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Drug Metabolism and Disposition, ISSN 0090-9556, 01/2010, Volume 38, Issue 1, pp. 92 - 99
The aim of the current study is to identify the human cytochrome P450 (P450) isoforms involved in the two oxidative steps in the bioactivation of clopidogrel... 
MECHANISM-BASED INHIBITION | ANTIAGGREGATING ACTIVITY | POLYMORPHISMS | TICLOPIDINE | PHARMACOKINETICS | HEALTHY-SUBJECTS | PHARMACOLOGY & PHARMACY | PRASUGREL | PHARMACODYNAMICS | MONOCLONAL-ANTIBODIES | ATORVASTATIN | Microsomes - metabolism | Humans | Aryl Hydrocarbon Hydroxylases - genetics | Cytochrome P-450 Enzyme System - metabolism | Sulfaphenazole - pharmacology | Microsomes - drug effects | Cytochrome P-450 CYP3A - genetics | Cytochrome P-450 CYP1A2 - genetics | Antibodies - immunology | Omeprazole - pharmacology | Microsomes, Liver - enzymology | Platelet Aggregation Inhibitors - pharmacokinetics | Ticlopidine - pharmacokinetics | Oxidoreductases, N-Demethylating - metabolism | Aryl Hydrocarbon Hydroxylases - immunology | Oxidation-Reduction | Enzyme Inhibitors - pharmacology | Ticlopidine - analogs & derivatives | Oxidoreductases, N-Demethylating - immunology | Cytochrome P-450 CYP3A - metabolism | Cell Line, Tumor | Cytochrome P-450 Enzyme System - genetics | Theophylline - pharmacology | Kinetics | Cytochrome P-450 CYP2C9 | Theophylline - analogs & derivatives | Oxidoreductases, N-Demethylating - genetics | Glutathione - metabolism | Ketoconazole - pharmacology | Biotransformation - physiology | Cytochrome P-450 CYP1A2 Inhibitors | Microsomes, Liver - drug effects | Ticlopidine - metabolism | NADP - metabolism | Platelet Aggregation Inhibitors - metabolism | Cytochrome P-450 CYP3A - immunology | Cell Line | Aryl Hydrocarbon Hydroxylases - antagonists & inhibitors | Cytochrome P-450 CYP1A2 - immunology | Biocatalysis | Mephenytoin - analogs & derivatives | Cytochrome P-450 CYP1A2 - metabolism | Aryl Hydrocarbon Hydroxylases - metabolism | Mephenytoin - pharmacology | Antibodies - pharmacology | Cytochrome P-450 CYP3A Inhibitors | Cytochrome P-450 CYP2C19 | Clopidogrel | Cytochrome P-450 CYP2B6 | Index Medicus
Journal Article
Life Sciences, ISSN 0024-3205, 12/2017, Volume 190, pp. 46 - 51
Journal Article
Molecular Psychiatry, ISSN 1359-4184, 2012, Volume 17, Issue 11, pp. 1116 - 1129
Coffee consumption is a model for addictive behavior. We performed a meta-analysis of genome-wide association studies (GWASs) on coffee intake from 8 Caucasian... 
CYP1A1/CYP1A2 | NRCAM | P450 | Parkinson's disease | CAB39L | coffee | CAFFEINE CONSUMPTION | HUMAN BRAIN | PSYCHIATRY | BIOCHEMISTRY & MOLECULAR BIOLOGY | NEUROSCIENCES | BLOOD-PRESSURE | PSYCHOMOTOR PERFORMANCE | MESSENGER-RNA | GENE-EXPRESSION | AGED FINNISH MEN | TYPE-2 DIABETES-MELLITUS | PARKINSONS-DISEASE | CYP1A2 GENOTYPE | Antigens, Neoplasm - genetics | Cell Line | Cytochrome P-450 CYP1A1 - genetics | Cell Adhesion Molecules - genetics | European Continental Ancestry Group - genetics | Genetic Predisposition to Disease - genetics | Gene Expression - drug effects | Humans | Protein-Serine-Threonine Kinases - genetics | Gene Expression Profiling - methods | Male | Parkinson Disease - genetics | Cytochrome P-450 CYP1A2 - genetics | Apoptosis Regulatory Proteins - genetics | Caffeine - pharmacology | Drinking - genetics | Female | Polymorphism, Single Nucleotide | Genome-Wide Association Study - methods | Coffee - genetics | Cohort analysis | Genotype | Research | Coffee | Gene expression | Health aspects | Identification and classification | Methods | Caffeine | Index Medicus | Ubiquitin | Neurodegenerative diseases | Drinking behavior | Cytochrome P450 | Linkage disequilibrium | Lymphoblastoid cell lines | proteasomes | Association analysis | Single-nucleotide polymorphism | CYP1A2 protein | Metabolism | Blood | Reviews | Polycyclic aromatic hydrocarbons | Replication | Movement disorders | CYP1A2 | CYP1A1 | Original
Journal Article
Cancer Chemotherapy and Pharmacology, ISSN 0344-5704, 1/2018, Volume 81, Issue 1, pp. 73 - 80
Dovitinib is an orally available multi tyrosine kinase inhibitor which inhibits VEGFR 1–3, FGFR 1–3, and PDGFR. This study was performed to investigate the... 
Fluvoxamine CYP1A2 | Medicine & Public Health | Dovitinib | Drug–drug interaction | Oncology | Cancer Research | TKI258 | Pharmacology/Toxicology | PHASE-II | OPEN-LABEL | SORAFENIB | CANCER | FLUOXETINE | FGFR | RENAL-CELL CARCINOMA | TRIAL | METABOLISM | ONCOLOGY | VEGFR | PHARMACOLOGY & PHARMACY | Drug-drug interaction | Area Under Curve | Humans | Middle Aged | Half-Life | Male | Antineoplastic Agents - therapeutic use | Antineoplastic Agents - administration & dosage | Drug Interactions | Fluvoxamine - administration & dosage | Benzimidazoles - administration & dosage | Antineoplastic Agents - adverse effects | Quinolones - pharmacokinetics | Quinolones - therapeutic use | Aged, 80 and over | Adult | Female | Antineoplastic Agents - pharmacology | Cytochrome P-450 CYP1A2 Inhibitors - adverse effects | Benzimidazoles - therapeutic use | Cytochrome P-450 CYP1A2 Inhibitors - therapeutic use | Fluvoxamine - therapeutic use | Drug Administration Schedule | Benzimidazoles - pharmacokinetics | Fluvoxamine - pharmacology | Neoplasms - drug therapy | Maximum Tolerated Dose | Quinolones - administration & dosage | Cytochrome P-450 CYP1A2 Inhibitors - pharmacology | Cytochrome P-450 CYP1A2 Inhibitors - administration & dosage | Aged | Tyrosine | Complications and side effects | Care and treatment | Drug interactions | Cytochrome P-450 | Pharmaceutical industry | Vascular endothelial growth factor | Tumors | Toxicity | Cytochrome P450 | Breast cancer | Pharmacology | CYP1A2 protein | Patients | Coefficient of variation | Steady state | Vascular endothelial growth factor receptors | Confidence intervals | Inhibitors | Drug interaction | Solid tumors | Pharmacokinetics | Drug dosages | Protein-tyrosine kinase | Fluvoxamine | Cancer | Smoking | Fibroblast growth factor receptors | Index Medicus
Journal Article
Effect of St. John's wort extract on intestinal expression of cytochrome P4501A2: studies in LS180 cells, 12/2002
BACKGROUND AND AIMS: St. John's Wort (SJW) is known to induce expression and activity of cytochrome P4503A4 (CYP3A4). However, its effects on other cytochrome... 
St. John's Wort, drug interactions, CYP1A2, induction
Journal
Human Molecular Genetics, ISSN 0964-6906, 2016, Volume 25, Issue 24, pp. 5472 - 5482
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 08/2017, Volume 60, Issue 15, pp. 6622 - 6637
Journal Article
FOOD AND CHEMICAL TOXICOLOGY, ISSN 0278-6915, 12/2018, Volume 122, pp. 38 - 48
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 08/2017, Volume 60, Issue 15, pp. 6678 - 6692
Porcupine is an O-acyltransferase that regulates Wnt secretion. Inhibiting porcupine may block the Wnt pathway which is often dysregulated in various cancers.... 
TARGET | CHEMISTRY, MEDICINAL | PATHWAY | MECHANISMS | BETA-CATENIN | WNT | CANCER | Acyltransferases - antagonists & inhibitors | Maleimides - administration & dosage | Cytochrome P-450 CYP3A Inhibitors - pharmacology | Antineoplastic Agents - chemical synthesis | Humans | Microsomes, Liver - metabolism | Maleimides - pharmacology | Cytochrome P-450 CYP3A Inhibitors - pharmacokinetics | Structure-Activity Relationship | Antineoplastic Agents - administration & dosage | Pyridazines - pharmacology | Pyridazines - chemical synthesis | Maleimides - pharmacokinetics | Cytochrome P-450 CYP1A2 Inhibitors - pharmacokinetics | Maleimides - chemical synthesis | HEK293 Cells | Pyridazines - administration & dosage | Female | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Cytochrome P-450 CYP2D6 Inhibitors - pharmacology | Wnt Signaling Pathway | Cytochrome P-450 CYP2D6 Inhibitors - pharmacokinetics | Cytochrome P-450 CYP3A Inhibitors - administration & dosage | Rats | Cytochrome P-450 CYP1A2 Inhibitors - chemical synthesis | Cytochrome P-450 CYP2D6 Inhibitors - administration & dosage | Cytochrome P-450 CYP3A Inhibitors - chemical synthesis | Xenograft Model Antitumor Assays | Animals | Cytochrome P-450 CYP1A2 Inhibitors - pharmacology | Cytochrome P-450 CYP2D6 Inhibitors - chemical synthesis | High-Throughput Screening Assays | Membrane Proteins - antagonists & inhibitors | Mice, Nude | Cytochrome P-450 CYP1A2 Inhibitors - administration & dosage | Cell Line, Tumor | Pyridazines - pharmacokinetics | Mice, Inbred BALB C | Index Medicus
Journal Article
Genetics and Molecular Research, ISSN 1676-5680, 04/2016, Volume 15, Issue 2
Journal Article