UofT Libraries is getting a new library services platform in January 2021.
Learn more about the change.
Search Articles
The Journal of biological chemistry, ISSN 0021-9258, 02/2015, Volume 290, Issue 8, pp. 5092 - 5104
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Cytochrome P-450 CYP2D6 - genetics | Catalytic Domain | Cytochrome P-450 CYP2D6 Inhibitors - chemistry | Secologanin Tryptamine Alkaloids - chemistry | Hydrogen Bonding | Humans | Cytochrome P-450 CYP2D6 - chemistry | Organic Chemicals - chemistry | Crystallography, X-Ray | Molecular Dynamics Simulation | Index Medicus | Protein Structure and Folding | Crystal Structure | Thioridazine | Cytochrome P450 | Quinidine | Drug Metabolism | Protein Structure | Cytochrome P450 2D6 (CYP2D6) | Quinine | Ajmalicine | Enzyme Inhibitor
Journal Article
Journal of clinical pharmacology, ISSN 0091-2700, 06/2018, Volume 58, Issue 6, pp. 750 - 761
Pain perception | Narcotics | Opioid receptors | Body weight | Cytochrome P450 | Arrestin | Pharmacology | Recruitment | Proteins | Analgesia | Receptors | Pain | Ligands | Mathematical models | Coupling | Pharmacokinetics | CYP2D6 protein | Index Medicus
Journal Article
Molecular pharmacology, ISSN 0026-895X, 05/2012, Volume 81, Issue 5, pp. 739 - 747
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Cytochrome P-450 CYP2D6 - genetics | Basic Helix-Loop-Helix Transcription Factors - physiology | CLOCK Proteins - physiology | Time Factors | CCAAT-Enhancer-Binding Protein-alpha - physiology | Humans | RNA, Messenger - analysis | Serum | Circadian Rhythm | Hepatocyte Nuclear Factor 4 - physiology | Hep G2 Cells | Index Medicus
Journal Article
Journal of medicinal chemistry, ISSN 0022-2623, 05/1999, Volume 42, Issue 9, pp. 1515 - 1524
Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Biological and medical sciences | Medical sciences | General pharmacology | Pharmacology. Drug treatments | Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions | Amino Acid Sequence | Pharmaceutical Preparations - metabolism | Quantum Theory | Molecular Conformation | Cytochrome P-450 CYP2D6 - chemistry | Cytochrome P-450 CYP2D6 - metabolism | Models, Molecular | Molecular Sequence Data | Ligands | Protein Conformation | Structure-Activity Relationship | Binding Sites | Index Medicus
Journal Article
Basic & clinical pharmacology & toxicology, ISSN 1742-7835, 10/2017, Volume 121, Issue 4, pp. 334 - 341
Pharmacology & Pharmacy | Toxicology | Life Sciences & Biomedicine | Science & Technology | Activation, Metabolic | Sesquiterpenes - metabolism | Apoptosis - drug effects | Humans | Dose-Response Relationship, Drug | Carcinoma, Hepatocellular - drug therapy | Time Factors | Carcinoma, Hepatocellular - genetics | Apoptosis Regulatory Proteins - genetics | Cell Cycle Proteins - genetics | Liver Neoplasms - pathology | Antineoplastic Agents, Phytogenic - metabolism | Liver Neoplasms - enzymology | Endoplasmic Reticulum Stress - drug effects | Liver Neoplasms - genetics | Oxidation-Reduction | Cell Cycle Proteins - metabolism | Liver Neoplasms - drug therapy | Carcinoma, Hepatocellular - enzymology | Cytochrome P-450 CYP1A2 - metabolism | Apoptosis Regulatory Proteins - metabolism | Hep G2 Cells | Carcinoma, Hepatocellular - pathology | Cytochrome P-450 CYP2C19 - metabolism | Cell Proliferation - drug effects | Sesquiterpenes - pharmacology | Antineoplastic Agents, Phytogenic - pharmacology | G1 Phase Cell Cycle Checkpoints - drug effects | Cell death | Cytochrome P-450 | Physiological aspects | Biochemistry | Stress (Physiology) | Hepatoma | Tumor proteins | Xenobiotics | Gene expression | Cell proliferation | Membranes | Bax protein | Toxicity | Genes | Genotoxicity | Cytotoxicity | Hepatocellular carcinoma | Myc protein | Kinases | Phase transitions | Anticancer properties | Proteins | Liver cancer | Mitochondria | Cell growth | Nerolidol | Cell cycle | Oxidation | Membrane potential | CYP2D6 protein | G1 phase | Cytochromes P450 | Enzymes | Cell survival | Cytochrome P450 | Caspase | CYP1A2 protein | Metabolism | Survival | Cyclins | Cyclin-dependent kinase 2 | Endoplasmic reticulum | Apoptosis | Index Medicus
Journal Article
Drug metabolism and disposition, ISSN 0090-9556, 08/2009, Volume 37, Issue 8, pp. 1682 - 1689
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Biological and medical sciences | Pharmacology. Drug treatments | Medical sciences | Cytochrome P-450 CYP2C9 | Catalytic Domain | Biocatalysis | NADPH-Ferrihemoprotein Reductase - metabolism | Hydroxylation | Dealkylation | Humans | Substrate Specificity | Dextromethorphan - metabolism | Aryl Hydrocarbon Hydroxylases - metabolism | Dextrorphan - metabolism | Models, Biological | Cytochrome P-450 CYP2D6 - metabolism | Kinetics | Spectrum Analysis | Binding Sites | Flurbiprofen - metabolism | Flurbiprofen - analogs & derivatives | Index Medicus
Journal Article
The FEBS journal, ISSN 1742-464X, 03/2014, Volume 281, Issue 5, pp. 1379 - 1392
hepatocyte nuclear factor 4α (HNF4α) | chicken | CCAAT/enhancer‐binding protein α (C/EBPα) | transcriptional regulation | cytochrome P450 (CYP) 2D49 | CCAAT/enhancer-binding protein α (C/EBPα) | hepatocyte nuclear factor 4α (HNF4α) | cytochrome P450 (CYP) 2D49 | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Cytochrome P-450 CYP2D6 - genetics | Hepatocyte Nuclear Factor 4 - metabolism | Promoter Regions, Genetic | Sequence Deletion | Avian Proteins - metabolism | CCAAT-Enhancer-Binding Protein-alpha - metabolism | Humans | Liver - metabolism | Transcriptional Activation | Cytochrome P-450 Enzyme System - metabolism | Molecular Sequence Data | Binding Sites - genetics | DNA - genetics | Gene Expression Regulation, Enzymologic | Animals | Regulatory Elements, Transcriptional | Base Sequence | Chickens | Cytochrome P-450 CYP2D6 - metabolism | Cytochrome P-450 Enzyme System - genetics | Mutation | Avian Proteins - genetics | Index Medicus
Journal Article
Journal of clinical pharmacology, ISSN 0091-2700, 06/2018, Volume 58, Issue 6, pp. 762 - 770
Pain perception | Computer simulation | Narcotics | Opioid receptors | Cytochrome P450 | Morphine | Arrestin | Pharmacology | Patients | Proteins | Analgesia | Pain | Metabolites | Simulation | Ligands | Mathematical models | Genotypes | CYP2D6 protein | Index Medicus
Journal Article
International journal of molecular sciences, ISSN 1422-0067, 2013, Volume 14, Issue 12, pp. 24514 - 24530
CYP 2D6 | Binding free energies | Thiourea ligands | LIE method | Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Protein Structure, Tertiary | Thiourea - metabolism | Thermodynamics | Cytochrome P-450 CYP2D6 - chemistry | Cytochrome P-450 CYP2D6 - metabolism | Models, Molecular | Protein Binding | Ligands | Thiourea - chemistry | Molecular Dynamics Simulation | Index Medicus | binding free energies | thiourea ligands
Journal Article
Drug metabolism and disposition, ISSN 0090-9556, 06/2011, Volume 39, Issue 6, pp. 974 - 983
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Biological and medical sciences | Pharmacology. Drug treatments | Medical sciences | Cytochrome P-450 CYP2D6 Inhibitors | Cytochrome P-450 CYP2D6 - genetics | Recombinant Proteins - antagonists & inhibitors | Humans | Cytochrome P-450 CYP2D6 - chemistry | Enzyme Inhibitors - pharmacology | Imidazoles - chemistry | Models, Molecular | Recombinant Proteins - chemistry | Imidazoles - pharmacology | Recombinant Proteins - genetics | Chromatography, High Pressure Liquid | Pyrimidines - pharmacology | Pyrimidines - chemistry | Heme - chemistry | Escherichia coli - genetics | Enzyme Inhibitors - chemistry | Protein Binding | Index Medicus
Journal Article
Molecular pharmaceutics, ISSN 1543-8384, 08/2016, Volume 13, Issue 8, pp. 2631 - 2640
morbid obesity | transporter | UGT2B17 | small intestine | CYP | BCRP/ABCG2 | drug-metabolizing enzymes | OATP2B1 | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Glucose Transporter Type 5 - metabolism | Peptide Transporter 1 | Humans | Cytochrome P-450 Enzyme System - metabolism | Male | Neoplasm Proteins - metabolism | ATP Binding Cassette Transporter, Sub-Family G, Member 2 - metabolism | Glucose Transporter Type 2 - metabolism | Organic Anion Transporters - metabolism | Jejunum - metabolism | Minor Histocompatibility Antigens - metabolism | Glucuronosyltransferase - metabolism | Cytochrome P-450 CYP3A - metabolism | Symporters | Cytochrome P-450 CYP2D6 - metabolism | Female | Sodium-Glucose Transporter 1 - metabolism | Intestine, Small - metabolism | In Vitro Techniques | Obesity, Morbid - metabolism | Cytochrome P-450 CYP2C9 - metabolism | Index Medicus
Journal Article