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Drug Metabolism and Disposition, ISSN 0090-9556, 08/2018, Volume 46, Issue 8, pp. 1053 - 1065
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 07/2017, Volume 45, Issue 7, p. 765
Highly selective cytochrome P450 CYP2J2 (CYP2J2) inhibitors suitable for reaction phenotyping are currently not available. (7S)-(+)-(4-Nitro-phenyl)-acrylic... 
Cytochrome | Hydroxylation | Hydroxylase | Liver | Cytochrome P450 | Acrylic acid | Data processing | Terfenadine | Metabolism | Microsomes | Inhibitors | Phenotyping | Isoforms | Drug metabolism | NADP
Journal Article
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 10/2015, Volume 764, pp. 480 - 488
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2012, Volume 7, Issue 6, p. e39197
Background: MicroRNAs (miRNAs) are small, noncoding RNA molecules of 20 to 22 nucleotides that regulate gene expression by binding to their 39 untranslated... 
APOPTOSIS | SIGNALING PATHWAYS | METABOLISM | BIOLOGY | ARACHIDONIC-ACID EPOXYGENASE | TUMOR-SUPPRESSOR | MOLECULAR-CLONING | PROLIFERATION | CELL-GROWTH | MICRORNAS | EXPRESSION | Cell Proliferation | Luciferases - metabolism | Cytochrome P-450 Enzyme Inhibitors | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - pathology | Humans | Gene Expression Regulation, Neoplastic | 3' Untranslated Regions - genetics | Cytochrome P-450 Enzyme System - metabolism | Lung Neoplasms - pathology | Male | Breast Neoplasms - enzymology | Female | Lung - metabolism | Tumor Cells, Cultured | Real-Time Polymerase Chain Reaction | Lung Neoplasms - genetics | Carcinoma, Squamous Cell - enzymology | Lung - pathology | Lung Neoplasms - enzymology | RNA, Messenger - genetics | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Phenotype | Animals | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Mice, Nude | Cytochrome P-450 Enzyme System - genetics | Mice | Mice, Inbred BALB C | MicroRNAs - genetics | Apoptosis | MicroRNA | Analysis | Luciferase | Cytochrome P-450 | Antisense RNA | Genetic aspects | Gene expression | Cancer | Cytochrome | Cell proliferation | Post-transcription | Genomics | Lung cancer | Colorectal cancer | Estrogen | Science | Biosynthesis | Nucleotides | Kinases | Western blotting | Cell adhesion & migration | Skin cancer | Proteins | Cell growth | Enzymatic activity | Animal tissues | Xenografts | Cell cycle | Tumor necrosis factor-TNF | Inhibition | Bioinformatics | Internal medicine | Tumor cells | Cytochrome P450 | MiRNA | Melanoma | Breast cancer | Ribonucleic acid--RNA | Medicine | Polymerase chain reaction | 3' Untranslated regions | MicroRNAs | Lymphomas | Gene therapy | Tumors | RNA | Ribonucleic acid
Journal Article
Chemico-Biological Interactions, ISSN 0009-2797, 06/2019, Volume 306, pp. 1 - 9
The inhibitory effects of antihypertensive drugs (dihydropyridine calcium channel blockers, angiotensin II receptor blockers, and angiotensin-converting enzyme... 
Antihypertensive drugs | Docking simulation | Cytochrome P450 2J2 | Inhibition | Inactivation | CYP2J2 | CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | INVOLVEMENT | ANTITUMOR-ACTIVITY | IN-VITRO | METABOLISM | SUBSTRATE | PHARMACOLOGY & PHARMACY | TOXICOLOGY | EXPRESSION | PROMOTES
Journal Article
International Journal of Molecular Sciences, ISSN 1661-6596, 07/2018, Volume 19, Issue 7, p. 2066
Journal Article
Drug Metabolism and Pharmacokinetics, ISSN 1347-4367, 02/2018, Volume 33, Issue 1, pp. 61 - 66
The human cytochrome P450 2J2 is involved in several metabolic reactions, including the oxidation of important therapeutics and epoxidation of endogenous... 
Terfenadine | Allele | Genetic variation | Cytochrome P450 | P450 2J2 | CYP2J2 | VARIANTS | IDENTIFICATION | POLYMORPHISMS | CLONING | MICROSOMES | PHARMACOLOGY & PHARMACY | EXPRESSION
Journal Article
Journal of Histochemistry and Cytochemistry, ISSN 0022-1554, 04/2004, Volume 52, Issue 4, pp. 447 - 454
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 09/2017, Volume 45, Issue 9, p. 990
The mechanism-based inactivation of human CYP2J2 by three terminal acetylenic compounds: N-(methylsulfonyl)-6-(2-propargyloxyphenyl)hexanamide (MS),... 
Cytochrome | Prostheses | Deactivation | Cytochrome P450 | Mass spectroscopy | Liquid chromatography | Iron | Inactivation | Heme | Carboxylation | NADP | Oxygenation | Mass spectrometry | Glutathione
Journal Article
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, ISSN 0022-1554, 04/2004, Volume 52, Issue 4, pp. 447 - 454
Soluble epoxide hydrolase (sEH) hydrolyzes a wide variety of endogenous and exogenous epoxides. Many of these epoxides are believed to be formed by cytochrome... 
METABOLITES | EPOXYGENASE | BIOACTIVATION | cytochrome P450 | ARACHIDONIC-ACID | soluble epoxide hydrolase | human tissues | BLOOD-PRESSURE | CELL BIOLOGY | BIOSYNTHESIS | LIVER | immunohistochemistry | HYPERTENSION | EPOXYEICOSATRIENOIC ACIDS | EXPRESSION
Journal Article
Prostaglandins and Other Lipid Mediators, ISSN 1098-8823, 12/2012, Volume 99, Issue 3-4, pp. 68 - 78
► Global cerebral ischemia-reperfusion model was used to investigate the effect of CYP2J2. ► Transgenic mice with endothelial overexpression of CYP2J2 are more... 
Neuroprotection | Cytochrome P450 epoxygenase | Stroke | Arachidonic acid | Global cerebral ischemia | ISCHEMIA/REPERFUSION INJURY | SIGNALING PATHWAYS | ARTERY OCCLUSION | BIOCHEMISTRY & MOLECULAR BIOLOGY | COPPER/ZINC SUPEROXIDE-DISMUTASE | NEURONAL CELL-DEATH | BLOOD-FLOW | FOREBRAIN ISCHEMIA | CELL BIOLOGY | TEMPORAL PROFILE | FREE-RADICAL GENERATION | EPOXYEICOSATRIENOIC ACIDS | Gene Expression - drug effects | Apoptosis - drug effects | Coronary Occlusion - genetics | Brain Ischemia - genetics | Cytochrome P-450 Enzyme System - metabolism | Male | Phosphatidylinositol 3-Kinases - metabolism | 8,11,14-Eicosatrienoic Acid - metabolism | Cerebral Infarction - genetics | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Proto-Oncogene Proteins c-akt - genetics | Cerebral Infarction - enzymology | Brain Ischemia - enzymology | Cell Hypoxia | 8,11,14-Eicosatrienoic Acid - analogs & derivatives | Cerebral Infarction - physiopathology | Apoptosis Regulatory Proteins - genetics | 8,11,14-Eicosatrienoic Acid - pharmacology | Proto-Oncogene Proteins c-akt - metabolism | Astrocytes - cytology | Astrocytes - drug effects | Cells, Cultured | Coronary Occlusion - enzymology | Mice, Transgenic | Brain Ischemia - physiopathology | Cerebrovascular Circulation | Apoptosis Regulatory Proteins - metabolism | Phosphatidylinositol 3-Kinases - genetics | Glucose - deficiency | Animals | Signal Transduction - drug effects | Apoptosis Regulatory Proteins - antagonists & inhibitors | Cytochrome P-450 Enzyme System - genetics | Mice | Protein Kinase Inhibitors - pharmacology | Coronary Occlusion - physiopathology | Astrocytes - metabolism | Unsaturated fatty acids | Cerebral ischemia | Prostaglandins | Polyvinylidene fluoride | Analysis | Cytochrome P-450 | Dimethyl sulfoxide | DNA polymerases | Genetic engineering | Endothelium | arachidonic acid | global cerebral ischemia | cytochrome P450 epoxygenase | stroke | neuroprotection
Journal Article
Journal Article
American Journal of Hypertension, ISSN 0895-7061, 2005, Volume 18, Issue 10, pp. 1276 - 1281
Journal Article
Pharmacogenetics and Genomics, ISSN 1744-6872, 01/2008, Volume 18, Issue 1, pp. 45 - 51
OBJECTIVEEpoxyeicosatrienoic acids have been recognized for their protective effects on the cardiovascular system. This study investigated whether two common... 
CYP2J2 | Genetics | Ischemic stroke | Cytochrome P450 | EPHX2 | Polymorphism | Genetics, Population | Humans | Middle Aged | Male | DNA Primers | Stroke - genetics | Epoxide Hydrolases - genetics | Stroke - enzymology | Genetic Variation | Base Sequence | China | Cytochrome P-450 Enzyme System - genetics | Female | polymorphism | genetics | cytochrome P450 | ischemic stroke
Journal Article