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animals (157) 157
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Journal of Cellular Physiology, ISSN 0021-9541, 10/2014, Volume 229, Issue 10, pp. 1437 - 1443
Journal Article
Science, ISSN 0036-8075, 7/2011, Volume 333, Issue 6039, pp. 233 - 238
Journal Article
Journal of Cellular Physiology, ISSN 0021-9541, 12/2017, Volume 232, Issue 12, pp. 3744 - 3761
Strategies to treat cachexia are still at its infancy. Enhanced muscle protein breakdown and ubiquitin‐proteasome system are common features of cachexia... 
muscle atrophy and myosin loss | muscle anabolism and catabolism and mitochondrial content | PARP activity | Parp‐1−/− and Parp‐2−/− mice | cancer‐induced cachexia | Parp-1 | cancer-induced cachexia | and Parp-2 | mice | POLY(ADP-RIBOSE) POLYMERASE | PHYSIOLOGY | LIMB MUSCLES | ADP-RIBOSE-POLYMERASE | THORACIC-SURGERY | CELL BIOLOGY | SKELETAL-MUSCLE | INHIBITION | EXPERIMENTAL-MODEL | MITOCHONDRIAL DYSFUNCTION | EXPRESSION | Diaphragm - pathology | Oxidative Stress | Mitochondria, Muscle - metabolism | Lung Neoplasms - pathology | NF-kappa B - metabolism | Mice, 129 Strain | Ubiquitination | Time Factors | Proteolysis | Cachexia - etiology | Muscle Proteins - metabolism | Poly (ADP-Ribose) Polymerase-1 - deficiency | Female | Biomarkers - metabolism | Lung Neoplasms - genetics | Muscle, Skeletal - enzymology | Cachexia - genetics | Lung Neoplasms - enzymology | Signal Transduction | Mitochondria, Muscle - pathology | Mice, Inbred C57BL | Organ Size | Genotype | Poly (ADP-Ribose) Polymerase-1 - metabolism | Diaphragm - enzymology | Lung Neoplasms - complications | Mice, Knockout | Phenotype | Poly(ADP-ribose) Polymerases - metabolism | Animals | Poly(ADP-ribose) Polymerases - genetics | Cachexia - enzymology | Cachexia - pathology | Muscle Fibers, Skeletal - pathology | Cell Line, Tumor | Poly(ADP-ribose) Polymerases - deficiency | Mice, Inbred BALB C | Muscle, Skeletal - pathology | Proteasome Endopeptidase Complex - metabolism | Poly (ADP-Ribose) Polymerase-1 - genetics | Apoptosis | Muscle Fibers, Skeletal - enzymology | Ubiquitin | Tyrosine | Oxidative stress | Lung cancer | Cachexia | Mitochondrial DNA | Muscle proteins | Monosaccharides | Ligases | Myosin | Genetic aspects | Sugars | Adenocarcinoma | Chromatin | Poly(ADP-ribose) | AKT protein | ADP | Nuclei | Body composition | Fibers | Proteins | Degradation | Atrophy | Genotype & phenotype | Signal transduction | Protein composition | Body composition (biology) | Ribose | Rodents | Diaphragm (anatomy) | Oxidation | Polymers | Deoxyribonucleic acid--DNA | NF-κB protein | Markers | Contractility | Muscles | Poly(ADP-ribose) polymerase | Inflammation | Metabolism | Muscle contraction | Chronic conditions | Poly(ADP-ribose) Polymerase 1 | Proteasomes | Catabolism | Nuclei (cytology) | Mice | Diaphragm | Cancer | 62D05 Sampling theory, sample surveys | 92D Genetics and population dynamics | 62H Multivariate analysis | 92 Biology and other natural sciences | Anàlisi multivariable | Matemàtica aplicada a les ciències | Classificació AMS | Multivariate analysis | Parp-1-/- and Parp-2-/- mice | Anàlisi numèrica | Genètica | Sampling (Statistics) | Mostreig (Estadística) | Matemàtiques i estadística | Genetics | Probabilitat | 62 Statistics | Àrees temàtiques de la UPC
Journal Article
American Journal of Physiology - Regulatory Integrative and Comparative Physiology, ISSN 0363-6119, 04/2016, Volume 310, Issue 8, pp. R707 - R710
Janus kinase inhibition prevents cancer- and myocardial infarction-mediated diaphragm muscle weakness in mice. Am J Physiol Regul lntegr Comp Physiol 310: R707... 
Wasting | Critical illness | Janus Kinase | Diaphragm | SYSTEM | wasting | CACHEXIA | ACTIVATION | PHYSIOLOGY | critical illness | CASPASE-3 | diaphragm | Janus kinase | DYSFUNCTION | FAILURE | Respiration Disorders - etiology | Diaphragm - drug effects | Colonic Neoplasms - drug therapy | Respiration Disorders - enzymology | Male | Colonic Neoplasms - physiopathology | Janus Kinase 3 - antagonists & inhibitors | Janus Kinase 1 - metabolism | Muscle Weakness - enzymology | Respiration - drug effects | Cachexia - etiology | Myocardial Infarction - physiopathology | Janus Kinase 3 - metabolism | Muscle Weakness - prevention & control | Respiration Disorders - prevention & control | Diaphragm - physiopathology | Disease Models, Animal | Myocardial Infarction - enzymology | Muscle Weakness - etiology | Mice, Inbred C57BL | Respiration Disorders - physiopathology | Janus Kinase 1 - antagonists & inhibitors | Colonic Neoplasms - complications | Diaphragm - enzymology | Myocardial Infarction - complications | Animals | Myocardial Infarction - drug therapy | Signal Transduction - drug effects | Cachexia - enzymology | Muscle Contraction - drug effects | Colonic Neoplasms - enzymology | Muscle Strength - drug effects | Protein Kinase Inhibitors - pharmacology | Muscle Weakness - physiopathology | Cachexia - physiopathology | Prevention | Phosphotransferases | Health aspects | Heart attack | Rapid Report
Journal Article
Rheumatology International, ISSN 0172-8172, 11/2012, Volume 32, Issue 11, pp. 3517 - 3523
The aim of this study was to evaluate the morphological changes in the spleen, the thymus and the knee joints of rats with experimental adjuvant arthritis... 
Spleen | Medicine & Public Health | Granulocytes | Rheumatoid arthritis | Rheumatology | Methotrexate | Adjuvant arthritis | Thymus | RHEUMATOID-ARTHRITIS | CACHEXIA | OXIDATIVE STRESS | TISSUE | RATS | RHEUMATOLOGY | GAMMA-GLUTAMYL-TRANSPEPTIDASE | INHIBITION | NEUTROPHIL MIGRATION | ASSOCIATION | TRANSFERASE | Methotrexate - pharmacology | Arthritis, Experimental - drug therapy | Synovial Membrane - enzymology | Rats, Inbred Lew | Knee Joint - enzymology | Synovial Membrane - pathology | Male | Spleen - drug effects | Synovial Membrane - drug effects | Methotrexate - therapeutic use | Thymus Gland - enzymology | Cartilage, Articular - enzymology | Arthritis, Experimental - pathology | Knee Joint - pathology | Granulocytes - drug effects | Spleen - enzymology | Arthritis, Rheumatoid - drug therapy | Thymus Gland - pathology | Granulocytes - pathology | Antirheumatic Agents - pharmacology | Spleen - pathology | Antirheumatic Agents - therapeutic use | Knee Joint - drug effects | Rats | Arthritis, Rheumatoid - enzymology | gamma-Glutamyltransferase - metabolism | Thymus Gland - drug effects | Arthritis, Rheumatoid - pathology | Granulocytes - enzymology | Cartilage, Articular - pathology | Animals | Arthritis, Experimental - enzymology | Cartilage, Articular - drug effects | Physiological aspects | Rheumatoid factor | Universities and colleges
Journal Article
American Journal of Physiology - Endocrinology and Metabolism, ISSN 0193-1849, 05/2013, Volume 304, Issue 10, pp. E1042 - E1052
Although catabolic signaling has a well-established role in muscle wasting during cancer cachexia, the suppression of anabolic signaling also warrants further... 
IGF-I | STAT | Exercise | Protein synthesis | Colorectal cancer | Wasting | AMPK | Cachexia | Inflammation | Muscle | IL-6 | MTOR | RAT SKELETAL-MUSCLE | wasting | SIGNALING PATHWAYS | PHYSIOLOGY | colorectal cancer | ACTIVATED PROTEIN-KINASE | TURNOVER | ATROPHY | cachexia | protein synthesis | exercise | INTERLEUKIN-6 | inflammation | INSULIN-RESISTANCE | muscle | ENDOCRINOLOGY & METABOLISM | mTOR | BEARING MICE | C2C12 MYOTUBES | AMP-Activated Protein Kinases - metabolism | Phosphorylation | Multiprotein Complexes | Neoplasms, Experimental - enzymology | Muscle, Skeletal - metabolism | Muscle Fibers, Skeletal - metabolism | Aminoimidazole Carboxamide - pharmacology | Mechanistic Target of Rapamycin Complex 1 | Interleukin-6 - blood | Cachexia - metabolism | Interleukin-6 - metabolism | Real-Time Polymerase Chain Reaction | STAT3 Transcription Factor - metabolism | Pyrazoles - pharmacology | Muscle, Skeletal - enzymology | Signal Transduction | AMP-Activated Protein Kinases - antagonists & inhibitors | Mice, Inbred C57BL | RNA, Messenger - genetics | Pyrimidines - pharmacology | Recombinant Proteins - pharmacology | Physical Conditioning, Animal - physiology | Blotting, Western | Proteins - genetics | Animals | Proteins - metabolism | Interleukin-6 - pharmacology | Cachexia - enzymology | RNA, Messenger - chemistry | Mice | TOR Serine-Threonine Kinases | Neoplasms, Experimental - metabolism | STAT3 Transcription Factor - antagonists & inhibitors | Proteins - antagonists & inhibitors | AMP-Activated Protein Kinases - genetics | Muscle Fibers, Skeletal - enzymology
Journal Article
Journal Article
American Journal of Physiology - Cell Physiology, ISSN 0363-6143, 03/2010, Volume 298, Issue 3, pp. C542 - C549
McClung JM, Judge AR, Powers SK, Yan Z. p38 MAPK links oxidative stress to autophagy-related gene expression in cachectic muscle wasting. Am J Physiol Cell... 
Atrophy | Cachexia | Skeletal muscle | KAPPA-B ACTIVATION | PHYSIOLOGY | UBIQUITIN LIGASE | cachexia | JUN NH2-TERMINAL KINASE | CELLULAR STRESSES | FOXO TRANSCRIPTION FACTORS | CELL BIOLOGY | SKELETAL-MUSCLE | SUBSTRATE-SPECIFICITY | PATHWAY | IN-VIVO | atrophy | skeletal muscle | Phosphorylation | Cachexia - chemically induced | Mitogen-Activated Protein Kinase 14 - antagonists & inhibitors | Male | NF-kappa B - metabolism | Muscle Fibers, Skeletal - drug effects | Muscular Atrophy - chemically induced | Aldehydes - metabolism | Muscular Atrophy - enzymology | Autophagy - drug effects | Lipopolysaccharides | Mitogen-Activated Protein Kinase 11 - metabolism | Ubiquitination | Transfection | Mitogen-Activated Protein Kinase 14 - metabolism | Forkhead Transcription Factors - metabolism | Autophagy - genetics | Hydrogen Peroxide - toxicity | Cell Line | Cachexia - genetics | Dexamethasone | Mice, Inbred C57BL | Muscular Atrophy - pathology | Gene Expression Regulation | Oxidants - toxicity | Oxidative Stress - genetics | Muscular Atrophy - genetics | Imidazoles - pharmacology | Signal Transduction - genetics | Mitogen-Activated Protein Kinase 11 - antagonists & inhibitors | Forkhead Transcription Factors - genetics | Animals | NF-kappa B - genetics | Cachexia - enzymology | Cachexia - pathology | Muscle Fibers, Skeletal - pathology | Glycolysis | Mice | Protein Kinase Inhibitors - pharmacology | Protein Processing, Post-Translational | Pyridines - pharmacology | Enzyme Activation | Oxidative Stress - drug effects | Proteasome Endopeptidase Complex - metabolism | Forkhead Box Protein O3 | Muscle Fibers, Skeletal - enzymology | Physiological aspects | Oxidative stress | Genetic aspects | Gene expression | Mitogens | Muscle Cell Biology and Cell Motility
Journal Article
Journal Article
Journal Article