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Xenobiotica, ISSN 0049-8254, 10/2012, Volume 42, Issue 10, pp. 989 - 1000
Frutinone is an active ingredient extracted from the lipophilic fraction of the Polygala Fruticosa demonstrating various antibacterial and fungal properties.... 
drug-herb interactions | docking simulations | inhibition | metabolism | Natural products | Drugherb interactions | Inhibition | Metabolism | Docking simulations | MECHANISM | DRUG-INTERACTIONS | MASS-SPECTROMETRY | DISCOVERY | HUMAN MICROSOMAL PROTEIN | IN-VITRO | CYTOCHROME-P450 ENZYMES | GRAPEFRUIT JUICE | LIVER | PHARMACOLOGY & PHARMACY | TOXICOLOGY | METABOLIC STABILITY | Coumarins - metabolism | Plant Extracts - chemistry | Anti-Infective Agents - pharmacology | Humans | Coumarins - chemistry | Hepatocytes - metabolism | Cytochrome P-450 CYP1A2 Inhibitors | Oxazines - metabolism | Time Factors | Cryopreservation | Isoenzymes - metabolism | Anti-Infective Agents - chemistry | Enzyme Inhibitors - chemistry | Mass Spectrometry | Chromones - pharmacology | Drug Evaluation, Preclinical | Hepatocytes - drug effects | Nitriles - metabolism | Polygala - chemistry | Catalytic Domain | Reproducibility of Results | Enzyme Inhibitors - pharmacology | Enzyme Inhibitors - analysis | Cytochrome P-450 CYP1A2 - metabolism | Chromones - analysis | Chromones - chemistry | Coumarins - pharmacology | Coumarins - analysis | Substrate Specificity - drug effects | Anti-Infective Agents - analysis | Molecular Docking Simulation | Kinetics | Metabolic Networks and Pathways - drug effects | Isoenzymes - antagonists & inhibitors | Index Medicus
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 06/2000, Volume 273, Issue 1, pp. 333 - 341
Human hepatocytes cultured serum-free for up to 6 weeks were used to study expression and induction of enzymes and membrane transport proteins involved in drug... 
P-glycoprotein | human hepatocytes | barbiturates | Cytochrome P450 | aromatic hydrocarbons | multidrug-resistance-associated protein | antibiotics | Antibiotics | Human hepatocytes | Aromatic hydrocarbons | Barbiturates | Multidrug-resistance-associated protein | CANALICULAR MEMBRANE | RAT HEPATOCYTES | BIOCHEMISTRY & MOLECULAR BIOLOGY | cytochrome P450 | PRIMARY CULTURES | IDENTIFICATION | BIOPHYSICS | METABOLISM | GENE FAMILY | GROWTH-FACTOR | EXPRESSION | HUMAN-LIVER | Cytochrome P-450 CYP2C9 | Isoenzymes - analysis | Mixed Function Oxygenases - biosynthesis | Phenobarbital - pharmacology | Steroid Hydroxylases - metabolism | Liver - enzymology | Cytochrome P-450 CYP3A | Humans | Vault Ribonucleoprotein Particles - genetics | Cytochrome P-450 Enzyme System - metabolism | Mixed Function Oxygenases - metabolism | Cytochrome P-450 CYP2E1 - metabolism | Steroid 16-alpha-Hydroxylase | Hepatocyte Growth Factor - pharmacology | RNA, Messenger - metabolism | Methylcholanthrene - pharmacology | ATP-Binding Cassette Transporters - genetics | Liver - drug effects | beta-Naphthoflavone - pharmacology | ATP Binding Cassette Transporter, Subfamily B, Member 1 - analysis | Enzyme Induction - drug effects | Neoplasm Proteins - genetics | Cytochrome P-450 Enzyme System - analysis | Liver - ultrastructure | Cell Size - drug effects | RNA, Messenger - genetics | Cells, Cultured | Cytochrome P-450 CYP1A1 - metabolism | Cytochrome P-450 CYP1A2 - metabolism | Blotting, Western | ATP Binding Cassette Transporter, Subfamily B, Member 1 - genetics | ATP-Binding Cassette Transporters - analysis | Cytochrome P-450 CYP1A2 - biosynthesis | Cytochrome P-450 CYP2C19 | Cytochrome P-450 Enzyme System - biosynthesis | Liver - cytology | Cytochrome P-450 CYP1A1 - biosynthesis | Epidermal Growth Factor - pharmacology | Rifampin - pharmacology | Isoenzymes - biosynthesis | Aryl Hydrocarbon Hydroxylases | Multidrug Resistance-Associated Proteins | Index Medicus
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