Sawada, Norie and Iwasaki, Motoki and Tsugane, Shoichiro and Naito, Mariko and Hishida, Asahi and Wakai, Kenji and Furusyo, Norihiro and Murakami, Yoshinori and Nakamura, Yusuke and Imoto, Issei and Inazawa, Johji and Oze, Isao and Sato, Naomi and Tanioka, Fumihiko and Sugimura, Haruhiko and Hirose, Hiroshi and Yoshida, Teruhiko and Matsuo, Keitaro and Kubo, Michiaki and Matsuda, Koichi
Cancer Science, ISSN 1347-9032, 12/2018, Volume 109, Issue 12, pp. 4015 - 4024
Gastric cancer is the third leading cause of cancer mortality in Japan and worldwide. Although previous studies identify various genetic variations associated... 
DEFB | CUX2 | genome‐wide association study | gastric cancer | ABO | genome-wide association study | SYSTEM | PROJECT | DESIGN | DUODENAL-ULCER | VARIANTS | ALDEHYDE DEHYDROGENASE | GENOTYPE | RISK | POLYMORPHISM | ONCOLOGY | DIFFUSE | Stomach Neoplasms - genetics | Genetic Predisposition to Disease | beta-Defensins - genetics | Humans | Japan | Middle Aged | Gene Expression Regulation | Male | Helicobacter Infections - genetics | Case-Control Studies | Homeodomain Proteins - genetics | Stomach Neoplasms - microbiology | Young Adult | Chromosomes, Human, Pair 9 - genetics | ABO Blood-Group System - genetics | Aged, 80 and over | Adult | Female | Aged | Polymorphism, Single Nucleotide | Genome-Wide Association Study - methods | Chromosomes, Human, Pair 12 - genetics | Chromosomes, Human, Pair 20 - genetics | Analysis | Oncology, Experimental | Genomics | Genetic research | Helicobacter infections | Disease susceptibility | Genetic aspects | Research | Stomach cancer | Cancer | Medical research | Disease | Mucosa | Principal components analysis | Infections | ABO system | Genomes | Genetic diversity | Gene expression | Studies | Biopsy | Chromosome 9 | Collaboration | Population | Chromosome 12 | Genetic factors | Health risk assessment | Gastric cancer | Blood groups | Public health | Polymorphism | Original
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11. Full Text Cux2 serves as a novel lineage marker of granule cell layer neurons from the rhombic lip in mouse and chick embryos
by Capaldo, Emily and Iulianella, Angelo
Developmental Dynamics, ISSN 1058-8388, 08/2016, Volume 245, Issue 8, pp. 881 - 896
Background: The rhombic lip (RL), a germinal zone in the developing hindbrain, gives rise to all of the excitatory neurons of the cerebellum. It is presently... 
fate restriction | Cux2 | granule cells | cerebellum | Cerebellum | Granule cells | Fate restriction | PURKINJE-CELLS | NEURAL PROGENITORS | MIGRATION | NEOCORTICAL PROJECTION NEURONS | ANATOMY & MORPHOLOGY | SPINAL-CORD | DEVELOPMENTAL BIOLOGY | CEREBRAL-CORTEX | QUAIL CHIMERAS | EPH RECEPTORS | EARLY CEREBELLAR DEVELOPMENT | EXPRESSION | Cell Proliferation - genetics | Cerebellum - metabolism | Homeodomain Proteins - metabolism | Cell Proliferation - physiology | Neurons - cytology | Stem Cells - cytology | Transcription Factors - genetics | Stem Cells - metabolism | Chick Embryo | Homeodomain Proteins - genetics | Rhombencephalon - cytology | Transcription Factors - metabolism | Cell Differentiation - genetics | Animals | Cerebellum - cytology | Rhombencephalon - metabolism | Mice | Neurons - metabolism | Cell Differentiation - physiology | Embryonic development | Neurons
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12. Full Text Cux2 refines the forelimb field by controlling expression of Raldh2 and Hox genes
by Ueda, Shogo and Cordeiro, Ingrid Rosenburg and Moriyama, Yuuta and Nishimori, Chika and Keiichi, Kai and Yu, Reiko and Nakato, Ryoichiro and Shirahige, Katsuhiko and Tanaka, Mikiko
Biology Open, ISSN 2046-6390, 2019, Volume 8, Issue 2, p. bio040584
In vertebrates, two pairs of buds that give rise to the fore- and hindlimbs form at discrete positions along the rostral-caudal axis of the body. The mechanism... 
Cux2 | Forelimb bud initiation | Forelimb field specification | CUT | INDUCTION | TBX5 | LIMB INITIATION | MOUSE MODELS | IDENTITY | MORPHOGENESIS | RETINOIC ACID SYNTHESIS | BIOLOGY | POLARIZING ACTIVITY | HINDLIMB
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13. Full Text Molecular Interaction between Projection Neuron Precursors and Invading Interneurons via Stromal-Derived Factor 1 (CXCL12)/CXCR4 Signaling in the Cortical Subventricular Zone/Intermediate Zone
by Tiveron, Marie-Catherine and Rossel, Mireille and Moepps, Barbara and Zhang, Yong Li and Seidenfaden, Ralph and Favor, Jack and Konig, Norbert and Cremer, Harold
Journal of Neuroscience, ISSN 0270-6474, 12/2006, Volume 26, Issue 51, pp. 13273 - 13278
Most cortical interneurons are generated in the subpallial ganglionic eminences and migrate tangentially to their final destinations in the neocortex. Within... 
Migration | Tangential | Cux1 | Cux2 | Neocortex | Pallium | Subpallium | PROGENITOR CELLS | NERVOUS-SYSTEM | FOREBRAIN | CXCR4 | neocortex | subpallium | DEVELOPING CEREBRAL-CORTEX | NEUROSCIENCES | pallium | PATTERN | TELENCEPHALON | migration | tangential | NEUROGENESIS | EXPRESSION | Interneurons - physiology | Cell Communication - physiology | Neurons - cytology | Stem Cells - cytology | Stem Cells - metabolism | Cerebral Cortex - cytology | Neural Pathways - physiology | Cell Movement - physiology | Cerebral Cortex - metabolism | Cerebral Ventricles - physiology | Receptors, CXCR4 - deficiency | Neurons - physiology | Receptors, CXCR4 - genetics | Interneurons - cytology | Neurons - metabolism | Chemokine CXCL12 | Cerebral Ventricles - metabolism | Mice, Inbred C57BL | Mice, Transgenic | Chemokines, CXC - genetics | Chemokines, CXC - deficiency | Receptors, CXCR4 - physiology | Animals | Interneurons - metabolism | Cerebral Cortex - physiology | Chemokines, CXC - physiology | Signal Transduction - physiology | Stem Cells - physiology | Mice | Cerebral Ventricles - cytology | Interneurons | Signal Transduction | Neurons | Chemokines, CXC | Cell Communication | Cerebral Cortex | Neural Pathways | Stem Cells | Life Sciences | Cerebral Ventricles | Development Biology | Receptors, CXCR4 | Cell Movement | Brief Communications
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14. Full Text Cux2 acts as a critical regulator for neurogenesis in the olfactory epithelium of vertebrates
by Wittmann, Walter and Iulianella, Angelo and Gunhaga, Lena and Medicinska fakulteten and Umeå centrum för molekylär medicin (UCMM) and Umeå universitet
Developmental Biology, ISSN 0012-1606, 04/2014, Volume 388, Issue 1, pp. 35 - 47
Signaling pathways and transcription factors are crucial regulators of vertebrate neurogenesis, exerting their function in a spatial and temporal manner.... 
BMP | Mouse | Olfactory | Notch | Development | Cux2 | Neurogenesis | Chick | PROGENITOR CELLS | CUT LOCUS | SPINAL-CORD | DEVELOPMENTAL BIOLOGY | NEURAL STEM-CELLS | CHICK-EMBRYO | HOMEOBOX GENE CUX-1 | DYNAMIC EXPRESSION | TRANSCRIPTION FACTOR | WING MARGIN | TRANSGENIC MICE | Immunohistochemistry | Cell Proliferation | Receptors, Notch - metabolism | Gene Silencing | Olfactory Mucosa - metabolism | Chick Embryo | Cell Lineage | Bone Morphogenetic Proteins - metabolism | Animals | In Situ Hybridization | Gene Expression Regulation, Developmental | Neurogenesis - physiology | Mice | Neurons - metabolism | Homeodomain Proteins - physiology | RNA, Small Interfering - metabolism | Epithelium | Analysis | Medical and Health Sciences | Medicin och hälsovetenskap
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15. Full Text Cux2 functions as an oncogene in papillary thyroid cancer
by Sun, Yihan and Ye, Danrong and Li, Yuefeng and Chen, Endong and Hao, Rutian and Cai, Yefeng and Wang, Qingxuan and Wang, Ouchen and Zhang, Xiaohua
OncoTargets and Therapy, ISSN 1178-6930, 2019, Volume 12, pp. 217 - 224
Background: In recent years, the incidence of thyroid cancer (TC), the most common endocrine malignancy, has been increasing. Emerging evidence indicates that... 
Oncogene | Papillary thyroid carcinoma | CUX2 | PROTEIN | oncogene | EPITHELIAL-MESENCHYMAL TRANSITION | ONCOLOGY | PSYCHOTIC FEATURES | PATHWAY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | RAS MUTATIONS | DISORDER | papillary thyroid carcinoma | EXPRESSION | ASSOCIATION | GENETIC ALTERATIONS | CUTL1 | DNA damage | Amino acids | Breast cancer | Metastasis | Gene expression | Kinases | Neurogenesis | Cell adhesion & migration | Proteins | Thyroid cancer | Insects | Cell cycle | DNA methylation | Tumorigenesis | Mutation | Deoxyribonucleic acid--DNA
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