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science & technology (115) 115
life sciences & biomedicine (112) 112
cyp17 (99) 99
humans (93) 93
male (61) 61
steroid 17-alpha-hydroxylase - genetics (60) 60
female (46) 46
prostate cancer (45) 45
cytochrome p-450 (35) 35
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steroid 17-alpha-hydroxylase - antagonists & inhibitors (23) 23
biochemistry & molecular biology (22) 22
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obstetrics & gynecology (19) 19
polymorphism, genetic (18) 18
case-control studies (17) 17
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cyp17 gene (16) 16
gynecology. andrology. obstetrics (16) 16
risk factors (16) 16
medicine & public health (15) 15
abiraterone (14) 14
androgens (14) 14
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cytochrome p450 (14) 14
genetic aspects (14) 14
genetic predisposition to disease (14) 14
polymerase chain reaction (13) 13
prostatic neoplasms - enzymology (13) 13
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fundamental and applied biological sciences. psychology (12) 12
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mutation (12) 12
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analysis (11) 11
pharmacology & pharmacy (11) 11
prostatic neoplasms - genetics (11) 11
testosterone (11) 11
abiraterone acetate (10) 10
enzymes (10) 10
androgen antagonists - therapeutic use (9) 9
antineoplastic agents - therapeutic use (9) 9
base sequence (9) 9
breast cancer (9) 9
gene expression (9) 9
genetics & heredity (9) 9
nephrology. urinary tract diseases (9) 9
tumors of the urinary system (9) 9
urinary tract. prostate gland (9) 9
androstenes (8) 8
biochemistry, general (8) 8
cell line, tumor (8) 8
health aspects (8) 8
ketoconazole (8) 8
meta-analysis (8) 8
mice (8) 8
polymorphism, restriction fragment length (8) 8
research (8) 8
steroidogenesis (8) 8
androstenols - therapeutic use (7) 7
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molecular sequence data (7) 7
physiological aspects (7) 7
polymorphism, single nucleotide (7) 7
promoter regions, genetic (7) 7
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rats (7) 7
receptors, androgen - metabolism (7) 7
urology & nephrology (7) 7
vertebrates: endocrinology (7) 7
aged, 80 and over (6) 6
androgens - biosynthesis (6) 6
aromatase - genetics (6) 6
care and treatment (6) 6
castration-resistant prostate cancer (6) 6
drug design (6) 6
enzyme inhibitors - pharmacology (6) 6
female genital diseases (6) 6
genetic polymorphism (6) 6
genetic predisposition to disease - genetics (6) 6
immunohistochemistry (6) 6
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1. Full Text The post-translational regulation of 17,20 lyase activity
by Miller, Walter L and Tee, Meng Kian
Molecular and cellular endocrinology, ISSN 0303-7207, 06/2015, Volume 408, pp. 99 - 106
CYP17 | Cytochrome b5 | P450c17 | Androgen | Prostate | P450 oxidoreductase | Cytochrome b 5 | Gene Expression Regulation, Enzymologic | Phosphorylation | Protein Biosynthesis | Animals | Models, Biological | Humans | Steroid 17-alpha-Hydroxylase - genetics | Steroid 17-alpha-Hydroxylase - metabolism | Steroid 17-alpha-Hydroxylase - chemistry | Mutation - genetics | Index Medicus
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2. Full Text Functional Analysis of Steroidogenic Factor 1 (sf-1) and 17α-Hydroxylase/Lyase (cyp17α) Promoters in Yellow Catfish Pelteobagrus fulvidraco
by Lv, Wu-Hong and Chen, Guang-Hui and Zhuo, Mei-Qin and Xu, Yi-Huan and Xu, Yi-Chuang and Tan, Xiao-Ying
International journal of molecular sciences, ISSN 1661-6596, 12/2020, Volume 22, Issue 1, p. 195
Enzymes | Transcription factors | Hydroxylase | Gene regulation | Stat3 protein | Steroidogenic factor 1 | Biosynthesis | Functional analysis | Metabolism | Promoters | Investigations | Proteins | Receptors | Catfish | Plasmids | Leptin | Electrophoretic mobility | Physiology | Mutation | Binding sites | Index Medicus | steroidogenesis | Pelteobagrus fulvidraco | sf-1 | cyp17α | transcriptional regulation
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3. Full Text Phase 1 study of seviteronel, a selective CYP17 lyase and androgen receptor inhibitor, in women with estrogen receptor-positive or triple-negative breast cancer
by Bardia, Aditya and Gucalp, Ayca and DaCosta, Noashir and Gabrail, Nashat and Danso, Michael and Ali, Haythem and Blackwell, Kimberly L and Carey, Lisa A and Eisner, Joel R and Baskin-Bey, Edwina S and Traina, Tiffany A
Breast cancer research and treatment, ISSN 0167-6806, 8/2018, Volume 171, Issue 1, pp. 111 - 120
Oncology | Breast cancer | Medicine & Public Health | CYP17 lyase | Androgen receptor | Seviteronel | Life Sciences & Biomedicine | Science & Technology | Androgen Receptor Antagonists - pharmacokinetics | Steroid 17-alpha-Hydroxylase - antagonists & inhibitors | Androgen Receptor Antagonists - therapeutic use | Humans | Middle Aged | Receptors, Androgen - metabolism | Androgen Receptor Antagonists - administration & dosage | Treatment Outcome | Antineoplastic Agents - therapeutic use | Antineoplastic Agents - administration & dosage | Triple Negative Breast Neoplasms - drug therapy | Biomarkers, Tumor | Breast Neoplasms - drug therapy | Androgen Receptor Antagonists - adverse effects | Breast Neoplasms - metabolism | Antineoplastic Agents - adverse effects | Triple Negative Breast Neoplasms - metabolism | Aged, 80 and over | Female | Aged | Antineoplastic Agents - pharmacokinetics | Women | Androgens | Estrogen | Cytochrome P-450 | Clinical trials | Phenols | Development and progression | Metastasis | Prostate cancer | Index Medicus | seviteronel | breast cancer | androgen receptor
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4. Full Text A population pharmacokinetic analysis of the oral CYP17 lyase and androgen receptor inhibitor seviteronel in patients with advanced/metastatic castration-resistant prostate cancer or breast cancer
by Peer, Cody J and Schmidt, Keith T and Kindrick, Jessica D and Eisner, Joel R and Brown, Victoria V and Baskin-Bey, Edwina and Madan, Ravi and Figg, William D
Cancer chemotherapy and pharmacology, ISSN 0344-5704, 10/2019, Volume 84, Issue 4, pp. 759 - 770
Population pharmacokinetics | Medicine & Public Health | Seviteronel CYP17 lyase | Oncology | Cancer Research | Pharmacology/Toxicology | Prostate cancer | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Science & Technology | Androgen Receptor Antagonists - pharmacokinetics | Steroid 17-alpha-Hydroxylase - antagonists & inhibitors | Humans | Biological Availability | Male | Drug Monitoring - methods | Prostatic Neoplasms, Castration-Resistant - drug therapy | Breast Neoplasms - drug therapy | Prostatic Neoplasms, Castration-Resistant - pathology | Dexamethasone - pharmacokinetics | Dose-Response Relationship, Drug | Drug Therapy, Combination - methods | Breast Neoplasms - pathology | Female | Triazoles - pharmacokinetics | Antineoplastic Agents - pharmacokinetics | Naphthalenes - pharmacokinetics | Neoplasm Staging | Clinical Trials, Phase II as Topic | Women | Cytochrome | Dexamethasone | Parameters | Computer simulation | Body weight | Sex | Oral administration | Breast cancer | Pharmacology | Prednisone | Metastases | Anticancer properties | Androgens | Inhibitors | Antitumor agents | Castration | Covariance | Men | Cytochromes | Pharmacokinetics | Prostate | Index Medicus
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5. Full Text A single amino acid residue, Ala 105, confers 16α-hydroxylase activity to human cytochrome P450 17α-hydroxylase/17,20 lyase
by Swart, Amanda C and Storbeck, Karl-Heinz and Swart, Pieter
The Journal of steroid biochemistry and molecular biology, ISSN 0960-0760, 2010, Volume 119, Issue 3, pp. 112 - 120
Homology model | CYP17 | Cytochrome P450c17 | 16-Hydroxyprogesterone | 17-Hydroxyprogesterone | Biochemistry & Molecular Biology | Endocrinology & Metabolism | Life Sciences & Biomedicine | Science & Technology
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6. Full Text 17α-Hydroxylase/17,20 lyase inhibitor VN/124-1 inhibits growth of androgen-independent prostate cancer cells via induction of the endoplasmic reticulum stress response
by Robert D. Bruno and Tony D. Gover and Angelika M. Burger and Angela M. Brodie and Vincent C.O. Njar
Molecular cancer therapeutics, ISSN 1535-7163, 09/2008, Volume 7, Issue 9, pp. 2828 - 2836
CYP17 inhibitors | VN/124-1 | prostate cancer | stress response | endoplasmic reticulum
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7. Full Text Modulation of expression of 17-Hydroxylase/17,20 lyase (CYP17) and P450 aromatase (CYP19) by inhibition of MEK1 in a human ovarian granulosa-like tumor cell line
by Huang, Xiao and Jin, Jiewen and Shen, Shanmei and Xia, Yanjie and Xu, Pei and Zou, Xiang and Wang, Hongwei and Yi, Long and Wang, Yong and Gao, Qian
Gynecological endocrinology, ISSN 0951-3590, 03/2016, Volume 32, Issue 3, pp. 201 - 205
c-fos | CYP17 | KGN | CYP19 | MEK/ERK | Endocrinology & Metabolism | Life Sciences & Biomedicine | Obstetrics & Gynecology | Science & Technology | Immunohistochemistry | Estradiol - metabolism | MAP Kinase Kinase 1 - antagonists & inhibitors | Humans | Proto-Oncogene Proteins c-fos - metabolism | Aromatase - metabolism | Androstenedione - metabolism | Flavonoids - therapeutic use | Granulosa Cell Tumor - metabolism | Cell Line, Tumor | Female | Flavonoids - pharmacology | Granulosa Cell Tumor - drug therapy | Ovarian Neoplasms - metabolism | Steroid 17-alpha-Hydroxylase - metabolism | Ovarian Neoplasms - drug therapy | Drug Screening Assays, Antitumor | Index Medicus
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8. Full Text Dehydroepiandrosterone formation is independent of cytochrome P450 17α-hydroxylase/17, 20 lyase activity in the mouse brain
by Liu, Ying and Pocivavsek, Ana and Papadopoulos, Vassilios
The Journal of steroid biochemistry and molecular biology, ISSN 0960-0760, 2009, Volume 115, Issue 3, pp. 86 - 90
CYP17 | Steroidogenesis | Androgen | Neurosteroids | Transgenic mice | Biochemistry & Molecular Biology | Endocrinology & Metabolism | Life Sciences & Biomedicine | Science & Technology
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9. Full Text Mono-(2-ethylhexyl) phthalate directly alters the expression of leydig cell genes and CYP17 lyase activity in cultured rat fetal testis
by Chauvigné, François and Plummer, Simon and Lesné, Laurianne and Cravedi, Jean-Pierre and Dejucq-Rainsford, Nathalie and Fostier, Alexis and Jégou, Bernard
PloS one, ISSN 1932-6203, 11/2011, Volume 6, Issue 11, pp. e27172 - e27172
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Testis - metabolism | Cells, Cultured | Fetus - pathology | Rats | Testosterone - biosynthesis | Male | Leydig Cells - drug effects | Lyases - metabolism | Testis - drug effects | Gene Expression Regulation - drug effects | 17-alpha-Hydroxyprogesterone - metabolism | Animals | Testis - pathology | Leydig Cells - metabolism | Diethylhexyl Phthalate - analogs & derivatives | Steroid 17-alpha-Hydroxylase - metabolism | Diethylhexyl Phthalate - pharmacology | Steroids - biosynthesis | Dihydrotestosterone - metabolism | Testosterone | DNA microarrays | Genes | Inhibin | Cytochrome P-450 | Genetic research | Esters | Gene expression | Cell culture | Lipids | Biosynthesis | Proteins | Dihydrotestosterone | Sterols | Metabolites | Rodents | Localization | Enzymes | Fetuses | Cloning | Exposure | Apolipoproteins | Intrauterine exposure | Insulin | Phthalates | Androgens | Steroidogenesis | Testes | Laboratory animals | Androstenedione | Endocrinology | Index Medicus | Life Sciences | Biochemistry, Molecular Biology
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10. Full Text Overexpression of theca-cell messenger RNA in polycystic ovary syndrome does not correlate with polymorphisms in the cholesterol side-chain cleavage and 17α-hydroxylase/C17-20 lyase promoters
by Daneshmand, Sad and Weitsman, Stacy R and Navab, Alireza and Jakimiuk, Artur J and Magoffin, Denis A
Fertility and sterility, ISSN 0015-0282, 2002, Volume 77, Issue 2, pp. 274 - 280
CYP11A | CYP17 | PCOS | mRNA | Theca cells | Life Sciences & Biomedicine | Obstetrics & Gynecology | Reproductive Biology | Science & Technology | Gynecology. Andrology. Obstetrics | Biological and medical sciences | Medical sciences | Female genital diseases | Tumors
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11. Full Text Expression of 20β-hydroxysteroid dehydrogenase and P450 17α-hydroxylase/c17–20 lyase during hCG-induced in vitro oocyte maturation in snake head murrel Channa striatus
by Sreenivasulu, G and Swapna, I and Rasheeda, M K and Ijiri, S and Adachi, S and Thangaraj, K and Senthilkumaran, B
Fish physiology and biochemistry, ISSN 0920-1742, 04/2005, Volume 31, Issue 2, pp. 227 - 230
Life Sciences | Animal Physiology | 20 β -HSD | Steroidogenic shift | Animal Biochemistry | Zoology | Freshwater & Marine Ecology | CYP17 | Channa striatus | Animal Anatomy / Morphology / Histology | Oocyte maturation | 20β-HSD
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12. Full Text 17-Hydroxylase/17,20 Lyase Deficiency Diagnosed during Childhood
by Wolthers, O.D and Rumsby, G and Techatraisak, K and Honour, J.W and Hindmarsh, P.C
Hormone research in paediatrics, ISSN 1663-2818, 2002, Volume 57, Issue 3-4, pp. 133 - 136
Case Report | XY sex reversal | Congenital adrenal hyperplasia | Urine steroid metabolites | CYP17 gene | 17α-Hydroxylase/17,20 lyase deficiency | Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Polymorphism, Single-Stranded Conformational | Adrenal Hyperplasia, Congenital - enzymology | Exons | Pedigree | Y Chromosome | Humans | Adolescent | Polymerase Chain Reaction | Female | Steroid 17-alpha-Hydroxylase - genetics | Adrenal Hyperplasia, Congenital - genetics | Child | Index Medicus
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13. Full Text 17α-Hydroxylase/C17-20 Lyase Cytochrome P450 mRNA Expressions and Enzyme Activities during the Development of Arthritis in Collagen-Induced Arthritis Mice
by Noriko TAGAWA and Kimie MURAOKA and Yoshihiro OKAMOTO and Mikio NISHIDA and Masanao KATAGIRI and Yoshiharu KOBAYASHI and Clinical Chemistry Laboratory and Department of Clinical Pharmacy and Division of Natural Science and Meijo University and Kobe Pharmaceutical University and Faculty of Pharmacy and Osaka Kyoiku University
Biological & pharmaceutical bulletin, ISSN 0918-6158, 2004, Volume 27, Issue 10, pp. 1663 - 1665
Dehydroepiandrosterone | CYP17 mRNA | Collagen-induced arthritis | Rheumatoid arthritis
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14. Full Text Highly-selective 4-(1,2,3-triazole)-based P450c17a 17,20-lyase inhibitors
by Rafferty, Stephen W and Eisner, Joel R and Moore, William R and Schotzinger, Robert J and Hoekstra, William J
Bioorganic & medicinal chemistry letters, ISSN 0960-894X, 06/2014, Volume 24, Issue 11, pp. 2444 - 2447
CYP17 lyase | Prostate cancer | Steroid 17-alpha-Hydroxylase - antagonists & inhibitors | Triazoles - chemistry | Antineoplastic Agents - chemical synthesis | Humans | Enzyme Inhibitors - pharmacology | Rats | Male | Structure-Activity Relationship | Antineoplastic Agents - chemistry | Enzyme Inhibitors - chemical synthesis | Dose-Response Relationship, Drug | Triazoles - pharmacology | Animals | Enzyme Inhibitors - chemistry | Drug Design | Prostatic Neoplasms - enzymology | Triazoles - chemical synthesis | Antineoplastic Agents - pharmacology | Molecular Structure | Steroid 17-alpha-Hydroxylase - metabolism | Prostatic Neoplasms - drug therapy | Drug Screening Assays, Antitumor | Triazoles | Index Medicus
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15. Full Text Design and synthesis of functionalized piperazin-1yl-(E)-stilbenes as inhibitors of 17α-hydroxylase-C17,20-lyase (Cyp17)
by Blass, Benjamin E and Iyer, Pravin and Abou-Gharbia, Magid and Childers, Wayne E and Gordon, John C and Ramanjulu, Mercy and Morton, George and Arumugam, Premkumar and Boruwa, Joshodeep and Ellingboe, John and Mitra, Sayan and Reddy Nimmareddy, Rajashekar and Paliwal, Shalini and Rajasekhar, Jamallamudi and Shivakumar, Savithiri and Srivastava, Pratima and Tangirala, Raghuram S and Venkataramanaiah, Konda and Bobbala, Ramreddy and Yanamandra, Mahesh and Krishnakanth Reddy, L
Bioorganic & medicinal chemistry letters, ISSN 0960-894X, 07/2018, Volume 28, Issue 13, pp. 2270 - 2274
Cortisol | Ketoconazole | Metabolic syndrome | 17α‐Hydroxylase‐C17,20‐lyase (Cyp17) | Steroid 17-alpha-Hydroxylase - antagonists & inhibitors | Guinea Pigs | Stereoisomerism | Microsomes, Liver - metabolism | Stilbenes - chemical synthesis | Half-Life | Piperazines - chemistry | Stilbenes - chemistry | Structure-Activity Relationship | Cytochrome P-450 Enzyme Inhibitors - pharmacokinetics | Animals | Cytochrome P-450 Enzyme Inhibitors - chemical synthesis | Drug Design | Stilbenes - pharmacokinetics | Piperazines - chemical synthesis | Cytochrome P-450 Enzyme Inhibitors - chemistry | Piperazines - pharmacokinetics | Index Medicus
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