X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
humans (224) 224
index medicus (199) 199
pharmacology & pharmacy (195) 195
cytochrome p-450 enzyme system - metabolism (151) 151
animals (150) 150
toxicology (126) 126
metabolism (118) 118
cyp (107) 107
cytochrome p-450 (102) 102
cytochrome p450 (98) 98
male (86) 86
biochemistry & molecular biology (76) 76
enzymes (70) 70
cytochrome p-450 enzyme system - genetics (65) 65
inhibition (62) 62
rats (60) 60
female (59) 59
liver (59) 59
in-vitro (58) 58
pharmacokinetics (58) 58
expression (53) 53
microsomes, liver - enzymology (53) 53
drug interactions (50) 50
microsomes, liver - drug effects (46) 46
microsomes, liver - metabolism (45) 45
induction (43) 43
physiological aspects (43) 43
human liver-microsomes (40) 40
liver - drug effects (39) 39
drug metabolism (38) 38
liver - enzymology (38) 38
metabolites (38) 38
chemistry, medicinal (36) 36
cytochrome (36) 36
cytochrome p-450 cyp1a2 - metabolism (35) 35
analysis (34) 34
cytochrome p-450 enzyme inhibitors (33) 33
cytochrome p-450 enzyme system - biosynthesis (33) 33
enzyme inhibitors - pharmacology (33) 33
biotransformation (32) 32
kinetics (32) 32
rat (32) 32
cyps (31) 31
isoenzymes - metabolism (31) 31
chemistry, multidisciplinary (29) 29
isoenzymes (29) 29
mice (29) 29
cytochrome p-450 enzyme system - chemistry (27) 27
p450 (27) 27
aryl hydrocarbon hydroxylases - metabolism (26) 26
cyp inhibition (26) 26
drugs (26) 26
rats, sprague-dawley (26) 26
drug-drug interactions (25) 25
microsomes (25) 25
enzyme induction - drug effects (24) 24
substrate specificity (24) 24
article (23) 23
cyp1a2 (22) 22
gene-expression (22) 22
adult (21) 21
cyp enzymes (21) 21
hydroxylation (21) 21
middle aged (21) 21
pharmaceutical preparations - metabolism (21) 21
cancer (20) 20
cell biology (20) 20
in-vivo (20) 20
liver - metabolism (20) 20
liver-microsomes (20) 20
oxidation (20) 20
proteins (20) 20
biomedicine (19) 19
chromatography, high pressure liquid (19) 19
cyp3a4 (19) 19
cytochromes p450 (19) 19
drug (19) 19
drug-metabolism (19) 19
hepatocytes (19) 19
pharmacology/toxicology (19) 19
toxicity (19) 19
dose-response relationship, drug (18) 18
recombinant proteins - metabolism (18) 18
research (18) 18
rna, messenger - metabolism (18) 18
cyp induction (17) 17
cytochrome p-450 cyp3a - metabolism (17) 17
drug-interactions (17) 17
identification (17) 17
3a4 (16) 16
aryl-hydrocarbon receptor (16) 16
cytochrome p-450 cyp1a1 - metabolism (16) 16
human hepatocytes (16) 16
oxidation-reduction (16) 16
oxidative stress (16) 16
rats, wistar (16) 16
rodents (16) 16
caffeine (15) 15
cytochrome-p450 (15) 15
gene expression (15) 15
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


British Journal of Clinical Pharmacology, ISSN 0306-5251, 12/2009, Volume 68, Issue 6, pp. 928 - 935
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Numerous cocktails using concurrent administration of several cytochrome P450 (CYP) isoform-selective probe drugs... 
in vivo drug-drug interaction | cocktail | CYP | in vivo drug–drug interaction | Cocktail | In vivo drug-drug interaction | DRUG | CAFFEINE | COMBINED PHENOTYPIC ASSESSMENT | METOPROLOL | OMEPRAZOLE TREATMENT | XANTHINE-OXIDASE | METABOLISM | ENZYMES | IN-VIVO | N-ACETYLTRANSFERASE-2 | PHARMACOLOGY & PHARMACY | Anti-Anxiety Agents - administration & dosage | Caffeine - administration & dosage | Anticoagulants - administration & dosage | Area Under Curve | Humans | Midazolam - administration & dosage | Cytochrome P-450 CYP1A2 - administration & dosage | Male | Metabolic Clearance Rate | Warfarin - administration & dosage | Caffeine - pharmacokinetics | Anti-Ulcer Agents - pharmacokinetics | Young Adult | Anti-Anxiety Agents - pharmacokinetics | Drug Interactions | Adult | Drug Therapy, Combination | Administration, Oral | Omeprazole - administration & dosage | Omeprazole - pharmacokinetics | Midazolam - pharmacokinetics | Anti-Ulcer Agents - administration & dosage | Central Nervous System Stimulants - pharmacokinetics | Anticoagulants - pharmacokinetics | Central Nervous System Stimulants - administration & dosage | Drug Combinations | Cytochrome P-450 CYP1A2 - pharmacokinetics | Omeprazole | Warfarin | Analysis | Drug interactions | Cytochrome P-450 | Physiological aspects | Liquid chromatography | Mass spectrometry | Caffeine | Drug Metabolism
Journal Article
International Journal of Molecular Sciences, ISSN 1661-6596, 01/2018, Volume 19, Issue 6, p. 1580
Journal Article
Toxicology, ISSN 0300-483X, 2016, Volume 344, pp. 7 - 18
Highlights • Oxidation and reduction of aristolochic acid I (AAI) dictate its (geno)toxicity in vivo. • Cytochrome P450 (CYP) 1A1 and 1A2 are induced in rats... 
Emergency | Aristolochic acid I | Cytochromes P450 1A1 and 1A2 | DNA adducts | Oxidative detoxification | Reductive activation | UROTHELIAL CANCER | NAD(P)H/QUINONE OXIDOREDUCTASE | METABOLIC-ACTIVATION | P-32 POSTLABELING ANALYSIS | CHINESE HERBS NEPHROPATHY | MASS-SPECTROMETRY | 1-PHENYLAZO-2-NAPHTHOL SUDAN-I | BALKAN ENDEMIC NEPHROPATHY | PHARMACOLOGY & PHARMACY | TOXICOLOGY | LIVER-MICROSOMES | Animals | Cytochrome P-450 CYP1A2 - biosynthesis | Rats, Wistar | DNA Adducts - antagonists & inhibitors | Enzyme Induction - drug effects | Rats | Male | Cytochrome P-450 CYP1A1 - biosynthesis | Enzyme Induction - physiology | Aristolochic Acids - toxicity | DNA Adducts - biosynthesis | Carcinogens - toxicity | DNA | Cytochrome P-450 | Metabolites | Liver | Cellulose | Physiological aspects | Genetic research | Enzymes | Kidneys | Lungs | Formations | Adducts | Cytochromes P450 | AAII, aristolochic acid II | UUC, upper urothelial tract carcinoma | dA-AAI, 7-deoxyadenosine-N6-yl)aristolactam I | AAIa, aristolochic acid Ia | cT, cycle threshold | HPLC, high performance liquid chromatography | HUFs, Hupki (human TP53 knock-in) mouse fibroblasts | r.t., retention time | dG-AAI, 7-deoxyguanosin-N2-yl)aristolactam I | MROD, methoxyresorufin O-demethylation | SD, standard deviation | NQO1, NAD(P)H:quinone oxidoreductase | CYP, cytochrome P450 | BEN, Balkan endemic nephropathy | dA-AAII, 7-deoxyadenosine-N6-yl)aristolactam II | POR, P450 oxidoreductase | PEI-cellulose, polyethylenimine-cellulose | RT-PCR, real-time polymerase chain reaction | AA, aristolochic acid | AAI, aristolochic acid I | UV–vis, ultraviolet–visible | bw, body weight | AAN, aristolochic acid nephropathy | RAL, relative adduct labeling | TLC, thin-layer chromatography
Journal Article
Toxicology, ISSN 0300-483X, 2009, Volume 265, Issue 3, pp. 69 - 79
Abstract The constitutive and inducible expression of aryl hydrocarbon receptor (AhR) and of the AhR-regulated genes coding for CYP1A1, CYP1A2, CYP1B1, CYP2S1,... 
Emergency | Pig CYPs | AhR | Brain CYPs | Pig Nrf2 | Brain antioxidant enzymes | β-Naphthoflavone induction | CYTOCHROMES P450 | XENOBIOTIC METABOLISM | POLYCYCLIC AROMATIC-HYDROCARBONS | GLUTATHIONE-PEROXIDASE | SUBSTRATE METABOLISM | ARACHIDONIC-ACID METABOLISM | beta-Naphthoflavone induction | TISSUE DISTRIBUTION | PHARMACOLOGY & PHARMACY | TOXICOLOGY | RAT-BRAIN | NUCLEAR TRANSLOCATOR | SUPEROXIDE-DISMUTASE | Gene Expression Regulation, Enzymologic - drug effects | Liver - enzymology | Glutathione Peroxidase - analysis | Brain - enzymology | RNA, Messenger - analysis | Male | RNA, Messenger - metabolism | RNA - genetics | RNA - isolation & purification | Glutathione Transferase - genetics | Liver - drug effects | Microsomes, Liver - drug effects | Swine | Polymerase Chain Reaction | beta-Naphthoflavone - pharmacology | DNA, Complementary - biosynthesis | Enzyme Induction - drug effects | NF-E2-Related Factor 2 - genetics | Microsomes, Liver - enzymology | Superoxide Dismutase - analysis | Isoenzymes | Enzyme Inhibitors - pharmacology | Receptors, Aryl Hydrocarbon - genetics | Receptors, Aryl Hydrocarbon - drug effects | Orchiectomy | Brain - drug effects | Glutathione Transferase - biosynthesis | Animals | Glutathione Reductase - analysis | Catalase - analysis | Cytochrome P-450 Enzyme System - biosynthesis | Cytochrome P-450 Enzyme System - genetics | NF-E2-Related Factor 2 - biosynthesis | Sus scrofa | Crosses, Genetic
Journal Article
Journal of Thoracic Disease, ISSN 2072-1439, 02/2018, Volume 10, Issue 2, pp. 825 - 834
Journal Article
Journal Article
CLINICAL HEMORHEOLOGY AND MICROCIRCULATION, ISSN 1386-0291, 2018, Volume 70, Issue 4, pp. 563 - 571
BACKGROUND: Drug induced liver injury (DILI) is the most frequent cause for failure of new drugs in clinical studies. Thus, toxicity studies are indispensable... 
DILI | Cytochrome P450 | drug induced liver injury | RIFAMPICIN | CYP3A4 | PREGNANE-X-RECEPTOR | INDUCED LIVER-INJURY | HepaFH3 | INHIBITION | liver toxicity | HEPG2 CELLS | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | liver in vitro model | CYP induction | DRUG-METABOLISM
Journal Article
European Biophysics Journal, ISSN 0175-7571, 3/2012, Volume 41, Issue 3, pp. 297 - 306
Journal Article