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index medicus (153) 153
azole resistance (112) 112
microbiology (112) 112
humans (104) 104
antifungal agents - pharmacology (103) 103
aspergillus fumigatus - drug effects (99) 99
cyp51a (95) 95
aspergillus fumigatus (94) 94
cyp51a gene (88) 88
aspergillus fumigatus - genetics (84) 84
fungal proteins - genetics (75) 75
mutation (73) 73
microbial sensitivity tests (68) 68
cytochrome p-450 enzyme system - genetics (65) 65
voriconazole (65) 65
infectious diseases (64) 64
drug resistance, fungal (61) 61
pharmacology & pharmacy (59) 59
aspergillosis - microbiology (57) 57
itraconazole (55) 55
azoles - pharmacology (53) 53
aspergillus fumigatus - isolation & purification (52) 52
invasive aspergillosis (51) 51
susceptibility (51) 51
mycology (48) 48
itraconazole resistance (47) 47
triazoles - pharmacology (42) 42
in-vitro (41) 41
aspergillosis - drug therapy (40) 40
drug resistance, fungal - genetics (39) 39
aspergillosis (38) 38
aspergillus (36) 36
antifungal agents - therapeutic use (35) 35
cross-resistance (34) 34
posaconazole (34) 34
antifungal agents (32) 32
mutations (32) 32
fumigatus (29) 29
fungicides (29) 29
triazoles (29) 29
resistance (28) 28
triazole resistance (28) 28
azoles (27) 27
fungi (27) 27
amphotericin-b (26) 26
epidemiology (26) 26
itraconazole - pharmacology (25) 25
14-alpha-sterol demethylase cyp51a (24) 24
drug resistance (23) 23
gene (23) 23
middle aged (23) 23
mycoses (23) 23
male (22) 22
mechanisms (22) 22
prevalence (22) 22
candida-albicans (21) 21
environment (21) 21
fungal proteins - metabolism (21) 21
female (20) 20
tr34/l98h (20) 20
aspergillosis - epidemiology (19) 19
azoles - therapeutic use (19) 19
cystic-fibrosis (19) 19
drug-resistance (19) 19
tr34/l98h mutations (19) 19
genotype (18) 18
infections (18) 18
aspergillus fumigatus - enzymology (17) 17
cytochrome p-450 enzyme system - metabolism (17) 17
mechanism (17) 17
municipalities (17) 17
pyrimidines - pharmacology (17) 17
adult (16) 16
animals (16) 16
drug resistance, fungal - drug effects (16) 16
genes (16) 16
identification (16) 16
skin and connective tissue diseases (16) 16
yard waste (16) 16
life sciences (15) 15
research (15) 15
aspergillus - drug effects (14) 14
filamentous fungi (14) 14
heterocyclic compounds (14) 14
high prevalence (14) 14
pesticides (14) 14
analysis (13) 13
aspergillus fumigatus - pathogenicity (13) 13
evolution (13) 13
in-vitro susceptibility (13) 13
l98h (13) 13
surveillance (13) 13
triazoles - therapeutic use (13) 13
veterinary sciences (13) 13
aged (12) 12
antifungal resistance (12) 12
aspergillus-fumigatus (12) 12
azole (12) 12
composting (12) 12
epidemiologic cutoff values (12) 12
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PLoS Pathogens, ISSN 1553-7366, 03/2007, Volume 3, Issue 3, p. e24
Journal Article
Medical Mycology, ISSN 1369-3786, 08/2016, Volume 54, Issue 6, pp. 616 - 627
Journal Article
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2016, Volume 6, Issue 1, p. 38833
Azoles are widely used for controlling fungal growth in both agricultural and medical settings. The target protein of azoles is CYP51, a lanosterol... 
RESPONSES | MECHANISM | PATHWAY | TR34/L98H | MULTIDISCIPLINARY SCIENCES | 14-ALPHA-DEMETHYLASE GENE | SUSCEPTIBILITY | PHENOTYPE | CRYPTOCOCCUS-NEOFORMANS | CYP51A | VIRULENCE | Lanosterol | Ergosterol | Azoles | Composting | Fungicides | Clonal deletion | Pesticides | Drug development | Conidia
Journal Article
Mycopathologia, ISSN 0301-486X, 8/2018, Volume 183, Issue 4, pp. 731 - 736
Azole resistance in Aspergillus fumigatus is an emerging problem, especially in immunocompromised patients. It has been reported worldwide, including in Asia,... 
Life Sciences | Medical Microbiology | Microbial Ecology | Azoles | Microbiology | CYP 51A | Aspergillus fumigatus | Posaconazole | Plant Sciences | Eukaryotic Microbiology | CYP51A | DIAGNOSIS | MANAGEMENT | PANDEMIC INFLUENZA | INVASIVE ASPERGILLOSIS | DISEASES | AZOLE RESISTANCE | INFECTION | COHORT | MYCOLOGY | NETHERLANDS | Triazoles - administration & dosage | Chemoprevention | Humans | Male | Fungal Proteins - genetics | Mutation, Missense | Aspergillus fumigatus - genetics | Bronchoalveolar Lavage Fluid - microbiology | Aspergillus fumigatus - isolation & purification | Invasive Pulmonary Aspergillosis - microbiology | Hematopoietic Stem Cell Transplantation - adverse effects | Cytochrome P-450 Enzyme System - genetics | Adult | Immunocompromised Host | Antifungal Agents - administration & dosage | Drug Resistance, Fungal | Republic of Korea | Health maintenance organizations | Medical colleges | Pneumonia | Bacterial pneumonia | Immunotherapy | Genes | Antifungal agents | Mycoses | Genetic aspects | Transplantation | Epidemiology | Hematopoietic stem cells | Klebsiella | Municipalities | Prophylaxis | Clinical isolates | Carbapenemase | Case reports | Stem cell transplantation | Patients | Bacteremia | Immunosuppressive agents | Hemopoiesis | Yard waste | Voriconazole | Aspergillosis | Immunocompromised hosts | Mutation | Itraconazole | Short Communication
Journal Article
Journal Article
Emerging Infectious Diseases, ISSN 1080-6040, 2011, Volume 17, Issue 10, pp. 1846 - 1854
The prevalence and spread of azole resistance in clinical Aspergillus fumigatus isolates in the Netherlands are currently unknown. Therefore, we performed a... 
VORICONAZOLE | INFECTIOUS DISEASES | INVASIVE ASPERGILLOSIS | FUNGAL DISEASE | ITRACONAZOLE RESISTANCE | NERVOUS-SYSTEM ASPERGILLOSIS | IN-VITRO SUSCEPTIBILITY | TRIAZOLE RESISTANCE | AMPHOTERICIN-B | MUTATIONS | IMMUNOLOGY | CYP51A GENE | Aspergillus fumigatus - drug effects | Prevalence | Prospective Studies | Humans | Middle Aged | Netherlands - epidemiology | Child, Preschool | Infant | Male | Azoles - therapeutic use | Aspergillosis - epidemiology | Antifungal Agents - therapeutic use | Microbial Sensitivity Tests | Young Adult | Aspergillus fumigatus - isolation & purification | Aged, 80 and over | Adult | Female | Child | Aspergillosis - drug therapy | Antifungal Agents - pharmacology | Drug Resistance, Fungal - genetics | Aspergillus fumigatus - genetics | Azoles - pharmacology | Adolescent | Aspergillosis - microbiology | Aged | Medical research | Fungicides | Leukemia | Genes | Cystic fibrosis | Transplantation | Drug resistance | Medical screening | Risk factors | Hematopoietic stem cells | Diseases | Netherlands | Amphotericin B | Gene mutations | Heterocyclic compounds | Cardiac patients | Transplantation of organs, tissues, etc | Medicine, Experimental | Strategic planning (Business) | Isolation (Hospital care) | Antiparasitic agents | Health aspects | Public health | Itraconazole | prevalence | antifungal drug resistance | Aspergillosis | CME | outcome assessment | Research | aspergillus | fungal infections | the Netherlands
Journal Article
Emerging Infectious Diseases, ISSN 1080-6040, 07/2009, Volume 15, Issue 7, pp. 1068 - 1076
Azoles are the mainstay of oral therapy for aspergillosis. Azole resistance in Aspergillus has been reported infrequently. The first resistant isolate in... 
SYSTEM | INFECTIOUS DISEASES | INVASIVE ASPERGILLOSIS | ITRACONAZOLE RESISTANCE | HIGH-RESOLUTION | CROSS-RESISTANCE | ANTIFUNGAL AGENTS | IN-VITRO SUSCEPTIBILITY | MECHANISMS | MUTATIONS | IMMUNOLOGY | CYP51A GENE | Aspergillus fumigatus - drug effects | Humans | Fungal Proteins - drug effects | Azoles - therapeutic use | Fungal Proteins - genetics | Pyrimidines - pharmacology | Aspergillus fumigatus - genetics | Disease Progression | Itraconazole - pharmacology | Antifungal Agents - therapeutic use | Itraconazole - therapeutic use | Triazoles - pharmacology | Cytochrome P-450 Enzyme System - drug effects | Pyrimidines - therapeutic use | Treatment Failure | Voriconazole | Cytochrome P-450 Enzyme System - genetics | Drug Resistance, Fungal | Amino Acid Substitution | Aspergillosis - drug therapy | Evolution, Molecular | Triazoles - therapeutic use | Lung diseases, Obstructive | Care and treatment | Methionine | Mycoses | Transplantation | Drug resistance | Hematopoietic stem cells | Endowments | Algorithms | Codon | Evolutionary biology | Amphotericin B | Gene mutations | Triazoles | Analysis | Antiparasitic agents | Cross infection | Nosocomial infections | Health aspects | Itraconazole | Aspergillus | population genetics | antifungal drug resistance | sterol 14-alpha demethylase CYP51A | Aspergillus fumigatus | azoles
Journal Article