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1. Full Text Central tenet of cancer cachexia therapy: Do patients with advanced cancer have exploitable anabolic potential?
by Prado, Carla M and Sawyer, Michael B and Ghosh, Sunita and Lieffers, Jessica R and Esfandiari, Nina and Antoun, Sami and Baracos, Vickie E
American Journal of Clinical Nutrition, ISSN 0002-9165, 10/2013, Volume 98, Issue 4, pp. 1012 - 1019
Background: Skeletal muscle wasting is considered the central feature of cachexia, but the potential for skeletal muscle anabolism in patients with advanced... 
TOMOGRAPHY | SKELETAL-MUSCLE | NUTRITION & DIETETICS | DOUBLE-BLIND TRIAL | RESECTION | TISSUE | SARCOPENIA | BODY-COMPOSITION | PROTEIN-SYNTHESIS | Body Composition | Muscular Atrophy | Humans | Middle Aged | Lung Neoplasms - pathology | Male | Tomography, X-Ray Computed | Neoplasms - complications | Cachexia - etiology | Female | Cholangiocarcinoma - complications | Pancreatic Neoplasms - pathology | Adipose Tissue - pathology | Neoplasms - mortality | Survival Rate | Metabolism | Lung Neoplasms - complications | Cholangiocarcinoma - pathology | Cachexia - pathology | Cachexia - therapy | Aged | Colorectal Neoplasms - complications | Muscle, Skeletal - pathology | Colorectal Neoplasms - pathology | Neoplasm Staging | Neoplasms - pathology | Longitudinal Studies | Pancreatic Neoplasms - complications | Physiological aspects | Muscles | Complications and side effects | Cachexia | Research
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2. Full Text Understanding, recognizing, and managing toxicities of targeted anticancer therapies
by Dy, Grace K and Adjei, Alex A
CA: A Cancer Journal for Clinicians, ISSN 0007-9235, 07/2013, Volume 63, Issue 4, pp. 249 - 279
Answer questions and earn CME/CNE Advances in genomics and molecular biology have identified aberrant proteins in cancer cells that are attractive targets for... 
toxicity | kinase inhibitors | therapeutic index | targeted agents | mechanism‐based toxicity | immunotherapeutic agents | off‐target toxicity | mechanism-based toxicity | off-target toxicity | MEK INHIBITOR TRAMETINIB | PULMONARY ARTERIAL-HYPERTENSION | I DOSE-ESCALATION | CHRONIC MYELOID-LEUKEMIA | GROWTH-FACTOR RECEPTOR | ONCOLOGY | PLACEBO-CONTROLLED TRIAL | III CLINICAL-TRIAL | SQUAMOUS-CELL CARCINOMAS | TIVANTINIB ARQ 197 | SIGNAL-REGULATED KINASE | Mood Disorders - chemically induced | Drug Eruptions - etiology | Peripheral Nervous System Diseases - chemically induced | Bone Marrow Diseases - chemically induced | Cachexia - chemically induced | Endocrine System Diseases - chemically induced | Pleural Effusion - chemically induced | Humans | Drug Eruptions - therapy | Immune System Diseases - chemically induced | Lung Diseases, Interstitial - chemically induced | Thrombocytopenia - chemically induced | Diarrhea - chemically induced | Neoplasms - drug therapy | Antineoplastic Agents - adverse effects | Exanthema - chemically induced | Hyperbilirubinemia - chemically induced | Venous Thromboembolism - chemically induced | Vision Disorders - chemically induced | Hemorrhage - chemically induced | Heart Diseases - chemically induced | Hyperlipidemias - chemically induced | Magnesium - blood | Antimitotic agents | Drugs | Prevention | Complications and side effects | Drug targeting | Antineoplastic agents | Health aspects | Risk factors | Proteins | Side effects | Genomics | Cytotoxicity | Molecular biology | Cancer therapies | Cells | Index Medicus | Abridged Index Medicus
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3. Full Text Marine polyunsaturated fatty acids and cancer therapy
by Vaughan, V.C and Hassing, M.-R and Lewandowski, P.A
British Journal of Cancer, ISSN 0007-0920, 02/2013, Volume 108, Issue 3, pp. 486 - 492
Polyunsaturated fatty acids (PUFAs) derived from marine sources, including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are widely consumed as... 
LEAN BODY-MASS | polyunsaturated fatty acids | cachexia | chemotherapy | BREAST-CANCER | eicosapentaenoic acid | ADVANCED LUNG-CANCER | PHASE-II TRIAL | ONCOLOGY | N-3 | docosahexaenoic acid | COLORECTAL-CANCER | DOUBLE-BLIND | FISH-OIL | Fish Oils - administration & dosage | Neoplasms - prevention & control | Animals | Humans | Fatty Acids, Unsaturated - administration & dosage | Minireview
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4. Full Text Cancer cachexia: Developing multimodal therapy for a multidimensional problem
by Fearon, K.C.H
European Journal of Cancer, ISSN 0959-8049, 2008, Volume 44, Issue 8, pp. 1124 - 1132
Abstract Cancer cachexia is a multi-factorial syndrome that encompasses a spectrum from early weight loss (pre-cachexia) to a state of severe incapacity... 
Hematology, Oncology and Palliative Medicine | Clinical trials | Cancer cachexia | Multimodal therapy | Pathophysiology | GASTROESOPHAGEAL CANCER | multimodal therapy | cancer cachexia | PANCREATIC-CANCER | WEIGHT-LOSS | SYSTEMIC INFLAMMATION | SKELETAL-MUSCLE | TUMOR-NECROSIS-FACTOR | MUSCLE PROTEIN-SYNTHESIS | ACUTE-PHASE | ONCOLOGY | pathophysiology | clinical trials | QUALITY-OF-LIFE | UBIQUITIN-PROTEASOME PATHWAY | Biomarkers - metabolism | Cachexia - mortality | Age Factors | Humans | Middle Aged | Neoplasms - mortality | Muscle, Skeletal - physiology | Neoplasms - complications | Proteins - metabolism | Cachexia - therapy | Cachexia - etiology | Muscular Atrophy - diagnosis | Quality of Life | Aged | Exercise - physiology | Muscular Atrophy - etiology | Cachexia | Health aspects | Analysis | Cancer
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5. Full Text Ghrelin: from discovery to cancer cachexia therapy
by Molfino, Alessio and Formiconi, Alessandra and Fanelli, Filippo Rossi and Muscaritoli, Maurizio
Current Opinion in Clinical Nutrition and Metabolic Care, ISSN 1363-1950, 09/2014, Volume 17, Issue 5, pp. 471 - 476
PURPOSE OF REVIEWDespite the high prevalence of cancer cachexia, a condition that negatively impacts patients’ prognosis and quality of life, effective... 
ghrelin | cancer | growth hormone secretagogue receptor antagonist | growth hormone secretagogue receptor agonist | muscle wasting | cachexia | APOPTOSIS | CELLS | NUTRITION & DIETETICS | INHIBITION | ANAMORELIN | GROWTH | ENDOCRINOLOGY & METABOLISM | FAT | APPETITE | Neoplasms - complications | Cachexia - drug therapy | Ghrelin - therapeutic use | Wasting Syndrome - drug therapy | Humans | Cachexia - etiology | Muscular Atrophy - drug therapy
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6. Nutritional Therapy in Gastrointestinal Cancers
by Garla, Priscila and Waitzberg, Dan Linetzky and Tesser, Alweyd
Gastroenterology Clinics of North America, ISSN 0889-8553, 03/2018, Volume 47, Issue 1, pp. 231 - 242
Malnutrition is the most frequent nutritional disorder in patients with gastrointestinal cancer and is associated with cachexia syndrome, worsening of... 
Cachexia | Immunonutrition | Early enteral nutrition | Nutrition screening | Malnutrition | Cancer | SURGERY | RANDOMIZED CONTROLLED-TRIALS | METAANALYSIS | FATTY-ACIDS | ENTERAL NUTRITION | SUPPORT THERAPY | ESPEN GUIDELINES | PERIOPERATIVE IMMUNONUTRITION | GASTROENTEROLOGY & HEPATOLOGY | EICOSAPENTAENOIC ACID | Malnutrition - therapy | Perioperative Care | Immune System | Malnutrition - prevention & control | Humans | Malnutrition - etiology | Gastrointestinal Neoplasms - complications | Palliative Care | Nutritional Status | Gastrointestinal Neoplasms - therapy | Nutritional Support | Nutrition Assessment
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7. Nutritional assessment and therapy in COPD: A European respiratory society statement
by Schols, Annemie M and Ferreira, Ivone M and Franssen, Frits M and Gosker, Harry R and Janssens, Wim and Muscaritoli, Maurizio and Pison, Christophe and Rutten-Van Mölken, Maureen and Slinde, Frode and Steiner, Michael C and Tkacova, Ruzena and Singh, Sally J
European Respiratory Journal, ISSN 0903-1936, 12/2014, Volume 44, Issue 6, pp. 1504 - 1520
Nutrition and metabolism have been the topic of extensive scientific research in chronic obstructive pulmonary disease (COPD) but clinical awareness of the... 
MALNOURISHED PATIENTS | OBSTRUCTIVE PULMONARY-DISEASE | BONE-MINERAL DENSITY | RESPIRATORY SYSTEM | CAUSE-SPECIFIC MORTALITY | 3RD NATIONAL-HEALTH | WHOLE-BODY PROTEIN | LUNG-FUNCTION | POLYUNSATURATED FATTY-ACIDS | RANDOMIZED CONTROLLED-TRIAL | VITAMIN-D DEFICIENCY | Body Composition | Cachexia - complications | Nutrition Disorders - diagnosis | Obesity - diet therapy | Pulmonary Disease, Chronic Obstructive - diagnosis | Cachexia - diagnosis | Obesity - complications | Europe | Humans | Risk Factors | Cachexia - diet therapy | Sarcopenia - complications | Sarcopenia - diagnosis | Nutrition Disorders - diet therapy | Pulmonary Disease, Chronic Obstructive - complications | Advisory Committees | Nutrition Assessment | Phenotype | Exercise | Societies, Medical | Obesity - diagnosis | Nutritional Status | Sarcopenia - diet therapy | Nutrition Disorders - complications | Index Medicus
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8. Full Text Novel targeted therapies for cancer cachexia
by Argilés, Josep M and López-Soriano, Francisco Javier and Stemmler, Britta and Busquets, Sílvia
Biochemical Journal, ISSN 0264-6021, 08/2017, Volume 474, Issue 16, pp. 2663 - 2678
Anorexia and metabolic alterations are the main components of the cachectic syndrome. Glucose intolerance, fat depletion, muscle protein catabolism and other... 
CELL LUNG-CANCER | SKELETAL-MUSCLE | TUMOR-NECROSIS-FACTOR | MEGESTROL-ACETATE | HYDROXY-BETA-METHYLBUTYRATE | LEAN BODY-MASS | GROWTH-HORMONE | RESISTANCE EXERCISE | BIOCHEMISTRY & MOLECULAR BIOLOGY | DOUBLE-BLIND | ANOREXIA-CACHEXIA | Exercise Therapy - methods | Neoplasms - metabolism | Androgen Receptor Antagonists - therapeutic use | Anorexia - therapy | Humans | Anorexia - metabolism | Anorexia - pathology | Ghrelin - agonists | Myostatin - antagonists & inhibitors | Neoplasms - therapy | Cachexia - pathology | Cachexia - therapy | Diet Therapy - methods | Myostatin - metabolism | Neoplasms - pathology | Cachexia - metabolism | Peptides - therapeutic use | Adrenergic beta-Antagonists - therapeutic use
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9. Full Text Exercise Training as Therapy for Cancer-Induced Cardiac Cachexia
by Antunes, J.M.M and Ferreira, Rita M.P and Moreira-Gonçalves, Daniel
Trends in Molecular Medicine, ISSN 1471-4914, 08/2018, Volume 24, Issue 8, pp. 709 - 727
Cancer-induced cardiac cachexia is an insidious syndrome with a dramatic impact on a patient’s quality of life and survival. Since exercise training provides... 
cancer | therapy | prevention | cardiac remodeling | physical activity | MEDICINE, RESEARCH & EXPERIMENTAL | STEM-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | HEART-FAILURE | INDUCED CARDIOMYOPATHY | CACHECTIC HEART | UBIQUITIN LIGASES | RAT MODEL | CELL BIOLOGY | SKELETAL-MUSCLE | CARDIOVASCULAR-DISEASE | AEROBIC EXERCISE | ATROPHY IN-VIVO | Cachexia - diagnosis | Humans | Heart Diseases - prevention & control | Cachexia - prevention & control | Exercise Therapy | Heart Diseases - diagnosis | Neoplasms - complications | Heart Diseases - etiology | Ventricular Remodeling | Animals | Exercise | Heart Diseases - therapy | Cachexia - therapy | Cachexia - etiology
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