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Journal Article
Journal Article
Journal Article
Journal Article
Pharmaceutical Research, ISSN 0724-8741, 5/2008, Volume 25, Issue 5, pp. 1063 - 1074
To assess the consequences of multiple inhibitors and differential inhibition mechanisms on the prediction of 12 gemfibrozil drug–drug interactions (DDIs). In... 
Biomedical Engineering | Biochemistry, general | CYP2C8 | Biomedicine | enzyme inhibition | Pharmacy | drug–drug interactions | Medical Law | Pharmacology/Toxicology | gemfibrozil | OATP1B1 | Enzyme inhibition | Drug-drug interactions | Gemfibrozil | PARALLEL PATHWAYS | CYP3A4 IN-VITRO | HUMAN LIVER-MICROSOMES | TRANSPLANT RECIPIENTS | HEPATIC-UPTAKE | CHEMISTRY, MULTIDISCIPLINARY | ATORVASTATIN | drug-drug interactions | PHARMACOKINETICS | PLASMA-CONCENTRATIONS | PHARMACOLOGY & PHARMACY | HEALTHY-VOLUNTEERS | CYCLOSPORINE | Cell Line | Cytochrome P-450 CYP2C8 | Hypolipidemic Agents - adverse effects | Predictive Value of Tests | Aryl Hydrocarbon Hydroxylases - antagonists & inhibitors | Area Under Curve | Humans | Immunosuppressive Agents - pharmacokinetics | Enzyme Inhibitors - pharmacology | Gemfibrozil - pharmacokinetics | Gemfibrozil - adverse effects | Aryl Hydrocarbon Hydroxylases - metabolism | Carrier Proteins - metabolism | Drug Interactions | Glucuronides - metabolism | Cyclosporine - adverse effects | Cyclosporine - pharmacokinetics | Immunosuppressive Agents - adverse effects | Kinetics | Hypolipidemic Agents - pharmacokinetics | Databases, Factual | Physiological aspects | Complications and side effects | Analysis | Drug interactions | Low density lipoproteins | Enzymes | Biomedical research | Inhibitor drugs | Predictions | Pharmacology | Models | Metabolism
Journal Article
Journal of Applied Toxicology, ISSN 0260-437X, 02/2013, Volume 33, Issue 2, pp. 100 - 108
ABSTRACT We developed methods for evaluating the ntial inhibition of human cytochrome P450 (CYP) enzymes, including CYP1A2, CYP2A6, CYP2B6, CYP2 C9, CYP2 C19,... 
metabolism‐dependent inhibition (MDI) | cytochrome P450 inhibition | liquid chromatography–tandem mass spectrometry | drug–drug interactions | drug metabolism | Drug metabolism | Metabolism-dependent inhibition (MDI) | Liquid chromatography-tandem mass spectrometry | Drug-drug interactions | Cytochrome P450 inhibition | 3A4 | FLUVOXAMINE | TANDEM MASS-SPECTROMETRY | CYP3A4 | drug-drug interactions | IN-VITRO | ANTIDEPRESSANTS | ENZYMES | CYP1A2 | liquid chromatography-tandem mass spectrometry | KETOCONAZOLE | TOXICOLOGY | metabolism-dependent inhibition (MDI) | Cytochrome P-450 Enzyme Inhibitors | Enzyme Inhibitors - metabolism | Humans | Microsomes, Liver - metabolism | Substrate Specificity | Chromatography, High Pressure Liquid | Tandem Mass Spectrometry | Pharmaceutical Preparations - metabolism | Drug Interactions | Spectrometry, Mass, Electrospray Ionization | Microsomes, Liver - drug effects | Drug-Related Side Effects and Adverse Reactions | Enzyme Inhibitors - chemistry | Enzyme Inhibitors - toxicity | Pharmaceutical Preparations - chemistry | Microsomes, Liver - enzymology | Molecular Structure | In Vitro Techniques | Niacinamide | Drug interactions | Cytochrome P-450 | Pharmacology | Metabolism | Biological assays | Toxicity | Mass spectrometry | Chromatography | Human | Drugs | Inhibitors | MDI | Inhibition | Assaying | Cytochromes P450
Journal Article