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Journal of Neurochemistry, ISSN 0022-3042, 09/2001, Volume 78, Issue 5, pp. 1029 - 1043
Effects of cytisine (cy), 3-bromocytisine (3-Br-cy), 5-bromocytisine (5-Br-cy) and 3,5-dibromocytisine (3,5-diBr-cy) on human (h) alpha 7-, alpha 4 beta 2- and... 
cytisine
Journal Article
Journal of Molecular Structure, ISSN 0022-2860, 2011, Volume 985, Issue 2, pp. 157 - 166
New halogenated derivatives of (-)-cytisine were synthesized: 3-bromo- -acetylcytisine, 5-bromo- -acetylcytisine, 3,5-dibromo- -acetylcytisine, 3-iodo-... 
Cytisine | X-ray of cytisine derivatives | Dynamic NMR spectroscopy | Conformational equilibrium | N-cytisine derivatives | NICOTINE | CHEMISTRY, PHYSICAL | FT-IR | NACHR LIGANDS | AGONISTS | FEATURES | AFFINITY | (-)-CYTISINE | RECEPTORS | Boats
Journal Article
The Journal of Organic Chemistry, ISSN 0022-3263, 08/2018, Volume 83, Issue 16, pp. 9088 - 9095
An asymmetric synthesis of (−)-cytisine has been achieved. The piperidine C-ring was formed using a stereodivergent intramolecular 6-endo aza-Michael addition.... 
ROUTE | CYTISINE | ENANTIOSELECTIVE SYNTHESIS | AMINES | LIBRARY | CHEMISTRY, ORGANIC | DERIVATIVES | ALKALOIDS
Journal Article
Journal of Organometallic Chemistry, ISSN 0022-328X, 02/2015, Volume 778, pp. 10 - 20
(−)-Cytisine has been used as a scaffold for the synthesis of three novel phosphino-benzenecarboxamide ligands. The latter were obtained from cytisine and... 
(−)-cytisine | Dynamic NMR | P,O-ligands | Allylic substitution | DFT calculations | Cytisine | CARBOXAMIDE LIGANDS | NICOTINIC RECEPTORS | AMIDO-PHOSPHINE LIGANDS | COMPLEXES | CHEMISTRY, ORGANIC | TROST MODULAR LIGAND | CHEMISTRY, INORGANIC & NUCLEAR | DIPHOSPHINE LIGAND | ACETYLCHOLINE-RECEPTORS | (-)-cytisine | CHIRAL DIAMINES | DERIVATIVES | Palladium
Journal Article
Tetrahedron, ISSN 0040-4020, 08/2018, Volume 74, Issue 32, pp. 4315 - 4322
The azido-Ugi reaction with natural alkaloid cytisine was investigated. It was demonstrated that the reaction could be performed with various carbonyls (both... 
Cytisine | Alkaloid | Isocyanide | Azido-Ugi reaction | Diastereselectivity | PERMEABILITY | ANALOGS | DRUG DISCOVERY | CHEMISTRY, ORGANIC | NICOTINIC ACETYLCHOLINE-RECEPTORS | NACHR LIGANDS | MULTICOMPONENT REACTIONS | TARGETS | (-)-CYTISINE | BRAIN | Ketones | Aldehydes | Alkaloids
Journal Article
Chemistry of Natural Compounds, ISSN 0009-3130, 3/2016, Volume 52, Issue 2, pp. 272 - 275
N-acylamino-acid derivatives of cytisine were prepared by reacting cytisine with methyl esters of aminoacid isocyanates. 
amino-acid derivatives | Pharmacy | isocyanates | N -derivatives of cytisine | Plant Sciences | cytisine | Organic Chemistry | N-derivatives of cytisine | CHEMISTRY, MEDICINAL | NOOTROPIC ACTIVITY | CHEMISTRY, ORGANIC | (-)-CYTISINE DERIVATIVES | Isocyanates | Esters | Amino acids
Journal Article
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 05/2005, Volume 48, Issue 10, pp. 3474 - 3477
Herein we describe a novel series of compounds from which varenicline (1, 6,7,8,9-tetrahydro-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine) has been identified... 
MORTALITY | ACETYLCHOLINE-RECEPTORS | CHEMISTRY, MEDICINAL | CYTISINE | MECAMYLAMINE | LIGANDS | BETA-2 SUBUNIT | MECHANISMS | RAT-BRAIN | DERIVATIVES | ADDICTION
Journal Article
Chemistry of Natural Compounds, ISSN 0009-3130, 9/2016, Volume 52, Issue 5, pp. 874 - 876
The new cytisine derivatives N-(3′-β-bromoethoxy-4′-methoxy-2′-bromobenzyl)cytisine and N-[2′-bromo-4′-methoxy-3′-(β-cytisinylethoxy)benzyl]cytisine were... 
dibromoethane | Plant Sciences | Pharmacy | cytisine | bis -cytisine derivative | Organic Chemistry | bis-cytisine derivative | CHEMISTRY, ORGANIC | CHEMISTRY, MEDICINAL | DERIVATIVES
Journal Article
Synlett, ISSN 0936-5214, 08/2014, Volume 25, Issue 13, pp. 1904 - 1908
Abstract Various alkoxy-substituted heterocyclic stannanes provide access to the corresponding substituted ‘pyridone’ moieties via Stille cross-coupling. Both... 
letter | pyridine | Stille coupling | heterocyclic stannane | STANNYLATION REACTIONS | CYTISINE | CHEMISTRY, ORGANIC | (-)-CYTISINE | ARYL | EXCHANGE-REACTIONS
Journal Article
Synlett, ISSN 0936-5214, 03/2010, Volume 2010, Issue 5, pp. 729 - 730
Abstract The first synthesis of (+)-kuraramine via oxidative cleavage of (-)-N-methylcytisine is reported. An alternative but unsuccessful approach to... 
letter | Kuraramine | Cytisine | Alkaloids | PHENYLDIMETHYLSILYL GROUP | OXIDATION | DIASTEREOSELECTIVE FUNCTIONALIZATION | kuraramine | alkaloids | CHEMISTRY, ORGANIC | (-)-CYTISINE | BOND | (+)-CYTISINE | cytisine
Journal Article
Chemistry of Natural Compounds, ISSN 0009-3130, 11/2019, Volume 55, Issue 6, pp. 1101 - 1105
Iodination of the 2-pyridone core of (–)-cytisine and methylcytisine by one equivalent of ICl or N-iodosuccinimide (NIS) in acidic solution gave primarily the... 
iodination | (–)-cytisine | methylcytisine | Pharmacy | quinolizidine alkaloids | 2-pyridone core | Plant Sciences | Organic Chemistry | CHEMISTRY, MEDICINAL | (-)-cytisine | CHEMISTRY, ORGANIC | IODINE | DERIVATIVES
Journal Article
MOLECULAR PHARMACOLOGY, ISSN 0026-895X, 09/2006, Volume 70, Issue 3, pp. 801 - 805
Varenicline, a new nicotinic ligand based on the structure of cytisine, has recently been approved by the U. S. Food and Drug Administration for use as a... 
SMOKING-CESSATION | ACETYLCHOLINE-RECEPTORS | CYTISINE | SUBTYPES | AFFINITY | ANALOGS | HEK293 CELLS | PHARMACOLOGY | ALPHA | PHARMACOLOGY & PHARMACY | SUBUNIT COMPOSITION
Journal Article
Synthesis, ISSN 0039-7881, 09/2018, Volume 50, Issue 17, pp. 3420 - 3429
Abstract The high regioselectivity associated with the iridium-catalysed borylation of pyridones has been exploited to provide a very direct and efficient... 
paper | iridium-catalyzed borylation | 2-pyridone | C-H functionalization | CC4 | cytisine | SMOKING-CESSATION | ARENES | CHEMISTRY, ORGANIC | NICOTINIC ACETYLCHOLINE-RECEPTORS | HETEROCYCLES | PARTIAL AGONIST | BINDING INTERACTIONS | PHARMACOLOGICAL EVALUATION | SELECTIVITY | 10-SUBSTITUTED CYTISINE DERIVATIVES | LATE-STAGE FUNCTIONALIZATION
Journal Article
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