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Journal Article
Nature chemistry, ISSN 1755-4349, 2017, Volume 9, Issue 7, pp. 629 - 634
C-H bonds are ubiquitous structural units of organic molecules. Although these bonds are generally considered to be chemically inert, the recent emergence of... 
INTRAMOLECULAR C(SP)-H AMINATION | MONOOXYGENASES | CYTOCHROME-P450 | EVOLUTION | AZIDATION | NATURAL-PRODUCTS | IN-VIVO | BOND FUNCTIONALIZATION | AMIDATION | CHEMISTRY, MULTIDISCIPLINARY | Enzymes | Transformation | Haem | Amines | Directed evolution | Catalysts | Cytochrome P450 | Iron | Enantiomers | Organic chemistry | Chemical bonds | Coordination compounds | Cytochrome P450 monooxygenase
Journal Article
Biochemistry, ISSN 0006-2960, 02/2018, Volume 57, Issue 5, pp. 817 - 826
Human hepatic cytochromes P450 (CYP) are integral to xenobiotic metabolism. CYP2B6 is a major catalyst of biotransformation of environmental toxicants,... 
SIDE-CHAINS | ACTIVE-SITE | STRUCTURAL BASIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | MAMMALIAN CYTOCHROME-P450 | LIVER-MICROSOMES | HUMAN CYTOCHROME-P450 2B6 | SITE-DIRECTED MUTAGENESIS | OXIDATIVE-METABOLISM | DRUG-METABOLISM | Cytochrome P-450 CYP2B1 - genetics | Aniline Compounds | Humans | Aryl Hydrocarbon Hydroxylases - genetics | NADPH Oxidases - metabolism | Substrate Specificity | Cytochrome P-450 Enzyme Inhibitors - metabolism | Structure-Activity Relationship | Environmental Pollutants - metabolism | Cytochromes b5 - metabolism | Cytochrome P-450 CYP2B6 - metabolism | Cytochrome P-450 CYP2B6 Inhibitors - metabolism | Cytochrome P-450 CYP2B6 - drug effects | Hydrocarbons, Halogenated - metabolism | Cytochrome P-450 CYP2B1 - chemistry | Cytochrome P450 Family 2 - genetics | Inhibitory Concentration 50 | Cytochrome P-450 CYP2B1 - metabolism | Molecular Structure | Aryl Hydrocarbon Hydroxylases - chemistry | Benzene Derivatives - pharmacology | Cytochrome P450 Family 2 - antagonists & inhibitors | Recombinant Proteins - metabolism | Rabbits | Aryl Hydrocarbon Hydroxylases - antagonists & inhibitors | Mutagenesis, Site-Directed | Oxidation-Reduction | Cytochrome P-450 CYP2B6 - genetics | Halogenated Diphenyl Ethers - pharmacology | Rats | Cytochrome P450 Family 2 - chemistry | Cytochrome P-450 CYP2B1 - antagonists & inhibitors | Aryl Hydrocarbon Hydroxylases - metabolism | Cytochrome P-450 CYP2B6 Inhibitors - pharmacology | Halogenated Diphenyl Ethers - metabolism | Cytochrome P-450 Enzyme Inhibitors - pharmacology | Animals | Cytochrome P450 Family 2 - metabolism | Alkylation - drug effects | Cytochrome P-450 CYP2B6 - chemistry | Amino Acid Substitution | Research | Chemical properties | Aniline | Cytochrome P-450 | Index Medicus
Journal Article
Angewandte Chemie (International ed.), ISSN 1433-7851, 2019, Volume 58, Issue 29, pp. 9959 - 9963
Journal Article
Angewandte Chemie (International ed.), ISSN 1433-7851, 2019, Volume 58, Issue 17, pp. 5668 - 5671
The conversion of saturated fatty acids to high value chiral hydroxy‐acids and lactones poses a number of synthetic challenges: the activation of unreactive... 
regioselectivity | lactones | cytochrome P450 | fatty acids | biocatalysis | OXIDATION | ACTIVATION | CYP102 | HYDROXYLATION | REACTIVITY | FATTY-ACIDS | CHEMISTRY, MULTIDISCIPLINARY | BM-3 | MONOOXYGENASES | Stereoselectivity | Cytochrome | Decalactone | Hydroxylation | Cytochrome P450 | Docking | Enantiomers | Fatty acids | Cytochrome P450 monooxygenase | Lactones | Cytochromes P450
Journal Article
International journal of molecular sciences, ISSN 1422-0067, 2019, Volume 20, Issue 18, p. 4562
Sesquiterpenes, the main components of plant essential oils, are bioactive compounds with numerous health-beneficial activities. Sesquiterpenes can interact... 
gene reporter assay | VITRO | ALPHA-HUMULENE | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | pregnane X receptor | PRECISION-CUT LIVER | sesquiterpene | cytochrome P450 3A4 | CHEMISTRY, MULTIDISCIPLINARY | mRNA expression | SLICES | INHIBITION | BETA-CARYOPHYLLENE OXIDE | ARYL-HYDROCARBON RECEPTOR | CYTOCHROME-P450 ENZYMES | GENE-EXPRESSION | protein expression | precision-cut liver slices | Monocyclic Sesquiterpenes - pharmacology | Liver - enzymology | Carbonyl Reductase (NADPH) - metabolism | Farnesol - pharmacology | Humans | Middle Aged | Cytochrome P-450 Enzyme System - metabolism | Pregnane X Receptor - agonists | Male | Metabolic Clearance Rate | Pregnane X Receptor - metabolism | Polycyclic Sesquiterpenes - pharmacology | Hepatocytes - metabolism | RNA, Messenger - metabolism | Hep G2 Cells | Receptors, Aryl Hydrocarbon - agonists | Cytochrome P450 Family 2 - metabolism | Cytochrome P-450 CYP3A - metabolism | Aldo-Keto Reductases - metabolism | Aged, 80 and over | Receptors, Aryl Hydrocarbon - metabolism | Female | Aged | Sesquiterpenes - pharmacology | Cytochrome | Alkaline phosphatase | Physiological effects | CYP1A protein | Liver | Bilirubin | Proteins | Receptors | Aromatic compounds | Sesquiterpenes | Physiology | Drug dosages | Nutraceuticals | Cytochromes P450 | Functional foods & nutraceuticals | Enzymes | Alanine | Cytochrome P450 | Remedies | Nuclear receptors | Patients | Herbal medicine | Prescription drugs | Alanine transaminase | Protein expression | Plasma levels | Aspartate aminotransferase
Journal Article
PloS one, ISSN 1932-6203, 2018, Volume 13, Issue 1, p. e0191058
[This corrects the article DOI: 10.1371/journal.pone.0187168.]. 
Cytochrome | Post-translation | Transcription | Cytochrome P450 | Cholesterol | Cytochromes P450
Journal Article
ChemCatChem, ISSN 1867-3880, 2018, Volume 10, Issue 14, pp. 2927 - 2927
The front cover artwork for Issue 14/2018 is provided by the Laboratory of Biocatalysis and Synthetic Biotechnology, East China University of Science and... 
Journal Article
Journal Article