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PLoS ONE, ISSN 1932-6203, 07/2015, Volume 10, Issue 7, pp. e0132992 - e0132992
Human pluripotent stem cell-derived hepatocytes have the potential to provide in vitro model systems for drug discovery and hepatotoxicity testing. However,... 
DNA METHYLATION | HUMAN LUNG | QUANTIFICATION | MULTIDISCIPLINARY SCIENCES | PLACENTA | HUMAN LIVER | HUMAN CYP1A1 | MECHANISMS | CYP2E1 | DIFFERENTIATION | EXPRESSION | Chromatin - metabolism | Cytochrome P-450 CYP1A1 - genetics | Cytochrome P-450 CYP1B1 - genetics | Epigenesis, Genetic | Human Embryonic Stem Cells - cytology | Humans | Cytochrome P-450 CYP1B1 - metabolism | Cytochrome P-450 CYP2E1 - genetics | Cytochrome P-450 CYP2E1 - metabolism | Hepatocytes - metabolism | DNA Methylation | Hepatocytes - cytology | Cytochrome P-450 CYP1A2 - genetics | Transcription, Genetic | Cell Differentiation | Chromatin - ultrastructure | Cell Line | Cytochrome P-450 CYP2D6 - genetics | Human Embryonic Stem Cells - metabolism | DNA Modification Methylases - metabolism | Histone Deacetylases - genetics | Signal Transduction | Histone Deacetylases - metabolism | Cytochrome P-450 CYP1A1 - metabolism | Organ Specificity | Cytochrome P-450 CYP1A2 - metabolism | DNA Modification Methylases - genetics | Histones - genetics | CpG Islands | Cytochrome P-450 CYP2D6 - metabolism | Protein Processing, Post-Translational | Histones - metabolism | Primary Cell Culture | Epigenetic inheritance | Methylation | Embryonic stem cells | Genes | Cytochrome P-450 | Cytochrome | Chromatin | Transcription | Toxicity | Gene regulation | Liver | Science | Demethylation | Rodents | Toxicity testing | DNA methylation | Inhibition | Hepatotoxicity | CYP2D6 protein | Deoxyribonucleic acid--DNA | CpG islands | Enzymes | Cytochrome P450 | CYP1A2 protein | Gene expression | Hepatocytes | Stem cells | Pluripotency | Combinatorial analysis | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
Biochemical Journal, ISSN 0264-6021, 01/2010, Volume 425, Issue 1, pp. 137 - 148
CsA (cyclosporin A) is a hydrophobic undecapeptide that inhibits CyPs (cyclophilins), a family of PPIases (peptidylprolyl cis-trans isomerases). In some... 
Ischaemia | Cyclosporin A (CsA) | Hippocampal neuron | Glutamate toxicity | Cyclophilin (CyP) | Necrosis | glutamate toxicity | PERMEABILITY TRANSITION PORE | OXIDATIVE STRESS | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | REPERFUSION INJURY | NEURONAL CELL-DEATH | INORGANIC-PHOSPHATE | HIPPOCAMPAL-NEURONS | cyclosporin A (CsA) | hippocampal neuron | ischaemia | cyclophilin (CyP) | necrosis | ISCHEMIA-REPERFUSION | CASPASE ACTIVATION | GLUTAMATE EXCITOTOXICITY | Oxygen - pharmacology | Cyclosporine - pharmacology | Mitochondria, Liver - metabolism | Neurons - cytology | Cyclophilins - metabolism | Membrane Potential, Mitochondrial - drug effects | Oxygen - metabolism | Mitochondria, Liver - physiology | Cyclophilins - antagonists & inhibitors | Enzyme Inhibitors - pharmacokinetics | Enzyme Inhibitors - chemistry | Cytoprotection - drug effects | Cyclosporine - pharmacokinetics | Cyclophilin A - genetics | Molecular Structure | Neurons - metabolism | Neurons - drug effects | Animals, Newborn | Cyclophilin A - metabolism | Cell Survival - drug effects | Glutamic Acid - pharmacology | Cells, Cultured | Enzyme Inhibitors - pharmacology | Rats | Cyclophilins - genetics | Glucose - pharmacology | Hippocampus - cytology | Rats, Sprague-Dawley | Animals | Cyclosporine - chemistry | Cell Line, Tumor | Glucose - metabolism | Protein Binding | Calcineurin - metabolism | Index Medicus | ESI–MS, electrospray ionization MS | NBA, Neurobasal A | THF, tetrahydrofuran | PyBOP, benzotriazol-1-yl-tris-pyrrolidinophosphonium hexafluorophosphate | CsA, cyclosporin A | DCM, dichloromethane | L-NAME, NG-nitro-L-arginine-methyl ester | DMEM, Dulbecco's minimal essential medium | R, ischaemia | NBQX, 2,3-dihydro-6-nitro-7-sulfamoylbenzoquinoxaline | HBSS, Hanks balanced salt solution | OGD, oxygen and glucose deprivation | PPIase, peptidylprolyl cis–trans isomerase | DMF, dimethylformamide | TMRE, tetramethylrhodamine ethyl ester | reperfusion | TPP+, triphenylphosphonium | PT, permeability transition | CyP, cyclophilin | FBS, fetal bovine serum | Fmoc, fluoren-9-ylmethoxycarbonyl | SMBz-CsA, [sarcosine-3(4-methylbenzoate)]-CsA | LDA, lithium diisopropylamide | mtCsA, mitochondrially targeted CsA | NMDA, N-methyl-D-aspartate | CyP-D+, cell line overexpressing CyP-D
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2016, Volume 11, Issue 3, pp. e0150955 - e0150955
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2016, Volume 11, Issue 5, pp. e0154629 - e0154629
Journal Article
Clinical Pharmacology & Therapeutics, ISSN 0009-9236, 07/2018, Volume 104, Issue 1, pp. 130 - 138
CYP2B6*6 and CYP2B6*18 are the most clinically important variants causing reduced CYP2B6 protein expression and activity. However, these variants do not... 
SNP | polymorphism | metabolism | CYP | bupropion | pharmacogenetics | efavirenz
Journal Article
Biochemical Journal, ISSN 0264-6021, 10/2004, Volume 383, Issue 1, pp. 101 - 109
Cyclophilin-D is a peptidylprolyl cis-trans isomerase of the mitochondrial matrix. It is involved in mitochondrial permeability transition, in which the... 
Cyclophilin-D | Mitochondria | Permeability transition | Apoptosis | Necrosis | OXIDATIVE STRESS | permeability transition | mitochondria | BIOCHEMISTRY & MOLECULAR BIOLOGY | apoptosis | INORGANIC-PHOSPHATE | RAT-LIVER MITOCHONDRIA | CELL-DEATH | cyclophilin-D | CA-2+-DEPENDENT PORE | necrosis | NITRIC-OXIDE | CYCLOSPORINE-A BINDING | CYTOCHROME-C RELEASE | HEART-MITOCHONDRIA | ADENINE-NUCLEOTIDE TRANSLOCASE | Amino Acid Sequence | Cell Line | Cyclosporine - pharmacology | Molecular Sequence Data | Rats | Necrosis - metabolism | Onium Compounds - metabolism | Ion Channels - physiology | Permeability | Recombinant Proteins - biosynthesis | Mitochondrial ADP, ATP Translocases - metabolism | Organophosphorus Compounds - metabolism | Organometallic Compounds | Mitochondrial Membrane Transport Proteins | Cyclophilins - biosynthesis | Animals | Caspases - metabolism | Cyclophilins - physiology | Apoptosis - physiology | Mitochondria - physiology | Fluorescent Dyes | Intracellular Membranes - metabolism | Index Medicus | PT, permeability transition | CyP-D(+) cells, stable cell line overexpressing CyP-D | GST, glutathione S-transferase | CyP, cyclophilin | ANT, adenine nucleotide translocase | CSA, cyclosporin A | AFC, 7-amino-4-trifluoromethylcoumarin | pCyP-D, precursor CyP-D | TPP+, tetraphenylphosphonium ion | ΔψM, mitochondrial inner-membrane potential | CCCP, carbonyl cyanide m-chlorophenylhydrazone | PPIase, peptidylprolyl cis–trans isomerase | TMRE, tetramethylrhodamine ethylester | VDAC, voltage-dependent anion channel | H95Q etc., His95→Gln substitution etc | mCyP-D, mature CyP-D
Journal Article
Yakugaku Zasshi, ISSN 0031-6903, 2017, Volume 137, Issue 3, pp. 249 - 255
Journal Article
Biological and Pharmaceutical Bulletin, ISSN 0918-6158, 2019, Volume 42, Issue 4, pp. 623 - 630
The metabolism of butyrylfentanyl, a new designer drug, was investigated using fresh human hepatocytes isolated from a liver-humanized mouse model. In the... 
Journal Article
09/2012
Purpose: Screening scale studies were performed with eight cultures for their ability to metabolize phenobarbital, an antiepileptic, sedative, hypnotic and... 
Fenofibrate | Phenobarbital | Inhibition studies | CYP 2C9 | Rhizopus stolonifer | Microbial metabolism
Web Resource
Research Paper - Effect of sodium sulfadimethylpyrimidine on multiple forms of cytochrome P450 in chicken, 12/2005
OBJECTIVE: To study the effect of sodium sulfadimethylpyrimidine (SDMP) on different forms of CYP 450 enzymes induced by phenobarbital (CYP 2B1, 2B2 and 3A),... 
sodium | mixed function oxidase | Aniline hydroxylase | aminopyrine N -demethylase | CYP 450 | sulfadimethylpyrimidine
Journal
Free Radical Biology and Medicine, ISSN 0891-5849, 03/2016, Volume 92, pp. 100 - 109
Familial Cerebral Cavernous Malformation type 1 (CCM1) is an autosomal dominant disease caused by mutations in the Krev Interaction Trapped 1 gene, and... 
Disease severity | Oxidative stress | Free radicals | Cerebral Cavernous Malformation (CCM) | Familial Cerebral Cavernous Malformation type 1 | Vascular brain lesions | Reactive oxygen species (ROS) | Matrix metalloproteinase (MMP) | Genetic markers set association study | Intracerebral hemorrhage | KRIT1/CCM1 | Inter-individual variability in disease susceptibility and outcome | Cytochrome P450 (CYP) | Cerebrovascular disease | EET epoxyeicosatrienoic acids | 1,25-dihydroxyvitamin D3 | D | 24-OHC 24(S)-hydroxycholesterol | SNP single nucleotide polymorphism | 25-hydroxyvitamin D3 | AA arachidonic acid | ICH intracerebral hemorrhage | Abbreviations CCM Cerebral Cavernous Malformation | LT leukotrienes | CYP cytochrome P450 | ROS reactive oxygen species | ECM extracellular matrix | 27-OHC 27-hydroxycholesterol | BBB blood-brain barrier | PG prostaglandins | 1,25-OH | NVU neurovascular unit | MMP matrix metalloproteinase | 25-OH-D | CHM common hispanic mutation | VITAMIN-D | SIGNALING PATHWAYS | REDUCES OXIDATIVE STRESS | CEREBROVASCULAR-DISEASE | WHITE-MATTER LESIONS | ENDOCRINOLOGY & METABOLISM | MEDIATED REGULATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | BLOOD-BRAIN-BARRIER | CHOLESTEROL 24-HYDROXYLASE | CORONARY-ARTERY-DISEASE | Brain - diagnostic imaging | Matrix Metalloproteinases - genetics | KRIT1 Protein | Microtubule-Associated Proteins - genetics | Humans | Middle Aged | Male | Hemangioma, Cavernous, Central Nervous System - genetics | Brain - metabolism | Adult | Female | Multigene Family - genetics | Severity of Illness Index | Hemangioma, Cavernous, Central Nervous System - diagnostic imaging | Oxidative Stress - genetics | Genotype | Proto-Oncogene Proteins - genetics | Magnetic Resonance Imaging | Phenotype | Hemangioma, Cavernous, Central Nervous System - pathology | Brain - pathology | Cytochrome P-450 Enzyme System - genetics | Heterozygote | Aged | Polymorphism, Single Nucleotide | Mutation | Brain | Genetic markers | Analysis | Pharmacy | Cytochrome P-450 | Genetic research | Drugstores | Brain damage | Epidemiology | Index Medicus | ECM, extracellular matrix | 27-OHC, 27-hydroxycholesterol | 25-OH-D3, 25-hydroxyvitamin D3 | CHM, common hispanic mutation | NVU, neurovascular unit | ICH, intracerebral hemorrhage | PG, prostaglandins | CCM, Cerebral Cavernous Malformation | KRIT1 | ROS, reactive oxygen species | CYP, cytochrome P450 | EET, epoxyeicosatrienoic acids | LT, leukotrienes | Original Contribution | BBB, blood–brain barrier | SNP, single nucleotide polymorphism | AA, arachidonic acid | 24-OHC, 24(S)-hydroxycholesterol | 1,25-OH2-D3, 1,25-dihydroxyvitamin D3 | CCM1 | MMP, matrix metalloproteinase
Journal Article
Journal of Atherosclerosis and Thrombosis, ISSN 1340-3478, 2016
Aim: To better understand the relationship between the interactions among rs17110453, rs751141, and rs9333025 variants and plasma levels of cytochrome P450... 
CYP metabolites | CYP genes | Cytochrome P450 | Ischemia Stroke | Polymorphism
Journal Article
Biological and Pharmaceutical Bulletin, ISSN 0918-6158, 2017, Volume 40, Issue 10, pp. 1654 - 1660
OTC drugs have an important role in self-medication. However, the pharmacokinetic properties of some OTC drugs have not been fully investigated and reports... 
Journal Article