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Journal Article
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, ISSN 0091-6749, 07/2013, Volume 132, Issue 1, pp. 205 - 213
Background: Cysteinyl leukotrienes (CysLTs) contribute to asthma pathogenesis, in part through cysteinyl leukotriene receptor 1 (CysLT1R). Recently discovered... 
IMMUNITY | INDUCED AIRWAY INFLAMMATION | IL-4 | IMMUNOLOGY | Asthma | CUTTING EDGE | CysLT1R | type 2 innate lymphoid cells | ALLERGY | MOUSE MODEL | cysteinyl leukotrienes | HUMAN MAST-CELLS | NATURAL HELPER-CELLS | PROSTAGLANDIN D-2 | T-CELLS
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 2017, Volume 794, pp. 147 - 153
CysLT receptors are known to be involved in the pathogenesis of asthma. However, the functional roles of CysLT receptors in this condition have not been... 
Bronchoconstriction | Cysteinyl leukotrienes | receptors | Air-trapping | CysLT | Asthma
Journal Article
JOURNAL OF IMMUNOLOGY, ISSN 0022-1767, 04/2009, Volume 182, Issue 7, pp. 4378 - 4385
Extracellular ATP is a mediator of intercellular communication and a danger signal. Release of this and other nucleotides modulates microglia responses via P2Y... 
EXTRACELLULAR ATP | NERVOUS-SYSTEM | CELLS | IN-VITRO | INFLAMMATORY PROCESSES | ALZHEIMERS-DISEASE | INTERLEUKIN-1-BETA RELEASE | IMMUNOLOGY | CYSTEINYL-LEUKOTRIENES | ASTROCYTES | PEPTIDE
Journal Article
Journal of Cellular Biochemistry, ISSN 0730-2312, 03/2020, Volume 121, Issue 3, pp. 2372 - 2384
Cysteinyl leukotrienes (CysLTs) are a group of eicosanoids that regulate the pathogenesis of various human diseases, mainly by signaling through the cysteinyl... 
CysLTR1 | cysteinyl leukotrienes | mouse phenotype | CRISPR/Cas9 system | point mutation
Journal Article
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 05/2016, Volume 113, Issue 22, pp. 6242 - 6247
Cysteinyl leukotrienes (cysLTs), leukotriene C-4 (LTC4), LTD4, and LTE4 are proinflammatory lipid mediators with pathobiologic function in asthma. LTE4, the... 
mucosal immunology | RESPONSIVENESS | MONTELUKAST | MULTIDISCIPLINARY SCIENCES | VASCULAR-PERMEABILITY | ASTHMATIC SUBJECTS | mast cells | epithelial cell | MICE LACKING | lung | GENE DISRUPTION REVEALS | cysteinyl leukotrienes | HISTAMINE | METHACHOLINE | EXPRESSION
Journal Article
The Journal of Allergy and Clinical Immunology, ISSN 0091-6749, 10/2018, Volume 142, Issue 4, pp. 1056 - 1057
Journal Article
JOURNAL OF EXPERIMENTAL MEDICINE, ISSN 0022-1007, 10/2009, Volume 206, Issue 11, pp. 2543 - 2555
Of the potent lipid inflammatory mediators comprising the cysteinyl leukotrienes (LTs; LTC4, LTD4, and LTE4), only LTE4 is stable and abundant in vivo.... 
MEDICINE, RESEARCH & EXPERIMENTAL | CYSTEINYL LEUKOTRIENES | IN-VITRO | HISTAMINE HYPERRESPONSIVENESS | CONTROLLED TRIAL | CYSLT RECEPTOR | 5-LIPOXYGENASE INHIBITOR | ASTHMATIC SUBJECTS | IMMUNOLOGY | HUMAN MAST-CELLS | GUINEA-PIG TRACHEAL | CYTOKINE GENERATION
Journal Article
Expert Review of Respiratory Medicine, ISSN 1747-6348, 12/2019, Volume 13, Issue 12, pp. 1169 - 1178
Introduction: Asthma is a chronic inflammatory disease of the airways with a large heterogeneity of clinical phenotypes. There has been increasing interest... 
cysteinyl leukotrienes | leukotriene receptor antagonist | Asthma
Journal Article
PLOS ONE, ISSN 1932-6203, 12/2016, Volume 11, Issue 12
Inflammation is a major burden in respiratory diseases, resulting in airway hyperresponsiveness. Our hypothesis is that resolution of inflammation may... 
ACTIVATION | CA2+ SENSITIVITY | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | RESOLUTION | RECEPTOR | AIRWAY SMOOTH-MUSCLE | MEDIATORS | HISTAMINE | CYSTEINYL-LEUKOTRIENES
Journal Article
Journal of Biological Regulators and Homeostatic Agents, ISSN 0393-974X, 03/2018, Volume 32, Issue 2, pp. 233 - 239
Journal Article
SCIENTIFIC REPORTS, ISSN 2045-2322, 12/2019, Volume 9, Issue 1, pp. 1 - 14
Regeneration is the unmatched liver ability for recovering its functional mass after tissue lost. Leukotrienes (LT) are a family of eicosanoids with the... 
EICOSANOIDS | INHIBITION | TRANSCRIPTION 3 | BIOSYNTHESIS | MULTIDISCIPLINARY SCIENCES | RECEPTOR | PROLIFERATION | CYSTEINYL-LEUKOTRIENES | PROMOTES | PROGRESSION | SIGNAL TRANSDUCER
Journal Article
Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA), ISSN 0952-3278, 04/2018, Volume 131, pp. 24 - 31
Compared with CysLT receptors, the functional role of CysLT receptors in asthma has not been clarified. The purpose of this study was to determine 1) whether... 
CysLT1 receptors | Cysteinyl leukotrienes | Airway remodeling | CysLT2 receptors | Eosinophil | receptors | CysLT
Journal Article
Prostaglandins Leukotrienes and Essential Fatty Acids, ISSN 0952-3278, 2003, Volume 69, Issue 2-3, pp. 111 - 116
LTC synthase conjugates LTA with glutathione (GSH) to form LTC , the parent compound of the cysteinyl leukotrienes. LTC synthase is a membrane protein that... 
Enzyme | Cysteinyl leukotrienes | Inflammation
Journal Article
The Journal of Allergy and Clinical Immunology, ISSN 0091-6749, 10/2018, Volume 142, Issue 4, pp. 1080 - 1089
Leukotriene (LT) E is the final active metabolite among the cysteinyl leukotrienes (CysLTs). Animal studies have identified a distinct LTE receptor, suggesting... 
lipid mediators in urine | receptors | cysteinyl leukotrienes | sputum cells | mass spectrometry | mast cells | bronchoconstriction | leukotrienes | Asthma
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 01/2017, Volume 794, pp. 147 - 153
CysLT receptors are known to be involved in the pathogenesis of asthma. However, the functional roles of CysLT receptors in this condition have not been... 
CysLT1 receptors | Cysteinyl leukotrienes | Bronchoconstriction | CysLT2 receptors | Air-trapping | Asthma
Journal Article
JOURNAL OF EXPERIMENTAL MEDICINE, ISSN 0022-1007, 04/2006, Volume 203, Issue 4, pp. 837 - 842
Neutrophils serve as a vanguard of the acute innate immune response to invading pathogens. Neutrophils are also abundant at sites of autoimmune inflammation,... 
RHEUMATOID-ARTHRITIS | MEDICINE, RESEARCH & EXPERIMENTAL | COLLAGEN-INDUCED ARTHRITIS | SERUM TRANSFER MODEL | CYSTEINYL LEUKOTRIENES | INFLAMMATORY RESPONSES | SYNOVIAL-FLUID | MAST-CELLS | DEFICIENT MICE | 5-LIPOXYGENASE | IMMUNOLOGY | AUTOIMMUNE-DISEASE
Journal Article
Progress in Neuropsychopharmacology & Biological Psychiatry, ISSN 0278-5846, 02/2017, Volume 73, pp. 19 - 30
Our previous studies showed that cysteinyl leukotrienes receptor 1 (CysLT R) is upregulated in amyloid-β (Aβ)-induced neurotoxicity and that administration of... 
Neuroinflammation | Stereotaxic injection | Cysteinyl leukotrienes receptor 1 | Pranlukast | STZ ICV | Memory | Index Medicus
Journal Article
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