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Journal of Cellular and Molecular Medicine, ISSN 1582-1838, 09/2012, Volume 16, Issue 9, pp. 2208 - 2218
Cells derived from the amniotic foetal membrane of human term placenta have drawn particular attention mainly for their plasticity and immunological... 
placenta | mesenchymal stem/stromal cells | cancer cell lines | cell proliferation | amniotic membrane | amnion‐derived cells | Cell proliferation | Amniotic membrane | Placenta | Amnion-derived cells | Cancer cell lines | Mesenchymal stem/stromal cells | MEDICINE, RESEARCH & EXPERIMENTAL | amnion-derived cells | TUMOR-CELLS | MESENCHYMAL STEM-CELLS | CELL BIOLOGY | TERM PLACENTA | THERAPY | mesenchymal stem | stromal cells | IN-VIVO | GROWTH | BONE | DIFFERENTIATION | T-CELLS | Cyclin D2 - genetics | Oncogene Proteins - genetics | Up-Regulation | Cyclin D2 - metabolism | Coculture Techniques | Cyclin-Dependent Kinase 4 - genetics | Humans | G1 Phase - drug effects | RNA, Messenger - metabolism | Cyclin E - genetics | Amnion - metabolism | Cyclin-Dependent Kinase Inhibitor p21 - genetics | Cyclin-Dependent Kinase Inhibitor p15 - genetics | U937 Cells | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Cyclin-Dependent Kinase 2 - metabolism | Amnion - cytology | Down-Regulation | RNA, Messenger - genetics | Cyclin-Dependent Kinase 6 - genetics | Oncogene Proteins - metabolism | Cyclin-Dependent Kinase 2 - genetics | Cyclin-Dependent Kinase 6 - metabolism | Cyclin-Dependent Kinase 4 - metabolism | Cell Division - drug effects | Cyclin H - metabolism | Cell Cycle Checkpoints - drug effects | Cell Line, Tumor | Cell Proliferation - drug effects | Cyclin E - metabolism | Cyclin-Dependent Kinase Inhibitor p15 - metabolism | HeLa Cells | Cyclin H - genetics | RNA | Dendritic cells | Oncology, Experimental | Cell cycle | Stem cells | Research | Gene expression | Cancer | Biotechnology | Mesenchyme | Leukemia | Metastasis | Kinases | Experiments | Cyclin-dependent kinase 4 | Cyclin D2 | Cell growth | Immunology | Lymphocytes | Penicillin | Fibroblasts | G1 phase | Therapeutic applications | Tumor cell lines | Cyclins | Cyclin-dependent kinase 2 | Studies | Monocytes | Biopsy | S phase | Cell lines | Lymphomas | Apoptosis | Tumors | Original
Journal Article
Journal Article
British Journal of Cancer, ISSN 0007-0920, 10/2017, Volume 117, Issue 8, pp. 1154 - 1163
Background: Overexpression of epidermal growth factor receptor (EGFR) occurs in approximately 90% of head and neck squamous cell carcinoma (HNSCC), and is... 
Erk1/2 | MAMMALIAN TARGET | ACTIVATION | head and neck cancer | cell proliferation | PHOSPHORYLATION | apoptosis | PHASE-II | Akt | SKLB188 | P53 | LUNG-CANCER | ONCOLOGY | RESISTANCE | EGF receptor | THERAPIES | MUTATIONS | PROGRESSION | Cyclin D1 - drug effects | Immunohistochemistry | Cyclin D1 - metabolism | Up-Regulation | Cyclin-Dependent Kinase Inhibitor p21 - drug effects | Apoptosis - drug effects | Carcinoma, Squamous Cell - metabolism | Humans | cdc25 Phosphatases - drug effects | Head and Neck Neoplasms - metabolism | Cyclin-Dependent Kinase 4 - drug effects | Cyclin-Dependent Kinase Inhibitor p27 - metabolism | Squamous Cell Carcinoma of Head and Neck | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | cdc25 Phosphatases - metabolism | In Situ Nick-End Labeling | Cyclin-Dependent Kinase 2 - metabolism | ErbB Receptors - antagonists & inhibitors | ErbB Receptors - metabolism | Signal Transduction | Purines - pharmacology | Cyclin A - metabolism | Down-Regulation | Cyclin-Dependent Kinase 4 - metabolism | Blotting, Western | Xenograft Model Antitumor Assays | Animals | Mice, Nude | Cyclin-Dependent Kinase 2 - drug effects | Cell Proliferation - drug effects | Cyclin A - drug effects | Mice | Molecular Docking Simulation | G1 Phase Cell Cycle Checkpoints - drug effects | In Vitro Techniques | Cyclin-Dependent Kinase Inhibitor p27 - drug effects | Cell proliferation | Drugs | Phosphorylation | Clinical trials | AKT protein | Hydrophobicity | Kinases | Hydrogen bonding | Western blotting | Molecular docking | Anticancer properties | Cyclin-dependent kinase | Cell growth | Epidermal growth factor | Hydrogen bonds | Xenografts | Cell cycle | Chemical bonds | Libraries | Inhibition | Recombinant | Medical research | Squamous cell carcinoma | Head | Approximation | Epidermal growth factor receptors | Cyclin-dependent kinases | Extracellular signal-regulated kinase | Caspase | Survivin | Cyclins | Mcl-1 protein | Cyclin-dependent kinase 2 | Signaling | Cyclin-dependent kinase inhibitor p21 | Inhibitors | Cyclin-dependent kinase inhibitor p27 | Head and neck cancer | Scaffolds | Tumors | Apoptosis | Translational Therapeutics | Erk1
Journal Article
Cancer Discovery, ISSN 2159-8274, 04/2016, Volume 6, Issue 4, pp. 353 - 367
Journal Article
International Journal of Molecular Sciences, ISSN 1422-0067, 2012, Volume 13, Issue 1, pp. 828 - 839
Objective: To investigate the effect of Lewis y overexpression on the expression of proliferation-related factors in ovarian cancer cells. Methods: mRNA levels... 
Cyclin | Cyclin-dependent kinase inhibitors | Lewis(y) antigen | Cyclin-dependent kinases | Cell cycle | PROTEIN-KINASE PATHWAY | ACTIVATION | cyclin | STIMULATION | CANCER CELLS | cell cycle | BIOCHEMISTRY & MOLECULAR BIOLOGY | G1 CYCLIN | CHEMISTRY, MULTIDISCIPLINARY | BETA | cyclin-dependent kinases | GROWTH | S-PHASE | cyclin-dependent kinase inhibitors | INHIBITOR | EXPRESSION | Cyclin D1 - metabolism | Cyclin-Dependent Kinase 4 - genetics | Humans | Ovarian Neoplasms - pathology | Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors | Cyclin A - genetics | Extracellular Signal-Regulated MAP Kinases - metabolism | RNA, Messenger - metabolism | Cyclin E - genetics | Cyclin-Dependent Kinase Inhibitor p27 - metabolism | Cyclin-Dependent Kinase Inhibitor p21 - genetics | Antibodies - immunology | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Female | Flavonoids - pharmacology | Ovarian Neoplasms - metabolism | Chromones - pharmacology | Proto-Oncogene Proteins c-akt - metabolism | Lewis Blood-Group System - immunology | Cyclin-Dependent Kinase 2 - metabolism | Fucosyltransferases - genetics | Cyclin A - metabolism | Cyclin-Dependent Kinase 6 - genetics | Cyclin-Dependent Kinase 2 - genetics | Cyclin-Dependent Kinase Inhibitor p16 - genetics | Morpholines - pharmacology | Cyclin-Dependent Kinase 6 - metabolism | Cyclin-Dependent Kinase 4 - metabolism | Fucosyltransferases - metabolism | Cyclin D1 - genetics | Signal Transduction - drug effects | Cell Line, Tumor | Cyclin-Dependent Kinase Inhibitor p16 - metabolism | Lewis Blood-Group System - metabolism | Lewis Blood-Group System - genetics | Cyclin E - metabolism | Cyclin-Dependent Kinase Inhibitor p27 - genetics | Cell proliferation | Galactoside 2- alpha -L-fucosyltransferase | Antibodies | Extracellular signal-regulated kinase | AKT protein | MAP kinase | mRNA | Gene expression | Cyclin-dependent kinase 4 | Western blotting | 1-Phosphatidylinositol 3-kinase | Cyclin-dependent kinase | Polymerase chain reaction | Signal transduction | Transfection | Cyclin A | Cyclin E | cyclin D1
Journal Article
Nature Communications, ISSN 2041-1723, 04/2015, Volume 6, Issue 1, p. 6769
CDK1 is the only essential cell cycle CDK in human cells and is required for successful completion of M-phase. It is the founding member of the CDK family and... 
ACTIVATION | COMPLEX | SPECIFICITY | ANAPHASE-PROMOTING COMPLEX/CYCLOSOME | PHOSPHORYLATION | CRYSTAL-STRUCTURE | SUBSTRATE | MULTIDISCIPLINARY SCIENCES | INHIBITORS | DEPENDENT KINASES | INSIGHTS | CDC2 Protein Kinase | Humans | Substrate Specificity | Crystallography, X-Ray | Cyclin A - genetics | Cell Cycle Proteins - chemistry | Protein Kinase Inhibitors - chemistry | Cyclin B - genetics | Peptides - chemical synthesis | Cattle | Cell Cycle Proteins - genetics | Conserved Sequence | Carrier Proteins - chemistry | Cyclin-Dependent Kinases - antagonists & inhibitors | Protein Stability | Cyclin-Dependent Kinases - genetics | Binding, Competitive | Protein Structure, Tertiary | Gene Expression | Cyclin-Dependent Kinases - chemistry | Peptides - chemistry | Protein Structure, Secondary | CDC2-CDC28 Kinases - chemistry | Cyclin-Dependent Kinase 2 - genetics | Models, Molecular | Cyclin-Dependent Kinase 2 - chemistry | Recombinant Fusion Proteins - chemistry | Carrier Proteins - genetics | Animals | Protein Binding | Recombinant Fusion Proteins - genetics | Cyclin B - chemistry | Kinetics | Adenosine Triphosphate - chemistry | CDC2-CDC28 Kinases - genetics | Cyclin A - chemistry | Cyclin-dependent kinase | Cyclin-dependent kinase 2 | Eukaryotes | Cyclin B | Cyclin A | Cell cycle | Dephosphorylation | Thermal stability | Substrates | Nature conservation | Crystal structure | Cancer
Journal Article
PLoS ONE, ISSN 1932-6203, 2010, Volume 5, Issue 11, p. e14082
Background: Epithelial cell transforming sequence 2 (ECT2) is a guanine nucleotide exchange factor for Rho family GTPase, which has been implicated in the... 
CYTOKINESIS REGULATOR ECT2 | OVEREXPRESSION | G2/M PHASE | LYMPH-NODE METASTASIS | MULTIDISCIPLINARY SCIENCES | RHO-GTPASES | G PHASE | CARCINOMA | ABERRANT EXPRESSION | PROGRESSION | CYCLE | Immunohistochemistry | Cyclin D1 - metabolism | Cell Proliferation | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - metabolism | Carcinoma, Squamous Cell - pathology | Cyclin-Dependent Kinase 4 - genetics | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Male | Mouth Neoplasms - metabolism | Cyclin E - genetics | Cyclin-Dependent Kinase Inhibitor p21 - genetics | RNA Interference | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Female | Mouth Neoplasms - genetics | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - genetics | Cyclin-Dependent Kinase 4 - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | G1 Phase | Cell Cycle | Cyclin D1 - genetics | Cell Line, Tumor | Mouth Neoplasms - pathology | Aged | Cyclin E - metabolism | Neoplasm Staging | DNA polymerases | Squamous cell carcinoma | Research | Comparative analysis | Mouth cancer | Cell proliferation | Flow cytometry | RNA-directed DNA polymerase | Oral cancer | Epithelial cells | Metastasis | Cyclin D1 | Kinases | Autophagy | Guanine | Cyclin-dependent kinase 4 | Maxillofacial surgery | Proteins | Cyclin-dependent kinase | Signal transduction | Rodents | Surgery | Cell cycle | Cyclin E | Cyclin-dependent kinase inhibitors | Guanine nucleotide exchange factor | Localization | Kip protein | G1 phase | Evaluation | Oral squamous cell carcinoma | Dentistry | Gene expression | Polymerase chain reaction | Medicine | Cytometry | Cyclin-dependent kinase inhibitor p21 | Cell lines | Cyclin-dependent kinase inhibitor p27 | Protein expression | Molecular biology | Cancer | Guanosinetriphosphatase | Apoptosis
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 04/2017, Volume 486, Issue 2, pp. 385 - 390
TEA domain transcription factor 4 (TEAD4), which has critical functions in the process of embryonic development, is expressed in various cancers. However, the... 
TEA domain transcription factor 4 | Human oral squamous cell carcinoma | Yes-associated protein (YAP) | TARGET | BIOMARKER | BIOCHEMISTRY & MOLECULAR BIOLOGY | HIPPO PATHWAY | YAP | FAMILY | BIOPHYSICS | DNA | PROGNOSTIC MARKER | EXPRESSION | RNA, Small Interfering - genetics | Cell Proliferation | Carcinoma, Squamous Cell - pathology | Humans | Middle Aged | Male | Cyclin E - genetics | Cyclin-Dependent Kinase Inhibitor p27 - metabolism | Cell Nucleus - metabolism | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Muscle Proteins - antagonists & inhibitors | Transcription, Genetic | Mouth Neoplasms - genetics | Cyclin-Dependent Kinase 2 - metabolism | DNA-Binding Proteins - antagonists & inhibitors | Signal Transduction | Cyclin-Dependent Kinase 2 - genetics | Cyclin-Dependent Kinase 6 - metabolism | Cyclin-Dependent Kinase 4 - metabolism | Muscle Proteins - genetics | Cell Nucleus - genetics | Cyclin D1 - genetics | Mouth Neoplasms - surgery | Cell Line, Tumor | RNA, Small Interfering - metabolism | Cyclin D1 - metabolism | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - metabolism | Cyclin-Dependent Kinase 4 - genetics | Gene Expression Regulation, Neoplastic | Carcinoma, Squamous Cell - surgery | Mouth Neoplasms - metabolism | Phosphoproteins - metabolism | DNA-Binding Proteins - metabolism | Cyclin-Dependent Kinase Inhibitor p21 - genetics | Muscle Proteins - metabolism | G1 Phase Cell Cycle Checkpoints | Female | Cyclin-Dependent Kinase 6 - genetics | Transcription Factors - antagonists & inhibitors | Phosphoproteins - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Transcription Factors - metabolism | Adaptor Proteins, Signal Transducing - genetics | Mouth Neoplasms - pathology | Aged | Cyclin E - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Cyclin-Dependent Kinase Inhibitor p27 - genetics | Immunohistochemistry | Medical colleges | Embryonic development | Squamous cell carcinoma | Growth | Analysis | DNA polymerases | Genetic transcription | Health aspects | Development and progression | TRANSCRIPTION FACTORS | CHAIN REACTIONS | BIOLOGICAL MARKERS | CELL PROLIFERATION | CELL CYCLE | INTERACTIONS | 60 APPLIED LIFE SCIENCES | PLANT GROWTH
Journal Article