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1. Full Text Contributions of ionic interactions and protein dynamics to cytochrome P450 2D6 (CYP2D6) substrate and inhibitor binding
by Wang, An and Stout, C. David and Zhang, Qinghai and Johnson, Eric F
The Journal of biological chemistry, ISSN 0021-9258, 02/2015, Volume 290, Issue 8, pp. 5092 - 5104
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Cytochrome P-450 CYP2D6 - genetics | Catalytic Domain | Cytochrome P-450 CYP2D6 Inhibitors - chemistry | Secologanin Tryptamine Alkaloids - chemistry | Hydrogen Bonding | Humans | Cytochrome P-450 CYP2D6 - chemistry | Organic Chemicals - chemistry | Crystallography, X-Ray | Molecular Dynamics Simulation | Index Medicus | Protein Structure and Folding | Crystal Structure | Thioridazine | Cytochrome P450 | Quinidine | Drug Metabolism | Protein Structure | Cytochrome P450 2D6 (CYP2D6) | Quinine | Ajmalicine | Enzyme Inhibitor
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2. Full Text Oliceridine (TRV130), a Novel G Protein–Biased Ligand at the μ‐Opioid Receptor, Demonstrates a Predictable Relationship Between Plasma Concentrations and Pain Relief. I: Development of a Pharmacokinetic/Pharmacodynamic Model
by Fossler, Michael J and Sadler, Brian M and Farrell, Colm and Burt, David A and Pitsiu, Maria and Skobieranda, Franck and Soergel, David G
Journal of clinical pharmacology, ISSN 0091-2700, 06/2018, Volume 58, Issue 6, pp. 750 - 761
Pain perception | Narcotics | Opioid receptors | Body weight | Cytochrome P450 | Arrestin | Pharmacology | Recruitment | Proteins | Analgesia | Receptors | Pain | Ligands | Mathematical models | Coupling | Pharmacokinetics | CYP2D6 protein | Index Medicus
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3. Full Text Time-dependent interaction between differentiated embryo chondrocyte-2 and CCAAT/enhancer-binding protein α underlies the circadian expression of CYP2D6 in serum- shocked HepG2 cells
by Matsunaga, Naoya and Inoue, Miki and Kusunose, Naoki and Kakimoto, Keisuke and Hamamura, Kengo and Hanada, Yuichi and Toi, Ayumi and Yoshiyama, Yuji and Sato, Fuyuki and Fujimoto, Katsumi and Koyanagi, Satoru and Ohdo, Shigehiro
Molecular pharmacology, ISSN 0026-895X, 05/2012, Volume 81, Issue 5, pp. 739 - 747
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Cytochrome P-450 CYP2D6 - genetics | Basic Helix-Loop-Helix Transcription Factors - physiology | CLOCK Proteins - physiology | Time Factors | CCAAT-Enhancer-Binding Protein-alpha - physiology | Humans | RNA, Messenger - analysis | Serum | Circadian Rhythm | Hepatocyte Nuclear Factor 4 - physiology | Hep G2 Cells | Index Medicus
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4. Full Text Novel Approach To Predicting P450-Mediated Drug Metabolism:  Development of a Combined Protein and Pharmacophore Model for CYP2D6
by de Groot, Marcel J and Ackland, Mark J and Horne, Valerie A and Alex, Alexander A and Jones, Barry C
Journal of medicinal chemistry, ISSN 0022-2623, 05/1999, Volume 42, Issue 9, pp. 1515 - 1524
Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Biological and medical sciences | Medical sciences | General pharmacology | Pharmacology. Drug treatments | Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions | Amino Acid Sequence | Pharmaceutical Preparations - metabolism | Quantum Theory | Molecular Conformation | Cytochrome P-450 CYP2D6 - chemistry | Cytochrome P-450 CYP2D6 - metabolism | Models, Molecular | Molecular Sequence Data | Ligands | Protein Conformation | Structure-Activity Relationship | Binding Sites | Index Medicus
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5. Full Text Cis‐Nerolidol Induces Endoplasmic Reticulum Stress and Cell Death in Human Hepatocellular Carcinoma Cells through Extensive CYP2C19 and CYP1A2 Oxidation
by Biazi, Bruna Isabela and Zanetti, Thalita Alves and Baranoski, Adrivanio and Corveloni, Amanda Cristina and Mantovani, Mário Sérgio
Basic & clinical pharmacology & toxicology, ISSN 1742-7835, 10/2017, Volume 121, Issue 4, pp. 334 - 341
Pharmacology & Pharmacy | Toxicology | Life Sciences & Biomedicine | Science & Technology | Activation, Metabolic | Sesquiterpenes - metabolism | Apoptosis - drug effects | Humans | Dose-Response Relationship, Drug | Carcinoma, Hepatocellular - drug therapy | Time Factors | Carcinoma, Hepatocellular - genetics | Apoptosis Regulatory Proteins - genetics | Cell Cycle Proteins - genetics | Liver Neoplasms - pathology | Antineoplastic Agents, Phytogenic - metabolism | Liver Neoplasms - enzymology | Endoplasmic Reticulum Stress - drug effects | Liver Neoplasms - genetics | Oxidation-Reduction | Cell Cycle Proteins - metabolism | Liver Neoplasms - drug therapy | Carcinoma, Hepatocellular - enzymology | Cytochrome P-450 CYP1A2 - metabolism | Apoptosis Regulatory Proteins - metabolism | Hep G2 Cells | Carcinoma, Hepatocellular - pathology | Cytochrome P-450 CYP2C19 - metabolism | Cell Proliferation - drug effects | Sesquiterpenes - pharmacology | Antineoplastic Agents, Phytogenic - pharmacology | G1 Phase Cell Cycle Checkpoints - drug effects | Cell death | Cytochrome P-450 | Physiological aspects | Biochemistry | Stress (Physiology) | Hepatoma | Tumor proteins | Xenobiotics | Gene expression | Cell proliferation | Membranes | Bax protein | Toxicity | Genes | Genotoxicity | Cytotoxicity | Hepatocellular carcinoma | Myc protein | Kinases | Phase transitions | Anticancer properties | Proteins | Liver cancer | Mitochondria | Cell growth | Nerolidol | Cell cycle | Oxidation | Membrane potential | CYP2D6 protein | G1 phase | Cytochromes P450 | Enzymes | Cell survival | Cytochrome P450 | Caspase | CYP1A2 protein | Metabolism | Survival | Cyclins | Cyclin-dependent kinase 2 | Endoplasmic reticulum | Apoptosis | Index Medicus
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6. Full Text CYP2D6-CYP2C9 Protein-Protein Interactions and Isoform-Selective Effects on Substrate Binding and Catalysis
by Murali Subramanian and Michael Low and Charles W. Locuson and Timothy S. Tracy
Drug metabolism and disposition, ISSN 0090-9556, 08/2009, Volume 37, Issue 8, pp. 1682 - 1689
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Biological and medical sciences | Pharmacology. Drug treatments | Medical sciences | Cytochrome P-450 CYP2C9 | Catalytic Domain | Biocatalysis | NADPH-Ferrihemoprotein Reductase - metabolism | Hydroxylation | Dealkylation | Humans | Substrate Specificity | Dextromethorphan - metabolism | Aryl Hydrocarbon Hydroxylases - metabolism | Dextrorphan - metabolism | Models, Biological | Cytochrome P-450 CYP2D6 - metabolism | Kinetics | Spectrum Analysis | Binding Sites | Flurbiprofen - metabolism | Flurbiprofen - analogs & derivatives | Index Medicus
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7. Full Text Transcriptional regulation of chicken cytochrome P450 2D49 basal expression by CCAAT/enhancer‐binding protein α and hepatocyte nuclear factor 4α
by Yang, Qi and Tang, Shulin and Dong, Linfeng and Chen, Qingmei and Liu, Xin and Jiang, Jun and Deng, Yiqun
The FEBS journal, ISSN 1742-464X, 03/2014, Volume 281, Issue 5, pp. 1379 - 1392
hepatocyte nuclear factor 4α (HNF4α) | chicken | CCAAT/enhancer‐binding protein α (C/EBPα) | transcriptional regulation | cytochrome P450 (CYP) 2D49 | CCAAT/enhancer-binding protein α (C/EBPα) | hepatocyte nuclear factor 4α (HNF4α) | cytochrome P450 (CYP) 2D49 | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Cytochrome P-450 CYP2D6 - genetics | Hepatocyte Nuclear Factor 4 - metabolism | Promoter Regions, Genetic | Sequence Deletion | Avian Proteins - metabolism | CCAAT-Enhancer-Binding Protein-alpha - metabolism | Humans | Liver - metabolism | Transcriptional Activation | Cytochrome P-450 Enzyme System - metabolism | Molecular Sequence Data | Binding Sites - genetics | DNA - genetics | Gene Expression Regulation, Enzymologic | Animals | Regulatory Elements, Transcriptional | Base Sequence | Chickens | Cytochrome P-450 CYP2D6 - metabolism | Cytochrome P-450 Enzyme System - genetics | Mutation | Avian Proteins - genetics | Index Medicus
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8. Full Text Oliceridine, a Novel G Protein–Biased Ligand at the μ‐Opioid Receptor, Demonstrates a Predictable Relationship Between Plasma Concentrations and Pain Relief. II: Simulation of Potential Phase 3 Study Designs Using a Pharmacokinetic/Pharmacodynamic Model
by Fossler, Michael J and Sadler, Brian M and Farrell, Colm and Burt, David A and Pitsiu, Maria and Skobieranda, Franck and Soergel, David G
Journal of clinical pharmacology, ISSN 0091-2700, 06/2018, Volume 58, Issue 6, pp. 762 - 770
Pain perception | Computer simulation | Narcotics | Opioid receptors | Cytochrome P450 | Morphine | Arrestin | Pharmacology | Patients | Proteins | Analgesia | Pain | Metabolites | Simulation | Ligands | Mathematical models | Genotypes | CYP2D6 protein | Index Medicus
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9. Full Text CYP 2D6 Binding Affinity Predictions Using Multiple Ligand and Protein Conformations
by Peric-Hassler, L and Stjernschantz, E.M and Oostenbrink, B.C and Geerke, D.P
International journal of molecular sciences, ISSN 1422-0067, 2013, Volume 14, Issue 12, pp. 24514 - 24530
CYP 2D6 | Binding free energies | Thiourea ligands | LIE method | Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Protein Structure, Tertiary | Thiourea - metabolism | Thermodynamics | Cytochrome P-450 CYP2D6 - chemistry | Cytochrome P-450 CYP2D6 - metabolism | Models, Molecular | Protein Binding | Ligands | Thiourea - chemistry | Molecular Dynamics Simulation | Index Medicus | binding free energies | thiourea ligands
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10. Full Text Substituted imidazole of 5-fluoro-2-[4-[(2-phenyl-1H-imidazol-5-yl)methyl]- 1-piperazinyl]pyrimidine inactivates cytochrome P450 2D6 by protein adduction
by Nagy, Leslie D and Mocny, Catherine S and Diffenderfer, Laura E and Hsi, David J and Butler, Brendan F and Arthur, Evan J and Fletke, Kyle J and Palamanda, Jairam R and Nomeir, Amin A and Furge, Laura Lowe
Drug metabolism and disposition, ISSN 0090-9556, 06/2011, Volume 39, Issue 6, pp. 974 - 983
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Biological and medical sciences | Pharmacology. Drug treatments | Medical sciences | Cytochrome P-450 CYP2D6 Inhibitors | Cytochrome P-450 CYP2D6 - genetics | Recombinant Proteins - antagonists & inhibitors | Humans | Cytochrome P-450 CYP2D6 - chemistry | Enzyme Inhibitors - pharmacology | Imidazoles - chemistry | Models, Molecular | Recombinant Proteins - chemistry | Imidazoles - pharmacology | Recombinant Proteins - genetics | Chromatography, High Pressure Liquid | Pyrimidines - pharmacology | Pyrimidines - chemistry | Heme - chemistry | Escherichia coli - genetics | Enzyme Inhibitors - chemistry | Protein Binding | Index Medicus
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11. Full Text Quantitative Atlas of Cytochrome P450, UDP-Glucuronosyltransferase, and Transporter Proteins in Jejunum of Morbidly Obese Subjects
by Miyauchi, Eisuke and Tachikawa, Masanori and Declèves, Xavier and Uchida, Yasuo and Bouillot, Jean-Luc and Poitou, Christine and Oppert, Jean-Michel and Mouly, Stéphane and Bergmann, Jean-François and Terasaki, Tetsuya and Scherrmann, Jean-Michel and Lloret-Linares, Célia
Molecular pharmaceutics, ISSN 1543-8384, 08/2016, Volume 13, Issue 8, pp. 2631 - 2640
morbid obesity | transporter | UGT2B17 | small intestine | CYP | BCRP/ABCG2 | drug-metabolizing enzymes | OATP2B1 | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Glucose Transporter Type 5 - metabolism | Peptide Transporter 1 | Humans | Cytochrome P-450 Enzyme System - metabolism | Male | Neoplasm Proteins - metabolism | ATP Binding Cassette Transporter, Sub-Family G, Member 2 - metabolism | Glucose Transporter Type 2 - metabolism | Organic Anion Transporters - metabolism | Jejunum - metabolism | Minor Histocompatibility Antigens - metabolism | Glucuronosyltransferase - metabolism | Cytochrome P-450 CYP3A - metabolism | Symporters | Cytochrome P-450 CYP2D6 - metabolism | Female | Sodium-Glucose Transporter 1 - metabolism | Intestine, Small - metabolism | In Vitro Techniques | Obesity, Morbid - metabolism | Cytochrome P-450 CYP2C9 - metabolism | Index Medicus
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12. Full Text Evaluation of CYP2D6 Protein Expression and Activity in the Small Intestine to Determine Its Metabolic Capability in the Japanese Population
by Kawakami, Momoko and Takenoshita-Nakaya, Sachiko and