X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (1520) 1520
Book Review (407) 407
Publication (231) 231
Book / eBook (28) 28
Book Chapter (10) 10
Conference Proceeding (4) 4
Data Set (1) 1
Dissertation (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
index medicus (1408) 1408
animals (948) 948
humans (876) 876
mice (509) 509
immunology (402) 402
receptors, cytoplasmic and nuclear - metabolism (358) 358
cell biology (285) 285
inflammation (268) 268
male (267) 267
biochemistry & molecular biology (249) 249
cells, cultured (219) 219
female (218) 218
proteins (189) 189
receptors, cytoplasmic and nuclear - genetics (181) 181
lipopolysaccharides - pharmacology (179) 179
activation (177) 177
mice, inbred c57bl (174) 174
signal transduction (171) 171
expression (170) 170
nf-kappa-b (156) 156
article (149) 149
macrophages (144) 144
rats (134) 134
analysis (131) 131
cell line (131) 131
gene expression (126) 126
gene-expression (123) 123
research (123) 123
cells (120) 120
physiological aspects (118) 118
microbiology (117) 117
cytokines (113) 113
mice, knockout (113) 113
receptors, cytoplasmic and nuclear - physiology (113) 113
macrophages - metabolism (107) 107
pharmacology & pharmacy (103) 103
abridged index medicus (101) 101
multidisciplinary sciences (100) 100
apoptosis (99) 99
lipopolysaccharide (99) 99
receptors, cytoplasmic and nuclear - agonists (99) 99
cytoplasmic domain (97) 97
ligands (95) 95
disease models, animal (91) 91
rodents (91) 91
research article (90) 90
rna, messenger - metabolism (90) 90
transcription factors - metabolism (90) 90
hematology (88) 88
tumor-necrosis-factor (88) 88
bacteria (87) 87
in-vivo (86) 86
physiology (85) 85
dendritic cells (83) 83
gene expression regulation (82) 82
health aspects (82) 82
innate immunity (81) 81
liver (81) 81
liver x receptors (79) 79
dna-binding proteins - metabolism (77) 77
adult (76) 76
in-vitro (75) 75
medicine (75) 75
biology (74) 74
neutrophils - immunology (73) 73
nuclear receptors (73) 73
lipids (72) 72
macrophages - immunology (72) 72
antineutrophil cytoplasmic antibodies (71) 71
cytoplasmic granules - metabolism (70) 70
liver - metabolism (70) 70
orphan nuclear receptors (70) 70
protein binding (70) 70
medicine, research & experimental (69) 69
neutrophils (69) 69
molecular sequence data (68) 68
nf-kappa b - metabolism (68) 68
disease (67) 67
toll-like receptors (67) 67
cytoplasmic membrane (66) 66
lipopolysaccharides (66) 66
metabolism (65) 65
vasculitis (65) 65
ppar-gamma (64) 64
life sciences (63) 63
rna, messenger - genetics (63) 63
inflammation - metabolism (62) 62
middle aged (62) 62
phosphorylation (62) 62
neutrophils - metabolism (61) 61
neurosciences (60) 60
dose-response relationship, drug (59) 59
genetic aspects (58) 58
necrosis-factor-alpha (58) 58
amino acid sequence (57) 57
autoantibodies (57) 57
biophysics (57) 57
oxidative stress (57) 57
autoimmunity (56) 56
escherichia-coli (56) 56
more...
Library Location Library Location
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (1549) 1549
Chinese (2) 2
Japanese (2) 2
French (1) 1
Italian (1) 1
Russian (1) 1
Spanish (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Nature, ISSN 0028-0836, 2014, Volume 514, Issue 7521, pp. 187 - 192
The murine caspase-11 non-canonical inflammasome responds to various bacterial infections. Caspase-11 activation-induced pyroptosis, in response to cytoplasmic... 
ACTIVATION | GRAM-NEGATIVE BACTERIA | MULTIDISCIPLINARY SCIENCES | CYTOPLASMIC LPS | NLRP3 | LIPID IVA | MECHANISMS | PYROPTOSIS | PROTEINS | TLR4 | LIPOPOLYSACCHARIDE RECOGNITION | Surface Plasmon Resonance | Epithelial Cells - metabolism | Caspases - immunology | Humans | Lipopolysaccharides - metabolism | Substrate Specificity | Caspases, Initiator - genetics | Genetic Complementation Test | Lipopolysaccharides - immunology | Caspases - metabolism | Caspases, Initiator - metabolism | Protein Multimerization - genetics | Cell Death - drug effects | Caspases - chemistry | Epithelial Cells - cytology | Caspases, Initiator - immunology | Lipid A - metabolism | Caspases - genetics | Cells, Cultured | Rhodobacter sphaeroides - chemistry | Mutant Proteins - metabolism | Keratinocytes - cytology | Macrophages - cytology | Enzyme Activation - drug effects | Immunity, Innate | Necrosis - chemically induced | Macrophages - metabolism | Animals | Rhodobacter sphaeroides - immunology | Keratinocytes - metabolism | Caspases, Initiator - chemistry | Mutant Proteins - chemistry | Lipopolysaccharides - pharmacology | Protein Binding | Macrophages - drug effects | Mice | Enzyme Activation - genetics | Inflammation - enzymology | Protein Multimerization - drug effects | Lipids | Septic shock | Immune response | Health aspects | Analysis | Proteins | Salmonella | Bacterial infections | E coli | Bacteria | Cytotoxicity | Mutation | Apoptosis | Index Medicus
Journal Article
细胞研究:英文版, ISSN 1001-0602, 2015, Volume 25, Issue 2, pp. 149 - 150
Inflammasomes are sensors that serve as activation platforms for caspase-1 -- a mechanism that set the prevailing paradigm for inflammatory caspase activation.... 
半胱氨酸蛋白酶 | 炎症 | 直接检测 | 胱天蛋白酶 | 通配符 | LPS | caspase | 细胞死亡 | ACTIVATION | INTRACELLULAR LPS | CYTOPLASMIC LPS | PROTECTS | CELL BIOLOGY | Lipopolysaccharides - metabolism | Animals | Caspases - metabolism | Caspases, Initiator - metabolism | Immunity, Innate | Humans | Index Medicus | Research Highlight
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 09/2017, Volume 140, pp. 64 - 72
Toll-like receptor (TLR) 4-independent recognition of lipopolysaccharide (LPS) in the cytosol by inflammatory caspases leads to non-canonical inflammasome... 
Inflammatory caspases | Interleukin-1beta (IL-1β) | Synthetic anti-endotoxin peptides | Pyroptosis | Cytoplasmic lipopolysaccharide (LPS) | DEFENSE | RECEPTOR | NLRP3 INFLAMMASOME | RELEASE | NONCANONICAL INFLAMMASOME ACTIVATION | IMMUNE-RESPONSES | CASPASES | TARGETS | PHARMACOLOGY & PHARMACY | IL-1-BETA | Interleukin-1beta (IL-1 beta) | Inflammasomes - metabolism | Pyroptosis - drug effects | Monocytes - cytology | Humans | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Cytoplasm - metabolism | Monocytes - metabolism | Monocytes - immunology | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Macrophages - secretion | Inflammasomes - drug effects | Interleukin-1beta - metabolism | Myeloid Cells - immunology | Myeloid Cells - drug effects | Toll-Like Receptor 4 - antagonists & inhibitors | Macrophages - immunology | Interleukin-1beta - secretion | Cell Survival - drug effects | Lipopolysaccharides - toxicity | Peptides - chemistry | Cells, Cultured | Keratinocytes - secretion | Sulfonamides - pharmacology | Toll-Like Receptor 4 - metabolism | Keratinocytes - immunology | Peptides - pharmacology | Monocytes - drug effects | Endotoxins - antagonists & inhibitors | Macrophages - metabolism | Myeloid Cells - secretion | Keratinocytes - drug effects | Keratinocytes - metabolism | Inflammasomes - immunology | Cell Line, Tumor | Myeloid Cells - metabolism | Macrophages - drug effects | Macrophage Activation - drug effects | Cytoplasm - drug effects | Cell Line, Transformed | Endotoxins - toxicity | Chromosomal proteins | Peptides | Interleukins | Cell death | Pharmacy | Septic shock | Skin | Macrophages | Mitogens | Index Medicus
Journal Article
BBA - Molecular and Cell Biology of Lipids, ISSN 1388-1981, 10/2019, Volume 1864, Issue 10, pp. 1503 - 1513
Outer membrane vesicles (OMVs) are secreted by Gram-negative bacteria and induce a stronger inflammatory response than pure LPS. After endocytosis of OMVs by... 
Cytoplasmic lipopolysaccharide | Outer membrane vesicles | Interleukin-1beta | Synthetic anti-endotoxin peptides | Pyroptosis | P2X7 receptor | ACTIVATION | LL-37 | MACROPHAGES | BIOCHEMISTRY & MOLECULAR BIOLOGY | MECHANISMS | RELEASE | CELL BIOLOGY | BIOPHYSICS | IL-1-BETA | CELL | Peptides | Interleukins | Microbiology | Escherichia coli | Physiological aspects | Inflammation | Macrophages | Mitogens | Index Medicus
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 242 - 14
Journal Article
PLoS Pathogens, ISSN 1553-7366, 04/2012, Volume 8, Issue 4, pp. e1002597 - e1002597
LPS-activated neutrophils secrete IL-1 beta by activation of TLR-4. Based on studies in macrophages, it is likely that ROS and lysosomal destabilization... 
B-CELL RECEPTOR | CYTOPLASMIC DOMAIN | APOPTOSIS | SIGNALING PATHWAYS | MICROBIOLOGY | NLRP3 INFLAMMASOME | NALP3 INFLAMMASOME | ADHESION | INHIBITION | VIROLOGY | SYK TYROSINE KINASE | PARASITOLOGY | LUMEN FORMATION | Neutrophil Activation - genetics | Inflammation - pathology | Inflammasomes - metabolism | Reactive Oxygen Species - metabolism | Protein-Tyrosine Kinases - metabolism | Lysosomes - genetics | Carcinoembryonic Antigen - genetics | Caspase 1 - metabolism | Multiprotein Complexes - genetics | Intracellular Signaling Peptides and Proteins - metabolism | Interleukin-1beta - genetics | Carcinoembryonic Antigen - metabolism | Multiprotein Complexes - metabolism | Inflammation - metabolism | Phosphorylation - genetics | Toll-Like Receptor 4 - agonists | Phosphorylation - immunology | Phosphorylation - drug effects | Intracellular Signaling Peptides and Proteins - genetics | Neutrophils - metabolism | Syk Kinase | Neutrophil Activation - immunology | Neisseria - immunology | Macrophages - pathology | Toll-Like Receptor 4 - genetics | Toll-Like Receptor 4 - immunology | Toll-Like Receptor 4 - metabolism | Mice, Knockout | Macrophages - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - metabolism | Lipopolysaccharides - pharmacology | Mice | Enzyme Activation - genetics | Lysosomes - immunology | Multiprotein Complexes - immunology | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - immunology | Neisseriaceae Infections - genetics | Neutrophil Activation - drug effects | Intracellular Signaling Peptides and Proteins - immunology | Caspase 1 - immunology | Enzyme Activation - immunology | Protein-Tyrosine Kinases - immunology | Protein-Tyrosine Kinases - genetics | Lysosomes - metabolism | Reactive Oxygen Species - immunology | Lysosomes - pathology | Interleukin-1beta - biosynthesis | Neisseriaceae Infections - pathology | Macrophages - immunology | Neutrophils - pathology | Neisseriaceae Infections - metabolism | Carcinoembryonic Antigen - immunology | Neutrophils - immunology | Interleukin-1beta - immunology | Inflammation - immunology | Enzyme Activation - drug effects | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - genetics | Inflammasomes - genetics | Animals | Neisseria - metabolism | Caspase 1 - genetics | Neisseriaceae Infections - immunology | Inflammasomes - immunology | Inflammation - genetics | Index Medicus | Phosphorylation | Reactive oxygen species | SHP-1 protein | Leukocytes | Macrophages | Caspase-1 | Lipopolysaccharides | Cell activation | CEACAM1 protein | Interleukin 1 | Bone marrow | Toll-like receptors | Meningitis | Gram-negative bacteria | Immune system | Pathogens | RNA-mediated interference | Inflammation | Leukocytes (neutrophilic) | Gonorrhea | TLR4 protein | Infection | Stem cells | CD66 antigen | Syk protein
Journal Article
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2017, Volume 7, Issue 1, pp. 1844 - 13
Journal Article
Journal Article
Journal Article
Journal of Lipid Research, ISSN 0022-2275, 11/2005, Volume 46, Issue 11, pp. 2377 - 2387
The acute-phase response (APR) suppresses type II nuclear hormone receptors and alters the expression of their target genes involved in lipid metabolism in the... 
Acute-phase response | Lipopolysaccharide | Lipid metabolism | SIGNALING PATHWAYS | LIPID-METABOLISM | CHOLESTEROL ACCUMULATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | lipid metabolism | LXR | acute-phase response | HEPATOMA-CELLS | TUMOR-NECROSIS-FACTOR | MESSENGER-RNA | GENE | lipopolysaccharide | EXPRESSION | Tumor Necrosis Factor-alpha - metabolism | ATP Binding Cassette Transporter, Sub-Family G, Member 1 | Histone Acetyltransferases | Luciferases - metabolism | Retinoid X Receptor alpha - metabolism | Humans | Lipopolysaccharides - metabolism | Receptors, Cytoplasmic and Nuclear - biosynthesis | DNA Primers - chemistry | RNA, Messenger - metabolism | Apolipoproteins E - metabolism | DNA-Binding Proteins - metabolism | Dose-Response Relationship, Drug | Kidney - metabolism | Transfection | Time Factors | Liver X Receptors | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | ATP-Binding Cassette Transporters - metabolism | Female | Transcription, Genetic | Orphan Nuclear Receptors | Fatty Acids - metabolism | Sterol Regulatory Element Binding Protein 1 - metabolism | RNA - metabolism | Cell Line | Interleukin-1 - metabolism | Cytokines - metabolism | Down-Regulation | Heat-Shock Proteins - metabolism | Mice, Inbred C57BL | Cells, Cultured | Inflammation | Models, Statistical | Reverse Transcriptase Polymerase Chain Reaction | Kidney Tubules - cytology | Transcription Factors - metabolism | Blotting, Northern | Animals | Nuclear Receptor Coactivator 1 | Mice | DNA-Binding Proteins - biosynthesis | Receptors, Cytoplasmic and Nuclear - metabolism | Index Medicus
Journal Article