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Cancer Chemotherapy and Pharmacology, ISSN 0344-5704, 7/2016, Volume 78, Issue 1, pp. 41 - 49
The Hedgehog pathway inhibitor vismodegib exhibits pH-dependent solubility, and in vitro studies have shown that vismodegib is a substrate of P-glycoprotein... 
Medicine & Public Health | CYP inhibitors | Clinical pharmacology | Oncology | Cancer Research | Pharmacology/Toxicology | Clinical drug–drug interaction | Pharmacokinetic | Proton-pump inhibitor | P-glycoprotein inhibitor | SINGLE | HUMAN PLASMA | ORAL ABSORPTION | MASS-SPECTROMETRY | GDC-0449 | ONCOLOGY | Clinical drug-drug interaction | PHARMACOLOGY & PHARMACY | HEALTHY-VOLUNTEERS | HEDGEHOG SIGNALING PATHWAY | SOLID-PHASE EXTRACTION | Fluconazole - pharmacology | Proton Pump Inhibitors - pharmacology | Cytochrome P-450 CYP3A Inhibitors - administration & dosage | Pyridines - administration & dosage | Cytochrome P-450 CYP3A Inhibitors - pharmacology | Area Under Curve | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Fluconazole - administration & dosage | Solubility | Pyridines - pharmacokinetics | Anilides - pharmacokinetics | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | Itraconazole - pharmacology | Cytochrome P-450 CYP2C9 Inhibitors - administration & dosage | Cytochrome P-450 CYP2C9 Inhibitors - pharmacology | Drug Interactions | Anilides - administration & dosage | Proton Pump Inhibitors - administration & dosage | Rabeprazole - pharmacology | Female | Itraconazole - administration & dosage | Hydrogen-Ion Concentration | Rabeprazole - administration & dosage | Drug interactions | Cytochrome P-450 | Original
Journal Article
Journal Article
Expert Opinion on Drug Metabolism & Toxicology, ISSN 1742-5255, 05/2019, Volume 15, Issue 5, pp. 417 - 427
Introduction: Drugs used in HIV treatment; all protease inhibitors, some non-nucleoside reverse transcriptase inhibitors, and pharmacoenhancers ritonavir and... 
drug-drug interactions | nanoparticles | CYP inhibitors | HIV | pharmacodynamics | Antiretroviral therapy | drug–drug interactions | EFFICACY | DRUG-INTERACTIONS | SAFETY | BIOCHEMISTRY & MOLECULAR BIOLOGY | SAQUINAVIR | PROTEASE INHIBITORS | PLASMA-CONCENTRATIONS | KETOCONAZOLE | PHARMACOLOGY & PHARMACY | LOPINAVIR/RITONAVIR | TOXICOLOGY | RITONAVIR | Index Medicus
Journal Article
Current Medicinal Chemistry, ISSN 0929-8673, 04/2013, Volume 20, Issue 13, pp. 1783 - 1799
Journal Article
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 08/2019, Volume 29, Issue 16, pp. 2016 - 2024
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 02/2015, Volume 25, Issue 3, pp. 529 - 541
Herein we report the optimization efforts to ameliorate the potent CYP3A4 time-dependent inhibition (TDI) and low aqueous solubility exhibited by a previously... 
Cytochrome P450 time-dependent inhibition | Tumor metabolism | CYP TDI | Nicotinamide phosphoribosyltransferase | Aqueous solubility | NAMPT | CHEMISTRY, MEDICINAL | ANALOGS | CHEMISTRY, ORGANIC | POTENT INHIBITORS | CANCER | DISCOVERY | METABOLISM | NAD BIOSYNTHESIS | CHEMISTRY | CHS-828 | PHASE-I | PIVOTAL ROLE | Humans | Half-Life | Crystallography, X-Ray | Cytochrome P-450 CYP3A Inhibitors - pharmacokinetics | Transplantation, Heterologous | Structure-Activity Relationship | Nicotinamide Phosphoribosyltransferase - antagonists & inhibitors | Pyrimidines - chemistry | Thermodynamics | Pyrimidines - toxicity | Enzyme Inhibitors - pharmacokinetics | Nicotinamide Phosphoribosyltransferase - metabolism | Cytochrome P-450 CYP3A Inhibitors - chemistry | Enzyme Inhibitors - chemistry | Cytochrome P-450 CYP3A - chemistry | Madin Darby Canine Kidney Cells | Water - chemistry | Female | Binding Sites | Protein Structure, Tertiary | Cytochrome P-450 CYP3A Inhibitors - toxicity | Solubility | Enzyme Inhibitors - therapeutic use | Molecular Dynamics Simulation | Neoplasms - drug therapy | Animals | Cytochrome P-450 CYP3A - metabolism | Mice, Nude | Pyrimidines - therapeutic use | Cell Membrane Permeability - drug effects | Dogs | Cell Line, Tumor | Protein Binding | Cell Proliferation - drug effects | Mice | Kinetics | Neoplasms - pathology | Niacinamide | Cytochrome P-450
Journal Article
Chest, ISSN 0012-3692, 2016, Volume 151, Issue 3, pp. 555 - 563
Background Smoking and COPD are risk factors for cardiovascular disease, and the pathogenesis may involve endothelial dysfunction. We tested the hypothesis... 
Pulmonary/Respiratory | clinical trial | endothelial function | soluble epoxide hydrolase inhibitor | smokers | COPD | EETs | ENDOTHELIAL DYSFUNCTION | MYOCARDIAL-INFARCTION | EPOXYGENASE | OBSTRUCTIVE PULMONARY-DISEASE | CIGARETTE-SMOKING | HYPERPOLARIZING FACTOR | CORONARY ATHEROSCLEROSIS | RESPIRATORY SYSTEM | PLASMINOGEN ACTIVATOR RELEASE | CARDIOVASCULAR-DISEASE | EPOXYEICOSATRIENOIC ACIDS | CRITICAL CARE MEDICINE | Fluconazole - pharmacology | Humans | Middle Aged | Endothelium, Vascular - drug effects | Male | Pulmonary Disease, Chronic Obstructive - physiopathology | 8,11,14-Eicosatrienoic Acid - metabolism | Case-Control Studies | Blood Vessels - physiopathology | Overweight - metabolism | 8,11,14-Eicosatrienoic Acid - analogs & derivatives | Cyclohexylamines - pharmacology | Smoking - physiopathology | Forearm - blood supply | Adult | Pulmonary Disease, Chronic Obstructive - metabolism | Bradykinin - pharmacology | Triazines - pharmacology | Vasodilator Agents - pharmacology | Endothelium, Vascular - physiopathology | Overweight - physiopathology | Smoking - metabolism | Endothelium, Vascular - metabolism | Blood Vessels - drug effects | Aged | Vasodilation - drug effects | In Vitro Techniques | Epoxide Hydrolases - antagonists & inhibitors | Plethysmography | Enzymes | Lung diseases, Obstructive | Care and treatment | Smokers | Research | Risk factors | Blood circulation disorders | Analysis | Epoxy compounds | Hydrolases | Diagnosis | Health aspects | Smoking | EET, epoxyeicosatrienoic acid | SNP, sodium nitroprusside | Original Research | LNAME, L-nitroarginine methyl ester | EDHF, endothelium-derived hyperpolarizing factor | NFκB, nuclear factor kappa light-chain enhancer of activated B cells | LNMMA, NG-monomethyl-L-arginine | tPA, tissue plasminogen activator | DHET, dihydroxyepoxyeicosatrienoic acid | NO, nitric oxide | sEH, soluble epoxide hydrolase | PAI-1, plasminogen activator inhibitor type 1 | CYP, cytochrome P450 | EC50, half maximal effective concentration
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 11/2011, Volume 52, Issue 48, pp. 6372 - 6375
Journal Article
World Journal of Gastroenterology, ISSN 1007-9327, 05/2008, Volume 14, Issue 19, pp. 2980 - 2985
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 08/2014, Volume 24, Issue 16, pp. 3979 - 3985
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 08/2018, Volume 28, Issue 14, pp. 2379 - 2381
Two new ritonavir analogs were designed and synthesized taking advantages of one-pot cascade condensation of β-azido diselenide and alkyl acids. The prepared... 
Antiviral | Selenazole | Ritonavir |