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index medicus (268) 268
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cyp17 (220) 220
male (171) 171
prostate cancer (131) 131
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abiraterone acetate (92) 92
animals (82) 82
steroid 17-alpha-hydroxylase - antagonists & inhibitors (78) 78
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endocrinology & metabolism (60) 60
pharmacology & pharmacy (60) 60
cytochrome p-450 (59) 59
steroid 17-alpha-hydroxylase - metabolism (59) 59
abiraterone (56) 56
chemistry, medicinal (53) 53
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docetaxel (52) 52
biochemistry & molecular biology (51) 51
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testosterone (45) 45
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steroid 17-alpha-hydroxylase - genetics (43) 43
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prostatic neoplasms, castration-resistant - drug therapy (39) 39
therapy (38) 38
biological evaluation (35) 35
castration (35) 35
orchiectomy (35) 35
expression (34) 34
ketoconazole (33) 33
treatment outcome (33) 33
care and treatment (32) 32
antineoplastic agents - therapeutic use (31) 31
increased survival (31) 31
urology & nephrology (31) 31
prostatic neoplasms - pathology (30) 30
androstenes (29) 29
cell line, tumor (29) 29
cyp17 inhibitors (29) 29
aged, 80 and over (28) 28
androgen antagonists - therapeutic use (28) 28
article (28) 28
human 17-alpha-hydroxylase-17,20-lyase cyp17 (28) 28
research (27) 27
castration-resistant prostate cancer (26) 26
enzyme inhibitors - pharmacology (26) 26
rats (26) 26
metastasis (25) 25
phase-ii (25) 25
prostatic neoplasms - surgery (25) 25
receptors, androgen - metabolism (25) 25
resistant prostate-cancer (25) 25
androgens - metabolism (24) 24
plus prednisone (24) 24
steroidal inhibitors (24) 24
drug therapy (23) 23
medicine & public health (23) 23
prostatic neoplasms - metabolism (23) 23
adult (22) 22
androstenols - therapeutic use (22) 22
enzymes (22) 22
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structure-activity relationship (22) 22
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androgen (21) 21
inhibitors (21) 21
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cytochrome p450 (20) 20
enzalutamide (20) 20
mice (20) 20
physiological aspects (20) 20
prostatic neoplasms, castration-resistant - pathology (20) 20
androstadienes - therapeutic use (19) 19
prostatic neoplasms - enzymology (19) 19
steroidogenesis (19) 19
steroids (19) 19
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dose-response relationship, drug (18) 18
men (18) 18
models, molecular (18) 18
prostate (18) 18
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antiandrogen (17) 17
antineoplastic agents, hormonal - therapeutic use (17) 17
aromatase inhibitors (17) 17
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chemistry, organic (16) 16
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Japanese Journal of Clinical Urology, ISSN 0385-2393, 04/2015, Volume 69, Issue 5, pp. 378 - 384
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 08/2008, Volume 7, Issue 8, pp. 2348 - 2357
We previously reported that our novel compound 3β-hydroxy-17-(1 H -benzimidazole-1-yl)androsta-5,16-diene (VN/124-1) is a potent 17α-hydroxylase/17,20-lyase... 
CYP17 inhibitor/antiandrogen | prostate cancer prevention and inhibition | IN-VITRO | POTENTIAL AGENTS | LNCAP | GENE | MECHANISM | ONCOLOGY | TESTOSTERONE | STRATEGY | CELL-GROWTH | PROGRESSION | ADRENAL ANDROGENS
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 11/2011, Volume 19, Issue 21, pp. 6383 - 6399
A novel naphthylmethylimidazole derivative and its related compounds were identified as 17,20-lyase inhibitors. Based on the structure–activity relationship... 
TAK-700 | 17,20-Lyase | Prostate cancer | Orteronel | ENANTIOSELECTIVE REFORMATSKY REACTION | BETA-HYDROXY ESTERS | CHEMISTRY, MEDICINAL | ASYMMETRIC-SYNTHESIS | ANDROGEN BIOSYNTHESIS | HUMAN 17-ALPHA-HYDROXYLASE-17,20-LYASE CYP17 | STEROIDAL INHIBITORS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | CYTOCHROME P450(17-ALPHA) | BIOLOGICAL EVALUATION | HUMAN-LIVER-MICROSOMES | 17-ALPHA-HYDROXYLASE-C17,20-LYASE P450 17 | Steroid 17-alpha-Hydroxylase - antagonists & inhibitors | Stereoisomerism | Antineoplastic Agents - chemical synthesis | Humans | Imidazoles - chemistry | Crystallography, X-Ray | Male | Structure-Activity Relationship | Enzyme Inhibitors - chemical synthesis | Enzyme Inhibitors - chemistry | Inhibitory Concentration 50 | Prostatic Neoplasms - blood | Antineoplastic Agents - pharmacology | Imidazoles - chemical synthesis | Testosterone - blood | Prostatic Neoplasms - drug therapy | Naphthalenes - chemical synthesis | Naphthalenes - chemistry | Magnetic Resonance Spectroscopy | Enzyme Inhibitors - pharmacology | Models, Molecular | Dehydroepiandrosterone - blood | Imidazoles - pharmacology | Antineoplastic Agents - chemistry | Molecular Dynamics Simulation | Haplorhini | Naphthalenes - pharmacology | Animals | Prostatic Neoplasms - enzymology | Care and treatment | Androgens | Dehydroepiandrosterone | Cytochrome P-450 | Electric utilities | Drug therapy | Cancer | Index Medicus
Journal Article
Journal of Steroid Biochemistry and Molecular Biology, ISSN 0960-0760, 04/2012, Volume 129, Issue 3-5, pp. 115 - 128
► Orteronel is a novel, selective, and potent inhibitor of 17,20-lyase. ► Orteronel potently suppressed androgen production in vitro in monkey adrenal cells. ►... 
TAK-700 | Androgen | 17,20-Lyase | Steroid hormone | Prostate cancer | Orteronel | NONHUMAN-PRIMATES | PLUS PREDNISONE | BIOCHEMISTRY & MOLECULAR BIOLOGY | THERAPY RESISTANCE | ANTITUMOR-ACTIVITY | CYP17 BLOCKADE | ANDROGEN-RECEPTOR | ENDOCRINOLOGY & METABOLISM | LNCAP CELLS | ABIRATERONE ACETATE | RESISTANT PROSTATE-CANCER | TUMOR-GROWTH | Steroid 17-alpha-Hydroxylase - antagonists & inhibitors | Dehydroepiandrosterone - antagonists & inhibitors | Humans | Macaca fascicularis | Male | Naphthalenes - blood | Ketoconazole - pharmacology | Steroids - metabolism | Testosterone - blood | Adrenal Glands - cytology | Adrenal Glands - drug effects | Hydrocortisone - blood | Steroids - blood | Cells, Cultured | Enzyme Inhibitors - pharmacology | Androgen Antagonists - pharmacology | Dehydroepiandrosterone - blood | Imidazoles - pharmacology | Naphthalenes - pharmacology | Orchiectomy | Imidazoles - blood | Animals | Testosterone - antagonists & inhibitors | Cell Line, Tumor | Steroid 17-alpha-Hydroxylase - metabolism | Androgens - metabolism | Hydrocortisone - antagonists & inhibitors | Phosphates | Enzymes | Niacinamide | Pituitary hormones | Albumin | ACTH | Glycoproteins | Monkeys | Glucose | Hormones | Dextrose | Chromatography | Purines | Dehydroepiandrosterone | Androgens | Physiological aspects | Luteinizing hormone | Neurohormones | Hormones, Sex | Steroid hormones | Index Medicus
Journal Article
Journal Article
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 2009, Volume 44, Issue 7, pp. 2765 - 2775
Journal Article
Journal Article
Breast Cancer Research and Treatment, ISSN 0167-6806, 8/2018, Volume 171, Issue 1, pp. 111 - 120
Journal Article
Journal Article