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Current Pharmaceutical Design, ISSN 1381-6128, 04/2011, Volume 17, Issue 10, pp. 1002 - 1024
In neurological insults, such as cerebral ischemia and traumatic brain injury, complex molecular mechanisms involving inflammation and apoptosis are known to... 
G protein-coupled receptor | Neuroprotection | Stroke | Bioactive conformation | Traumatic brain injury | PACAP | Peptide drug design | VIP | CYCLASE-ACTIVATING POLYPEPTIDE | VASOACTIVE-INTESTINAL-PEPTIDE | BLOOD-BRAIN-BARRIER | CEREBELLAR GRANULE CELLS | HUMAN-SERUM-ALBUMIN | GLUCAGON-LIKE PEPTIDE-1 | PROTEIN-COUPLED RECEPTOR | N-TERMINAL ECTODOMAIN | PHARMACOLOGY & PHARMACY | CENTRAL-NERVOUS-SYSTEM | DIABETIC DB/DB MICE | Neuroprotective Agents - therapeutic use | Receptors, G-Protein-Coupled - metabolism | Apoptosis - drug effects | Brain Injuries - drug therapy | Humans | Astrocytes - pathology | Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide - metabolism | Drug Discovery - methods | Nerve Growth Factors - metabolism | Brain Ischemia - immunology | Brain Injuries - immunology | Neuroprotective Agents - adverse effects | Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide - physiology | Cytokines - immunology | Astrocytes - drug effects | Cell Survival - drug effects | Pituitary Adenylate Cyclase-Activating Polypeptide - adverse effects | Pituitary Adenylate Cyclase-Activating Polypeptide - physiology | Animals | Pituitary Adenylate Cyclase-Activating Polypeptide - therapeutic use | Brain Ischemia - drug therapy | Pituitary Adenylate Cyclase-Activating Polypeptide - metabolism | Brain Ischemia - pathology | Brain Injuries - pathology | Astrocytes - metabolism | Drugs | Cytokines | Astrocytes | Macromolecules | Inflammation | Drug development | Neuroprotective agents | Blood | Microglia | Pituitary adenylate cyclase-activating polypeptide | Chemical modification | Neurotransmitters | Side effects | Molecular modelling | Ischemia | Pharmacokinetics | Apoptosis
Journal Article
Journal Article
Journal Article
1985, ISBN 0881670790, Volume 19., xvii, 334
Book
Peptides, ISSN 0196-9781, 2008, Volume 29, Issue 6, pp. 919 - 932
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a 38- or 27-amino acid neuropeptide with promising therapeutic applications for the treatment of... 
Plasma metabolites | Stable analogs | PAC1 receptor agonists | Dipeptidyl peptidase IV | PACAP | CEREBELLAR GRANULE NEURONS | CYCLASE-ACTIVATING POLYPEPTIDE | VASOACTIVE-INTESTINAL-PEPTIDE | stable analogs | BIOCHEMISTRY & MOLECULAR BIOLOGY | INSULIN-SECRETION | ENDOGENOUS PACAP | plasma metabolites | GLUCAGON-LIKE PEPTIDE-1 | STRUCTURAL REQUIREMENTS | IN-VIVO | PC-12 CELLS | dipeptidyl peptidase IV | PHARMACOLOGY & PHARMACY | ADENYLATE-CYCLASE | Cricetulus | Humans | Pituitary Adenylate Cyclase-Activating Polypeptide - chemical synthesis | Molecular Sequence Data | PC12 Cells | Dose-Response Relationship, Drug | Pituitary Adenylate Cyclase-Activating Polypeptide - isolation & purification | Protein Isoforms - metabolism | Time Factors | Protein Isoforms - chemistry | Pituitary Adenylate Cyclase-Activating Polypeptide - pharmacology | Pituitary Adenylate Cyclase-Activating Polypeptide - blood | Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I - metabolism | CHO Cells | Amino Acid Sequence | Cricetinae | Cell Size - drug effects | Pituitary Adenylate Cyclase-Activating Polypeptide - chemistry | Rats | Electroporation | Animals | Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I - drug effects | Cell Differentiation - drug effects | Pituitary Adenylate Cyclase-Activating Polypeptide - metabolism | Protein Binding | Cell Proliferation - drug effects | Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I - genetics | DNA, Complementary | Protein Isoforms - genetics
Journal Article
Biochemistry, ISSN 0006-2960, 06/2011, Volume 50, Issue 25, pp. 5590 - 5600
Journal Article
Journal Article
Antioxidants & Redox Signaling, ISSN 1523-0864, 01/2017, Volume 26, Issue 3, pp. 17 - 121
Significance: Soluble guanylyl/guanylate cyclase (sGC) is the primary receptor for nitric oxide (NO) and is central to the physiology of blood pressure... 
Forum Review Articles | H-NOX domain | coiled-coil domain | stimulator compound | hypertension | molecular evolution | guanylate cyclase | MANDUCA-SEXTA | LIGAND-BINDING | PULMONARY-HYPERTENSION | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | coiled -coil domain | MAMMALIAN ADENYLYL-CYCLASE | H-NOX FAMILY | CARBON-MONOXIDE | ENDOCRINOLOGY & METABOLISM | HEME-PROTEIN SENSORS | SIGNALING HELIX | RESONANCE RAMAN | Protein Subunits | Gene Expression | Heme - metabolism | Signal Transduction | Soluble Guanylyl Cyclase - antagonists & inhibitors | Soluble Guanylyl Cyclase - metabolism | Humans | Molecular Conformation | Models, Molecular | Guanylate Cyclase - metabolism | Guanosine Triphosphate - metabolism | Soluble Guanylyl Cyclase - chemistry | Structure-Activity Relationship | Drug Discovery | Animals | Soluble Guanylyl Cyclase - genetics | Heme - chemistry | Protein Binding | Guanosine Triphosphate - chemistry | Protein Interaction Domains and Motifs | Enzyme Activation | Nitric Oxide - metabolism | Guanylate Cyclase - chemistry | Energy transformation | Control | Nitric oxide | Analysis | Blood pressure | Chemical properties | Guanylate cyclase | Drugs | Memory | Homology | Activation | Catalytic activity | Small angle X ray scattering | Proteins | Signal transduction | X-ray scattering | Resonance scattering | Elongated structure | Heme | Catalysis | Crystal structure | Binding | Wound healing | Crosslinking | Pharmacology | Electron microscopy | Chemical compounds | Domains | Molecular evolution | Organic chemistry | Molecular modelling | Transduction | X ray scattering | Drug discovery | Energy transfer | Forum Review
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 12/2013, Volume 288, Issue 49, pp. 35307 - 35320
Journal Article
Pharmacology and Therapeutics, ISSN 0163-7258, 2009, Volume 121, Issue 3, pp. 294 - 316
Vasoactive intestinal peptide (VIP) and the pituitary adenylate cyclase activating polypeptides (PACAPs) share 68% identity at the amino acid level and belong... 
Receptor variants | G-protein coupled receptor | PACAP | VIP | PACR | VPACR | CYCLASE-ACTIVATING POLYPEPTIDE | HUMAN NEUROBLASTOMA-CELLS | VASOACTIVE-INTESTINAL-PEPTIDE | WATERY-DIARRHEA SYNDROME | DIFFERENTIAL SIGNAL-TRANSDUCTION | GILA MONSTER VENOM | STIMULATES ADENYLATE-CYCLASE | PROTEIN-COUPLED-RECEPTORS | PHARMACOLOGY & PHARMACY | CENTRAL-NERVOUS-SYSTEM | PHOSPHOLIPASE-C ACTIVATION | Amino Acid Sequence | Signal Transduction | Receptors, Vasoactive Intestinal Peptide, Type II - agonists | Receptors, Vasoactive Intestinal Polypeptide, Type I - physiology | Mice, Transgenic | Pituitary Adenylate Cyclase-Activating Polypeptide - physiology | Organ Specificity | Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I - physiology | Phospholipase D - metabolism | Receptors, Vasoactive Intestinal Peptide, Type II - genetics | Receptors, Vasoactive Intestinal Polypeptide, Type I - genetics | Receptors, Vasoactive Intestinal Peptide, Type II - physiology | Animals | Vasoactive Intestinal Peptide - physiology | Receptors, Vasoactive Intestinal Polypeptide, Type I - agonists | Base Sequence | Ligands | Mice | Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I - agonists | Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I - genetics | Cyclic AMP - metabolism | Hypertension | Coenzymes | Inositol | Somatotropin releasing hormone | Peptides | Guanosine | Leukemia | Inositol phosphates | Amino acids | Lipids | Cyclic adenylic acid | Hormones | Muscle proteins | Embryonic stem cells | Hamsters | Adenylate cyclase | Synthesis | Analysis | Physiological aspects | Phospholipases | Nuclear magnetic resonance | Adenylic acid | Concentration camps | Adenosine triphosphate
Journal Article