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1. Full Text Assessment of inter-racial variability in CYP3A4 activity and inducibility among healthy adult males of Caucasian and South Asian ancestries
by van Dyk, Madelé and Marshall, Jean-Claude and Sorich, Michael J and Wood, Linda S and Rowland, Andrew
European journal of clinical pharmacology, ISSN 0031-6970, 7/2018, Volume 74, Issue 7, pp. 913 - 920
Biomedicine | Inter-racial variability | Caucasian | South Asian | Pharmacology/Toxicology | Pharmacokinetics | Inducibility | Cytochrome P450 3A4 | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Rifampin - pharmacokinetics | Cytochrome P-450 CYP3A Inhibitors - pharmacology | Rifampin - blood | Area Under Curve | Humans | Asian Continental Ancestry Group - genetics | Cytochrome P-450 CYP3A Inhibitors - pharmacokinetics | Male | Cytochrome P-450 CYP3A Inducers - blood | Clarithromycin - blood | Young Adult | Cytochrome P-450 CYP3A - genetics | Clarithromycin - pharmacokinetics | Cytochrome P-450 CYP3A Inducers - pharmacokinetics | Adult | Continental Population Groups | European Continental Ancestry Group - genetics | Cytochrome P-450 CYP3A Inhibitors - blood | Enzyme Induction | Genotype | Midazolam - pharmacokinetics | Cytochrome P-450 CYP3A Inducers - pharmacology | Midazolam - blood | Cytochrome P-450 CYP3A - metabolism | Rifampin - pharmacology | Clarithromycin - pharmacology | Physiological aspects | Medical colleges | Rifampin | Analysis | Cytochrome P-450 | Cytochrome | Clarithromycin | Statistical analysis | Cytochrome P450 | Variability | Whites | Exposure | Males | Metabolism | Substrates | Midazolam | Genotypes | Asians | Index Medicus
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2. Full Text Clobetasol Propionate Is a Heme-Mediated Selective Inhibitor of Human Cytochrome P450 3A5
by Wright, William C and Chenge, Jude and Wang, Jingheng and Girvan, Hazel M and Yang, Lei and Chai, Sergio C and Huber, Andrew D and Wu, Jing and Oladimeji, Peter O and Munro, Andrew W and Chen, Taosheng
Journal of medicinal chemistry, ISSN 0022-2623, 02/2020, Volume 63, Issue 3, pp. 1415 - 1433
Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Heme - metabolism | Cytochrome P-450 CYP3A Inhibitors - pharmacology | Humans | Enzyme Assays | Molecular Dynamics Simulation | High-Throughput Screening Assays | Cytochrome P-450 CYP3A Inhibitors - metabolism | Heme - chemistry | Cytochrome P-450 CYP3A - metabolism | Cytochrome P-450 CYP3A Inhibitors - chemistry | Cytochrome P-450 CYP3A - chemistry | Cell Line, Tumor | Protein Binding | Molecular Docking Simulation | Clobetasol - chemistry | Clobetasol - metabolism | Clobetasol - pharmacology | Index Medicus
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3. Full Text Investigation of combined CYP3A4 inductive/inhibitory properties by studying statin interactions: a model study with the renin inhibitor ACT-178882
by Dingemanse, Jasper and Nicolas, Laurent B and van Bortel, Luc
European journal of clinical pharmacology, ISSN 0031-6970, 6/2014, Volume 70, Issue 6, pp. 675 - 684
Biomedicine | ACT-178882 | Induction | Simvastatin | Drug–drug interaction | Atorvastatin | Inhibition | Pharmacology/Toxicology | Drug-drug interaction | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Biological and medical sciences | Pharmacology. Drug treatments | Medical sciences | Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage | Pyrroles - pharmacokinetics | Cytochrome P-450 CYP3A Inhibitors - pharmacology | Heptanoic Acids - pharmacokinetics | Humans | Hydroxymethylglutaryl-CoA Reductase Inhibitors - blood | Middle Aged | Cyclopropanes - blood | Substrate Specificity | Male | Cyclopropanes - adverse effects | Simvastatin - blood | Cytochrome P-450 CYP3A Inducers - adverse effects | Cytochrome P-450 CYP3A Inducers - blood | Young Adult | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacokinetics | Pyridines - adverse effects | Drug Interactions | Cyclopropanes - administration & dosage | Pyrroles - administration & dosage | Heptanoic Acids - administration & dosage | Adult | Cyclopropanes - pharmacology | Cytochrome P-450 CYP3A - biosynthesis | Cytochrome P-450 CYP3A Inhibitors - administration & dosage | Pyridines - administration & dosage | Cytochrome P-450 CYP3A Inhibitors - blood | Simvastatin - administration & dosage | Pyrroles - blood | Simvastatin - pharmacokinetics | Cytochrome P-450 CYP3A Inducers - administration & dosage | Pyridines - blood | Cytochrome P-450 CYP3A Inducers - pharmacology | Cytochrome P-450 CYP3A - metabolism | Adolescent | Pyridines - pharmacology | Cytochrome P-450 CYP3A Inhibitors - adverse effects | Heptanoic Acids - blood | Metabolites | Analysis | Cytochrome P-450 | Dosage and administration | Investigations | Antilipemic agents | Hypertension | Clinical trials | Pharmacology | Inhibitor drugs | Statins | Index Medicus
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4. Full Text Structure–Activity Relationships of Rationally Designed Ritonavir Analogues: Impact of Side-Group Stereochemistry, Headgroup Spacing, and Backbone Composition on the Interaction with CYP3A4
by Samuels, Eric R and Sevrioukova, Irina
Biochemistry (Easton), ISSN 0006-2960, 04/2019, Volume 58, Issue 15, pp. 2077 - 2087
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Binding, Competitive | Cytochrome P-450 CYP3A Inhibitors - pharmacology | Stereoisomerism | Humans | Models, Molecular | Crystallography, X-Ray | Structure-Activity Relationship | Ritonavir - chemistry | Cytochrome P-450 CYP3A Inhibitors - metabolism | Biocatalysis - drug effects | Cytochrome P-450 CYP3A - metabolism | Ritonavir - metabolism | Cytochrome P-450 CYP3A Inhibitors - chemistry | Cytochrome P-450 CYP3A - chemistry | Drug Design | Protein Binding | Protein Domains | Ligands | Molecular Structure | Spectrophotometry | Index Medicus
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5. Drugs behave as substrates, inhibitors and inducers of human cytochrome P450 3A4
by Zhou, Shu-Feng
Current drug metabolism, ISSN 1389-2002, 05/2008, Volume 9, Issue 4, pp. 310 - 322
Substrate | Inducer | Inhibitor | CYP3A4 | Pharmacology & Pharmacy | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cytochrome P-450 CYP3A - biosynthesis | Pharmaceutical Preparations - metabolism | Animals | Cytochrome P-450 CYP3A Inhibitors | Cytochrome P-450 CYP3A - genetics | Cytochrome P-450 CYP3A - metabolism | Humans | Enzyme Inhibitors - pharmacology | Enzyme Induction - drug effects | Index Medicus
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6. Full Text Perspective: 4β-hydroxycholesterol as an emerging endogenous biomarker of hepatic CYP3A
by Mao, Jialin and Martin, Iain and McLeod, James and Nolan, Gail and van Horn, Robert and Vourvahis, Manoli and Lin, Yvonne S
Drug metabolism reviews, ISSN 0360-2532, 01/2017, Volume 49, Issue 1, pp. 18 - 34
4?-Hydroxycholesterol | CYP3A | endogenous | clinical | induction | drug development | inhibition | biomarker | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Biomarkers - urine | Cytochrome P-450 CYP3A Inhibitors - pharmacology | Humans | Liver - metabolism | Hydrocortisone - urine | Hydroxycholesterols - pharmacokinetics | Biomarkers - blood | Drug Discovery | Cytochrome P-450 CYP3A Inducers - pharmacology | Drug Interactions | Liver - drug effects | Midazolam - blood | Cytochrome P-450 CYP3A - metabolism | Models, Biological | Hydroxycholesterols - blood | Cytochrome P-450 CYP3A - drug effects | Index Medicus
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7. Full Text Pharmacokinetic interaction of intravenous fentanyl with ketoconazole
by Ziesenitz, Victoria C and König, Sonja K and Mahlke, Nina S and Skopp, Gisela and Haefeli, Walter E and Mikus, Gerd
Journal of clinical pharmacology, ISSN 0091-2700, 06/2015, Volume 55, Issue 6, pp. 708 - 717
CYP3A inhibition | ketoconazole | fentanyl | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Fentanyl - administration & dosage | Prospective Studies | Fentanyl - metabolism | Ketoconazole - administration & dosage | Humans | Middle Aged | Fentanyl - pharmacokinetics | Midazolam - administration & dosage | Cytochrome P-450 CYP3A Inhibitors - pharmacokinetics | Male | Healthy Volunteers | Young Adult | Tandem Mass Spectrometry | Drug Interactions | Fentanyl - blood | Chromatography, Liquid | Adult | Female | Fentanyl - urine | Cytochrome P-450 CYP3A Inhibitors - administration & dosage | Ketoconazole - pharmacokinetics | Cross-Over Studies | Administration, Intravenous | Cytochrome P-450 CYP3A - blood | Analgesics, Opioid - administration & dosage | Cytochrome P-450 CYP3A - metabolism | Fentanyl - analogs & derivatives | Analgesics, Opioid - pharmacokinetics | Cytochrome P-450 CYP3A - urine | Naloxone - administration & dosage | Ketoconazole | Fentanyl | Drug interactions | Physiological aspects | Dosage and administration | Observations | Pharmacokinetics | Index Medicus
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8. Full Text Acetaminophen analog N-acetyl-m-aminophenol, but not its reactive metabolite, N-acetyl-p-benzoquinone imine induces CYP3A activity via inhibition of protein degradation
by Santoh, Masataka and Sanoh, Seigo and Ohtsuki, Yuya and Ejiri, Yoko and Kotake, Yaichiro and Ohta, Shigeru
Biochemical and biophysical research communications, ISSN 0006-291X, 05/2017, Volume 486, Issue 3, pp. 639 - 644
Protein degradation | Spheroid | Hepatocyte | Acetaminophen | Cytochrome P450 | N-acetyl-m-aminophenol | Biochemistry & Molecular Biology | Biophysics | Life Sciences & Biomedicine | Science & Technology | Acetaminophen - metabolism | Cytochrome P-450 CYP3A Inducers - metabolism | Cytochrome P-450 CYP3A Inhibitors - pharmacology | Glutathione - metabolism | Stereoisomerism | Male | Structure-Activity Relationship | Hepatocytes - metabolism | Proteolysis - drug effects | Hepatocytes - cytology | Cytochrome P-450 CYP3A - genetics | Acetaminophen - pharmacology | Benzoquinones - metabolism | Hepatocytes - drug effects | Imines - metabolism | Gene Expression Regulation | Rats | Imines - pharmacology | Rats, Sprague-Dawley | Benzoquinones - pharmacology | Triazoles - pharmacology | Animals | Cytochrome P-450 CYP3A Inducers - pharmacology | Cytochrome P-450 CYP3A Inhibitors - metabolism | Cytochrome P-450 CYP3A - metabolism | Protein Stability - drug effects | Acetylcysteine - pharmacology | Primary Cell Culture | Cysteine | Metabolites | RNA | Proteolysis | Quinone | Cytochrome P-450 | Cystine | Index Medicus
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9. Full Text Quercetin nanoparticles alter pharmacokinetics of bromocriptine, reflecting its enhanced inhibitory action on liver and intestinal CYP 3A enzymes in rats
by Palle, Suresh and Neerati, Prasad
Xenobiotica, ISSN 0049-8254, 10/2018, Volume 48, Issue 10, pp. 1028 - 1036
CYP3A | quercetin | Bioavailability | bromocriptine | Pharmacology & Pharmacy | Toxicology | Life Sciences & Biomedicine | Science & Technology | Bromocriptine - administration & dosage | Cytochrome P-450 CYP3A Inhibitors - administration & dosage | Liver - enzymology | Cytochrome P-450 CYP3A Inhibitors - blood | Cytochrome P-450 CYP3A Inhibitors - pharmacology | Nanoparticles - chemistry | Rats, Wistar | Administration, Oral | Nanoparticles - ultrastructure | Cytochrome P-450 CYP3A Inhibitors - pharmacokinetics | Male | Microsomes - enzymology | Bromocriptine - pharmacology | Calibration | Permeability | Microsomes - drug effects | Animals | Bromocriptine - blood | Quercetin - pharmacology | Cytochrome P-450 CYP3A - metabolism | Bromocriptine - pharmacokinetics | Biological Transport - drug effects | Intestines - enzymology | Index Medicus
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10. Full Text Identification of the human cytochrome P450 enzymes involved in the two oxidative steps in the bioactivation of clopidogrel to its pharmacologically active metabolite
by Kazui, Miho and Nishiya, Yumi and Ishizuka, Tomoko and Hagihara, Katsunobu and Farid, Nagy A and Okazaki, Osamu and Ikeda, Toshihiko and Kurihara, Atsushi
Drug metabolism and disposition, ISSN 0090-9556, 01/2010, Volume 38, Issue 1, pp. 92 - 99
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Biological and medical sciences | Pharmacology. Drug treatments | Medical sciences | Microsomes - metabolism | Humans | Aryl Hydrocarbon Hydroxylases - genetics | Cytochrome P-450 Enzyme System - metabolism | Sulfaphenazole - pharmacology | Microsomes - drug effects | Cytochrome P-450 CYP3A - genetics | Cytochrome P-450 CYP1A2 - genetics | Antibodies - immunology | Omeprazole - pharmacology | Microsomes, Liver - enzymology | Platelet Aggregation Inhibitors - pharmacokinetics | Ticlopidine - pharmacokinetics | Oxidoreductases, N-Demethylating - metabolism | Aryl Hydrocarbon Hydroxylases - immunology | Oxidation-Reduction | Enzyme Inhibitors - pharmacology | Ticlopidine - analogs & derivatives | Oxidoreductases, N-Demethylating - immunology | Cytochrome P-450 CYP3A - metabolism | Cell Line, Tumor | Cytochrome P-450 Enzyme System - genetics | Theophylline - pharmacology | Kinetics | Cytochrome P-450 CYP2C9 | Theophylline - analogs & derivatives | Oxidoreductases, N-Demethylating - genetics | Glutathione - metabolism | Ketoconazole - pharmacology | Biotransformation - physiology | Cytochrome P-450 CYP1A2 Inhibitors | Microsomes, Liver - drug effects | Ticlopidine - metabolism | NADP - metabolism | Platelet Aggregation Inhibitors - metabolism | Cytochrome P-450 CYP3A - immunology | Cell Line | Aryl Hydrocarbon Hydroxylases - antagonists & inhibitors | Cytochrome P-450 CYP1A2 - immunology | Biocatalysis | Mephenytoin - analogs & derivatives | Cytochrome P-450 CYP1A2 - metabolism | Aryl Hydrocarbon Hydroxylases - metabolism | Mephenytoin - pharmacology | Antibodies - pharmacology | Cytochrome P-450 CYP3A Inhibitors | Cytochrome P-450 CYP2C19 | Clopidogrel | Cytochrome P-450 CYP2B6 | Index Medicus
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