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Biochemistry, ISSN 0006-2960, 10/2014, Volume 53, Issue 42, pp. 6695 - 6705
Formation of transient complexes of cytochrome P450 (P450) with another protein of the endoplasmic reticulum membrane, cytochrome b5 (cyt b5), dictates the... 
Cytochrome P-450 CYP1A2 - chemistry | Humans | Protein Conformation | Molecular Docking Simulation | Cytochromes b5 - chemistry | Static Electricity | Molecular Dynamics Simulation | Index Medicus
Journal Article
Basic & Clinical Pharmacology & Toxicology, ISSN 1742-7835, 10/2017, Volume 121, Issue 4, pp. 334 - 341
Of late, many studies are attempting to find new molecules with anticancer properties, especially those with the capability to inhibit cell growth. The aim of... 
CANCER-CELLS | APOPTOSIS | COMET ASSAY | C-MYC | PHARMACOLOGY & PHARMACY | ANTICANCER DRUGS | KINASE INHIBITORS | TOXICITY | TOXICOLOGY | MELANOMA-CELLS | INDUCTION | CYCLE | Activation, Metabolic | Sesquiterpenes - metabolism | Apoptosis - drug effects | Humans | Dose-Response Relationship, Drug | Carcinoma, Hepatocellular - drug therapy | Time Factors | Carcinoma, Hepatocellular - genetics | Apoptosis Regulatory Proteins - genetics | Cell Cycle Proteins - genetics | Liver Neoplasms - pathology | Antineoplastic Agents, Phytogenic - metabolism | Liver Neoplasms - enzymology | Endoplasmic Reticulum Stress - drug effects | Liver Neoplasms - genetics | Oxidation-Reduction | Cell Cycle Proteins - metabolism | Liver Neoplasms - drug therapy | Carcinoma, Hepatocellular - enzymology | Cytochrome P-450 CYP1A2 - metabolism | Apoptosis Regulatory Proteins - metabolism | Hep G2 Cells | Carcinoma, Hepatocellular - pathology | Cytochrome P-450 CYP2C19 - metabolism | Cell Proliferation - drug effects | Sesquiterpenes - pharmacology | Antineoplastic Agents, Phytogenic - pharmacology | G1 Phase Cell Cycle Checkpoints - drug effects | Cell death | Cytochrome P-450 | Physiological aspects | Biochemistry | Stress (Physiology) | Hepatoma | Tumor proteins | Xenobiotics | Gene expression | Cell proliferation | Membranes | Bax protein | Toxicity | Genes | Genotoxicity | Cytotoxicity | Hepatocellular carcinoma | Myc protein | Kinases | Phase transitions | Anticancer properties | Proteins | Liver cancer | Mitochondria | Cell growth | Nerolidol | Cell cycle | Oxidation | Membrane potential | CYP2D6 protein | G1 phase | Cytochromes P450 | Enzymes | Cell survival | Cytochrome P450 | Caspase | CYP1A2 protein | Metabolism | Survival | Cyclins | Cyclin-dependent kinase 2 | Endoplasmic reticulum | Apoptosis | Index Medicus
Journal Article
Journal Article
Life Sciences, ISSN 0024-3205, 08/2019, Volume 230, pp. 97 - 103
Journal Article
Molecular Therapy, ISSN 1525-0016, 06/2017, Volume 25, Issue 6, pp. 1420 - 1433
The function of hepatocytes largely depends on their position in the liver lobule. Although the method of differentiating hepatocytes from human pluripotent... 
adenovirus vector | differentiation | WIF-1 | liver zonation | human ES cells | human iPS cells | WNT7B | drug metabolizing enzyme | WNT8B | hepatocytes | MEDICINE, RESEARCH & EXPERIMENTAL | ACTIVATED PROTEIN-KINASE | FATTY-ACID-METABOLISM | TRANSDUCTION | LIVER ZONATION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | ADENOVIRUS VECTOR | EMBRYONIC STEM-CELLS | GENETICS & HEREDITY | GENERATION | GENE-TRANSFER | DIFFERENTIATION | FUNCTIONAL HEPATOCYTES | Embryonic Stem Cells - metabolism | RNA, Small Interfering - genetics | Embryonic Stem Cells - cytology | Humans | Culture Media, Conditioned - pharmacology | Gene Expression Profiling | Hepatocytes - metabolism | Wnt Proteins - metabolism | Gene Knockdown Techniques | Cell Differentiation - genetics | Hepatocytes - cytology | Wnt Proteins - genetics | Gene Expression Regulation, Developmental | Induced Pluripotent Stem Cells - cytology | Fibroblasts - metabolism | Induced Pluripotent Stem Cells - metabolism | Cell Line | Pharmacogenetics | Cells, Cultured | Repressor Proteins - genetics | Gene Expression Regulation, Enzymologic | Animals | Wnt Signaling Pathway - drug effects | Energy Metabolism | Adaptor Proteins, Signal Transducing - genetics | Biomarkers | Mice | Tricarboxylic acid cycle | Enzymes | Statistical analysis | Wnt protein | Research & development--R&D | Secretion | Liver | Cytochrome P450 | Lipids | Glucose | CYP1A2 protein | Metabolism | Kinases | Gene expression | Citric acid | Proteins | Urea | Hepatocytes | Efficiency | Stem cells | Protein expression | Pluripotency | Gluconeogenesis | Glutamine | Original
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2016, Volume 11, Issue 5, pp. e0155135 - e0155135
Oxidative reactions that are catalyzed by cytochromes P450 1A (CYP1A) lead to formation of carcinogenic derivatives of arylamines and polycyclic aromatic... 
RAT-LIVER | CYP1A1 EXPRESSION | MEDIATED INDUCTION | ARYL-HYDROCARBON RECEPTOR | POLYCYCLIC AROMATIC-HYDROCARBONS | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | HEP G2 CELLS | KNOCKOUT MICE | CCAAT/ENHANCER-BINDING-PROTEIN | VITAMIN-A | Transcription, Genetic - drug effects | Benzo(a)pyrene - toxicity | Liver - enzymology | Rats, Wistar | RNA, Messenger - genetics | Receptors, Aryl Hydrocarbon - genetics | Male | Signal Transduction - genetics | DNA - metabolism | Aryl Hydrocarbon Receptor Nuclear Translocator - metabolism | Cytochrome P-450 CYP1A1 - metabolism | Enzyme Activation - drug effects | RNA, Messenger - metabolism | Gene Expression Regulation - drug effects | Vitamin K 3 - pharmacology | Animals | Liver - drug effects | Signal Transduction - drug effects | Protein Binding - drug effects | Lipid Peroxidation - drug effects | Receptors, Aryl Hydrocarbon - metabolism | Weight Gain - drug effects | Aryl Hydrocarbon Receptor Nuclear Translocator - genetics | Cytochrome | Animal models | Transcription factors | CYP1A protein | Amines | Toxicity | Liver | Genes | Gene regulation | Hydrocarbons | CCAAT/enhancer-binding protein | Carcinogenesis | Signal transduction | Carcinogens | Enzymatic activity | Polycyclic aromatic hydrocarbons | Rodents | Biocompatibility | Pollutants | Deoxyribonucleic acid--DNA | Cytochromes P450 | Organic compounds | Menadione | Cytochrome P450 | Rats | Chemical reactions | CYP1A2 protein | Biophysics | Gene expression | Pyrene | Signaling | Flavonoids | Cellular biology | Oct-1 protein | Cytochromes | Ligands | Molecular biology | Acute toxicity | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
BBA - Biomembranes, ISSN 0005-2736, 01/2017, Volume 1859, Issue 1, pp. 104 - 116
Anchorage of recombinant proteins onto the outer membrane of gram-negative bacteria is an attractive solution for protein library screening and whole cell... 
Autodisplay | Cytochrome P450 1A2 | Autotransporter, outer membrane linker | Cytochrome P450 reductase | DESIGN | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | CELL-SURFACE | V SECRETION | P450 OXIDOREDUCTASE | BIOPHYSICS | FUNCTIONAL EXPRESSION | RECOMBINANT PROTEINS | AUTOTRANSPORTER | REDUCTASE | Acetaminophen - metabolism | Substrate Specificity | Cell Membrane - genetics | Cytochromes c - genetics | Recombinant Fusion Proteins - metabolism | Adhesins, Escherichia coli - genetics | Cell Membrane - chemistry | Oxazines - metabolism | Cytochrome P-450 CYP1A2 - genetics | Cloning, Molecular | Escherichia coli - metabolism | Cell Membrane - metabolism | Protein Interaction Domains and Motifs | Binding Sites | Protein Conformation, alpha-Helical | Catalytic Domain | Gene Expression | Adhesins, Escherichia coli - metabolism | Cytochrome P-450 CYP1A2 - chemistry | Acetaminophen - chemistry | Cytochromes c - metabolism | Models, Molecular | Recombinant Fusion Proteins - chemistry | Cytochrome P-450 CYP1A2 - metabolism | Plasmids - metabolism | Amino Acid Motifs | Genetic Engineering | Protein Conformation, beta-Strand | Escherichia coli - genetics | Plasmids - chemistry | Protein Binding | Recombinant Fusion Proteins - genetics | Oxazines - chemistry | Kinetics | Cytochrome c | Recombinant proteins | Analysis | Cytochrome P-450
Journal Article
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 03/2018, Volume 46, Issue 3, p. 197
Cytochromes P450s (P450s) catalyze oxygenation reactions via interactions with their redox partners. However, other proteins, particularly other P450s, also... 
Cytochrome | Bioluminescence | Complex formation | Energy use | Energy measurement | Cytochrome P450 | Fluorescence | Chemical reactions | Phospholipids | NADPH-ferrihemoprotein reductase | CYP1A2 protein | Proteins | Green fluorescent protein | Cells (biology) | NADPH-cytochrome P450 reductase | Cytochromes | NADP | Catalysis | Oxygenation | Energy transfer | Reductase
Journal Article
Biopharmaceutics & Drug Disposition, ISSN 0142-2782, 07/2018, Volume 39, Issue 7, pp. 344 - 353
Journal Article