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11/2013
Background: The cytochrome P450 enzymes (CYP) play an important role in the metabolism of many therapeutic agents. The activities of different enzymes exhibit... 
CYP2C8 | CYP2B6 | polymorphism | allele frequency
Web Resource
Biochemistry, ISSN 0006-2960, 02/2018, Volume 57, Issue 5, pp. 817 - 826
Human hepatic cytochromes P450 (CYP)' are integral to xenobiotic metabolism. CYP2B6 is a major catalyst of biotransformation of environmental toxicants,... 
SIDE-CHAINS | ACTIVE-SITE | STRUCTURAL BASIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | MAMMALIAN CYTOCHROME-P450 | LIVER-MICROSOMES | HUMAN CYTOCHROME-P450 2B6 | SITE-DIRECTED MUTAGENESIS | OXIDATIVE-METABOLISM | DRUG-METABOLISM | Cytochrome P-450 CYP2B1 - genetics | Aniline Compounds | Humans | Aryl Hydrocarbon Hydroxylases - genetics | NADPH Oxidases - metabolism | Substrate Specificity | Cytochrome P-450 Enzyme Inhibitors - metabolism | Structure-Activity Relationship | Environmental Pollutants - metabolism | Cytochromes b5 - metabolism | Cytochrome P-450 CYP2B6 - metabolism | Cytochrome P-450 CYP2B6 Inhibitors - metabolism | Cytochrome P-450 CYP2B6 - drug effects | Hydrocarbons, Halogenated - metabolism | Cytochrome P-450 CYP2B1 - chemistry | Cytochrome P450 Family 2 - genetics | Inhibitory Concentration 50 | Cytochrome P-450 CYP2B1 - metabolism | Molecular Structure | Aryl Hydrocarbon Hydroxylases - chemistry | Benzene Derivatives - pharmacology | Cytochrome P450 Family 2 - antagonists & inhibitors | Recombinant Proteins - metabolism | Rabbits | Aryl Hydrocarbon Hydroxylases - antagonists & inhibitors | Mutagenesis, Site-Directed | Oxidation-Reduction | Cytochrome P-450 CYP2B6 - genetics | Halogenated Diphenyl Ethers - pharmacology | Rats | Cytochrome P450 Family 2 - chemistry | Cytochrome P-450 CYP2B1 - antagonists & inhibitors | Aryl Hydrocarbon Hydroxylases - metabolism | Cytochrome P-450 CYP2B6 Inhibitors - pharmacology | Halogenated Diphenyl Ethers - metabolism | Cytochrome P-450 Enzyme Inhibitors - pharmacology | Animals | Cytochrome P450 Family 2 - metabolism | Alkylation - drug effects | Cytochrome P-450 CYP2B6 - chemistry | Amino Acid Substitution | Research | Chemical properties | Aniline | Cytochrome P-450 | Index Medicus
Journal Article
The Journal of Clinical Pharmacology, ISSN 0091-2700, 12/2016, Volume 56, Issue 12, pp. 1538 - 1549
Journal Article
Journal Article
Journal Article
11/2010
Nicotine is the primary substance in tobacco causing addiction. In humans the majority (70-80%) of nicotine is inactivated to cotinine in a reaction... 
CYP2A6 | Pharmacogenetics | CYP2B6 | 0419 | Nicotine
Dissertation
Therapeutic Drug Monitoring, ISSN 0163-4356, 01/2015, Volume 37, Issue 5, pp. 589 - 593
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2015, Volume 10, Issue 6, pp. e0130583 - e0130583
Objectives The main aim of this study was to investigate the effect of CYP2B6 gene polymorphisms on efavirenz (EFV) plasma concentrations in Han Chinese... 
POPULATION | THERAPY | PHARMACOKINETICS | ALLELE FREQUENCIES | MULTIDISCIPLINARY SCIENCES | HAPLOTYPE STRUCTURE | PHARMACOGENETICS | SOUTHERN CHINESE | NEVIRAPINE | CYTOCHROME P4502B6 GENE | ADVERSE EVENTS | Reverse Transcriptase Inhibitors - blood | Humans | Middle Aged | Asian Continental Ancestry Group - genetics | Male | Cytochrome P-450 CYP2B6 - metabolism | Young Adult | Haplotypes - genetics | Reverse Transcriptase Inhibitors - pharmacokinetics | Benzoxazines - pharmacokinetics | China | Adult | Anti-HIV Agents - therapeutic use | Benzoxazines - blood | Female | Anti-HIV Agents - blood | Reverse Transcriptase Inhibitors - therapeutic use | Drug Therapy, Combination | HIV Infections - blood | Cytochrome P-450 CYP2B6 - genetics | Cytochrome P-450 CYP2B6 Inducers - blood | Gene Frequency | HIV Infections - genetics | Genotype | Benzoxazines - therapeutic use | Cytochrome P-450 CYP2B6 Inducers - pharmacokinetics | Anti-HIV Agents - pharmacokinetics | Adolescent | Alleles | HIV Infections - drug therapy | Aged | Inactivation, Metabolic - genetics | Polymorphism, Single Nucleotide | Drug Monitoring | Antiviral agents | Ligases | Analysis | Genes | Cytochrome P-450 | HIV patients | Single nucleotide polymorphisms | HIV (Viruses) | Health aspects | HIV infection | High performance liquid chromatography | Haplotypes | Antiretroviral drugs | Statistical analysis | Linkage disequilibrium | Viruses | Infections | Single-nucleotide polymorphism | Liquid chromatography | High-performance liquid chromatography | Patients | Efavirenz | Genotyping | Acquired immune deficiency syndrome--AIDS | Protease inhibitors | Human immunodeficiency virus--HIV | CYP2B6 gene | Index Medicus | AIDS | HIV | Acquired immune deficiency syndrome | Human immunodeficiency virus
Journal Article
Journal Article
Journal Article