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animals (20) 20
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Biochemical journal, ISSN 1470-8728, 2007, Volume 408, Issue 3, pp. 297 - 315
The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a panel of 70-80 protein kinases... 
Drug discovery | Kinase profiling | Protein kinase | Anti-cancer drugs | Inhibitor specificity | RHO-ASSOCIATED KINASE | TUMOR PROGRESSION | FAMILY-MEMBERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-PROLIFERATION | protein kinase | P38 MAP KINASE | CYCLIN-DEPENDENT KINASES | RECEPTOR TYROSINE KINASES | drug discovery | kinase profiling | SB 203580 | anti-cancer drugs | ISOFORMS IN-VITRO | P90 RSK | inhibitor specificity | Amino Acid Sequence | Cell Line | Phosphorylation | Recombinant Proteins - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Drug Design | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Spodoptera | Yes1, Yamaguchi sarcoma viral oncogene homologue 1 | CSK, C-terminal Src kinase | Lck, lymphocyte cell-specific protein-tyrosine kinase | EGF, epidermal growth factor | FGF-R, fibroblast-growth-factor receptor | PAK, p21-activated protein kinase | PDK, 3-phosphoinositide-dependent protein kinase | PI3K, phosphatidylinositol (phosphoinositide) 3-kinase | NEK, NIMA (never in mitosis in Aspergillus nidulans)-related kinase | RSK, p90 ribosomal S6 kinase | HEK-293 cells, human embryonic kidney-293 cells | VEGF, vascular endothelial growth factor (vasoendothelial growth factor) | EF2K, elongation-factor-2 kinase | CK, casein kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | ATM, ataxia telangiectasia mutated | SRPK, serine-arginine protein kinase | IL-1, interleukin 1 | MNK, MAPK-integrating protein kinase | ROCK, Rho-dependent protein kinase | CaMKK, CaMK kinase | GST, glutathione transferase | MKK1, MAPK kinase-1 (also called MEK1, MAPK or ERK kinase 1) | GAK, cyclin G-associated kinase | FMK, fluoromethylketone | MST, mammalian homologue Ste20-like kinase | PKA, cAMP-dependent protein kinase | FKBP, FK506-binding protein | PPAR, peroxisome-proliferator-activated receptor | IKK, inhibitory κB kinase | PH, pleckstrin homology | MBP, myelin basic protein | AICAR, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside | MAPKAP-K, MAPK-activated protein kinase | Sf21, Spodoptera frugiperda (fall armyworm) 21 | MARK, microtubule-affinity-regulating kinase | PIM, provirus integration site for Moloney murine leukaemia virus | LPS, lipopolysaccharide | MSK, mitogen- and stress-activated protein kinase | MAPK, mitogen-activated protein kinase | MELK, maternal embryonic leucine-zipper kinase | His6, hexahistidine | CAK, cyclin-dependent kinase-activating kinase | Eph-A2, Ephrin A2 receptor | PLK, polo-like kinase | ATF2, activating transcription factor 2 | PKD, protein kinase D | Src, sarcoma kinase | AMPK, AMP-activated protein kinase | MMS, methyl methanesulfonate | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | TORC1, mTOR (mammalian target of rapamycin)–raptor (regulatory associated protein of mTOR) complex | BRSK, brain-specific kinase | RIP2, receptor-interacting protein 2 | IGF-1, insulin-like growth factor-1 | S6K1, S6 kinase 1 | DYRK, dual-specificity tyrosine-phosphorylated and -regulated kinase | HIPK, homeodomain-interacting protein kinase | ZMP, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside monophosphate | PRAK, p38-regulated activated kinase | PKC, protein kinase C | Src-I1, Src inhibitor 1 | TANK, TRAF (tumour-necrosis-factor-receptor-associated factor)-family-member-associated nuclear factor κB activator | NFAT, nuclear factor for activated T-cells | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | CaMK, calmodulin-dependent kinase | CDK, cyclin-dependent protein kinase | NDRG, N-myc downstream-regulated gene | SmMLCK, smooth-muscle myosin light-chain kinase | TBK1, TANK-binding kinase 1 | PRK, protein kinase C-related kinase | SGK, serum- and glucocorticoid-induced kinase
Journal Article
Biochemical journal, ISSN 0264-6021, 02/2010, Volume 426, Issue 1, pp. 109 - 118
Activation of AMPK (AMP-activated protein kinase) by phosphorylation at Thr(172) is catalysed by at least two distinct upstream kinases, i.e... 
calmodulin-dependent protein kinase (CaMK) | AMP-activated protein kinase-related kinase (ARK) | calmodulin-dependent protein kinase kinase (CaMKK) | AMP-activated protein kinase (AMPK) | TUMOR-SUPPRESSOR LKB1 | LOCALIZATION | MECHANISM | Ca2+/calmodulin-dependent protein kinase kinase (CaMKK) | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | RECEPTOR | CASCADE | UPSTREAM KINASE | Ca2+/calmodulin-dependent protein kinase (CaMK) | SUBSTRATE-SPECIFICITY | INHIBITION | CLONING | Amino Acid Sequence | Cell Line | AMP-Activated Protein Kinases - metabolism | Immunoprecipitation | Calcium - metabolism | Humans | Molecular Sequence Data | Calcimycin - pharmacology | Phenformin - pharmacology | Cyclic AMP - pharmacology | Sequence Homology, Amino Acid | Calcium - physiology | Adenosine Triphosphate - metabolism | Calcium-Calmodulin-Dependent Protein Kinase Kinase - metabolism | Protein Binding | Adenosine Diphosphate - metabolism | HeLa Cells | Phosphorylation - drug effects | Ionophores - pharmacology | ACC, acetyl-CoA carboxylase | calmodulin-dependent protein kinase kinase | HEK, human embryonic kidney | MARK, microtubule affinity-regulating kinase | AMPK, AMP-activated protein kinase | TBS, Tris-buffered saline | BRSK, brain-specific kinase | UBA, ubiquitin-associated | MO25, mouse protein 25 | CaMK, Ca2 | ARK, AMPK-related kinase | NUAK, SNF1 (sucrose-non-fermenting kinase-1)-like kinase | AMPactivated protein kinase-related kinase (ARK) | GST, glutathione transferase | STRAD, Ste20-related adaptor | GFP, green fluorescent protein | calmodulin-dependent protein kinase | SIK, salt-inducible kinase | calmodulindependent protein kinase (CaMK) | Ca2 | AICAR, 5-amino-4-imidazolecarboxamide riboside | FBS, foetal bovine serum | CaMKK, Ca2
Journal Article
Pharmaceuticals (Basel, Switzerland), ISSN 1424-8247, 2019, Volume 12, Issue 1, p. 8
...+/calmodulin-stimulated protein kinase (CaMK) family. These enzymes control a broad range of cancer-related functions in a multitude of tumour types... 
CaMKI | CaMKK | CaMKII | CaMKIV | Anti-cancer drugs | SUPPRESSES TUMOR-GROWTH | ANDROGEN RECEPTOR | CA-2+ CALMODULIN | II INHIBITOR PROTEIN | FACTOR-KAPPA-B | FAS-MEDIATED APOPTOSIS | C-FLIP EXPRESSION | PROSTATE-CANCER | GASTRIC ADENOCARCINOMA CELLS | PHARMACOLOGY & PHARMACY | MOLECULAR-CLONING | anti-cancer drugs
Journal Article
Stroke (1970), ISSN 0039-2499, 09/2013, Volume 44, Issue 9, pp. 2559 - 2566
Journal Article
Cellular signalling, ISSN 0898-6568, 2011, Volume 23, Issue 10, pp. 1686 - 1690
.... Here we show that Calcium/Calmodulin-dependent kinase IV (CaMK IV) specifically binds to the C terminus of PHB2 and phosphorylates PHB2 at serine 91... 
MEF2 | Phosphorylation | PHB2 | CaMKIV | Interaction | CELLS | COMPLEX | ACTIVATION | PROTEIN | MITOCHONDRIA | CELL BIOLOGY | ESTROGEN-RECEPTOR ACTIVITY | MUSCLE DIFFERENTIATION | HISTONE DEACETYLASES | INTERACTS | EXPRESSION | Cell Line | Immunoprecipitation | Calcium-Calmodulin-Dependent Protein Kinase Type 4 - metabolism | Transcriptional Activation | Gene Expression Regulation | Myogenic Regulatory Factors - metabolism | Substrate Specificity | Recombinant Fusion Proteins - metabolism | Blotting, Western | Transcription Factors - metabolism | Two-Hybrid System Techniques | Animals | Transfection | Transcription, Genetic | Mice | Repressor Proteins - metabolism | Phosphates | Albumin | Gene expression | Phosphotransferases | Protein binding | Co-Ip, Co–immunoprecipitation | ER, estrogen receptor | mut, mutant | S1P, spningosine − 1- phosphate | AP-1, activator protein 1 | SARS-CoV, severe acute respiratory syndrome coronavirus | wt, wild type | HDAC, histone deacetylases | calmodulin-dependent kinases | DM, differentiation medium | GM, growth medium | bHLH, basic helix-loop-helix | CaMKK, Calcium | BSA, bovine serum albumin | MEF2, myocyte enhancer factor2 | PHB1, Prohibitin 1 | FBS, fetal bovine serum | WCEs, Whole cell extracts | Big 3, brefeldin A-inhibited guanine nucleotide-exchange protein 3 | CREB, cyclic-AMP response element binding protein | ca, constitutively active | CaMK IV, Calcium | PHB2, Prohibitin 2;CaMKs, calcium | Calmodulin-dependent kinase kinase | ROR, retinoid orphan receptor | Calmodulin-dependent kinase IV | RNF2, ring finger 2
Journal Article
Drug design, development and therapy, ISSN 1177-8881, 01/2020, Volume 14, pp. 2715 - 2723
Journal Article
Trends in Endocrinology & Metabolism, ISSN 1043-2760, 2016, Volume 27, Issue 10, pp. 706 - 718
...) to trigger a variety of downstream processes and pathways. Central to the actions of Ca2+ /CaM is the activation of a highly conserved Ca2+ /CaM kinase (CaMK... 
Endocrinology & Metabolism | AMPK | calcium | calmodulin | CaMKK2 | CaMKIV | RESPONSE ELEMENT | ENERGY-BALANCE | THYROID-HORMONE | CAMKK-BETA | CALMODULIN GENES | ENDOCRINOLOGY & METABOLISM | CALCIUM INTAKE | MOLECULAR-CLONING | CA2+/CALMODULIN-DEPENDENT PROTEIN-KINASE | BINDING PROTEIN | BONE MASS | Calcium | Calmodulin
Journal Article
International journal of molecular sciences, ISSN 1661-6596, 05/2019, Volume 20, Issue 9, p. 2063
Journal Article
Biochimica et biophysica acta. General subjects, ISSN 0304-4165, 10/2018, Volume 1862, Issue 10, pp. 2304 - 2313
Journal Article