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cysteine - metabolism (13) 13
extracellular glutamate (13) 13
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Biological Psychiatry, ISSN 0006-3223, 2009, Volume 65, Issue 10, pp. 841 - 845
Journal Article
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 07/2005, Volume 25, Issue 27, pp. 6389 - 6393
Withdrawal from chronic cocaine reduces extracellular glutamate levels in the nucleus accumbens by decreasing cystine/glutamate exchange (xc-). Activating xc-... 
Cocaine | Cystine/glutamate exchange | Accumbens | EPSC | Glutamate | mGluR | accumbens | cocaine | BEHAVIORAL SENSITIZATION | RELEASE | NEUROSCIENCES | ADDICTION | NUCLEUS-ACCUMBENS | cystine/glutamate exchange | CYSTINE | RELAPSE | TRANSPORT | SYSTEM X(C)(-) | LONG-TERM DEPRESSION | REINSTATEMENT | glutamate | Receptors, Metabotropic Glutamate - drug effects | Prefrontal Cortex - physiopathology | Male | Receptors, Metabotropic Glutamate - metabolism | Cocaine-Related Disorders - physiopathology | Amino Acids - pharmacology | Cystine - pharmacology | Self Administration | Prefrontal Cortex - drug effects | Receptors, Presynaptic - drug effects | Biological Transport | Consummatory Behavior - physiology | Neural Conduction - drug effects | Cystine - analogs & derivatives | Extinction, Psychological - physiology | Xanthenes - pharmacology | Nucleus Accumbens - physiopathology | Rats | Neural Conduction - physiology | Excitatory Amino Acid Antagonists - pharmacology | Rats, Sprague-Dawley | Receptors, Presynaptic - metabolism | Cocaine - administration & dosage | Animals | Cocaine - toxicity | Cystine - metabolism | Cystine - therapeutic use | Cocaine-Related Disorders - drug therapy | Glutamic Acid - metabolism | Nucleus Accumbens - drug effects | Receptors, Metabotropic Glutamate - antagonists & inhibitors | Index Medicus | glutamate exchange | cystine
Journal Article
Journal Article
Frontiers in Systems Neuroscience, ISSN 1662-5137, 11/2011, Volume 5, Issue 2011, pp. 94 - 94
Extracellular glutamate of glial origin modulates glial and neuronal glutamate release and synaptic plasticity. Estimates of the tonic basal concentration of... 
Synapse | Glia | Glutamate | Glutamate uptake | Cystine-glutamate exchange | mGluR
Journal Article
Biological Psychiatry, ISSN 0006-3223, 2010, Volume 67, Issue 1, pp. 81 - 84
Journal Article
Journal Article
SCIENTIFIC REPORTS, ISSN 2045-2322, 05/2019, Volume 9
Post-septic neurological and psychiatric illness (PSNPI) including dementia and depression may be observed after sepsis. However, the etiology of PSNPI and... 
DEPRESSION | INHIBITION | CYSTINE/GLUTAMATE EXCHANGE TRANSPORTER | MULTIDISCIPLINARY SCIENCES | SULFASALAZINE | XCT | INDUCTION | BLOOD-BRAIN-BARRIER | CEREBRAL-ISCHEMIA | EXPRESSION | GLUTAMATE EXCITOTOXICITY
Journal Article
BRAIN, ISSN 0006-8950, 01/2015, Volume 138, pp. 53 - 68
Amyotrophic lateral sclerosis is the most common adult-onset motor neuron disease and evidence from mice expressing amyotrophic lateral sclerosis-causing SOD1... 
ACTIVATION | SOD1(G93A) MOUSE MODEL | ALS | xCT | NEUROSCIENCES | CLINICAL NEUROLOGY | CELL-DEATH | MOTOR-NEURON DEGENERATION | neuroinflammation | CYSTINE/GLUTAMATE EXCHANGE TRANSPORTER | GLUTAMATE | motoneuron | EXTEND SURVIVAL | excitotoxicity | EXPRESSION | DISEASE PROGRESSION
Journal Article
JOURNAL OF NEUROCHEMISTRY, ISSN 0022-3042, 12/2015, Volume 135, Issue 6, pp. 1062 - 1079
Journal Article
Neuron, ISSN 0896-6273, 2004, Volume 43, Issue 3, pp. 401 - 413
Journal Article
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS, ISSN 1871-5273, 07/2010, Volume 9, Issue 3, pp. 373 - 382
The glutamate/cystine antiporter system x(c)(-) transports cystine into cells in exchange for the important neurotransmitter glutamate at a ratio of 1:1. It is... 
Oxidative stress | AMINO-ACID-TRANSPORT | glutathione | FOCAL CEREBRAL-ISCHEMIA | xCT | LIPOXYGENASE INHIBITORS | PROTECT NEURONAL CELLS | N-ACETYLCYSTEINE | GLUTATHIONE SYNTHESIS | NEUROSCIENCES | EAAT | PROGRAMMED CELL-DEATH | CYSTINE/GLUTAMATE EXCHANGE TRANSPORTER | IN-VIVO | PHARMACOLOGY & PHARMACY | RAT-BRAIN | glutamate
Journal Article
JOURNAL OF PSYCHIATRIC RESEARCH, ISSN 0022-3956, 01/2016, Volume 72, pp. 58 - 63
Background: The cystine/glutamate antiporter system x(c)(-), playing a critical role in the regulation of glutamate release, might be implicated in the... 
OXIDATIVE STRESS | TRANSPORTER | PSYCHIATRY | System x(c)(-) | Schizophrenia | SLC3A2 | SLC7A11 | PLASMA-MEMBRANE | CYSTINE | D-SERINE | CYSTINE/GLUTAMATE ANTIPORTER | D-ASPARTATE | GENE-EXPRESSION | EXCHANGE | glutamate | BLOOD
Journal Article
Experimental Cell Research, ISSN 0014-4827, 12/2017, Volume 361, Issue 1, pp. 178 - 191
Extracellular cystine, the oxidized form of cysteine (Cys), is taken up by cells via the cystine transporter xCT. xCT is not expressed in the liver but is... 
xCT | Cysteine | Ophthalmic acid | Autophagy | Cystine | Glutathione | CELLS | ACETAMINOPHEN-INDUCED HEPATOTOXICITY | PLASMA-MEMBRANE | CELL BIOLOGY | METABOLISM | ONCOLOGY | SYSTEM X(C)(-) | CYSTINE/GLUTAMATE EXCHANGE TRANSPORTER | INHIBITS AUTOPHAGY | EXPRESSION | METHIONINE | Cell death | Mass spectrometry | Index Medicus
Journal Article