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by Jiang, NN and Du , SZ and Ye, YS and Yan, H and Yang, XW and Yang, J and Nian, Y and Xu, G
TETRAHEDRON LETTERS, ISSN 0040-4039, 11/2019, Volume 60, Issue 45
Hyphenone A (1), a new type of bicyclic polyprenylated acylphloroglucinols (BPAPs) featured with an unprecedented 3,3-diisoprenylated 1,3,5-trione core, were... 
PRENYLATED ACYLPHLOROGLUCINOLS | BIOSYNTHESIS | Hyphenone A | CHEMISTRY, ORGANIC | HYPERFORIN | ROOTS | MEROTERPENOIDS | Polyprenylated acylphloroglucinol | Hypericum henryi | DERIVATIVES | XANTHONES | Ca(v)3.1 T-type calcium channel
Journal Article
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, ISSN 0031-6768, 12/2015, Volume 467, Issue 12, pp. 2519 - 2527
Low-voltage-activated Ca(V)3 channels are distinguished among other voltage-activated calcium channels by the most negative voltage activation threshold. The... 
MEMBRANE EXPRESSION | VOLTAGE | ACTIVATION | PHYSIOLOGY | Ca(V)3.1 | Activation kinetic | Ca(V)3.3 | CA2+ CHANNELS | T-TYPE CHANNELS | STRUCTURAL DETERMINANTS | CHILDHOOD ABSENCE EPILEPSY | INACTIVATION | KINETICS | Gating current | T-type calcium channels | MODULATION
Journal Article
CELLULAR AND MOLECULAR LIFE SCIENCES, ISSN 1420-682X, 05/2013, Volume 70, Issue 9, pp. 1653 - 1661
Journal Article
by Kim, CH
BRAIN RESEARCH, ISSN 0006-8993, 10/2015, Volume 1622, pp. 204 - 216
The molecular mechanism of temporal lobe epilepsy has not been clearly identified. T-type calcium channels play a role in burst firing in neurons and have been... 
IDIOPATHIC GENERALIZED EPILEPSIES | Ca(v)3.1 alpha 1G T-type calcium channel | SYNAPTIC REORGANIZATION | CA2+ CHANNELS | RECURRENT SEIZURES | STATUS EPILEPTICUS MODELS | NEUROSCIENCES | RAT MODEL | CHILDHOOD ABSENCE EPILEPSY | PILOCARPINE MODEL | Temporal lobe epilepsy | Seizure | DENTATE GYRUS | RELAY NEURONS | Kainic acid | Status epilepticus
Journal Article
Brain Research, ISSN 0006-8993, 10/2015, Volume 1622, pp. 204 - 216
The molecular mechanism of temporal lobe epilepsy has not been clearly identified. T-type calcium channels play a role in burst firing in neurons and have been... 
Ca v 3.1 α1G T-type calcium channel | Temporal lobe epilepsy | Seizure | Kainic acid | Status epilepticus
Journal Article
INTERNATIONAL JOURNAL OF ONCOLOGY, ISSN 1019-6439, 07/2012, Volume 41, Issue 1, pp. 267 - 275
T-type voltage-gated Ca2+ channels have unique electrophysiological properties, suitable for generating Ca2+ oscillations and waves and thus controlling the... 
PROTEIN | proliferation | Ca(v)3.1 | CA2+ CHANNELS | apoptosis | T-type voltage-gated Ca2+ channel | TUMOR-CELLS | IDENTIFICATION | tumor suppression | OVEREXPRESSION | GENE | ONCOLOGY | CLONING | MIBEFRADIL | DIFFERENTIATION | EXPRESSION
Journal Article
ACTA PHYSIOLOGICA, ISSN 1748-1708, 04/2013, Volume 207, Issue 4, pp. 709 - 720
Aim Using mice deficient in the CaV3.1 T-type Ca2+ channel, the aim of the present study was to elucidate the molecular identity of non-L-type channels... 
TERMINAL MESENTERIC-ARTERY | PHYSIOLOGY | RAT | Ca(V)3.1 T-type channel | ENDOTHELIAL FUNCTION | mesenteric artery | BLOOD-PRESSURE | voltage-gated calcium channel | SMOOTH-MUSCLE | EFONIDIPINE | CALCIUM-CHANNELS | arteriolar tone | MIBEFRADIL | CEREBRAL-ARTERIES | HYPERTENSION | myogenic response
Journal Article
CHANNELS, ISSN 1933-6950, 2018, Volume 12, Issue 1, pp. 378 - 387
Contributions of voltage sensing S4 segments in domains I - IV of Ca(V)3.1 channel to channel activation were analyzed. Neutralization of the uppermost charge... 
ACTIVATION | PHYSIOLOGY | voltage sensor | Ca(V)3.1 | T-type calcium channel | MEMBRANE | BIOCHEMISTRY & MOLECULAR BIOLOGY | voltage regulation | DEPENDENCE | PAIN | channel gating | ASPARAGINE-LINKED GLYCOSYLATION | EXPRESSION | MOLECULAR REGIONS
Journal Article
Channels (Austin, Tex.), ISSN 1933-6950, 05/2011, Volume 5, Issue 3, pp. 251 - 261
Journal Article
CELL CALCIUM, ISSN 0143-4160, 11/2012, Volume 52, Issue 5, pp. 377 - 387
Growth factors and hormones have both short- and long-term regulatory effects on the functional expression of voltage gated Ca2+ (Ca-v) channels. In... 
Ca(v)3.1 channels | Rab11 | INDUCTION | Insulin | CELL BIOLOGY | Ca2+ channels | CALCIUM-CHANNELS | CLONING | FUNCTIONAL EXPRESSION | EPIDERMAL-GROWTH-FACTOR | PITUITARY-CELLS | Endosome recycling | CA-2 | RAB GTPASES
Journal Article
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ISSN 0006-291X, 06/2011, Volume 410, Issue 1, pp. 19 - 23
T-type Ca2+ channels have been implicated in tremorogenesis and motor coordination. The alpha 1 subunit of the Ca(v)3.1 T-type Ca2+ channel is highly expressed... 
OLIVARY NEURONS INVITRO | SYSTEM | SUBUNIT KNOCKOUT MICE | SUBTYPES | HARMALINE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CIRCUITS | GABA(A) receptor alpha 1 subunit knockout | BIOPHYSICS | Ca(v)3.1 T-type Ca2+ channel | IONIC CONDUCTANCES | DISORDER | Motor coordination | Essential tremor | EXPRESSION | Double knockout mice
Journal Article
CELLULAR AND MOLECULAR NEUROBIOLOGY, ISSN 0272-4340, 12/2009, Volume 29, Issue 8, pp. 1265 - 1273
The activity of low voltage-activated Ca2+ (Ca(V)3) channels is tightly coupled to neurotransmitter and hormone secretion. Previous studies have shown that... 
ACTION-POTENTIALS | Dexamethasone | GH cells | Ca(V)3.1 | ACTIVATED CALCIUM CURRENT | ANTERIOR-PITUITARY-CELLS | Cortisol | PROLACTIN SECRETION | HORMONE-RELEASING HORMONE | NEUROSCIENCES | NERVE GROWTH-FACTOR | CELL BIOLOGY | Ca2+ channels | FUNCTIONAL EXPRESSION | SMOOTH-MUSCLE-CELLS | NEUROENDOCRINE CELLS | HEK-293 cells
Journal Article
CHANNELS, ISSN 1933-6950, 05/2010, Volume 4, Issue 3, pp. 163 - 167
A-type potassium current generated by the K(V)4 family of channels is an important factor regulating the frequency, latency and dendritic backpropagation of... 
PROTEIN | ISOFORMS | POTASSIUM CHANNELS | KV4.2 | BIOCHEMISTRY & MOLECULAR BIOLOGY | first spike latency | Ca(V)3 | CURRENTS | SUBUNIT MESSENGER-RNA | gain | K(V)4 | T-type | NEURONS | A-type | K+ CHANNELS | MODULATION
Journal Article
by He, BJ and Hu, F and Shang, XL and Han, LX and Wu, GY and Li, JY and Sun, JS
PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, ISSN 1000-3282, 09/2014, Volume 41, Issue 9, pp. 877 - 886
The notable features for inactivation of Ca(v)3 channels are fast inactivating rate and strong voltage-dependence. We have investigated the molecular basis for... 
ACTIVATION | CONTRIBUTE | ALPHA(1G) | BIOCHEMISTRY & MOLECULAR BIOLOGY | CA2+ CHANNELS | SURFACE EXPRESSION | voltage-dependence of inactivation | GATING PROPERTIES | molecular determinant | SODIUM-CHANNEL | STRUCTURAL DETERMINANTS | BIOPHYSICS | Ca(v)3.1 calcium channel | electrophysiology | KINETICS | I-II LOOP
Journal Article
MOLECULAR AND CELLULAR BIOCHEMISTRY, ISSN 0300-8177, 01/2009, Volume 320, Issue 1-2, pp. 173 - 183
The effect of the dexamethasone (Dex) on the regulation of the T-type Ca2+ channel expressions was investigated in primary cultures of neonatal rat ventricular... 
Dexamethasone | PACEMAKER CELLS | FACTOR-KAPPA-B | Glucocorticoid receptors | CURRENTS | Gene expression | CELL BIOLOGY | CA2+ CURRENT | CALCIUM-CHANNELS | T-type Ca(v)3.1 Channel | RAT-HEART | MICE | ATRIOVENTRICULAR-BLOCK | FETAL | DIFFERENTIATION | NF kappa B
Journal Article
CELL CALCIUM, ISSN 0143-4160, 10/2009, Volume 46, Issue 4, pp. 293 - 302
We investigated the biophysical mechanism of inhibition of recombinant T-type calcium channels Ca(V)3.1 and Ca(V)3.2 by nitrous oxide (N2O). To identify... 
SYSTEM | CHROMAFFIN-CELLS | MECHANISM | Single-channel analysis | Ca(V)3.1 | Ca(V)3.2 | T-type calcium channel | CA2+ CHANNELS | MOLECULAR SUBSTRATE | CURRENTS | RAT SENSORY NEURONS | CELL BIOLOGY | CLONING | ALPHA-1H | Nitrous oxide | EXPRESSION
Journal Article
FEBS LETTERS, ISSN 0014-5793, 11/2002, Volume 531, Issue 2, pp. 235 - 240
Intramembrane charge movement originating from Ca(v)3.1 (T-type) channel expressed in HEK 293 cells was investigated. Ion current was blocked by 1 mM La3+.... 
Ca(v)3.1 channel | PIG VENTRICULAR MYOCYTES | BIOCHEMISTRY & MOLECULAR BIOLOGY | CA2+ CHANNELS | charge movement | T-TYPE | SODIUM-CHANNEL | ALPHA(1G) SUBUNIT | IONIC CURRENT | CELL BIOLOGY | INACTIVATION | SKELETAL-MUSCLE | low-voltage activated calcium channel | BIOPHYSICS | INTRAMEMBRANE CHARGE MOVEMENT | VOLTAGE SENSOR | channel gating
Journal Article
GENERAL PHYSIOLOGY AND BIOPHYSICS, ISSN 0231-5882, 03/2011, Volume 30, Issue 1, pp. 100 - 105
T-type calcium channels are involved in a variety of physiological and pathophysiological processes, and thus could be therapeutic targets. However, there is... 
PHYSIOLOGY | VARIANTS | Ca(v)3.1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | THROUGHPUT ELECTROPHYSIOLOGY | BLOCK | RECEPTOR | T-Type calcium channel | MAMMALIAN-CELLS | ABSENCE EPILEPSY | INHIBITION | BIOPHYSICS | CA2+ CHANNEL | Drug discovery | Automated patch-clamp | VERAPAMIL
Journal Article
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