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PLoS ONE, ISSN 1932-6203, 2014, Volume 9, Issue 9, pp. e105070 - e105070
Nephrotoxicity is a dose-dependent side effect of cisplatin limiting its clinical usage in the field of cancer chemotherapy. Fisetin is a bioactive flavonoid... 
ACUTE KIDNEY INJURY | OXIDATIVE STRESS | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | MITOCHONDRIAL DYSFUNCTION | PATHOLOGICAL ROLE | MECHANISMS | MICE | RENAL INJURY | CELL-DEATH | PROTECTS | Tumor Necrosis Factor-alpha - metabolism | Phosphorylation | Caspase 9 - genetics | Caspase 9 - metabolism | Kidney - pathology | Blood Urea Nitrogen | Tumor Necrosis Factor-alpha - genetics | Caspase 3 - metabolism | Male | Cytochromes c - genetics | I-kappa B Proteins - metabolism | I-kappa B Proteins - genetics | Transcription Factor RelA - genetics | Antineoplastic Agents - toxicity | Proto-Oncogene Proteins c-bcl-2 - metabolism | Kidney - metabolism | Cisplatin - toxicity | Caspase 3 - genetics | Flavonoids - pharmacology | Cisplatin - antagonists & inhibitors | NF-KappaB Inhibitor alpha | Kidney - drug effects | Signal Transduction | Cytochromes c - metabolism | Gene Expression Regulation | Rats | Antioxidants - pharmacology | Flavonoids - pharmacokinetics | Rats, Sprague-Dawley | Animals | Nitric Oxide Synthase Type II - genetics | Transcription Factor RelA - metabolism | Creatinine - blood | Peroxidase - genetics | Antioxidants - pharmacokinetics | Proto-Oncogene Proteins c-bcl-2 - genetics | Nitric Oxide Synthase Type II - metabolism | Peroxidase - metabolism | Cytochrome | Bcl-2 protein | Syngeneic grafts | C protein | Cytotoxicity | Cytosol | Caspase-3 | NAD(P)H oxidase | Antioxidants | Proteins | Elevation | Mitochondria | Enzymatic activity | Animal tissues | Bioindicators | Medical research | NF-κB protein | Committees | Gene expression | Studies | Cytochrome c | Urea | Chemistry | Chemotherapy | Flavonoids | Caspase-9 | Biomarkers | Kidney transplantation | Oxidative stress | Enzyme activity | Bax protein | Platinum | Rodents | CYBB protein | Peroxidase | Pharmaceutical sciences | Creatinine | Translocation | Antiinflammatory agents | Kidneys | Caspase | Inflammation | Pharmacology | Cisplatin | Acids | Apoptosis | Cancer | Index Medicus
Journal Article
Immunity, ISSN 1074-7613, 08/2017, Volume 47, Issue 2, pp. 363 - 373.e5
Inhibition of cytosolic DNA sensing represents a strategy that tumor cells use for immune evasion, but the underlying mechanisms are unclear. Here we have... 
NADPH OXIDASE | INNATE IMMUNE RECOGNITION | HEMATOPOIETIC STEM-CELLS | THERAPEUTIC TARGET | NON-HODGKIN-LYMPHOMA | IMMUNOLOGY | IMMUNOGENIC TUMORS | MEDIATED PHAGOCYTOSIS | SIRP-ALPHA | GMP-AMP SYNTHASE | CONTROLS PHAGOSOMAL PH | Colonic Neoplasms - genetics | Tumor Escape | Membrane Glycoproteins - metabolism | Dendritic Cells - immunology | Humans | NADPH Oxidases - metabolism | CD47 Antigen - immunology | Colonic Neoplasms - immunology | Interferon Type I - metabolism | Antigens, Differentiation - metabolism | Membrane Proteins - metabolism | Nucleotidyltransferases - metabolism | Macrophages - immunology | Disease Models, Animal | Colonic Neoplasms - therapy | Signal Transduction | Membrane Proteins - genetics | Mice, Inbred C57BL | Cells, Cultured | CD47 Antigen - metabolism | NADPH Oxidase 2 | Mice, Knockout | DNA, Mitochondrial - immunology | Animals | Antibodies, Blocking - therapeutic use | Cross-Priming | Mice | Receptors, Immunologic - metabolism | Oxidase | Acidification | Mitochondrial DNA | Kinases | Macrophages | Cancer therapies | Cytosol | Immunity | NAD(P)H oxidase | Degradation | Proteins | Cell activation | CYBB protein | Inhibition | Deoxyribonucleic acid--DNA | Antigen presentation | Antigens | Dendritic cells | AMP | Tumor cells | Priming | Adaptive immunity | Interferon | Detection | Tumors | Index Medicus
Journal Article
by Yuan, HP and Zhang, XY and Huang, XQ and Lu, YG and Tang, WQ and Man, Y and Wang, S and Xi, JZ and Li, JA
PLOS ONE, ISSN 1932-6203, 12/2010, Volume 5, Issue 12, pp. e15726 - e15726
Dysfunction of beta-cell is one of major characteristics in the pathogenesis of type 2 diabetes. The combination of obesity and type 2 diabetes, characterized... 
DIABETES-MELLITUS | HUMAN PANCREATIC-ISLETS | OXIDATIVE STRESS | TRANSCRIPTION FACTOR PDX-1 | FREE FATTY-ACIDS | MULTIDISCIPLINARY SCIENCES | LONG-TERM EXPOSURE | GENE-EXPRESSION | RAT ISLETS | INDUCED INSULIN-SECRETION | ENDOPLASMIC-RETICULUM STRESS | Palmitic Acid - metabolism | Oleic Acid - metabolism | Reactive Oxygen Species - metabolism | Membrane Glycoproteins - metabolism | Mitogen-Activated Protein Kinase 8 - metabolism | NADPH Oxidases - metabolism | Tumor Suppressor Protein p53 - metabolism | Cytoplasm - metabolism | Mitochondria - metabolism | NADPH Oxidase 2 | MAP Kinase Signaling System | Fatty Acids, Nonesterified - metabolism | Insulin - metabolism | Animals | Cell Nucleus - metabolism | MAP Kinase Kinase 4 - metabolism | Forkhead Transcription Factors - metabolism | Forkhead Box Protein O1 | Insulin-Secreting Cells - cytology | Mice | p38 Mitogen-Activated Protein Kinases - metabolism | Apoptosis | Oxidative stress | Transcription factors | Phosphorylation | Pathogenesis | p53 Protein | AKT protein | Glucose | Palmitic acid | Phosphatase | NAD(P)H oxidase | Hyperglycemia | Cell growth | FOXO1 protein | Rodents | CYBB protein | Pancreas | Localization | Diabetes mellitus (non-insulin dependent) | Drug dosages | Biomedical engineering | Translocation | Obesity | NF-κB protein | Oxygen | Engineering schools | Preservation | Diabetes mellitus | MAP kinase | JNK protein | Insulin | Fatty acids | Medicine | Hospitals | Molecular modelling | Nitric oxide | Insulin resistance | Diabetes | Clinical medicine | Endoplasmic reticulum | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2012, Volume 7, Issue 7, pp. e40277 - e40277
S100A8 and S100A9 are two calcium binding Myeloid Related Proteins, and important mediators of inflammatory diseases. They were recently introduced as partners... 
Calgranulin B - metabolism | Calgranulin A - metabolism | Antibodies, Monoclonal - biosynthesis | Cross-Linking Reagents - pharmacology | Cytosol - immunology | Humans | Cytosol - drug effects | Herpesvirus 4, Human - drug effects | NADPH Oxidases - metabolism | Molecular Sequence Data | Protein Transport - drug effects | Structure-Activity Relationship | Cytochrome b Group - metabolism | Calgranulin A - chemistry | Lymphocytes - virology | Bacterial Secretion Systems - drug effects | Pseudomonas aeruginosa - metabolism | Protein Binding - drug effects | Calgranulin B - chemistry | Protein Structure, Tertiary | Recombinant Proteins - metabolism | Amino Acid Sequence | Neutrophils - enzymology | Herpesvirus 4, Human - physiology | Neutrophils - drug effects | Recombinant Proteins - chemistry | Enzyme Activation - drug effects | Cell-Free System | NADPH Oxidases - isolation & purification | Cytochrome b Group - isolation & purification | Lymphocytes - drug effects | Lymphocytes - enzymology | Cytochrome | Residues | Enzymes | Phosphorylation | Dehydrogenases | Calcium | Leukemia | Escherichia coli | Neutrophils | Oxidase | Amino acid sequence | Cystic fibrosis | Activation | Kinases | NAD(P)H oxidase | Inflammatory diseases | Proteins | Cytochrome b558 | Acids | Lymphocytes | CYBB protein | Aging | Chimeras | Recombinant | Index Medicus | Calgranulin B | Biotechnology | Bacterial Secretion Systems | Calgranulin A | Recombinant Proteins | Cytosol | Life Sciences | Computer Science | Pseudomonas aeruginosa | Cross-Linking Reagents | Antibodies, Monoclonal | Herpesvirus 4, Human | Protein Transport | Cytochrome b Group | Protein Binding | Enzyme Activation | NADPH Oxidase
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2017, Volume 114, Issue 41, pp. E8711 - E8720
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2013, Volume 8, Issue 2, pp. e57254 - e57254
The purpose of the current study was to evaluate the effect of 12/15-lipoxygenase (12/15-LOX) metabolites on retinal endothelial cell (REC) barrier function.... 
DIABETIC-RETINOPATHY | OXIDATIVE STRESS | MULTIDISCIPLINARY SCIENCES | MOUSE MODEL | KINASE | ANGIOTENSIN-II | GROWTH-FACTOR | ADHESION MOLECULES | VASCULAR NAD(P)H OXIDASE | EXPRESSION | PROTEIN-TYROSINE-PHOSPHATASE | Retina - drug effects | Diabetic Retinopathy - drug therapy | Retina - metabolism | Reactive Oxygen Species - metabolism | Arachidonate 12-Lipoxygenase - metabolism | Gene Expression - drug effects | Membrane Glycoproteins - metabolism | NADPH Oxidases - metabolism | Diabetic Retinopathy - pathology | Vascular Endothelial Growth Factor Receptor-2 - genetics | Dextrans | Hydroxyeicosatetraenoic Acids - pharmacology | NADPH Oxidases - genetics | Vascular Endothelial Growth Factor Receptor-2 - agonists | Biological Transport - drug effects | Zonula Occludens-1 Protein - metabolism | 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid - pharmacology | Zonula Occludens-1 Protein - genetics | Endothelial Cells - metabolism | Flavanones - pharmacology | Enzyme Inhibitors - pharmacology | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Fluorescein-5-isothiocyanate - analogs & derivatives | Mice, Transgenic | Electric Impedance | Arachidonate 15-Lipoxygenase - metabolism | NADPH Oxidase 2 | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - genetics | Diabetic Retinopathy - metabolism | Diabetic Retinopathy - genetics | Membrane Glycoproteins - genetics | Animals | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - metabolism | Signal Transduction - drug effects | Cell Membrane Permeability - drug effects | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - antagonists & inhibitors | Mice | Endothelial Cells - pathology | Retina - pathology | Endothelial Cells - drug effects | Oxidases | Dextran | Phosphatases | Metabolites | Permeability | Vascular endothelial growth factor | Monomolecular films | Endothelium | Multiplexing | Health sciences | Diabetic retinopathy | Immunoassay | Reactive oxygen species | Vascular cell adhesion molecule 1 | Oxidase | Retina | Biology | Kinases | Phosphatase | NAD(P)H oxidase | Interleukin 6 | Proteins | Hyperglycemia | Cell growth | Rodents | CYBB protein | Age | Tyrosine | Intercellular adhesion molecule 1 | Diabetes mellitus | Inflammation | Dentistry | Fatty acids | Zonula occludens-1 protein | Substrates | Endothelial cells | Vascular endothelial growth factor receptors | Medicine | Inhibitors | Arachidonate 12-lipoxygenase | Liquid oxygen | In vivo methods and tests | Diabetes | Lipoxygenase | Protein-tyrosine-phosphatase | Index Medicus
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2012, Volume 7, Issue 4, pp. e34892 - e34892
Background: New therapeutic targets for cardiac hypertrophy, an independent risk factor for heart failure and death, are essential. HNO is a novel redox... 
CARDIAC SARCOPLASMIC-RETICULUM | NATRIURETIC-PEPTIDE | ANTIHYPERTROPHIC ACTIONS | OXIDATIVE STRESS | ADULT-RAT CARDIOMYOCYTES | CYCLIC-GMP | MULTIDISCIPLINARY SCIENCES | II-INDUCED HYPERTROPHY | IN-VIVO | NITRIC-OXIDE | ANTIOXIDANT ACTIONS | Reactive Oxygen Species - metabolism | Natriuretic Peptide, Brain - metabolism | NADPH Oxidases - metabolism | Cardiomegaly - pathology | Phosphoproteins - metabolism | Superoxides - metabolism | Microfilament Proteins - metabolism | p38 Mitogen-Activated Protein Kinases - metabolism | Angiotensin II - adverse effects | Phosphorylation - drug effects | Endothelin-1 - metabolism | Cardiomegaly - drug therapy | Rats | Guanylate Cyclase - metabolism | Soluble Guanylyl Cyclase | Cell Adhesion Molecules - metabolism | Nitrites - pharmacology | Myocytes, Cardiac - pathology | Reactive Oxygen Species - antagonists & inhibitors | Animals | Myocytes, Cardiac - drug effects | Cyclic GMP - metabolism | Signal Transduction - drug effects | Nitrogen Oxides - pharmacology | Cardiomegaly - chemically induced | Myocytes, Cardiac - metabolism | Cardiomegaly - metabolism | Receptors, Cytoplasmic and Nuclear - metabolism | Oxidases | Heart failure | Heart | Heart enlargement | Vasodilators | Protein biosynthesis | Superoxide | Muscle proteins | Angiotensin | Myosin | Health aspects | Protein kinases | Mitogens | Natriuretic peptides | Neonates | Phosphorylation | Salts | Peptides | Protein kinase G | Oxidase | Guanylate cyclase | NAD(P)H oxidase | Vasodilation | Risk factors | Rodents | Cyclic GMP | CYBB protein | Angiotensin II | Heart diseases | Hypertension | Brain natriuretic peptide | Therapeutic applications | MAP kinase | Cardiomyocytes | Pharmacology | Vasodilator-stimulated phosphoprotein | Signaling | Sodium | Protein synthesis | Protein kinase | Diabetes | Laboratory animals | Hypertrophy | Apoptosis | Index Medicus
Journal Article