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Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 07/2007, Volume 35, Issue 7, pp. 1032 - 1041
In our study, we tested the hypothesis whether valproic acid (VPA) in therapeutic concentrations has potential to affect expression of CYP3A4 and MDR1 via... 
INTESTINAL MDR1 | RAT-LIVER | ENHANCER MODULE | HUMAN HEPATOCYTES | CYP2B GENE | CELL LINES | PHARMACOLOGY & PHARMACY | ANTIEPILEPTIC DRUGS | TRANSCRIPTIONAL REGULATION | HISTONE DEACETYLASE | NUCLEAR RECEPTOR | Transcription, Genetic - drug effects | Up-Regulation | Oxidoreductases, N-Demethylating - genetics | Receptors, Steroid - metabolism | Retinoid X Receptor alpha - metabolism | Cytochrome P-450 CYP3A | Humans | Transcriptional Activation - drug effects | Aryl Hydrocarbon Hydroxylases - genetics | Hepatocytes - metabolism | Promoter Regions, Genetic - drug effects | RNA, Messenger - metabolism | Anticonvulsants - pharmacology | Valproic Acid - pharmacology | Transcription Factors - drug effects | Testosterone - metabolism | Transfection | Luciferases | Electrophoretic Mobility Shift Assay | Genes, Reporter | Hepatocytes - drug effects | ATP Binding Cassette Transporter, Subfamily B, Member 1 - biosynthesis | Hydroxylation | Receptors, Cytoplasmic and Nuclear - drug effects | Enzyme Induction | Retinoid X Receptor alpha - drug effects | Receptors, Steroid - drug effects | Reverse Transcriptase Polymerase Chain Reaction | ATP Binding Cassette Transporter, Subfamily B, Member 1 - genetics | Drug Synergism | Transcription Factors - metabolism | Cell Line, Tumor | Cytochrome P-450 Enzyme System - biosynthesis | Cytochrome P-450 Enzyme System - genetics | Oximes - pharmacology | Thiazoles - pharmacology | Rifampin - pharmacology | Pregnane X Receptor | Cytochrome P-450 CYP2B6 | Hepatocytes - enzymology | Receptors, Cytoplasmic and Nuclear - metabolism
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 07/2012, Volume 84, Issue 1, pp. 93 - 103
Pregnancy alters the rate and extent of drug metabolism, but little is known about the underlying molecular mechanism. We have found that 17β-estradiol (E2)... 
Pregnancy | Nuclear receptors | Estradiol | Cytochrome P450 2B6 | Cytochrome P450 286 | PROTEIN | MECHANISM | ALPHA | X-RECEPTOR | NUCLEAR TRANSLOCATION | TARGET GENES | CAR | CONSTITUTIVE ANDROSTANE RECEPTOR | CYP2B GENE | PHARMACOLOGY & PHARMACY | DRUG-METABOLISM | Estradiol - blood | Gene Expression Regulation, Enzymologic - drug effects | Oxidoreductases, N-Demethylating - genetics | Receptors, Estrogen - metabolism | Estrogens - pharmacology | Oligonucleotide Array Sequence Analysis | Transcription Factor AP-1 - genetics | Humans | Middle Aged | Transcriptional Activation | Aryl Hydrocarbon Hydroxylases - genetics | Gene Expression Profiling | Chromatography, High Pressure Liquid | Estrogens - blood | Transcription Factor AP-1 - metabolism | Luciferases - genetics | Pregnancy - genetics | Dose-Response Relationship, Drug | Tandem Mass Spectrometry | Cell Nucleus - metabolism | Chromatin Immunoprecipitation | Adult | Female | Electrophoretic Mobility Shift Assay | Oxidoreductases, N-Demethylating - metabolism | Binding Sites | Real-Time Polymerase Chain Reaction | Estradiol - pharmacology | Genes, Reporter | Hepatocytes - drug effects | Promoter Regions, Genetic | Receptors, Estrogen - genetics | Nuclear Proteins - metabolism | Receptors, Cytoplasmic and Nuclear - genetics | Aryl Hydrocarbon Hydroxylases - metabolism | Hep G2 Cells | Pregnancy - blood | Cytochrome P-450 CYP2B6 | Hepatocytes - enzymology | Receptors, Cytoplasmic and Nuclear - metabolism | Pregnant women | Genes | Estrogen | Cytochrome P-450 | Phenols | Hormones, Sex | Enzymes | Cytochrome P450 | Gene regulation | Estrogen receptors | Data processing | Gene deletion | Nuclear transport | Promoters | Molecular modelling | Hepatocytes | Electrophoretic mobility | Drug metabolism | Mutation | nuclear receptors | pregnancy | estradiol
Journal Article
Journal Article
Molecular Pharmacology, ISSN 0026-895X, 12/2000, Volume 58, Issue 6, pp. 1441 - 1450
Journal Article
by Ning, R and Zhan, YR and He, SC and Hu, JH and Zhu, Z and Hu, G and Yan, BF and Yang, J and Liu, W
FRONTIERS IN PHARMACOLOGY, ISSN 1663-9812, 11/2017, Volume 8, p. 866
Inflammatory burden is a primary cellular event in many liver diseases, and the overall capacity of drug elimination is decreased. PXR (pregnane X receptor)... 
CELLS | ENHANCER MODULE | TRANSCRIPTION | DOWN-REGULATION | target genes | PREGNANE-X-RECEPTOR | interleukin-6 | hepatocytes | NUCLEAR RECEPTOR | DEC1 | PROXIMAL PROMOTER | CYP2B GENE | LIVER | PXR/CAR | PHARMACOLOGY & PHARMACY
Journal Article
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 2007, Volume 218, Issue 1, pp. 37 - 44
Journal Article
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 03/2012, Volume 679, Issue 1-3, pp. 139 - 143
Journal Article
CURRENT DRUG METABOLISM, ISSN 1389-2002, 12/2003, Volume 4, Issue 6, pp. 515 - 525
Journal Article
Frontiers in Pharmacology, ISSN 1663-9812, 10/2018, Volume 9, p. 993
The constitutive androstane receptor (CAR) is a nuclear receptor involved mainly in xenobiotic and endobiotic metabolism regulation. CAR is activated directly... 
Nuclear receptor | Metabolism | CAR | Cytochrome P450 | Gene regulation | HEPATIC GLUCONEOGENESIS | CELLS | TYROSINE KINASE | ACTIVE/ANDROSTANE RECEPTOR | GENE-REGULATION | cytochrome P450 | PREGNANE-X-RECEPTOR | gene regulation | HUMAN HEPATOCYTES | CYP2B GENE | nuclear receptor | PHARMACOLOGY & PHARMACY | metabolism | EXPRESSION | Physiological aspects | Epidermal growth factor
Journal Article