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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 02/2018, Volume 115, Issue 6, pp. 1316 - 1321
Missense mutations that disrupt the RING domain of the tumor suppressor gene BRCA1 lead to increased risk of breast and ovarian cancer. The BRCA1 RING domain... 
BARD1 | Ubiquitin | Breast cancer | BRCA1 | Transcriptional repression | INHERITED MUTATIONS | MOLECULAR ETIOLOGY | OVARIAN-CANCER RISK | TUMOR SUPPRESSION | MULTIDISCIPLINARY SCIENCES | DNA-DAMAGE | breast cancer | ubiquitin | UBIQUITIN LIGASE ACTIVITY | BREAST-CANCER | transcriptional repression | GERMLINE MUTATIONS | RING DOMAIN | BRCA2 MUTATION | Cytochrome P-450 CYP1A1 - genetics | Humans | Male | Mutation, Missense | Ubiquitination | Cytochrome P-450 CYP3A - genetics | BRCA1 Protein - metabolism | Tumor Suppressor Proteins - chemistry | Tumor Suppressor Proteins - genetics | Estrogens - genetics | Protein Domains | Female | Estrogens - metabolism | Tumor Suppressor Proteins - metabolism | Gene Expression Regulation | Ubiquitin-Protein Ligases - metabolism | Nucleosomes - metabolism | Cytochrome P-450 CYP1A1 - metabolism | Ubiquitin-Protein Ligases - chemistry | BRCA1 Protein - genetics | Breast Neoplasms - genetics | Histones - genetics | Cytochrome P-450 CYP3A - metabolism | Histones - metabolism | Ubiquitin-Protein Ligases - genetics | Gene mutations | Oncology, Experimental | Genetic aspects | Research | Binding proteins | Cancer | Ovarian carcinoma | Histone H2A | Epithelial cells | Genes | Gene regulation | Estrogens | Ovarian cancer | Proteins | Missense mutation | Ubiquitin-protein ligase | Binding | BRCA1 protein | Cytochrome P450 | Health risks | Metabolism | Gene expression | Reintroduction | Zinc | Mutants | Gene silencing | Breast | Tumor suppressor genes | Nucleosomes | Mutation | Structure-function relationships | Index Medicus | Biological Sciences
Journal Article
Biochemistry, ISSN 0006-2960, 03/2016, Volume 55, Issue 7, pp. 1058 - 1069
Membrane-bound cytochrome P4503A4 (CYP3A4) is the major source of enzymatic drug metabolism. Although several structural models of CYP3A4 in various ligand... 
EXCHANGE MASS-SPECTROMETRY | PHOSPHOLIPID-BILAYER NANODISCS | PROTEIN | 3A4 | BIOCHEMISTRY & MOLECULAR BIOLOGY | STATE | CHANNELS | BINDING | RECONSTITUTION | RESIDUES | Cytochrome P-450 CYP3A Inhibitors - pharmacology | Membrane Microdomains - metabolism | Protein Unfolding - drug effects | Humans | Enzyme Stability - drug effects | Phosphatidylcholines - metabolism | Recombinant Fusion Proteins - metabolism | Ketoconazole - pharmacology | Apolipoprotein A-I - genetics | Deuterium Exchange Measurement | Cytochrome P-450 CYP3A - genetics | Cytochrome P-450 CYP3A - chemistry | Protein Engineering | Membrane Proteins - metabolism | Peptide Fragments - genetics | Apolipoprotein A-I - chemistry | Protein Structure, Tertiary | Recombinant Proteins - metabolism | Peptide Fragments - metabolism | Membrane Proteins - genetics | Membrane Microdomains - chemistry | Models, Molecular | Recombinant Proteins - chemistry | Apolipoprotein A-I - metabolism | Phosphatidylcholines - chemistry | Recombinant Fusion Proteins - chemistry | Peptide Fragments - chemistry | Membrane Proteins - chemistry | Cytochrome P-450 CYP3A - metabolism | Membrane Microdomains - drug effects | Calorimetry, Differential Scanning | Ligands | Protein Conformation | Lipid Bilayers - chemistry | Lipid Bilayers - metabolism | Molecular dynamics | Chemical properties | Research | Analysis | Ligands (Biochemistry) | Cytochrome P-450 | Index Medicus
Journal Article
BBA - Proteins and Proteomics, ISSN 1570-9639, 01/2018, Volume 1866, Issue 1, pp. 116 - 125
Chimerogenesis involving cytochromes P450 is a successful approach to generate catalytically self-sufficient enzymes. However, the connection between the... 
Molecular lego | Drug-drug interaction | Chimeric enzymes | Cytochrome P450 3A4 | DRUG-INTERACTIONS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CYTOCHROME-P450 3A4 | CLINICAL-RELEVANCE | IN-VITRO | ELECTRON-TRANSFER | BIOPHYSICS | METABOLISM | HOMOTROPIC COOPERATIVITY | ENZYMES | BINDING | NADPH-Ferrihemoprotein Reductase - genetics | NADPH-Ferrihemoprotein Reductase - antagonists & inhibitors | Humans | Bacterial Proteins - chemistry | Ketoconazole - metabolism | NADPH-Ferrihemoprotein Reductase - chemistry | Substrate Specificity | Structure-Activity Relationship | Recombinant Fusion Proteins - metabolism | Testosterone - metabolism | Cytochrome P-450 CYP3A - genetics | Cytochrome P-450 CYP3A Inhibitors - chemistry | Cytochrome P-450 CYP3A - chemistry | Protein Engineering | Protein Interaction Domains and Motifs | Binding Sites | Bacillus megaterium - genetics | Bacterial Proteins - antagonists & inhibitors | Protein Conformation, alpha-Helical | Gene Expression | NADPH-Ferrihemoprotein Reductase - metabolism | Bacterial Proteins - genetics | Ketoconazole - chemistry | Recombinant Fusion Proteins - chemistry | Testosterone - chemistry | Cytochrome P-450 CYP3A Inhibitors - metabolism | Protein Conformation, beta-Strand | Cytochrome P-450 CYP3A - metabolism | Bacillus megaterium - enzymology | Protein Binding | Recombinant Fusion Proteins - genetics | Bacterial Proteins - metabolism | Ligands | Molecular Docking Simulation | Kinetics | Glycine | Enzymes | Analysis | Index Medicus
Journal Article
Journal Article
Annals of Hepatology, ISSN 1665-2681, 07/2016, Volume 15, Issue 4, pp. 568 - 576
Introduction and Aim. TGF-beta, signalling islrivolved in pathogenesis and progress of hepatocellular-carcinoma (HCC). This bioinformatics,study consequently... 
Hepatocellular carcinoma | Differentially expressed genes | Protein-protein interaction network | Transcription factors | Transcription factor-target regulatory network | CYTOSCAPE | MECHANISMS | NETWORKS | DISCOVERY | EPITHELIAL-MESENCHYMAL TRANSITION | GROWTH-FACTOR-BETA | INVASION | Transcription factor-target regolatory network | DATABASE | GASTROENTEROLOGY & HEPATOLOGY | EXPRESSION | PROGRESSION | Humans | Databases, Genetic | Endosomal Sorting Complexes Required for Transport - genetics | Gene Expression Profiling | Smad3 Protein - metabolism | Protein Interaction Maps | SOXB1 Transcription Factors - metabolism | Glucuronosyltransferase - genetics | Smad3 Protein - genetics | Cytochrome P-450 CYP3A - genetics | SOXB1 Transcription Factors - genetics | Carcinoma, Hepatocellular - genetics | Smad2 Protein - genetics | Tumor Suppressor Proteins - genetics | Cullin Proteins - metabolism | Nedd4 Ubiquitin Protein Ligases | Hepatocyte Nuclear Factor 4 - metabolism | Cell Adhesion - genetics | Tumor Suppressor Proteins - metabolism | Liver Neoplasms - genetics | Endosomal Sorting Complexes Required for Transport - metabolism | Smad2 Protein - metabolism | Ubiquitin-Protein Ligases - metabolism | Hepatocyte Nuclear Factor 4 - genetics | Signal Transduction - genetics | Transcription Factors - genetics | Cullin Proteins - genetics | Transcription Factors - metabolism | Glucuronosyltransferase - metabolism | Cytochrome P-450 CYP3A - metabolism | Liver Neoplasms - metabolism | Cell Line, Tumor | Ubiquitin-Protein Ligases - genetics | Transforming Growth Factor beta - metabolism | Carcinoma, Hepatocellular - metabolism | Index Medicus
Journal Article
Journal Article
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 05/2017, Volume 486, Issue 3, pp. 639 - 644
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 07/2015, Volume 23, Issue 13, pp. 3269 - 3277
Protein kinase C theta (PKCθ) plays a critical role in T cell signaling and has therapeutic potential for T cell-mediated diseases such as transplant rejection... 
Protein kinase C theta (PKCθ) | CYP3A4 time-dependent inhibition (TDI) | P-glycoprotein (P-gp) | DESIGN | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | Protein kinase C theta (PKC theta) | SOTRASTAURIN | THERAPY | DISEASES | AEB071 | GLYCOPROTEIN | ABSORPTION | PKC-THETA | CYCLOSPORINE | Protein Kinase C - genetics | Pyrimidines - chemical synthesis | Humans | Microsomes, Liver - metabolism | Protein Kinase C-theta | Structure-Activity Relationship | Pyrimidines - chemistry | Protein Kinase Inhibitors - chemistry | Drug Interactions | Cytochrome P-450 CYP3A - genetics | T-Lymphocytes - metabolism | Isoenzymes - metabolism | Microsomes, Liver - drug effects | Protein Kinase C - metabolism | T-Lymphocytes - drug effects | T-Lymphocytes - pathology | Protein Kinase Inhibitors - chemical synthesis | Gene Expression | Signal Transduction | Isoenzymes - genetics | Protein Kinase C - antagonists & inhibitors | Pyrimidines - pharmacology | ATP Binding Cassette Transporter, Subfamily B, Member 1 - genetics | ATP Binding Cassette Transporter, Subfamily B, Member 1 - metabolism | Cytochrome P-450 CYP3A - metabolism | Halogenation | Protein Kinase Inhibitors - pharmacology | Isoenzymes - antagonists & inhibitors | Drug Resistance, Neoplasm - drug effects | Physicians (General practice) | Liability (Law) | Protein kinases | Drug interactions | Complications and side effects | Rheumatoid factor | Cytochrome P-450 | Arthritis | Drug discovery | T cells | Index Medicus
Journal Article
Antiviral Research, ISSN 0166-3542, 04/2017, Volume 140, pp. 37 - 44
Journal Article
Journal Article
International Journal of Pharmaceutics, ISSN 0378-5173, 02/2019, Volume 556, pp. 172 - 180
Quizartinib, a second-generation FLT3 inhibitor, is in clinical development for the treatment of acute myeloid leukemia. We studied its pharmacokinetic... 
Brain penetration | ABCB1 | Quizartinib | FLT3 | CYP3A enzymes | ABCG2 | INTERNAL TANDEM DUPLICATION | INTENSIVE CHEMOTHERAPY | PROGNOSTIC-FACTORS | ACUTE MYELOID-LEUKEMIA | SORAFENIB | ORAL AVAILABILITY | IMPACT | SUNITINIB | TYROSINE KINASE INHIBITOR | PHARMACOLOGY & PHARMACY | ABC TRANSPORTERS | Index Medicus
Journal Article