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1. Purmorphamine activates the Hedgehog pathway by targeting Smoothened
by Sinha, S and Chen, JK
NATURE CHEMICAL BIOLOGY, ISSN 1552-4450, 01/2006, Volume 2, Issue 1, pp. 29 - 30
Hedgehog (Hh) signaling is an important regulator of embryonic patterning, tissue regeneration, stem cell renewal and cancer growth. A purine derivative named... 
INHIBITION | SMALL-MOLECULE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CYCLOPAMINE | OSTEOGENESIS
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2. Full Text New Spiro‐Lactam C‐nor‐D‐homo Steroids
by Roumana, Aggeliki and Yektaoğlu, Aybike and Pliatsika, Dimanthi and Bantzi, Marina and Nikolaropoulos, Sotiris S and Giannis, Athanassios and Fousteris, Manolis A
European Journal of Organic Chemistry, ISSN 1434-193X, 08/2018, Volume 2018, Issue 30, pp. 4147 - 4160
The design and diastereoselective synthesis of new C17 spiro‐lactam C‐nor‐D‐homo steroids is described. These constitute structurally simplified analogues of... 
Amination | Diastereoselectivity | Cyclopamine | Spiro‐lactam | Rearrangement | Spiro-lactam | TERATOGENIC COMPOUNDS | ASYMMETRIC-SYNTHESIS | CHEMISTRY, ORGANIC | CELL LUNG | VERATRUM CALIFORNICUM DURAND | TERT-BUTANESULFINYL IMINES | POTENT | CYCLOPAMINE ANALOGS | PROSTATE-CANCER | INHIBITORS | HEDGEHOG SIGNALING PATHWAY
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3. Full Text Heteronanoparticles by self-Assembly of Doxorubicin and Cyclopamine Conjugates
by Fumagalli, Gaia and Stella, Barbara and Pastushenko, Ievgenia and Ricci, Francesca and Christodoulou, Michael S and Damia, Giovanna and Mazza, Davide and Arpicco, Silvia and Giannini, Clelia and Morosi, Lavinia and Dosio, Franco and Sotiropoulou, Panagiota A and Passarella, Daniele
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 09/2017, Volume 8, Issue 9, pp. 953 - 957
The preparation of heteronanoparticles (NPs) with doxorubicin (DOXO) and cyclopamine (CYP) conjugates is presented. Biological evaluation on A431 cell lines... 
cancer | doxorubicin | Self-assembled-nanoparticles | drug toxicity | cyclopamine | CHEMISTRY, MEDICINAL | BUILDING-BLOCKS | PODOPHYLLOTOXIN | CANCER STEM-CELLS | PACLITAXEL
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4. Full Text Hypoxia induced Sonic Hedgehog signaling regulates cancer stemness, epithelial-to-mesenchymal transition and invasion in cholangiocarcinoma
by Bhuria, Vikas and Xing, Jun and Scholta, Tim and Bui, Khac Cuong and Nguyen, Mai Ly Thi and Malek, Nisar P and Bozko, Przemyslaw and Plentz, Ruben R
Experimental Cell Research, ISSN 0014-4827, 12/2019, Volume 385, Issue 2, p. 111671
Aberrant activation of Sonic Hedgehog (SHH) pathway has been implicated in a variety of cancers including cholangiocarcinoma (CC); however, the influencing... 
Epithelial to mesenchymal transition | Hypoxia | Sonic Hedgehog pathway | Cancer stem cells | Cholangiocarcinoma | Cyclopamine
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5. Full Text Paracrine hedgehog signaling in cancer
by Theunissen, Jan-Willem and De Sauvage, Frederic J
Cancer Research, ISSN 0008-5472, 08/2009, Volume 69, Issue 15, pp. 6007 - 6010
Ligand-dependent and ligand-independent activation of the Hedgehog (Hh) signaling pathway is involved in tumorigenesis. The importance of mutations in Hh... 
STEM-CELLS | ONCOLOGY | SONIC HEDGEHOG | PATHWAY | PANCREATIC-CANCER | GROWTH | SELF-RENEWAL | CYCLOPAMINE | COMPARTMENT | MEDULLOBLASTOMA | REQUIREMENT | Neoplasms - metabolism | Hedgehog Proteins - metabolism | Animals | Signal Transduction | Humans
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6. Vismodegib and the Hedgehog Pathway Inhibitors: A Historical Perspective to Current Clinical Application
by Tang, Jennifer C and Hanke, C William and Caro, Ivor
Journal of drugs in dermatology : JDD, ISSN 1545-9616, 05/2018, Volume 17, Issue 5, pp. 506 - 508
Vismodegib (Erivedge, Genentech-Roche) is the first in class of Hedgehog pathway inhibitors approved for treatment of metastatic basal cell carcinoma (BCC), or... 
PROGENITORS | GENE | BASAL-CELL CARCINOMA | CYCLOPAMINE | MUTATIONS | HUMAN HOMOLOG | DERMATOLOGY
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7. Full Text Design of Hedgehog pathway inhibitors for cancer treatment
by Bariwal, Jitender and Kumar, Virender and Dong, Yuxiang and Mahato, Ram I
Medicinal Research Reviews, ISSN 0198-6325, 05/2019, Volume 39, Issue 3, pp. 1137 - 1204
Hedgehog (Hh) signaling is involved in the initiation and progression of various cancers and is essential for embryonic and postnatal development. This pathway... 
Smoothened | SMO | Hedgehog inhibitor | nanomedicine | cancer | GDC‐0449 | cyclopamine | structure‐activity relationship (SAR) | GDC-0449 | structure-activity relationship (SAR) | A-RING ANALOGS | CHEMISTRY, MEDICINAL | SIDE-CHAIN ANALOGS | CELL-GROWTH | POTENT SMOOTHENED ANTAGONIST | IN-VITRO | SIGNALING PATHWAY | SMALL-MOLECULE INHIBITORS | CYCLOPAMINE ANALOGS | BIOLOGICAL EVALUATION | PHARMACOLOGY & PHARMACY | HIGHLY POTENT | Animals | Signal Transduction | Humans | Hedgehog Proteins - metabolism | Antineoplastic Agents - therapeutic use | Structure-Activity Relationship | Hedgehog Proteins - antagonists & inhibitors | Smoothened Receptor - metabolism | Antineoplastic Agents - chemistry | Neoplasms - drug therapy | Embryonic development | Care and treatment | Cancer
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8. Full Text Synthesis of Demissidine and Solanidine
by Zhang, Zhi-Dan and Shi, Yong and Wu, Jing-Jing and Lin, Jing-Rong and Tian, Wei-Sheng
Organic Letters, ISSN 1523-7060, 06/2016, Volume 18, Issue 12, pp. 3038 - 3040
Demissidine and solanidine, two steroidal alkaloids, are synthesized in eight steps from tigogenin acetate and diosgenin acetate, respectively, which involve... 
METABOLITES | AZIDES | SCHMIDT REACTION | CARBOCATIONS | CHEMISTRY, ORGANIC | CYCLOPAMINE | SQUALAMINE | SOLANUM-TUBEROSUM | ALPHA-CHACONINE | GLYCOALKALOIDS | ALKALOIDS
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9. Full Text Cytotoxic effects induced by a combination of cydopamine and gefitinib, the selective hedgehog and epidermal growth factor receptor signaling inhibitors, in prostate cancer cells
by Mimeault, Murielle and Moore, Erik and Moniaux, Nicolas and Hénichart, Jean-Pierre and Depreux, Patrick and Lin, Ming-Fong and Batra, Surinder K
International Journal of Cancer, ISSN 0020-7136, 02/2006, Volume 118, Issue 4, pp. 1022 - 1031
Hedgehog signaling | Growth inhibition | Prostate cancer | Apoptotic death | EGFR | Cyclopamine
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10. Full Text Cilia-Associated Oxysterols Activate Smoothened
by Raleigh, David R and Sever, Navdar and Choksi, Pervinder K and Sigg, Monika Abedin and Hines, Kelly M and Thompson, Bonne M and Elnatan, Daniel and Jaishankar, Priyadarshini and Bisignano, Paola and Garcia-Gonzalo, Francesc R and Krup, Alexis Leigh and Eberl, Markus and Byrne, Eamon F.X and Siebold, Christian and Wong, Sunny Y and Renslo, Adam R and Grabe, Michael and McDonald, Jeffrey G and Xu, Libin and Beachy, Philip A and Reiter, Jeremy F
Molecular Cell, ISSN 1097-2765, 10/2018, Volume 72, Issue 2, pp. 316 - 327.e5
Primary cilia are required for Smoothened to transduce vertebrate Hedgehog signals, but how Smoothened accumulates in cilia and is activated is incompletely... 
CBP | HSD11β2 | oxysterol | Hedgehog | primary cilium | Smoothened | sterol | medulloblastoma | cilia | lipid | OXIDATION | CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | 7-DEHYDROCHOLESTEROL | TRAFFICKING | CYCLOPAMINE | PROTEINS | BINDING | LEMLI-OPITZ SYNDROME | HEDGEHOG | MODULATION | CELL BIOLOGY | Physiological aspects | Medical colleges | Lipids | Gliomas
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11. Full Text Targeting the tumour microenvironment with an enzyme-responsive drug delivery system for the efficient therapy of breast and pancreatic cancers
by Renoux, Brigitte and Raes, Florian and Legigan, Thibaut and Péraudeau, Elodie and Eddhif, Balkis and Poinot, Pauline and Tranoy-Opalinski, Isabelle and Alsarraf, Jérôme and Koniev, Oleksandr and Kolodych, Sergii and Lerondel, Stéphanie and Le Pape, Alain and Clarhaut, Jonathan and Papot, Sébastien
Chemical Science, ISSN 2041-6520, 2017, Volume 8, Issue 5, pp. 3427 - 3433
The development of novel therapeutic strategies allowing the destruction of tumour cells while sparing healthy tissues is one of the main challenges of cancer... 
CYCLOPAMINE GLUCURONIDE PRODRUG | MONOTHERAPY | INHIBITION | ENDOGENOUS SERUM-ALBUMIN | EFFICACY | DOXORUBICIN | BETA-GLUCURONIDASE | RELEASE | ANTITUMOR-ACTIVITY | CHEMISTRY, MULTIDISCIPLINARY | CHEMOTHERAPY | Chemical Sciences | Catalysis
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12. Full Text A novel type of functional epirubicin liposomes modified with DSPE-PEG2000-cyclopamine conjugate for eliminating heterogeneous breast cancer cells
by Hu, Yingjie and Zhang, Jingying and Liu, Lei and Yan, Yan and Mu, Limin and Bai, Jing and Wu, Jiashuan and Lu, Wanliang
Journal of Chinese Pharmaceutical Sciences, ISSN 1003-1057, 04/2017, Volume 26, Issue 4
Heterogeneity | Cyclopamine conjugate | Breast cancer | Epirubin | Liposomes
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13. Full Text GLI1 and CTNNB1 knockdown activates NOTCH and mTOR signalling in NB4 myeloid leukaemia cells
by Okuhashi, Yuki and Itoh, Mai and Tohda, Shuji
Anticancer Research, ISSN 0250-7005, 11/2018, Volume 38, Issue 11, pp. 6329 - 6332
Background: Hedgehog (HH), WNT, NOTCH, and mechanistic target of rapamycin (mTOR) signalling pathways are known to regulate the progression of cancer; however,... 
NOTCH | Hedgehog | siRNA | WNT | Leukaemia | STEM-CELLS | PROLIFERATION | ONCOLOGY | PATHWAY | GROWTH | leukaemia | CYCLOPAMINE | DIFFERENTIATION | SONIC-HEDGEHOG
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14. Full Text Rapid, direct activity assays for Smoothened reveal Hedgehog pathway regulation by membrane cholesterol and extracellular sodium
by Myers, Benjamin R and Neahring, Lila and Zhang, Yunxiao and Roberts, Kelsey J and Beachy, Philip A
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2017, Volume 114, Issue 52, pp. E11141 - E11150
Hedgehog signaling specifies tissue patterning and renewal, and pathway components are commonly mutated in certain malignancies. Although central to ensuring... 
Hedgehog | Smoothened | Cholesterol | Patched | CELLS | ACTIVATION | MULTIDISCIPLINARY SCIENCES | TRAFFICKING | PROTEIN-COUPLED RECEPTORS | IDENTIFICATION | PRIMARY CILIUM | cholesterol | Na+ | CYCLOPAMINE | CANCER PROGRESSION | BINDING | MODULATION | Physiological aspects | Extracellular matrix | Biological assay | Observations | Cholesterol metabolism | Methods | Hedgehog proteins | Biological Sciences | PNAS Plus
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15. Full Text Divergent Synthesis of Solanidine and 22-epi-Solanidine
by Hou, Ling-Li and Shi, Yong and Zhang, Zhi-Dan and Wu, Jing-Jing and Yang, Qing-Xiong and Tian, Wei-Sheng
The Journal of Organic Chemistry, ISSN 0022-3263, 07/2017, Volume 82, Issue 14, pp. 7463 - 7469
A divergent synthesis of solanidine and 22-epi-solanidine, two 25S natural steroidal alkaloids, from 25R-configured diosgenin acetate, is described. Initially,... 
HIGHLY ENANTIOSELECTIVE SYNTHESIS | STEROIDAL ALKALOIDS | METABOLITES | ANTICANCER | PROPARGYLAMINES | CHEMISTRY, ORGANIC | CYCLOPAMINE | DEMISSIDINE | ALPHA-CHACONINE | SOLASODINE | GLYCOALKALOIDS
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16. Full Text Fish in chips: an automated microfluidic device to study drug dynamics in vivo using zebrafish embryos
by Zheng, Chunhong and Zhou, Hongwei and Liu, Xinxing and Pang, Yuhong and Zhang, Bo and Huang, Yanyi
ISSN 1359-7345, 12/2013, Volume 5, Issue 8, pp. 981 - 984
Interference of the Hedgehog (Hh) signaling pathway by cyclopamine leads to abnormal embryonic development. We monitor this dynamical drug effect in zebrafish... 
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17. Full Text Hedgehog inhibitors in rhabdomyosarcoma: a comparison of 4 compounds and responsiveness of 4 cell lines
by Rosalie eRidzewski and Diana eRettberg and Kai eDittmann and Nicole eCuvelier and Simone eFulda and Heidi eHahn
Frontiers in Oncology, 06/2015, Volume 5
Rhabdomyosarcoma (RMS) are the most common soft tissue sarcoma in children and are divided into two major histological subgroups, i.e. embryonal (ERMS) and... 
HHA | GDC-0449 | LDE225 | Rhabdomyosarcoma | Cyclopamine
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18. Full Text Molecular pathways: The hedgehog signaling pathway in cancer
by McMillan, Ross and Matsui, William
Clinical Cancer Research, ISSN 1078-0432, 09/2012, Volume 18, Issue 18, pp. 4883 - 4888
The Hedgehog (Hh) signaling pathway regulates embryonic development and may be aberrantly activated in a wide variety of human cancers. Efforts to target... 
STEM-CELLS | INHIBITION | ONCOLOGY | TRANSCRIPTION | CYCLOPAMINE | MUTATIONS | PROTEINS | TUMOR-GROWTH | MEDULLOBLASTOMA | HUMAN HOMOLOG | PRIMARY CILIA | Neoplasms - metabolism | Receptors, G-Protein-Coupled - metabolism | Signal Transduction - drug effects | Humans | Smoothened Receptor | Translational Medical Research | Receptors, G-Protein-Coupled - antagonists & inhibitors | Hedgehog Proteins - metabolism | Neoplasms - drug therapy | Smoothened antagonists | basal cell carcinoma | Hedgehog | clinical trials
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19. Full Text Cyclopamine and jervine induce COX-2 overexpression in human erythroleukemia cells but only cyclopamine has a pro-apoptoticeffect
by Ghezali, Lamia and Leger, David Yannick and Limami, Youness and Cook-Moreau, Jeanne and Beneytout, Jean-Louis and Liagre, Bertrand
Experimental Cell Research, ISSN 0014-4827, 04/2013, Volume 319, Issue 7, pp. 1043 - 1053
Erythroleukemia is generally associated with a very poor response and survival to current available therapeutic agents. Cyclooxygenase-2 (COX-2) has been... 
Erythroleukemia | Cyclooxygenase-2 | Jervine | Cyclopamine | Apoptosis | Acute leukemia | COX-2 inhibitors | Enzymes | Progesterone | Cellular biology | Leukemia | Steroids
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20. Targeting the tumour microenvironment with an enzyme-responsive drug delivery system for the efficient therapy of breast and pancreatic cancers
by Renoux, Brigitte and Raes, Florian and Legigan, Thibaut and Peraudeau, Elodie and Eddhif, Balkis and Poinot, Pauline and Tranoy-Opalinski, Isabelle and Alsarraf, Jerome and Koniev, Oleksandr and Kolodych, Sergii and Lerondel, Stephanie and Le Pape, Alain and Clarhaut, Jonathan and Papot, Sebastien
Chemical Science, ISSN 2041-6520, 05/2017, Volume 8, Issue 5, pp. 3427 - 3433
The development of novel therapeutic strategies allowing the destruction of tumour cells while sparing healthy tissues is one of the main challenges of cancer... 
Covalence | Drug delivery systems | Side effects | Effectiveness | Strategy | Mice | Tumors | Cancer
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